LOCUS       NM_020843               5033 bp    mRNA    linear   PRI 09-OCT-2024
DEFINITION  Homo sapiens S-phase cyclin A associated protein in the ER
            (SCAPER), transcript variant 1, mRNA.
ACCESSION   NM_020843 XM_005254419
VERSION     NM_020843.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5033)
  AUTHORS   Wormser,O., Levy,Y., Bakhrat,A., Bonaccorsi,S., Graziadio,L.,
            Gatti,M., AbuMadighem,A., McKenney,R.J., Okada,K., El Riati,S.,
            Har-Vardi,I., Huleihel,M., Levitas,E., Birk,O.S. and Abdu,U.
  TITLE     Absence of SCAPER causes male infertility in humans and Drosophila
            by modulating microtubule dynamics during meiosis
  JOURNAL   J Med Genet 58 (4), 254-263 (2021)
   PUBMED   32527956
  REMARK    GeneRIF: Absence of SCAPER causes male infertility in humans and
            Drosophila by modulating microtubule dynamics during meiosis.
REFERENCE   2  (bases 1 to 5033)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 5033)
  AUTHORS   Tatour,Y., Bar-Joseph,H., Shalgi,R. and Ben-Yosef,T.
  TITLE     Male sterility and reduced female fertility in SCAPER-deficient
            mice
  JOURNAL   Hum Mol Genet 29 (13), 2240-2249 (2020)
   PUBMED   32510560
  REMARK    GeneRIF: Male sterility and reduced female fertility in
            SCAPER-deficient mice.
REFERENCE   4  (bases 1 to 5033)
  AUTHORS   Fasham,J., Arno,G., Lin,S., Xu,M., Carss,K.J., Hull,S., Lane,A.,
            Robson,A.G., Wenger,O., Self,J.E., Harlalka,G.V., Salter,C.G.,
            Schema,L., Moss,T.J., Cheetham,M.E., Moore,A.T., Raymond,F.L.,
            Chen,R., Baple,E.L., Webster,A.R. and Crosby,A.H.
  CONSRTM   NIHR Bioresource Rare Diseases Consortium
  TITLE     Delineating the expanding phenotype associated with SCAPER gene
            mutation
  JOURNAL   Am J Med Genet A 179 (8), 1665-1671 (2019)
   PUBMED   31192531
  REMARK    GeneRIF: Delineating the expanding phenotype associated with SCAPER
            gene mutation.
REFERENCE   5  (bases 1 to 5033)
  AUTHORS   Kahrizi,K., Huber,M., Galetzka,D., Dewi,S., Schroder,J., Weis,E.,
            Kariminejad,A., Fattahi,Z., Ropers,H.H., Schweiger,S., Najmabadi,H.
            and Winter,J.
  TITLE     Homozygous variants in the gene SCAPER cause syndromic intellectual
            disability
  JOURNAL   Am J Med Genet A 179 (7), 1214-1225 (2019)
   PUBMED   31069901
  REMARK    GeneRIF: Homozygous variants in the gene SCAPER cause syndromic
            intellectual disability.
REFERENCE   6  (bases 1 to 5033)
  AUTHORS   Shin,S.Y., Fauman,E.B., Petersen,A.K., Krumsiek,J., Santos,R.,
            Huang,J., Arnold,M., Erte,I., Forgetta,V., Yang,T.P., Walter,K.,
            Menni,C., Chen,L., Vasquez,L., Valdes,A.M., Hyde,C.L., Wang,V.,
            Ziemek,D., Roberts,P., Xi,L., Grundberg,E., Waldenberger,M.,
            Richards,J.B., Mohney,R.P., Milburn,M.V., John,S.L., Trimmer,J.,
            Theis,F.J., Overington,J.P., Suhre,K., Brosnan,M.J., Gieger,C.,
            Kastenmuller,G., Spector,T.D. and Soranzo,N.
  CONSRTM   Multiple Tissue Human Expression Resource (MuTHER) Consortium
  TITLE     An atlas of genetic influences on human blood metabolites
  JOURNAL   Nat Genet 46 (6), 543-550 (2014)
   PUBMED   24816252
REFERENCE   7  (bases 1 to 5033)
  AUTHORS   Tsang,W.Y. and Dynlacht,B.D.
