LOCUS       NP_057324                606 aa            linear   PRI 28-APR-2025
DEFINITION  scavenger receptor class A member 3 isoform 1 [Homo sapiens].
ACCESSION   NP_057324
VERSION     NP_057324.2
DBSOURCE    REFSEQ: accession NM_016240.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 606)
  AUTHORS   Kim,J., You,H.J. and Youn,C.
  TITLE     SCARA3 inhibits cell proliferation and EMT through AKT signaling
            pathway in lung cancer
  JOURNAL   BMC Cancer 22 (1), 552 (2022)
   PUBMED   35578316
  REMARK    GeneRIF: SCARA3 inhibits cell proliferation and EMT through AKT
            signaling pathway in lung cancer.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 606)
  AUTHORS   An,J., Guo,X. and Yan,B.
  TITLE     DICER-AS1 functions as competing endogenous RNA that targets CSR1
            by sponging microRNA-650 and suppresses gastric cancer progression
  JOURNAL   J Int Med Res 49 (9), 3000605211041466 (2021)
   PUBMED   34586953
  REMARK    GeneRIF: DICER-AS1 functions as competing endogenous RNA that
            targets CSR1 by sponging microRNA-650 and suppresses gastric cancer
            progression.
REFERENCE   3  (residues 1 to 606)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (residues 1 to 606)
  AUTHORS   Peng,H., Guo,Q., Su,T., Xiao,Y., Li,C.J., Huang,Y. and Luo,X.H.
  TITLE     Identification of SCARA3 with potential roles in metabolic
            disorders
  JOURNAL   Aging (Albany NY) 13 (2), 2149-2167 (2020)
   PUBMED   33318306
  REMARK    GeneRIF: Identification of SCARA3 with potential roles in metabolic
            disorders.
REFERENCE   5  (residues 1 to 606)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (residues 1 to 606)
  AUTHORS   Wang,Y., Fu,W., Xie,F., Wang,Y., Chu,X., Wang,H., Shen,M., Wang,Y.,
            Wang,Y., Sun,W., Lei,R., Yang,L., Wu,H., Foo,J., Liu,J., Jin,L. and
            Huang,W.
  TITLE     Common polymorphisms in ITGA2, PON1 and THBS2 are associated with
            coronary atherosclerosis in a candidate gene association study of
            the Chinese Han population
  JOURNAL   J Hum Genet 55 (8), 490-494 (2010)
   PUBMED   20485444
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (residues 1 to 606)
  AUTHORS   Zhu,Z.H., Yu,Y.P., Shi,Y.K., Nelson,J.B. and Luo,J.H.
  TITLE     CSR1 induces cell death through inactivation of CPSF3
  JOURNAL   Oncogene 28 (1), 41-51 (2009)
   PUBMED   18806823
  REMARK    GeneRIF: CSR1 appears to induce cell death through a novel
            mechanism by hijacking a critical RNA processing enzyme CPSF3.
REFERENCE   8  (residues 1 to 606)
  AUTHORS   Yu,G., Tseng,G.C., Yu,Y.P., Gavel,T., Nelson,J., Wells,A.,
            Michalopoulos,G., Kokkinakis,D. and Luo,J.H.
  TITLE     CSR1 suppresses tumor growth and metastasis of prostate cancer
  JOURNAL   Am J Pathol 168 (2), 597-607 (2006)
   PUBMED   16436673
  REMARK    GeneRIF: Down-regulation of CSR1 protein expression by promoter
            methylation is associated with tumor growth and metastasis of
            prostate cancer
REFERENCE   9  (residues 1 to 606)
  AUTHORS   Han,H.J., Tokino,T. and Nakamura,Y.
  TITLE     CSR, a scavenger receptor-like protein with a protective role
            against cellular damage causedby UV irradiation and oxidative
            stress
  JOURNAL   Hum Mol Genet 7 (6), 1039-1046 (1998)
   PUBMED   9580669
REFERENCE   10 (residues 1 to 606)
  AUTHORS   Han,H.J. and Nakamura,Y.
  TITLE     Dinucleotide repeat polymorphism in the first intron of the CSR
            gene
  JOURNAL   J Hum Genet 43 (3), 212-213 (1998)
   PUBMED   9747040
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC013643.10.
            
            On Aug 12, 2003 this sequence version replaced NP_057324.1.
            
            Summary: This gene encodes a macrophage scavenger receptor-like
            protein. This protein has been shown to deplete reactive oxygen
            species, and thus play an important role in protecting cells from
            oxidative stress. The expression of this gene is induced by
            oxidative stress. Alternatively spliced transcript variants
            encoding distinct isoforms have been described. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1), also known as CSR1, encodes
            the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.83766.1,
                                           SRR1660803.160518.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000301904.4/ ENSP00000301904.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..606
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p21.1"
     Protein         1..606
                     /product="scavenger receptor class A member 3 isoform 1"
                     /note="macrophage scavenger receptor-like 1; cellular
                     stress response protein; cellular stress response gene
                     protein"
                     /calculated_mol_wt=65006
     Site            57..77
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6AZY7.1)"
     Site            115
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q6AZY7.1)"
     Site            182
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q6AZY7.1)"
     Site            224
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q6AZY7.1)"
     Site            257
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q6AZY7.1)"
     Site            313
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q6AZY7.1)"
     Site            337
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q6AZY7.1)"
     Site            365
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q6AZY7.1)"
     Site            400
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q6AZY7.1)"
     Site            430
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q6AZY7.1)"
     Site            451
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q6AZY7.1)"
     Region          454..606
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6AZY7.1)"
     Region          <468..>583
                     /region_name="gly_rich_SclB"
                     /note="LPXTG-anchored collagen-like adhesin Scl2/SclB;
                     NF038329"
                     /db_xref="CDD:468478"
     CDS             1..606
                     /gene="SCARA3"
                     /gene_synonym="APC7; CSR; CSR1; MSLR1; MSRL1"
                     /coded_by="NM_016240.3:300..2120"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS34871.1"
                     /db_xref="GeneID:51435"
                     /db_xref="HGNC:HGNC:19000"
                     /db_xref="MIM:602728"
ORIGIN      
        1 mkvrsaggdg dalcvteedl agddedmptf pctqkgrpgp rcsrcqknls lhtsvrilyl
       61 flalllvava vlaslvfrkv dslsedislt qsiydkklvl mqknlqgldp kalnncsfch
      121 eagqlgpeir klqeelegiq klllaqevql dqtlqaqevl sttsrqisqe mgscsfsihq
      181 vnqslglfla qvrgwqatta gldlslkdlt qecydvkaav hqinftvgqt sewihgiqrk
      241 tdeetltlqk ivtdwqnytr lfsglrttst ktgeavkniq atlgassqri sqnsesmhdl
      301 vlqvmglqlq ldnissfldd heenmhdlqy hthyaqnrtv erfeslegrm asheieigti
      361 ftninatdnh vhsmlkyldd vrlsctlgfh thaeelyyln ksvsimlgtt dllrerfsll
      421 sarldlnvrn lsmiveemka vdtqhgeilr nvtilrgapg ppgprgfkgd mgvkgpvggr
      481 gpkgdpgslg plgpqgpqgq pgeagpvger gpvgprgfpg lkgskgsfgt ggprgqpgpk
      541 gdigppgpeg ppgspgpsgp qgkpgiagkt gspgqrgamg pkgepgiqgp pglpgppgpp
      601 gsqsfy
//
