LOCUS       NM_016240               3787 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens scavenger receptor class A member 3 (SCARA3),
            transcript variant 1, mRNA.
ACCESSION   NM_016240
VERSION     NM_016240.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3787)
  AUTHORS   Kim,J., You,H.J. and Youn,C.
  TITLE     SCARA3 inhibits cell proliferation and EMT through AKT signaling
            pathway in lung cancer
  JOURNAL   BMC Cancer 22 (1), 552 (2022)
   PUBMED   35578316
  REMARK    GeneRIF: SCARA3 inhibits cell proliferation and EMT through AKT
            signaling pathway in lung cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3787)
  AUTHORS   An,J., Guo,X. and Yan,B.
  TITLE     DICER-AS1 functions as competing endogenous RNA that targets CSR1
            by sponging microRNA-650 and suppresses gastric cancer progression
  JOURNAL   J Int Med Res 49 (9), 3000605211041466 (2021)
   PUBMED   34586953
  REMARK    GeneRIF: DICER-AS1 functions as competing endogenous RNA that
            targets CSR1 by sponging microRNA-650 and suppresses gastric cancer
            progression.
REFERENCE   3  (bases 1 to 3787)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 3787)
  AUTHORS   Peng,H., Guo,Q., Su,T., Xiao,Y., Li,C.J., Huang,Y. and Luo,X.H.
  TITLE     Identification of SCARA3 with potential roles in metabolic
            disorders
  JOURNAL   Aging (Albany NY) 13 (2), 2149-2167 (2020)
   PUBMED   33318306
  REMARK    GeneRIF: Identification of SCARA3 with potential roles in metabolic
            disorders.
REFERENCE   5  (bases 1 to 3787)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 3787)
  AUTHORS   Wang,Y., Fu,W., Xie,F., Wang,Y., Chu,X., Wang,H., Shen,M., Wang,Y.,
            Wang,Y., Sun,W., Lei,R., Yang,L., Wu,H., Foo,J., Liu,J., Jin,L. and
            Huang,W.
  TITLE     Common polymorphisms in ITGA2, PON1 and THBS2 are associated with
            coronary atherosclerosis in a candidate gene association study of
            the Chinese Han population
  JOURNAL   J Hum Genet 55 (8), 490-494 (2010)
   PUBMED   20485444
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 3787)
  AUTHORS   Zhu,Z.H., Yu,Y.P., Shi,Y.K., Nelson,J.B. and Luo,J.H.
  TITLE     CSR1 induces cell death through inactivation of CPSF3
  JOURNAL   Oncogene 28 (1), 41-51 (2009)
   PUBMED   18806823
  REMARK    GeneRIF: CSR1 appears to induce cell death through a novel
            mechanism by hijacking a critical RNA processing enzyme CPSF3.
REFERENCE   8  (bases 1 to 3787)
  AUTHORS   Yu,G., Tseng,G.C., Yu,Y.P., Gavel,T., Nelson,J., Wells,A.,
            Michalopoulos,G., Kokkinakis,D. and Luo,J.H.
  TITLE     CSR1 suppresses tumor growth and metastasis of prostate cancer
  JOURNAL   Am J Pathol 168 (2), 597-607 (2006)
   PUBMED   16436673
  REMARK    GeneRIF: Down-regulation of CSR1 protein expression by promoter
            methylation is associated with tumor growth and metastasis of
            prostate cancer
REFERENCE   9  (bases 1 to 3787)
  AUTHORS   Han,H.J., Tokino,T. and Nakamura,Y.
  TITLE     CSR, a scavenger receptor-like protein with a protective role
            against cellular damage causedby UV irradiation and oxidative
            stress
  JOURNAL   Hum Mol Genet 7 (6), 1039-1046 (1998)
   PUBMED   9580669
REFERENCE   10 (bases 1 to 3787)
  AUTHORS   Han,H.J. and Nakamura,Y.