  TITLE     Double identity of SCAPER: a substrate and regulator of cyclin
            A/Cdk2
  JOURNAL   Cell Cycle 7 (6), 702-705 (2008)
   PUBMED   18245951
  REMARK    GeneRIF: By sequestering cyclin A/Cdk2, SCAPER is capable of
            directing the activity of this kinase complex away from the nucleus
            and regulating cyclin A/Cdk2 equilibrium in distinct subcellular
            compartments.
REFERENCE   8  (bases 1 to 5033)
  AUTHORS   Laura,V., Emanuela,B., Corrado,A., Giuseppe,N. and Annalisa,B.
  TITLE     Detection of an unstable non-coding tandem repeat in the ZNF291
            gene
  JOURNAL   Mol Cell Probes 21 (5-6), 405-407 (2007)
   PUBMED   17553665
  REMARK    GeneRIF: An unstable [CCTG](n) repeat in the second intron of the
            ZNF291 gene, on chromosome 15q21-24, was identified.
REFERENCE   9  (bases 1 to 5033)
  AUTHORS   Tsang,W.Y., Wang,L., Chen,Z., Sanchez,I. and Dynlacht,B.D.
  TITLE     SCAPER, a novel cyclin A-interacting protein that regulates cell
            cycle progression
  JOURNAL   J Cell Biol 178 (4), 621-633 (2007)
   PUBMED   17698606
  REMARK    GeneRIF: Study describes the biochemically purification and
            identification of SCAPER, a novel protein that specifically
            interacts with cyclin A/Cdk2 in vivo.
REFERENCE   10 (bases 1 to 5033)
  AUTHORS   Forsyth,R. and Gunay-Aygun,M.
  TITLE     Bardet-Biedl Syndrome Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301537
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC051643.5, AC016343.5, AC015798.7, AC090751.9, AC090179.4 and
            AC027243.20.
            
            On Nov 23, 2018 this sequence version replaced NM_020843.3.
            
            Transcript Variant: This variant (1) encodes isoform a.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.112964.1,
                                           SRR1803614.38639.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000563290.6/ ENSP00000454973.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                AC051643.5         61093-61134
            43-107              AC051643.5         82557-82621
            108-225             AC051643.5         103900-104017
            226-296             AC016343.5         3530-3600
            297-494             AC016343.5         19478-19675
            495-595             AC016343.5         56776-56876
            596-712             AC016343.5         61045-61161
            713-873             AC016343.5         65969-66129
            874-1136            AC016343.5         86292-86554
            1137-1349           AC016343.5         89455-89667
            1350-1520           AC016343.5         94321-94491
            1521-1596           AC016343.5         95771-95846
            1597-1714           AC016343.5         95955-96072
            1715-1826           AC016343.5         96337-96448
            1827-1967           AC016343.5         107461-107601
            1968-2123           AC015798.7         16966-17121
            2124-2266           AC015798.7         21613-21755
            2267-2348           AC015798.7         44366-44447
            2349-2501           AC015798.7         47348-47500
            2502-2609           AC015798.7         48485-48592
            2610-2746           AC015798.7         84561-84697
            2747-2812           AC015798.7         128521-128586
            2813-2939           AC090751.9         196963-197089       c
