LOCUS       NM_173833               3971 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens scavenger receptor class A member 5 (SCARA5),
            transcript variant 1, mRNA.
ACCESSION   NM_173833
VERSION     NM_173833.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3971)
  AUTHORS   Lu,X.S., Huang,M.L., Chen,L.B., Liu,S.C., Huang,Z.X. and Liu,S.M.
  TITLE     SCARA5 as a downstream factor of PCAT29, inhibits proliferation,
            migration, and invasion of bladder cancer
  JOURNAL   Genomics 115 (5), 110667 (2023)
   PUBMED   37315873
  REMARK    GeneRIF: SCARA5 as a downstream factor of PCAT29, inhibits
            proliferation, migration, and invasion of bladder cancer.
REFERENCE   2  (bases 1 to 3971)
  AUTHORS   Jiang,X., Jiang,Y., An,D., Jiang,X., Zhou,S., Liu,Y., Tian,R.,
            Li,Z., Zhao,X., Xiang,T., Ji,P. and Yang,Y.
  TITLE     Methylated tumor suppressor gene SCARA5 inhibits the proliferation,
            migration and invasion of nasopharyngeal carcinoma
  JOURNAL   Epigenomics 15 (11), 635-650 (2023)
   PUBMED   37554122
  REMARK    GeneRIF: Methylated tumor suppressor gene SCARA5 inhibits the
            proliferation, migration and invasion of nasopharyngeal carcinoma.
REFERENCE   3  (bases 1 to 3971)
  AUTHORS   Lu,X., Chen,L., Liu,S., Cao,Y. and Huang,Z.
  TITLE     m6A-mediated upregulation of lncRNA RMRP boosts the progression of
            bladder cancer via epigenetically suppressing SCARA5
  JOURNAL   Epigenomics 15 (7), 401-415 (2023)
   PUBMED   37337726
  REMARK    GeneRIF: m[6]A-mediated upregulation of lncRNA RMRP boosts the
            progression of bladder cancer via epigenetically suppressing
            SCARA5.
REFERENCE   4  (bases 1 to 3971)
  AUTHORS   Liu,Y., Xiong,R., Xiao,T., Xiong,L., Wu,J., Li,J., Feng,G., Song,G.
            and Liu,K.
  TITLE     SCARA5 induced ferroptosis to effect ESCC proliferation and
            metastasis by combining with Ferritin light chain
  JOURNAL   BMC Cancer 22 (1), 1304 (2022)
   PUBMED   36513999
  REMARK    GeneRIF: SCARA5 induced ferroptosis to effect ESCC proliferation
            and metastasis by combining with Ferritin light chain.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3971)
  AUTHORS   Antoni,G., Oudot-Mellakh,T., Dimitromanolakis,A., Germain,M.,
            Cohen,W., Wells,P., Lathrop,M., Gagnon,F., Morange,P.E. and
            Tregouet,D.A.
  TITLE     Combined analysis of three genome-wide association studies on vWF
            and FVIII plasma levels
  JOURNAL   BMC Med Genet 12, 102 (2011)
   PUBMED   21810271
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3971)
  AUTHORS   Morange,P.E., Saut,N., Antoni,G., Emmerich,J. and Tregouet,D.A.
  TITLE     Impact on venous thrombosis risk of newly discovered gene variants
            associated with FVIII and VWF plasma levels
  JOURNAL   J Thromb Haemost 9 (1), 229-231 (2011)
   PUBMED   21029358
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 3971)
  AUTHORS   Duncan,W.C., Shaw,J.L., Burgess,S., McDonald,S.E., Critchley,H.O.
            and Horne,A.W.
  TITLE     Ectopic pregnancy as a model to identify endometrial genes and
            signaling pathways important in decidualization and regulated by
            local trophoblast
  JOURNAL   PLoS One 6 (8), e23595 (2011)
   PUBMED   21858178
  REMARK    GeneRIF: Data show that decidualization was associated with
            increased expression of 428 genes including SCARA5 (181-fold), DKK1
            (71-fold) and PROK1 (32-fold), and decreased expression of 230
            genes including MMP-7 (35-fold) and SFRP4 (21-fold).
REFERENCE   8  (bases 1 to 3971)
  AUTHORS   Li,J.Y., Paragas,N., Ned,R.M., Qiu,A., Viltard,M., Leete,T.,
            Drexler,I.R., Chen,X., Sanna-Cherchi,S., Mohammed,F., Williams,D.,
            Lin,C.S., Schmidt-Ott,K.M., Andrews,N.C. and Barasch,J.