  TITLE     Dinucleotide repeat polymorphism in the first intron of the CSR
            gene
  JOURNAL   J Hum Genet 43 (3), 212-213 (1998)
   PUBMED   9747040
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC013643.10.
            
            On Nov 26, 2018 this sequence version replaced NM_016240.2.
            
            Summary: This gene encodes a macrophage scavenger receptor-like
            protein. This protein has been shown to deplete reactive oxygen
            species, and thus play an important role in protecting cells from
            oxidative stress. The expression of this gene is induced by
            oxidative stress. Alternatively spliced transcript variants
            encoding distinct isoforms have been described. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1), also known as CSR1, encodes
            the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.83766.1,
                                           SRR1660803.160518.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000301904.4/ ENSP00000301904.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-306               AC013643.10        21835-22140
            307-405             AC013643.10        37635-37733
            406-525             AC013643.10        39441-39560
            526-624             AC013643.10        44715-44813
            625-1668            AC013643.10        46429-47472
            1669-3787           AC013643.10        58833-60951
FEATURES             Location/Qualifiers
     source          1..3787
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p21.1"
     gene            1..3787
                     /gene="SCARA3"
                     /gene_synonym="APC7; CSR; CSR1; MSLR1; MSRL1"
                     /note="scavenger receptor class A member 3"
                     /db_xref="GeneID:51435"
                     /db_xref="HGNC:HGNC:19000"
                     /db_xref="MIM:602728"
     exon            1..306
                     /gene="SCARA3"
                     /gene_synonym="APC7; CSR; CSR1; MSLR1; MSRL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             300..2120
                     /gene="SCARA3"
                     /gene_synonym="APC7; CSR; CSR1; MSLR1; MSRL1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     macrophage scavenger receptor-like 1; cellular stress
                     response protein; cellular stress response gene protein"
                     /codon_start=1
                     /product="scavenger receptor class A member 3 isoform 1"
                     /protein_id="NP_057324.2"
                     /db_xref="CCDS:CCDS34871.1"
                     /db_xref="GeneID:51435"
                     /db_xref="HGNC:HGNC:19000"
                     /db_xref="MIM:602728"
                     /translation="MKVRSAGGDGDALCVTEEDLAGDDEDMPTFPCTQKGRPGPRCSR
                     CQKNLSLHTSVRILYLFLALLLVAVAVLASLVFRKVDSLSEDISLTQSIYDKKLVLMQ
                     KNLQGLDPKALNNCSFCHEAGQLGPEIRKLQEELEGIQKLLLAQEVQLDQTLQAQEVL
                     STTSRQISQEMGSCSFSIHQVNQSLGLFLAQVRGWQATTAGLDLSLKDLTQECYDVKA
                     AVHQINFTVGQTSEWIHGIQRKTDEETLTLQKIVTDWQNYTRLFSGLRTTSTKTGEAV
                     KNIQATLGASSQRISQNSESMHDLVLQVMGLQLQLDNISSFLDDHEENMHDLQYHTHY