            2940-3055           AC090751.9         127664-127779       c
            3056-3179           AC090751.9         94017-94140         c
            3180-3412           AC090179.4         152074-152306       c
            3413-3568           AC090179.4         122520-122675       c
            3569-3806           AC090179.4         99374-99611         c
            3807-3956           AC090179.4         94158-94307         c
            3957-4148           AC027243.20        17193-17384
            4149-4200           AC027243.20        20045-20096
            4201-5033           AC027243.20        22597-23429
FEATURES             Location/Qualifiers
     source          1..5033
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q24.3"
     gene            1..5033
                     /gene="SCAPER"
                     /gene_synonym="IDDRP; MSTP063; Zfp291; ZNF291"
                     /note="S-phase cyclin A associated protein in the ER"
                     /db_xref="GeneID:49855"
                     /db_xref="HGNC:HGNC:13081"
                     /db_xref="MIM:611611"
     exon            1..42
                     /gene="SCAPER"
                     /gene_synonym="IDDRP; MSTP063; Zfp291; ZNF291"
                     /inference="alignment:Splign:2.1.0"
     exon            43..107
                     /gene="SCAPER"
                     /gene_synonym="IDDRP; MSTP063; Zfp291; ZNF291"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..4304
                     /gene="SCAPER"
                     /gene_synonym="IDDRP; MSTP063; Zfp291; ZNF291"
                     /note="isoform a is encoded by transcript variant 1; zinc
                     finger protein 291; s phase cyclin A-associated protein in
                     the endoplasmic reticulum"
                     /codon_start=1
                     /product="S phase cyclin A-associated protein in the
                     endoplasmic reticulum isoform a"
                     /protein_id="NP_065894.2"
                     /db_xref="CCDS:CCDS53962.1"
                     /db_xref="GeneID:49855"
                     /db_xref="HGNC:HGNC:13081"
                     /db_xref="MIM:611611"
                     /translation="MMASFQRSNSHDKVRRIVAEEGRTARNLIAWSVPLESKDDDGKP
                     KCQTGGKSKRTIQGTHKTTKQSTAVDCKITSSTTGDKHFDKSPTKTRHPRKIDLRARY
                     WAFLFDNLRRAVDEIYVTCESDQSVVECKEVLMMLDNYVRDFKALIDWIQLQEKLEKT
                     DAQSRPTSLAWEVKKMSPGRHVIPSPSTDRINVTSNARRSLNFGGSTGTVPAPRLAPT
                     GVSWADKVKAHHTGSTASSEITPAQSCPPMTVQKASRKNERKDAEGWETVQRGRPIRS
                     RSTAVMPKVSLATEATRSKDDSDKENVCLLPDESIQKGQFVGDGTSNTIESHPKDSLH
                     SCDHPLAEKTQFTVSTLDDVKNSGSIRDNYVRTSEISAVHIDTECVSVMLQAGTPPLQ
                     VNEEKFPAEKARIENEMDPSDISNSMAEVLAKKEELADRLEKANEEAIASAIAEEEQL
                     TREIEAEENNDINIETDNDSDFSASMGSGSVSFCGMSMDWNDVLADYEARESWRQNTS
                     WGDIVEEEPARPPGHGIHMHEKLSSPSRKRTIAESKKKHEEKQMKAQQLREKLREEKT
                     LKLQKLLEREKDVRKWKEELLDQRRRMMEEKLLHAEFKREVQLQAIVKKAQEEEAKVN
                     EIAFINTLEAQNKRHDVLSKLKEYEQRLNELQEERQRRQEEKQARDEAVQERKRALEA
                     ERQARVEELLMKRKEQEARIEQQRQEKEKAREDAARERARDREERLAALTAAQQEAME
                     ELQKKIQLKHDESIRRHMEQIEQRKEKAAELSSGRHANTDYAPKLTPYERKKQCSLCN
                     VLISSEVYLFSHVKGRKHQQAVRENTSIQGRELSDEEVEHLSLKKYIIDIVVESTAPA
                     EALKDGEERQKNKKKAKKIKARMNFRAKEYESLMETKNSGSDSPYKAKLQRLAKDLLK
                     QVQVQDSGSWANNKVSALDRTLGEITRILEKENVADQIAFQAAGGLTALEHILQAVVP
