LOCUS       XM_047447732            5148 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens SREBF chaperone (SCAP), transcript variant
            X1, mRNA.
ACCESSION   XM_047447732
VERSION     XM_047447732.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000003.12) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5148
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
     gene            1..5148
                     /gene="SCAP"
                     /note="SREBF chaperone; Derived by automated computational
                     analysis using gene prediction method: Gnomon. Supporting
                     evidence includes similarity to: 150 ESTs, 486 long SRA
                     reads, 3 Proteins, and 85% coverage of the annotated
                     genomic feature by RNAseq alignments, including 19 samples
                     with support for all annotated introns"
                     /db_xref="GeneID:22937"
                     /db_xref="HGNC:HGNC:30634"
                     /db_xref="MIM:601510"
     CDS             1136..4975
                     /gene="SCAP"
                     /codon_start=1
                     /product="sterol regulatory element-binding protein
                     cleavage-activating protein isoform X1"
                     /protein_id="XP_047303688.1"
                     /db_xref="GeneID:22937"
                     /db_xref="HGNC:HGNC:30634"
                     /db_xref="MIM:601510"
                     /translation="MTLTERLREKISRAFYNHGLLCASYPIPIILFTGFCILACCYPL
                     LKLPLPGTGPVEFTTPVKDYSPPPVDSDRKQGEPTEQPEWYVGAPVAYVQQIFVKSSV
                     FPWHKNLLAVDVFRSPLSRAFQLVEEIRNHVLRDSSGIRSLEELCLQVTDLLPGLRKL
                     RNLLPEHGCLLLSPGNFWQNDWERFHADPDIIGTIHQHEPKTLQTSATLKDLLFGVPG
                     KYSGVSLYTRKRMVSYTITLVFQHYHAKFLGSLRARLMLLHPSPNCSLRAESLVHVHF
                     KEEIGVAELIPLVTTYIILFAYIYFSTRKIDMVKSKWGLALAAVVTVLSSLLMSVGLC
                     TLFGLTPTLNGGEIFPYLVVVIGLENVLVLTKSVVSTPVDLEVKLRIAQGLSSESWSI
                     MKNMATELGIILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMLFFTTVLSIDIRRMELA
                     DLNKRLPPEACLPSAKPVGQPTRYERQLAVRPSTPHTITLQPSSFRNLRLPKRLRVVY
                     FLARTRLAQRLIMAGTVVWIGILVYTDPAGLRNYLAAQVTEQSPLGEGALAPMPVPSG
                     MLPPSHPDPAFSIFPPDAPKLPENQTSPGESPERGGPAEVVHDSPVPEVTWGPEDEEL
                     WRKLSFRHWPTLFSYYNITLAKRYISLLPVIPVTLRLNPREALEGRHPQDGRSAWPPP
                     GPIPAGHWEAGPKGPGGVQAHGDVTLYKVAALGLATGIVLVLLLLCLYRVLCPRNYGQ
                     LGGGPGRRRRGELPCDDYGYAPPETEIVPLVLRGHLMDIECLASDGMLLVSCCLAGHV
                     CVWDAQTGDCLTRIPRPGRQRRDSGVGSGLEAQESWERLSDGGKAGPEEPGDSPPLRH
                     RPRGPPPPSLFGDQPDLTCLIDTNFSAQPRSSQPTQPEPRHRAVCGRSRDSPGYDFSC
                     LVQRVYQEEGLAAVCTPALRPPSPGPVLSQAPEDEGGSPEKGSPSLAWAPSAEGSIWS
                     LELQGNLIVVGRSSGRLEVWDAIEGVLCCSSEEVSSGITALVFLDKRIVAARLNGSLD
                     FFSLETHTALSPLQFRGTPGRGSSPASPVYSSSDTVACHLTHTVPCAHQKPITALKAA
                     AGRLVTGSQDHTLRVFRLEDSCCLFTLQGHSGAITTVYIDQTMVLASGGQDGAICLWD
                     VLTGSRVSHVFAHRGDVTSLTCTTSCVISSGLDDLISIWDRSTGIKFYSIQQDLGCGA
                     SLGVISDNLLVTGGQGCVSFWDLNYGDLLQTVYLGKNSEAQPARQILVLDNAAIVCNF
                     GSELSLVYVPSVLEKLD"