  TITLE     Scara5 is a ferritin receptor mediating non-transferrin iron
            delivery
  JOURNAL   Dev Cell 16 (1), 35-46 (2009)
   PUBMED   19154717
REFERENCE   9  (bases 1 to 3971)
  AUTHORS   Jiang,Y., Oliver,P., Davies,K.E. and Platt,N.
  TITLE     Identification and characterization of murine SCARA5, a novel class
            A scavenger receptor that is expressed by populations of epithelial
            cells
  JOURNAL   J Biol Chem 281 (17), 11834-11845 (2006)
   PUBMED   16407294
REFERENCE   10 (bases 1 to 3971)
  AUTHORS   Sarraj,M.A., McClive,P.J., Wilmore,H.P., Loveland,K.L. and
            Sinclair,A.H.
  TITLE     Novel scavenger receptor gene is differentially expressed in the
            embryonic and adult mouse testis
  JOURNAL   Dev Dyn 234 (4), 1026-1033 (2005)
   PUBMED   16245330
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC069113.9 and AC104997.4.
            
            On Nov 23, 2018 this sequence version replaced NM_173833.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK172746.1, DRR138524.1168012.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467144 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000354914.8/ ENSP00000346990.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-417               AC069113.9         173520-173936       c
            418-544             AC069113.9         168767-168893       c
            545-673             AC069113.9         147677-147805       c
            674-1348            AC069113.9         102834-103508       c
            1349-1429           AC069113.9         90926-91006         c
            1430-1528           AC069113.9         88411-88509         c
            1529-1585           AC069113.9         86041-86097         c
            1586-1783           AC104997.4         4557-4754
            1784-3971           AC104997.4         12253-14440
FEATURES             Location/Qualifiers
     source          1..3971
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p21.1"
     gene            1..3971
                     /gene="SCARA5"
                     /gene_synonym="NET33; Tesr"
                     /note="scavenger receptor class A member 5"
                     /db_xref="GeneID:286133"
                     /db_xref="HGNC:HGNC:28701"
                     /db_xref="MIM:611306"
     exon            1..417
                     /gene="SCARA5"
                     /gene_synonym="NET33; Tesr"
                     /inference="alignment:Splign:2.1.0"
     exon            418..544
                     /gene="SCARA5"
                     /gene_synonym="NET33; Tesr"
                     /inference="alignment:Splign:2.1.0"
     CDS             433..1920
                     /gene="SCARA5"
                     /gene_synonym="NET33; Tesr"
                     /note="isoform 1 is encoded by transcript variant 1;
                     testis expressed scavenger receptor; scavenger receptor
                     hlg; scavenger receptor class A, member 5 (putative)"
                     /codon_start=1
                     /product="scavenger receptor class A member 5 isoform 1"
                     /protein_id="NP_776194.2"
                     /db_xref="CCDS:CCDS6064.1"
                     /db_xref="GeneID:286133"
                     /db_xref="HGNC:HGNC:28701"
                     /db_xref="MIM:611306"
                     /translation="MENKAMYLHTVSDCDTSSICEDSFDGRSLSKLNLCEDGPCHKRR
                     ASICCTQLGSLSALKHAVLGLYLLVFLILVGIFILAVSRPRSSPDDLKALTRNVNRLN
                     ESFRDLQLRLLQAPLQADLTEQVWKVQDALQNQSDSLLALAGAVQRLEGALWGLQAQA