                     ATNVNTVLRIPPKSLCNAINVYNLTCNNCSENCSDVLFSNKITFLMDLLIHQLTVYVP
                     DENNTILGRNTNKQVFEGLTTGLLKVSAVVLGCLIANRPDGNCQPATPKIPTQEMKNK
                     PSQGDPFNNRVQDLISYVVNMGLIDKLCACFLSVQGPVDENPKMAIFLQHAAGLLHAM
                     CTLCFAVTGRSYSIFDNNRQDPTGLTAALQATDLAGVLHMLYCVLFHGTILDPSTASP
                     KENYTQNTIQVAIQSLRFFNSFAALHLPAFQSIVGAEGLSLAFRHMASSLLGHCSQVS
                     CESLLHEVIVCVGYFTVNHPDNQVIVQSGRHPTVLQKLCQLPFQYFSDPRLIKVLFPS
                     LIAACYNNHQNKIILEQEMSCVLLATFIQDLAQTPGQAENQPYQPKGKCLGSQDYLEL
                     ANRFPQQAWEEARQFFLKKEKK"
     exon            108..225
                     /gene="SCAPER"
                     /gene_synonym="IDDRP; MSTP063; Zfp291; ZNF291"
                     /inference="alignment:Splign:2.1.0"
     exon            226..296
                     /gene="SCAPER"
                     /gene_synonym="IDDRP; MSTP063; Zfp291; ZNF291"
                     /inference="alignment:Splign:2.1.0"
     exon            297..494
                     /gene="SCAPER"
                     /gene_synonym="IDDRP; MSTP063; Zfp291; ZNF291"
                     /inference="alignment:Splign:2.1.0"
     exon            495..595
                     /gene="SCAPER"
                     /gene_synonym="IDDRP; MSTP063; Zfp291; ZNF291"
                     /inference="alignment:Splign:2.1.0"
     exon            596..712
                     /gene="SCAPER"
                     /gene_synonym="IDDRP; MSTP063; Zfp291; ZNF291"
                     /inference="alignment:Splign:2.1.0"
     exon            713..873
                     /gene="SCAPER"
                     /gene_synonym="IDDRP; MSTP063; Zfp291; ZNF291"
                     /inference="alignment:Splign:2.1.0"
     exon            874..1136
                     /gene="SCAPER"
                     /gene_synonym="IDDRP; MSTP063; Zfp291; ZNF291"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1349
                     /gene="SCAPER"
                     /gene_synonym="IDDRP; MSTP063; Zfp291; ZNF291"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1520
                     /gene="SCAPER"
                     /gene_synonym="IDDRP; MSTP063; Zfp291; ZNF291"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..1596
                     /gene="SCAPER"
                     /gene_synonym="IDDRP; MSTP063; Zfp291; ZNF291"
                     /inference="alignment:Splign:2.1.0"
     exon            1597..1714
                     /gene="SCAPER"
                     /gene_synonym="IDDRP; MSTP063; Zfp291; ZNF291"
                     /inference="alignment:Splign:2.1.0"
     exon            1715..1826
                     /gene="SCAPER"
                     /gene_synonym="IDDRP; MSTP063; Zfp291; ZNF291"
                     /inference="alignment:Splign:2.1.0"
     exon            1827..1967
                     /gene="SCAPER"
                     /gene_synonym="IDDRP; MSTP063; Zfp291; ZNF291"
                     /inference="alignment:Splign:2.1.0"
     exon            1968..2123
                     /gene="SCAPER"
                     /gene_synonym="IDDRP; MSTP063; Zfp291; ZNF291"
                     /inference="alignment:Splign:2.1.0"
     exon            2124..2266
                     /gene="SCAPER"
                     /gene_synonym="IDDRP; MSTP063; Zfp291; ZNF291"
                     /inference="alignment:Splign:2.1.0"
     exon            2267..2348
                     /gene="SCAPER"
                     /gene_synonym="IDDRP; MSTP063; Zfp291; ZNF291"
