LOCUS       NP_776194                495 aa            linear   PRI 28-APR-2025
DEFINITION  scavenger receptor class A member 5 isoform 1 [Homo sapiens].
ACCESSION   NP_776194
VERSION     NP_776194.2
DBSOURCE    REFSEQ: accession NM_173833.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 495)
  AUTHORS   Lu,X.S., Huang,M.L., Chen,L.B., Liu,S.C., Huang,Z.X. and Liu,S.M.
  TITLE     SCARA5 as a downstream factor of PCAT29, inhibits proliferation,
            migration, and invasion of bladder cancer
  JOURNAL   Genomics 115 (5), 110667 (2023)
   PUBMED   37315873
  REMARK    GeneRIF: SCARA5 as a downstream factor of PCAT29, inhibits
            proliferation, migration, and invasion of bladder cancer.
REFERENCE   2  (residues 1 to 495)
  AUTHORS   Jiang,X., Jiang,Y., An,D., Jiang,X., Zhou,S., Liu,Y., Tian,R.,
            Li,Z., Zhao,X., Xiang,T., Ji,P. and Yang,Y.
  TITLE     Methylated tumor suppressor gene SCARA5 inhibits the proliferation,
            migration and invasion of nasopharyngeal carcinoma
  JOURNAL   Epigenomics 15 (11), 635-650 (2023)
   PUBMED   37554122
  REMARK    GeneRIF: Methylated tumor suppressor gene SCARA5 inhibits the
            proliferation, migration and invasion of nasopharyngeal carcinoma.
REFERENCE   3  (residues 1 to 495)
  AUTHORS   Lu,X., Chen,L., Liu,S., Cao,Y. and Huang,Z.
  TITLE     m6A-mediated upregulation of lncRNA RMRP boosts the progression of
            bladder cancer via epigenetically suppressing SCARA5
  JOURNAL   Epigenomics 15 (7), 401-415 (2023)
   PUBMED   37337726
  REMARK    GeneRIF: m[6]A-mediated upregulation of lncRNA RMRP boosts the
            progression of bladder cancer via epigenetically suppressing
            SCARA5.
REFERENCE   4  (residues 1 to 495)
  AUTHORS   Liu,Y., Xiong,R., Xiao,T., Xiong,L., Wu,J., Li,J., Feng,G., Song,G.
            and Liu,K.
  TITLE     SCARA5 induced ferroptosis to effect ESCC proliferation and
            metastasis by combining with Ferritin light chain
  JOURNAL   BMC Cancer 22 (1), 1304 (2022)
   PUBMED   36513999
  REMARK    GeneRIF: SCARA5 induced ferroptosis to effect ESCC proliferation
            and metastasis by combining with Ferritin light chain.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 495)
  AUTHORS   Antoni,G., Oudot-Mellakh,T., Dimitromanolakis,A., Germain,M.,
            Cohen,W., Wells,P., Lathrop,M., Gagnon,F., Morange,P.E. and
            Tregouet,D.A.
  TITLE     Combined analysis of three genome-wide association studies on vWF
            and FVIII plasma levels
  JOURNAL   BMC Med Genet 12, 102 (2011)
   PUBMED   21810271
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 495)
  AUTHORS   Morange,P.E., Saut,N., Antoni,G., Emmerich,J. and Tregouet,D.A.
  TITLE     Impact on venous thrombosis risk of newly discovered gene variants
            associated with FVIII and VWF plasma levels
  JOURNAL   J Thromb Haemost 9 (1), 229-231 (2011)
   PUBMED   21029358
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (residues 1 to 495)
  AUTHORS   Duncan,W.C., Shaw,J.L., Burgess,S., McDonald,S.E., Critchley,H.O.
            and Horne,A.W.
  TITLE     Ectopic pregnancy as a model to identify endometrial genes and
            signaling pathways important in decidualization and regulated by
            local trophoblast
  JOURNAL   PLoS One 6 (8), e23595 (2011)
   PUBMED   21858178
  REMARK    GeneRIF: Data show that decidualization was associated with
            increased expression of 428 genes including SCARA5 (181-fold), DKK1
            (71-fold) and PROK1 (32-fold), and decreased expression of 230
            genes including MMP-7 (35-fold) and SFRP4 (21-fold).
REFERENCE   8  (residues 1 to 495)
  AUTHORS   Li,J.Y., Paragas,N., Ned,R.M., Qiu,A., Viltard,M., Leete,T.,
            Drexler,I.R., Chen,X., Sanna-Cherchi,S., Mohammed,F., Williams,D.,
            Lin,C.S., Schmidt-Ott,K.M., Andrews,N.C. and Barasch,J.