                     VQTEQAVALLRDRTGQQSDTAQLELYQLQVESNSSQLLLRRHAGLLDGLARRVGILGE
                     ELADVGGVLRGLNHSLSYDVALHRTRLQDLRVLVSNASEDTRRLRLAHVGMELQLKQE
                     LAMLNAVTEDLRLKDWEHSIALRNISLAKGPPGPKGDQGDEGKEGRPGIPGLPGLRGL
                     PGERGTPGLPGPKGDDGKLGATGPMGMRGFKGDRGPKGEKGEKGDRAGDASGVEAPMM
                     IRLVNGSGPHEGRVEVYHDRRWGTVCDDGWDKKDGDVVCRMLGFRGVEEVYRTARFGQ
                     GTGRIWMDDVACKGTEETIFRCSFSKWGVTNCGHAEDASVTCNRH"
     exon            545..673
                     /gene="SCARA5"
                     /gene_synonym="NET33; Tesr"
                     /inference="alignment:Splign:2.1.0"
     exon            674..1348
                     /gene="SCARA5"
                     /gene_synonym="NET33; Tesr"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1429
                     /gene="SCARA5"
                     /gene_synonym="NET33; Tesr"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..1528
                     /gene="SCARA5"
                     /gene_synonym="NET33; Tesr"
                     /inference="alignment:Splign:2.1.0"
     exon            1529..1585
                     /gene="SCARA5"
                     /gene_synonym="NET33; Tesr"
                     /inference="alignment:Splign:2.1.0"
     exon            1586..1783
                     /gene="SCARA5"
                     /gene_synonym="NET33; Tesr"
                     /inference="alignment:Splign:2.1.0"
     exon            1784..3971
                     /gene="SCARA5"
                     /gene_synonym="NET33; Tesr"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3784..3789
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCARA5"
                     /gene_synonym="NET33; Tesr"
                     /note="hexamer: AATAAA"
     polyA_site      3821
                     /gene="SCARA5"
                     /gene_synonym="NET33; Tesr"
     regulatory      3948..3953
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCARA5"
                     /gene_synonym="NET33; Tesr"
                     /note="hexamer: AATAAA"
     polyA_site      3971
                     /gene="SCARA5"
                     /gene_synonym="NET33; Tesr"
                     /note="major polyA site"
ORIGIN      
        1 atacggactg gcggcgagag cagctgcagt tcgcatctca ggcagtacct agaggagctg
       61 ccggtgcctc ctcagaacat ctcctgatcg ctacccagga ccaggcacca aggacaggga
      121 gtcccaggcg cacacccccc attctgggtc ccccaggccc agacccccac tctgccacag
      181 gttgcatctt gacctggtcc tcctgcagaa gtggcccctg tggtcctgct ctgagactcg
      241 tccctgggcg cccctgcagc ccctttctat gactccatct ggatttggct ggctgtgggg
      301 acgcggtccg aggggcggcc tggctctcag cgtggtggca gccagctctc tggccaccat
      361 ggcaaatgct gagatctgag gggacaaggc tctacagcct cagccagggg cactcagctg
      421 ttgcagggtg tgatggagaa caaagctatg tacctacaca ccgtcagcga ctgtgacacc
      481 agctccatct gtgaggattc ctttgatggc aggagcctgt ccaagctgaa cctgtgtgag
      541 gatggtccat gtcacaaacg gcgggcaagc atctgctgta cccagctggg gtccctgtcg
      601 gccctgaagc atgctgtcct ggggctctac ctgctggtct tcctgattct tgtgggcatc
      661 ttcatcttag cagtgtccag gccgcgcagc tcccctgacg acctgaaggc cctgactcgc
      721 aatgtgaacc ggctgaatga gagcttccgg gacttgcagc tgcggctgct gcaggctccg
      781 ctgcaagcgg acctgacgga gcaggtgtgg aaggtgcagg acgcgctgca gaaccagtca
      841 gactcgttgc tggcgctggc gggcgcagtg cagcggctgg agggcgcgct gtgggggctg
      901 caggcgcagg cggtgcagac cgagcaggcg gtggccctgc tgcgggaccg cacgggccag
      961 cagagcgaca cggcgcagct ggagctctac cagctgcagg tggagagcaa cagtagccag
     1021 ctgctgctga ggcgccacgc gggcctgctg gacgggctgg cgcgcagggt gggcatcctg
     1081 ggcgaggagc tggccgacgt gggcggcgtg ctgcgcggcc tcaaccacag cctgtcctac