                     /inference="alignment:Splign:2.1.0"
     exon            2349..2501
                     /gene="SCAPER"
                     /gene_synonym="IDDRP; MSTP063; Zfp291; ZNF291"
                     /inference="alignment:Splign:2.1.0"
     exon            2502..2609
                     /gene="SCAPER"
                     /gene_synonym="IDDRP; MSTP063; Zfp291; ZNF291"
                     /inference="alignment:Splign:2.1.0"
     exon            2610..2746
                     /gene="SCAPER"
                     /gene_synonym="IDDRP; MSTP063; Zfp291; ZNF291"
                     /inference="alignment:Splign:2.1.0"
     exon            2747..2812
                     /gene="SCAPER"
                     /gene_synonym="IDDRP; MSTP063; Zfp291; ZNF291"
                     /inference="alignment:Splign:2.1.0"
     exon            2813..2939
                     /gene="SCAPER"
                     /gene_synonym="IDDRP; MSTP063; Zfp291; ZNF291"
                     /inference="alignment:Splign:2.1.0"
     exon            2940..3055
                     /gene="SCAPER"
                     /gene_synonym="IDDRP; MSTP063; Zfp291; ZNF291"
                     /inference="alignment:Splign:2.1.0"
     exon            3056..3179
                     /gene="SCAPER"
                     /gene_synonym="IDDRP; MSTP063; Zfp291; ZNF291"
                     /inference="alignment:Splign:2.1.0"
     exon            3180..3412
                     /gene="SCAPER"
                     /gene_synonym="IDDRP; MSTP063; Zfp291; ZNF291"
                     /inference="alignment:Splign:2.1.0"
     exon            3413..3568
                     /gene="SCAPER"
                     /gene_synonym="IDDRP; MSTP063; Zfp291; ZNF291"
                     /inference="alignment:Splign:2.1.0"
     exon            3569..3806
                     /gene="SCAPER"
                     /gene_synonym="IDDRP; MSTP063; Zfp291; ZNF291"
                     /inference="alignment:Splign:2.1.0"
     exon            3807..3956
                     /gene="SCAPER"
                     /gene_synonym="IDDRP; MSTP063; Zfp291; ZNF291"
                     /inference="alignment:Splign:2.1.0"
     exon            3957..4148
                     /gene="SCAPER"
                     /gene_synonym="IDDRP; MSTP063; Zfp291; ZNF291"
                     /inference="alignment:Splign:2.1.0"
     exon            4149..4200
                     /gene="SCAPER"
                     /gene_synonym="IDDRP; MSTP063; Zfp291; ZNF291"
                     /inference="alignment:Splign:2.1.0"
     exon            4201..5033
                     /gene="SCAPER"
                     /gene_synonym="IDDRP; MSTP063; Zfp291; ZNF291"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4622..4627
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCAPER"
                     /gene_synonym="IDDRP; MSTP063; Zfp291; ZNF291"
                     /note="hexamer: AATAAA"
     polyA_site      4646
                     /gene="SCAPER"
                     /gene_synonym="IDDRP; MSTP063; Zfp291; ZNF291"
     regulatory      4719..4724
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCAPER"
                     /gene_synonym="IDDRP; MSTP063; Zfp291; ZNF291"
                     /note="hexamer: AATAAA"
     regulatory      4731..4736
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCAPER"
                     /gene_synonym="IDDRP; MSTP063; Zfp291; ZNF291"
                     /note="hexamer: ATTAAA"