ORIGIN      
        1 acattgttat gcaaccatca tcactatcca tttccagaat gttttcatta ttctacatag
       61 aaactatcga tccaggagcc atatgtagaa agctgaaact ggatcccttc cttacacctt
      121 atacaaaaat caattcaaga tggattaaag acttaaatgt tagacctaaa accataaaaa
      181 ccctagaaga aaacctaggc aataccattc aggccatagg catgggcaag gacttcatga
      241 ctaaaacacc aaaagcaatg gcaacaaaag ccaaaattga caaatgggat ctaattaaac
      301 taaagagctt ctacacagca aaagaaacta ccatcagact gaacaggcaa cctacagagt
      361 gggagaaaat ttttacaatc tacccatctg acaaagggct aatatccaga atctacaaag
      421 aacttaaaca gatttacaag aaaaaaatca aacaacccta tcaaaaagtg ggtgaagcat
      481 atgaacagac acttctcaaa agaagacatt tatgcagcca acagacacat gaaaaaatgc
      541 ttgtcgtcac tggccatcag agaaatgcaa atcaaaacca caatgagata ccctcacacc
      601 agttagaatg gggatcatta aaaagtcagg aaacaacagg tgctggagag gatgtggaga
      661 aataggaacc cttttacact gttggtggga ctgtaaacta gttcaaccat tgtggaagac
      721 agtgtggcga ttcctcaagg atctagaact agaaatacca tttgacccag ccatcccatt
      781 actgggcata tacccaaagg attataaatc atgctgctat aaaggcacat gcacacgtat
      841 gtttattacg gcactattca caatagcaaa gacttggaac caacccaaat gtccatcaat
      901 gatagactgg attaagaaaa tgtggcacat atacaccatg gaatactatg cagccataaa
      961 aaaaggttag atgggtagtg ctgacatcat aacaaggttc aagaatgact catctcacat
     1021 gtgtgtgaaa cacccaggta cctgcacatg ttgttctttg tcagtgctgt caagtgtgtg
     1081 ccagggtgat ccatggtcac tttccgggat ggcagcaagg tgacttcggc tgaggatgac
     1141 cctgactgaa aggctgcgtg agaagatatc tcgggccttc tacaaccatg ggctcctctg
     1201 tgcatcctat cccatcccca tcatcctctt cacagggttc tgcatcttag cctgctgcta
     1261 cccactgctg aaactcccct tgccaggaac aggacctgtg gaattcacca cccctgtgaa
     1321 ggattactcg cccccacctg tggactctga ccgcaaacaa ggagagccta ctgagcagcc
     1381 tgagtggtat gtgggtgccc cggtggctta tgtccagcag atatttgtga agtcctcagt
     1441 gtttccctgg cacaagaacc tcctggcagt agatgtattt cgttcacctt tgtcccgggc
     1501 attccaactg gtggaggaga tccggaacca cgtgctgaga gacagctctg ggatcaggag
     1561 cttggaggag ttgtgtctgc aagtgaccga cctgctgcca ggccttagga agctcaggaa
     1621 cctactccct gagcatggat gcctgctgct gtcccctggg aacttctggc agaatgactg
     1681 ggaacgcttc catgctgatc ctgacatcat tgggaccatc caccagcacg agcctaaaac
     1741 cctgcagact tcagccacac tcaaagactt gttatttggt gttcctggga agtacagcgg
     1801 ggtgagcctc tacaccagga agaggatggt ctcctacacc atcaccctgg tcttccagca
     1861 ctaccatgcc aagttcctgg gcagcctgcg tgcccgcctg atgcttctgc accccagccc
     1921 caactgcagc cttcgggcgg agagcctggt ccacgtgcac ttcaaggagg agattggtgt
     1981 cgctgagctc atcccccttg tgaccaccta catcatcttg tttgcctaca tctacttctc
     2041 cacgcggaag atcgacatgg tcaagtccaa gtgggggctg gccctggctg ccgtggtcac
     2101 agtgctcagc tcgctgctca tgtctgtggg actctgcaca ctcttcggcc tgacgcccac
     2161 cctcaatggc ggcgagattt tcccctacct tgtggtggtt attgggttag agaatgtgtt
     2221 ggtgctcacc aagtctgtgg tctcaacccc ggtagacctg gaggtgaagc tgcggatcgc
     2281 ccaaggccta agcagcgaga gctggtccat catgaagaac atggccacgg agctgggcat
     2341 catcctcatc ggctacttca ccctagtgcc cgccatccag gagttctgtc tctttgctgt
     2401 cgtggggctg gtgtctgact tcttccttca gatgctgttt ttcaccactg tcctgtccat
     2461 tgacattcgc cggatggagc tagcagacct gaacaagcga ctgccccctg aggcctgcct
     2521 gccctcagcc aagccagtgg gacagccaac gcgctacgag cggcagctgg ctgtgaggcc