     1141 gacgtggccc tccaccgcac gcggctgcag gacctgcggg tgctggtgag caacgccagc
     1201 gaggacacgc gccgcctgcg cctggcgcac gtaggcatgg agctgcagct gaagcaggag
     1261 ctggccatgc tcaacgcggt caccgaggac ctgcgcctca aggactggga gcactccatc
     1321 gcactgcgga acatctccct cgcgaaaggg ccaccgggac ccaaaggtga tcagggggat
     1381 gaaggaaagg aaggcaggcc tggcatccct ggattgcctg gacttcgagg tctgcccggg
     1441 gagagaggta ccccaggatt gcccgggccc aagggcgatg atgggaagct gggggccaca
     1501 ggaccaatgg gcatgcgtgg gttcaaaggt gaccgaggcc caaaaggaga gaaaggagag
     1561 aaaggagaca gagctgggga tgccagtggc gtggaggccc cgatgatgat ccgcctggtg
     1621 aatggctcag gtccgcacga gggccgcgtg gaagtgtacc acgaccggcg ttggggcacc
     1681 gtgtgtgacg acggctggga caagaaggac ggagacgtgg tgtgccgcat gctcggcttc
     1741 cgcggtgtgg aggaggtgta ccgcacagct cgattcgggc aaggcactgg gaggatctgg
     1801 atggatgacg ttgcctgcaa gggcacagag gaaaccatct tccgctgcag cttctccaaa
     1861 tggggggtga caaactgtgg acatgccgaa gatgccagcg tgacatgcaa cagacactga
     1921 aagtgggcag agcccaagtt cggggtcctg cacagagcac ccttcctgca tccctggggt
     1981 ggggcacagc tcggggccac cctgaccatg cctcgaccac accccgtcca gcattctcag
     2041 tcctcacacc tgcatcccag gaccgtgggg gccggtcgtc atttccctct tgaacatgtg
     2101 ctccgaagta taactctggg acctactgcc cgtctctctc ttccaccagg ttcctgcatg
     2161 aggagccctg atcaactgga tcaccacttt gcccagcctc tgaacaccat gcaccaggcc
     2221 tcaatatccc agttcccttt ggccttttag ttacaggtga atgctgagaa tgtgtcagag
     2281 acaagtgcag cagcagcgat ggttggtagt atagatcatt tactcttcag acaattccca
     2341 aacctccatt agtccaagag tttctacatc ttcctcccca gcaagaggca acgtcaagtg
     2401 atgaatttcc cccctttact ctgcctctgc tccccatttg ctagtttgag gaagtgacat
     2461 agaggagaag ccagctgtag gggcaagagg gaaatgcaag tcacctgcag gaatccagct
     2521 agatttggag aagggaatga aactaacatt gaatgactac catggcacgc taaatagtat
     2581 cttgggtgcc aaattcatgt atccacttag ctgcattggt ccagggcatg tcagtctgga
     2641 tacagcctta cctccaggta gcacttaact ggtccattca cctagactgc aagtaagaag
     2701 acaaaatgac tgagaccgtg tgcccacctg aacttattgt ctttacttgg cctgagctaa
     2761 aagcttgggt gcaggacctg tgtaactaga aagttgccta cttcagaacc tccagggcgt
     2821 gagtgcaagg tcaaacatga ctggcttcca ggccgaccat caatgtagga ggagagctga
     2881 tgtggagggt gacatggggg ctgcccatgt taaacctgag tccagtgctc tggcattggg
     2941 cagtcacggt taaagccaag tcatgtgtgt ctcagctgtt tggaggtgat gattttgcat
     3001 cttccaagcc tcttcaggtg tgaatctgtg gtcaggaaaa cacaagtcct aatggaaccc
     3061 ttagggggga aggaaatgaa gattccctat aacctctggg ggtggggagt aggaataagg
     3121 ggccttgggc ctccataaat ctgcaatctg caccctcctc ctagagacag ggagatcgtg
     3181 ttctgctttt tacatgagga gcagaactgg gccatacaca tgttcaagaa ctaggggagc
     3241 tacctggtag caagtgagtg cagacccacc tcaccttggg ggaatctcaa actcataggc
     3301 ctcagataca cgatcacctg tcatatcagg tgagcactgg cctgcttggg gagagacctg
     3361 ggcccctcca ggtgtaggaa cagcaacact cctggctgac aactaagcca atatggccct
     3421 aggtcattct tgcttccaat atgcttgcca ctccttaaat gtcctaatga tgagaaactc
     3481 tctttctgac caattgctat gtttacataa cacgcatgta ctcatgcatc ccttgccaga
     3541 gcccatatat gtatgcatat ataaacatag cactttttac tacatagctc agcacattgc
     3601 aaggtttgca tttaagttaa aaaaaaaaaa aaaaaaaaac taaaggtgaa agatgccaca
     3661 ttgaacaaac taaattccca acccggttct ggcaaagaat ccagttatcc cttccatgaa
     3721 gacgcacata actctcttac ttggtctttc cattagggac aacataagtc ttgttttaca
     3781 tcaaataaaa acaatgttaa aaagtgtgtg aaccttaaaa atggaagtct actagtttac
     3841 atacctactt cagaggacat ggaaatgacc atgggcctgc atttcaggga ccaaagcaaa
     3901 ttaggcctgg cctaaaatac atcagacctt ttgtaagaaa gaatttcaat aaagcaaaaa
     3961 acatgtcaca a
//