  TITLE     Scara5 is a ferritin receptor mediating non-transferrin iron
            delivery
  JOURNAL   Dev Cell 16 (1), 35-46 (2009)
   PUBMED   19154717
REFERENCE   9  (residues 1 to 495)
  AUTHORS   Jiang,Y., Oliver,P., Davies,K.E. and Platt,N.
  TITLE     Identification and characterization of murine SCARA5, a novel class
            A scavenger receptor that is expressed by populations of epithelial
            cells
  JOURNAL   J Biol Chem 281 (17), 11834-11845 (2006)
   PUBMED   16407294
REFERENCE   10 (residues 1 to 495)
  AUTHORS   Sarraj,M.A., McClive,P.J., Wilmore,H.P., Loveland,K.L. and
            Sinclair,A.H.
  TITLE     Novel scavenger receptor gene is differentially expressed in the
            embryonic and adult mouse testis
  JOURNAL   Dev Dyn 234 (4), 1026-1033 (2005)
   PUBMED   16245330
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC069113.9 and AC104997.4.
            
            On May 16, 2004 this sequence version replaced NP_776194.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK172746.1, DRR138524.1168012.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467144 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000354914.8/ ENSP00000346990.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p21.1"
     Protein         1..495
                     /product="scavenger receptor class A member 5 isoform 1"
                     /note="testis expressed scavenger receptor; scavenger
                     receptor hlg; scavenger receptor class A, member 5
                     (putative)"
                     /calculated_mol_wt=53863
     Site            61..81
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6ZMJ2.1)"
     Region          66..>288
                     /region_name="EnvC"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; COG4942"
                     /db_xref="CDD:443969"
     Site            102
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|HAMAP-Rule:MF_03070; propagated from
                     UniProtKB/Swiss-Prot (Q6ZMJ2.1)"
     Site            134
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|HAMAP-Rule:MF_03070; propagated from
                     UniProtKB/Swiss-Prot (Q6ZMJ2.1)"
     Site            193
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|HAMAP-Rule:MF_03070; propagated from
                     UniProtKB/Swiss-Prot (Q6ZMJ2.1)"
     Site            231
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|HAMAP-Rule:MF_03070; propagated from
                     UniProtKB/Swiss-Prot (Q6ZMJ2.1)"
     Site            254
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|HAMAP-Rule:MF_03070; propagated from
                     UniProtKB/Swiss-Prot (Q6ZMJ2.1)"
     Region          301..386
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6ZMJ2.1)"
     Region          <304..>383
                     /region_name="gly_rich_SclB"
                     /note="LPXTG-anchored collagen-like adhesin Scl2/SclB;
                     NF038329"
                     /db_xref="CDD:468478"
     Region          393..493
                     /region_name="SR"
                     /note="Scavenger receptor Cys-rich; smart00202"
                     /db_xref="CDD:214555"
     Site            397
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|HAMAP-Rule:MF_03070; propagated from
                     UniProtKB/Swiss-Prot (Q6ZMJ2.1)"
     CDS             1..495
                     /gene="SCARA5"
                     /gene_synonym="NET33; Tesr"
                     /coded_by="NM_173833.6:433..1920"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS6064.1"
                     /db_xref="GeneID:286133"
                     /db_xref="HGNC:HGNC:28701"
                     /db_xref="MIM:611306"
ORIGIN      
        1 menkamylht vsdcdtssic edsfdgrsls klnlcedgpc hkrrasicct qlgslsalkh
       61 avlglyllvf lilvgifila vsrprsspdd lkaltrnvnr lnesfrdlql rllqaplqad
      121 lteqvwkvqd alqnqsdsll alagavqrle galwglqaqa vqteqavall rdrtgqqsdt
      181 aqlelyqlqv esnssqlllr rhaglldgla rrvgilgeel advggvlrgl nhslsydval
      241 hrtrlqdlrv lvsnasedtr rlrlahvgme lqlkqelaml navtedlrlk dwehsialrn
      301 islakgppgp kgdqgdegke grpgipglpg lrglpgergt pglpgpkgdd gklgatgpmg
      361 mrgfkgdrgp kgekgekgdr agdasgveap mmirlvngsg phegrvevyh drrwgtvcdd
      421 gwdkkdgdvv crmlgfrgve evyrtarfgq gtgriwmddv ackgteetif rcsfskwgvt
      481 ncghaedasv tcnrh
//