     polyA_site      4741
                     /gene="SCAPER"
                     /gene_synonym="IDDRP; MSTP063; Zfp291; ZNF291"
                     /note="major polyA site"
     polyA_site      4757
                     /gene="SCAPER"
                     /gene_synonym="IDDRP; MSTP063; Zfp291; ZNF291"
     regulatory      5012..5017
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCAPER"
                     /gene_synonym="IDDRP; MSTP063; Zfp291; ZNF291"
                     /note="hexamer: AATAAA"
     polyA_site      5033
                     /gene="SCAPER"
                     /gene_synonym="IDDRP; MSTP063; Zfp291; ZNF291"
ORIGIN      
        1 gggacgcttt gagccgcccc gaactaagca gggcggtcgg gggagtcata ctccatgggt
       61 ttatgtgata aatgatcttg gcatagaaga gaatttaaag aatgatggct tcattccagc
      121 gctccaatag tcatgacaaa gtaaggagaa tagttgcaga ggagggtcgt acagcaagaa
      181 acctaatagc ttggagtgtt ccactagaaa gcaaagatga tgatggaaaa cctaaatgtc
      241 aaactggtgg aaaatctaag aggaccattc aaggcactca taaaactact aaacagagta
      301 ctgcagtgga ctgtaaaata acatcgtcta cgactggaga taaacacttt gataaaagtc
      361 ccactaaaac aaggcaccct cggaaaattg atctaagagc tcgatactgg gcatttcttt
      421 ttgataatct tcgccgagca gtagatgaaa tctatgtaac ttgcgaatca gatcagagtg
      481 tggtcgaatg taaggaggtg ctaatgatgc tggataacta tgtaagagat ttcaaagcat
      541 tgattgactg gattcagctt caggaaaagc tagagaagac agatgctcaa agcagaccaa
      601 catcattggc atgggaagta aagaagatgt ctccgggacg ccatgtgatt ccaagtccat
      661 caacagatag aataaatgta acatcaaatg ctcgacgaag cttaaatttt ggaggttcaa
      721 ctggcacagt gccagctcct cgtctggctc ccacaggtgt cagttgggct gacaaggtaa
      781 aggctcatca tacaggctct actgcttctt cagaaataac acccgcccag tcttgcccac
      841 caatgacagt gcagaaggcc tcacgcaaaa atgaacggaa agatgctgaa ggatgggaga
      901 ccgttcagag aggaaggcct attcgttctc gatcaacagc agtgatgcca aaagtttcat
      961 tggcaacaga agccacaaga tcaaaggatg acagtgataa agaaaatgta tgtcttttac
     1021 ctgatgaaag catacagaaa ggtcaatttg ttggagatgg aacttctaat actatagaat
     1081 ctcatcccaa agactcatta cactcttgtg accatcctct tgccgaaaaa acccagttca
     1141 cagtgagtac attggatgat gtgaagaatt ctggcagtat tcgagacaat tatgttcgaa
     1201 cttctgaaat atctgctgtc cacattgata cagagtgtgt ttcagttatg ctgcaagctg
     1261 gtacacctcc tttacaagta aatgaagaaa aatttccagc agagaaagca aggatagaaa
     1321 atgaaatgga cccttcagat atttcaaatt ccatggcaga agtccttgct aaaaaagaag
     1381 agctagcaga tcgtctagaa aaggccaatg aagaagccat tgctagtgct attgctgaag
     1441 aagaacagtt aactagagaa attgaagctg aagaaaacaa tgatattaac attgaaactg
     1501 acaacgacag tgatttttct gccagcatgg gcagtgggag tgtttctttc tgtggtatgt
     1561 ccatggactg gaacgatgtc cttgcagatt atgaagctcg tgagtcttgg cgccaaaata
     1621 catcctgggg ggacattgta gaagaagaac ctgctagacc tccagggcat ggaattcaca
     1681 tgcatgaaaa actttcttca ccctctcgta aaagaacaat tgcagaatct aagaagaaac
     1741 atgaagaaaa acaaatgaaa gcacagcagc taagggaaaa gttacgcgaa gagaaaacat
     1801 tgaagcttca gaaattgtta gaaagggaga aggatgtccg gaagtggaag gaagaattgc
     1861 tagatcaacg acgcaggatg atggaagaaa aattacttca tgctgagttt aagcgagaag
     1921 tgcagttaca agcaattgtg aaaaaagcac aagaagaaga agctaaggta aatgaaattg
     1981 cctttataaa tacccttgaa gcccagaata aacgtcatga tgttttatca aaattgaagg
     2041 aatatgaaca gaggcttaat gagctacagg aagagcgtca gagaagacag gaagaaaagc
     2101 aagcacgtga tgaagctgtg caggaacgca agagagctct agaggcagag cggcaggccc
     2161 gtgtagaaga attgttaatg aagaggaaag aacaagaagc ccgaattgaa caacagaggc
     2221 aagaaaagga aaaagcccgt gaggatgcag cccgggaaag agctagagac agggaagaac