                     AQNRTVERFESLEGRMASHEIEIGTIFTNINATDNHVHSMLKYLDDVRLSCTLGFHTH
                     AEELYYLNKSVSIMLGTTDLLRERFSLLSARLDLNVRNLSMIVEEMKAVDTQHGEILR
                     NVTILRGAPGPPGPRGFKGDMGVKGPVGGRGPKGDPGSLGPLGPQGPQGQPGEAGPVG
                     ERGPVGPRGFPGLKGSKGSFGTGGPRGQPGPKGDIGPPGPEGPPGSPGPSGPQGKPGI
                     AGKTGSPGQRGAMGPKGEPGIQGPPGLPGPPGPPGSQSFY"
     exon            307..405
                     /gene="SCARA3"
                     /gene_synonym="APC7; CSR; CSR1; MSLR1; MSRL1"
                     /inference="alignment:Splign:2.1.0"
     exon            406..525
                     /gene="SCARA3"
                     /gene_synonym="APC7; CSR; CSR1; MSLR1; MSRL1"
                     /inference="alignment:Splign:2.1.0"
     exon            526..624
                     /gene="SCARA3"
                     /gene_synonym="APC7; CSR; CSR1; MSLR1; MSRL1"
                     /inference="alignment:Splign:2.1.0"
     exon            625..1668
                     /gene="SCARA3"
                     /gene_synonym="APC7; CSR; CSR1; MSLR1; MSRL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1669..3787
                     /gene="SCARA3"
                     /gene_synonym="APC7; CSR; CSR1; MSLR1; MSRL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3767..3772
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCARA3"
                     /gene_synonym="APC7; CSR; CSR1; MSLR1; MSRL1"
                     /note="hexamer: AGTAAA"
     polyA_site      3787
                     /gene="SCARA3"
                     /gene_synonym="APC7; CSR; CSR1; MSLR1; MSRL1"
                     /note="major polyA site"
ORIGIN      
        1 agacctcgcg gggccccagc gggaagcgcg ggcggcggcg ggatgcgcgc tctgggcggc
       61 ggggcgcggc gctaggcgcc cggcggggct tccccaggct gcgaccccgc gggaccctcc
      121 actcctcccg ccgcctccgc agcccgcgcg ccggagcatg agtcccggcc ggagccccac
      181 ggccgcgggc ggcgcctagg acggcgatcc gcgccctgga ggatccgccg gccgcccggc
      241 tccactacag ctccagccgc ctgcagcggg gccctcctga ggccccagag gaagagacca
      301 tgaaagtgag gtcggccggc ggcgatggag atgccttgtg cgttacagaa gaggacctgg
      361 cgggtgacga cgaggacatg ccgaccttcc catgcaccca gaagggccgg ccagggcccc
      421 gctgcagccg ctgccagaag aacctatctt tgcacacatc ggtgcggatt ctttacctct
      481 tcctggccct gctcctggtg gccgtggctg tgttggcctc tctggttttc agaaaagtgg
      541 actctctctc cgaagacatc tccttgaccc agtctattta tgacaagaag cttgtgttaa
      601 tgcagaaaaa tctccagggc ctggatccga aagccctgaa caactgctct ttctgccatg
      661 aagctgggca gctggggcca gagatccgaa aactgcagga ggagctggag ggaattcaga
      721 agctgcttct ggcccaggag gtgcagctgg accagacctt acaggcccag gaggtgctct
      781 ccaccaccag cagacaaatc tcccaggaga tgggcagttg ctccttctcc atccaccagg
      841 ttaaccagtc tctggggctc ttcctggccc aggtgagagg ctggcaggcc accacagctg
      901 gcctggacct ctctctgaag gacctcaccc aggagtgcta cgatgtcaag gctgcagtgc
      961 accagatcaa cttcaccgtg gggcagactt ccgagtggat ccacgggatc cagcggaaga
     1021 cagacgagga gaccctgacc ctccagaaga ttgtcaccga ctggcagaac tacacacggc
     1081 tcttcagcgg cctgcgcacc acctccacca agactggaga ggcggtcaag aacatccagg
     1141 ccaccctggg ggcctcctca cagcgcatca gccagaactc agagagcatg cacgacctgg
     1201 tactccaggt catgggcttg cagctgcagc tggataacat ctcgtccttc ctggatgacc