     2581 gtccacaccc cacaccatca cgttgcagcc gtcttccttc cgaaacctgc ggctccccaa
     2641 gaggctgcgt gttgtctact tcctggcccg cacccgcctg gcacagcgcc tcatcatggc
     2701 tggcaccgtt gtctggattg gcatcctggt atacacagac ccagcagggc tgcgcaacta
     2761 cctcgctgcc caggtgacgg aacagagccc attgggtgag ggagccctgg ctcccatgcc
     2821 cgtgcctagt ggcatgctgc cccccagcca cccggaccct gccttctcca tcttcccacc
     2881 tgatgcccct aagctacctg agaaccagac gtcgccaggc gagtcacctg agcgtggagg
     2941 tccagcagag gttgtccatg acagcccagt cccagaggta acctgggggc ctgaggatga
     3001 ggaactttgg aggaaattgt ccttccgcca ctggccgacg ctcttcagct attacaacat
     3061 cacactggcc aagaggtaca tcagcctgct gcccgtcatc ccagtcacgc tccgcctgaa
     3121 cccgagggag gctctggagg gccggcaccc tcaggacggc cgcagtgcct ggcccccacc
     3181 ggggcccata cctgctgggc actgggaagc aggacccaag ggcccaggtg gggtgcaggc
     3241 ccatggagac gtcacgctgt acaaggtggc ggcgctgggc ctggccaccg gcatcgtctt
     3301 ggtgctgctg ctgctctgcc tctaccgcgt gctatgcccg cgcaactacg ggcagctggg
     3361 tggtgggccc gggcggcgga ggcgcgggga gctgccctgc gacgactacg gctatgcgcc
     3421 acccgagacg gagatcgtgc cgcttgtgct gcgcggccac ctcatggaca tcgagtgcct
     3481 ggccagcgac ggcatgctgc tggtgagctg ctgcctggca ggccacgtct gcgtgtggga
     3541 cgcgcagacc ggggattgcc taacgcgcat tccgcgccca ggcaggcagc gccgggacag
     3601 tggcgtgggc agcgggcttg aggctcagga gagctgggaa cgactttcag atggtgggaa
     3661 ggctggtcca gaggagcctg gggacagccc tcccctgaga caccgccccc ggggccctcc
     3721 gccgccttcc ctcttcgggg accagcctga cctcacctgc ttaattgaca ccaacttttc
     3781 agcgcagcct cggtcctcac agcccactca gcccgagccc cggcaccggg cggtctgtgg
     3841 ccgctctcgg gactccccag gctatgactt cagctgcctg gtgcagcggg tgtaccagga
     3901 ggaggggctg gcggccgtct gcacaccagc cctgcgccca ccctcgcctg ggccggtgct
     3961 gtcccaggcc cctgaggacg agggtggctc ccccgagaaa ggctcccctt ccctcgcctg
     4021 ggcccccagt gccgagggtt ccatctggag cttggagctg cagggcaacc tcatcgtggt
     4081 ggggcggagc agcggccggc tggaggtgtg ggacgccatt gaaggggtgc tgtgctgcag
     4141 cagcgaggag gtctcctcag gcattaccgc tctggtgttc ttggacaaaa ggattgtggc
     4201 tgcacggctc aacggttccc ttgatttctt ctccttggag acccacactg ccctcagccc
     4261 cctgcagttt agagggaccc cagggcgggg cagttcccct gcctctccag tgtacagcag
     4321 cagcgacaca gtggcctgtc acctgaccca cacagtgccc tgtgcacacc aaaaacccat
     4381 cacagccctg aaagccgctg ctgggcgctt ggtgactggg agccaagacc acacactgag
     4441 agtgttccgt ctggaggact cgtgctgcct cttcaccctt cagggccact caggggccat
     4501 cacgaccgtg tacattgacc agaccatggt gctggccagt ggaggacaag atggggccat
     4561 ctgcctgtgg gatgtactga ctggcagccg ggtcagccat gtgtttgctc accgtgggga
     4621 tgtcacctcc cttacctgta ccacctcctg tgtcatcagc agtggcctgg atgacctcat
     4681 cagcatctgg gaccgcagca caggcatcaa gttctactcc attcagcagg acctgggctg
     4741 tggtgcaagc ttgggtgtca tctcagacaa cctgctggtg actggcggcc agggctgtgt
     4801 ctccttttgg gacctaaact acggggacct gttacagaca gtctacctgg ggaagaacag
     4861 tgaggcccag cctgcccgcc agatcctggt gctggacaac gctgccattg tctgcaactt
     4921 tggcagtgag ctcagcctgg tgtatgtgcc ctctgtgctg gagaagctgg actgagcgca
     4981 gggcctcctt gcccaggcag gaggctgggg tgctgtgtgg gggccaatgc actgaacctg
     5041 gacttggggg aaagagccga gtatcttcca gccgctgcct cctgactgta ataatattaa
     5101 acttttttaa aaaaccatat catcatctgt caggcacttt gggagcta
//