     2281 gattggcagc actcacagct gctcaacaag aagctatgga agagttacag aaaaaaattc
     2341 agctcaagca tgatgaaagt attcgaaggc acatggaaca gattgaacaa agaaaagaaa
     2401 aagctgctga gctaagcagt gggcgacatg caaatactga ttatgccccc aaactgaccc
     2461 cttatgaaag aaagaagcag tgttctctct gcaatgtcct gatctcttca gaggtatatc
     2521 tttttagcca tgttaaaggg agaaaacacc agcaagccgt gagagagaat accagcatcc
     2581 aggggcgtga actgtcagat gaagaagtgg agcatctttc cttgaagaag tacattattg
     2641 acattgtggt tgaaagtaca gctccagcag aagctttgaa agatggagaa gagcggcaaa
     2701 aaaataaaaa aaaagccaaa aagataaaag cccggatgaa cttcagggct aaggaatatg
     2761 agagtttaat ggaaaccaaa aattctggct ctgattcacc ttataaagca aagcttcagc
     2821 gattagccaa agatcttcta aaacaagtac aagttcaaga cagtggctca tgggcaaaca
     2881 ataaagtgtc tgctttggat cggaccctag gagagatcac tagaatactg gaaaaagaga
     2941 atgtggcaga tcagattgca tttcaagctg ctggtggatt aacagccctt gaacacatcc
     3001 ttcaagcagt agtcccagcc acaaatgtga acacagtttt aagaattcct cctaagtctc
     3061 tctgcaatgc aatcaatgtt tacaacctca cctgcaataa ctgttcagaa aactgcagtg
     3121 atgttctgtt tagtaacaag attaccttct taatggacct cctgatacac cagttgacgg
     3181 tttatgttcc agatgaaaat aatactattt tggggagaaa tacaaataaa caagtttttg
     3241 aaggcttgac aactggactt ctcaaagtca gtgctgtggt tttgggctgc ctgattgcca
     3301 atcgaccaga tggaaactgc cagccagcta ccccaaaaat accaacacag gaaatgaaaa
     3361 acaaaccctc acaaggtgat ccttttaaca atcgagttca ggaccttatc agctacgtgg
     3421 tgaacatggg tctgattgac aaactgtgtg cctgcttcct ctcggtgcaa ggcccagtgg
     3481 atgagaatcc caagatggcc atatttctgc agcatgccgc aggactctta catgcaatgt
     3541 gtacactgtg ctttgctgtc actggaaggt catacagcat atttgacaat aatcgccagg
     3601 atcccacagg gctgacagct gctcttcagg caaccgacct ggctggagtt cttcatatgc
     3661 tctactgtgt cctcttccat ggcaccatct tggaccccag cactgccagt cccaaggaga
     3721 attacactca aaataccatc caagtggcca ttcagagttt acgtttcttc aacagctttg
     3781 cagctcttca tctgcctgct tttcagtcta ttgtaggggc agagggcttg tcccttgcat
     3841 tccggcacat ggccagctcc ctgctgggcc actgcagcca agtctcctgt gaaagcctcc
     3901 ttcatgaggt catcgtctgt gtgggctact tcactgtcaa ccacccagat aaccaggtga
     3961 tcgtgcagtc cggccgccac cccacagtgc tgcagaagct ctgccagttg cccttccagt
     4021 atttcagtga cccacggctg atcaaagtac tgttcccttc acttatcgct gcttgttaca
     4081 acaaccatca gaacaagatc attctggagc aagagatgag ctgtgtttta ctggccactt
     4141 tcattcagga tttggcacag actccaggtc aagcggaaaa ccagccttac caacccaaag
     4201 ggaaatgcct tggttcccaa gactatcttg agctggctaa cagatttcct cagcaggcct
     4261 gggaagaagc tcgacagttt ttcttgaaaa aagagaaaaa ataaatgttt tggttgattc
     4321 tgtatttgag tacccttgtt aatattttaa attgtccaaa caaacattct aattgttcct
     4381 taagaactca ttttcccatg tttatactct tcccacactg tagatatggc atgtacttta
     4441 cactatttat aatgactgta gatacttgaa tgttctactt gctaattttg caagttgagt
     4501 ttatttcatt tatgcagagt atcttggagt ttggtaattt ccatcttatg ataatatata
     4561 ctttgcattt gtgatatggg tgaaaggaga cataaaatta gcaagtctgt tttgttcttg
     4621 taataaagta acttattctg ttttcattgt tgacttttca tgttaaggaa atacgaatct
     4681 gaaagaaaaa tgttaactcc agctcttgaa gtatcttaaa taaagactta attaaagttt
     4741 acctgctcta aatttaactt tttaaggtct acggtaaaga tatttgcaac acttttgcat
     4801 tctgactaca taatatgttt gggggctatt tgaaatcaac ttagggcgtt gtattcattg
     4861 gtctgcccga actctcctag cagataatcc tctcttggca ttgccgagct gaaattactc
     4921 tcctaaggaa aaattagtga taaaaaagat gtgtcctagt gaatcaccct agagtatttt
     4981 ctcacatggt tgtgaaatga agcaacgctg aaataaaagt cacacagaaa gtc
//