     1261 acgaagagaa catgcatgat cttcagtacc atacccacta cgcccagaac cgcactgtgg
     1321 agaggtttga gtctctggaa ggacgcatgg cttctcacga gattgaaatt ggcaccatct
     1381 tcaccaacat caatgccacc gacaaccacg tgcacagcat gctcaagtac ctggatgacg
     1441 tgcggctctc ctgcacgctg ggcttccaca cccatgccga ggagctctac tacctgaaca
     1501 agtctgtctc catcatgctg ggcaccacag acctgctccg ggagcgcttc agcctgctca
     1561 gtgcccggct ggacctcaac gtccggaacc tctccatgat cgtggaggag atgaaggcag
     1621 tggacacaca gcatggagaa atccttcgca atgtcaccat cctacgaggt gcccccggcc
     1681 ctccaggacc aagaggattc aaaggagata tgggcgtgaa agggcctgtt ggcggcagag
     1741 gcccgaaagg agaccccggc agcttgggcc ccctgggacc ccagggtcct caggggcaac
     1801 ctggagaggc cgggcctgtg ggagaaaggg gccctgttgg ccctcgaggg ttcccaggcc
     1861 tcaaaggctc aaagggcagc tttggaactg gagggccgag aggacagcca ggcccaaaag
     1921 gggacatagg gcccccaggg ccagaagggc ccccggggtc tccagggccc tcagggcctc
     1981 agggaaaacc gggaattgca gggaagacag ggtcaccagg ccagcggggg gccatggggc
     2041 ctaagggtga accagggatc cagggtcccc ctggtctccc ggggcctcca ggtccaccag
     2101 gaagccagag cttctactga ggagggctgt ggcagagcca ctgtcacaca gaatgccgga
     2161 ggggcgcaga gcagatccag gccccagaaa gcctcaccta cagacagctg tggtcctctg
     2221 attccaatga gggggctccc cagggctgac cctgcagctt tgggctcccc catagtgact
     2281 gtgccatagg aaagcagccc ctcctcacac atacatgtgc acatgcacac acatgcatgc
     2341 acacacatgc acacatacac gcacatgcac acatacacat gcatgcacac atacacaggc
     2401 atacatgcat gcacacacac atgcacgcac acacacatgc acacatacac gtgcacacat
     2461 acacaggcac acatgcatgc acacatacac atgcacacac acatgcacac atatatgcac
     2521 aggcacacac atgtacgcac acacacatgc actgcacaca tatccatgca cacaaacaca
     2581 tatatacaca tgcacataca cagatttttc tgctggccag gtgggccaac tgggtttccc
     2641 tggctgggca ggaggagagg gcagaggaag accccctctc ctgtgactga gcctgccagg
     2701 gaggcagcta cctcgggagg aaggtctcac atctgtctct gggcacccat gctggccagc
     2761 agtttcccag ggctccctgg ggttgaaaag ccccaaggaa acctttgcgg gtggggcgtt
     2821 actgccaaaa ctccagaggc aaagtggacc tggcaaccac aagaccctcc ccataagcag
     2881 gggaccagca tacccgggag ctgtccctgt ctgtcacagc acagtggggc cacgaggctg
     2941 acattctctg gccttgcaca cagtgccccc tgagaagttc aacatttatt tcttcacgtg
     3001 tccagaaaat tcctcaattc atccttgcct ctgcccttca ggagcagcct ggaaggaatc
     3061 caagcaggag tttcatctgc atgggggcac tctgcaggcc ctggaacatt gggcctgagt
     3121 ggagatggga gacagaggca ggccagaagg ttctctctgc acagctgcct cccttgctct
     3181 ccctgaggct ggcctgcccc attccccaag ggggctcctc tggagtggtg gggaggatta
     3241 ggctgcagaa gggccaaccc cttgcaacag ggcagctctc gcctcccgca cacggctctc
     3301 ctgatcacag ctgcatgccg accttgtccc accgggaccc acaatggccc gagccctctt
     3361 tgcatgggca gccagctgga ctaggagtgg gaagggcctg gacactcaca gaggccccct
     3421 ctgtcatcac tccttggcac ccaccaactt cctgcacaca ctggcagaga ggggcgctgg
     3481 gaaatcaccc cacagggtgg aggtctcctg ttggctacac tctaaagctg ctttgccttc
     3541 atgttcaaac agattcaggc accaccccct ccaccgcccg caaggttagg gcatagagtt
     3601 gtctccttcc caacacggac ccagagagca gcccttccct gctcaaagcc tttccgcacc
     3661 ctcctgactg tcctggatgt gcaactggtt tgcactgcac accccacggc catgtaactc
     3721 tcctgtccac atatgataat accattctgc atagtattac tgactcagta aagagctatt
     3781 tccagga
//
