LOCUS       NM_052923               5935 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens SCAN domain containing 3 (SCAND3), transcript variant
            1, mRNA.
ACCESSION   NM_052923 XM_166375
VERSION     NM_052923.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5935)
  AUTHORS   Akbarzadeh,M., Riahi,P., Kolifarhood,G., Lanjanian,H., Alipour,N.,
            Najd Hassan Bonab,L., Reza Moghadas,M., Sabour,S., Azizi,F. and
            Daneshpour,M.S.
  TITLE     The AGT epistasis pattern proposed a novel role for ZBED9 in
            regulating blood pressure: Tehran Cardiometabolic genetic study
            (TCGS)
  JOURNAL   Gene 831, 146560 (2022)
   PUBMED   35577038
  REMARK    GeneRIF: The AGT epistasis pattern proposed a novel role for ZBED9
            in regulating blood pressure: Tehran Cardiometabolic genetic study
            (TCGS).
REFERENCE   2  (bases 1 to 5935)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   3  (bases 1 to 5935)
  AUTHORS   Kolifarhood,G., Sabour,S., Akbarzadeh,M., Sedaghati-Khayat,B.,
            Guity,K., Rasekhi Dehkordi,S., Amiri Roudbar,M., Hadaegh,F.,
            Azizi,F. and Daneshpour,M.S.
  TITLE     Genome-wide association study on blood pressure traits in the
            Iranian population suggests ZBED9 as a new locus for hypertension
  JOURNAL   Sci Rep 11 (1), 11699 (2021)
   PUBMED   34083597
  REMARK    GeneRIF: Genome-wide association study on blood pressure traits in
            the Iranian population suggests ZBED9 as a new locus for
            hypertension.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5935)
  AUTHORS   Zhang,X., Zhou,H., Zhang,Y., Cai,L., Jiang,G., Li,A., Miao,Y.,
            Li,Q., Qiu,X. and Wang,E.
  TITLE     ZNF452 facilitates tumor proliferation and invasion via activating
            AKT-GSK3beta signaling pathway and predicts poor prognosis of
            non-small cell lung cancer patients
  JOURNAL   Oncotarget 8 (24), 38863-38875 (2017)
   PUBMED   28418919
  REMARK    GeneRIF: the present study indicated that ZNF452 may be an upstream
            regulator of AKT-GSK3beta signaling pathway and facilitates
            proliferation and invasion of non-small cell lung cancer
REFERENCE   5  (bases 1 to 5935)
  AUTHORS   Hayward,A., Ghazal,A., Andersson,G., Andersson,L. and Jern,P.
  TITLE     ZBED evolution: repeated utilization of DNA transposons as
            regulators of diverse host functions
  JOURNAL   PLoS One 8 (3), e59940 (2013)
   PUBMED   23533661
REFERENCE   6  (bases 1 to 5935)
  AUTHORS   Llorens,C., Bernet,G.P., Ramasamy,S., Feschotte,C. and Moya,A.
  TITLE     On the transposon origins of mammalian SCAND3 and KRBA2, two
            zinc-finger genes carrying an integrase/transposase domain
  JOURNAL   Mob Genet Elements 2 (5), 205-210 (2012)
   PUBMED   23550032
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY517631.1 and AL049543.17.
            
            On May 17, 2019 this sequence version replaced NM_052923.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY517631.1, BC110834.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000452236.3/ ENSP00000395259.2
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4840              AY517631.1         38-4877
            4841-5935           AL049543.17        33985-35079
FEATURES             Location/Qualifiers
     source          1..5935
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.1"
     gene            1..5935
                     /gene="SCAND3"
                     /gene_synonym="Buster4; dJ1186N24.3; FAM200D; ZBED9;
                     ZFP38-L; ZNF305P2; ZNF452"
                     /note="SCAN domain containing 3"
                     /db_xref="GeneID:114821"
                     /db_xref="HGNC:HGNC:13851"
                     /db_xref="MIM:615254"
     exon            1..1001
                     /gene="SCAND3"
                     /gene_synonym="Buster4; dJ1186N24.3; FAM200D; ZBED9;
                     ZFP38-L; ZNF305P2; ZNF452"
                     /inference="alignment:Splign:2.1.0"
     CDS             582..4559
                     /gene="SCAND3"
                     /gene_synonym="Buster4; dJ1186N24.3; FAM200D; ZBED9;
                     ZFP38-L; ZNF305P2; ZNF452"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger protein 452; zinc finger protein 305 pseudogene 2;
                     SCAN domain-containing protein 3; zinc finger BED
                     domain-containing protein 9; transposon-derived Buster4
                     transposase-like protein; zinc finger BED-type containing
                     9"
                     /codon_start=1
                     /product="SCAN domain-containing protein 3 isoform 1"
                     /protein_id="NP_443155.1"
                     /db_xref="CCDS:CCDS34355.1"
                     /db_xref="GeneID:114821"
                     /db_xref="HGNC:HGNC:13851"
                     /db_xref="MIM:615254"
                     /translation="MEAVSRVFPALAGQAPEEQGEIIKVKVKEEDHTWDQESALRRNL
                     SYTRELSRQRFRQFCYQETPGPREALSQLRELCRQWLNPEIHTKEQILELLVLEQFLT
                     ILPEELQSWVREHNPESGEEVVTLLEDLERELDEPRQQVSQGTYGQEVSMEEMIPLDS
                     AKESLGTQLQSMEDRMECESPEPHPLQDNGSFLWFSMMSQSMGGDNLSSLDTNEAEIE
                     PENMREKFFRSLARLLENKSNNTKIFSKAKYCQLIKEVKEAKAKAKKESVDYRRLARF
                     DVILVQGNEKLIEAVNGETDKIRYYLHSEDLFDILHNTHLSIGHGGRTRMEKELQAKY
                     KNITKEVIMLYLTLCKPCQQKNSKLKKVLTSKSIKEVSSRCQVDLIDMQLNPDGEYRF
                     ILHYQDLCTKLTFLRSLKSKRPTEVAHALLDIFTIIGAPSVLQSDNGREFSSQVVSEL
                     SNIWPELKIVHGKSQTCQSQSSAEQTEDIRKRIFSWMQTNNSSHWTEFLWFIQMSQNQ
                     PYHRSMQQTPCESAFSSEAKLGLSHSQLTEELVASLHTENELDQADKELENTLRAQYE
                     ENIETGTDSSDIEENLSVTPKVAEKSPPESRLRFLSCVVCEKECTGVNSCISCDGNIH
                     AICGVPSQHGTEGCGRQITCSLCYETSTMKRKHDEIQRSLPVKPSKMLKPSGTPFSPD
                     KVGDWMAKQASLDFFVKKRHAFSEHSSSNKRNVNNRSYPEEGKTKRVHASFTRKYDPS
                     YIEFGFVAVIDGEVLKPQCIICGDVLANEAMKPSKLKRHLYSKHKEISSQPKEFFERK
                     SSELKSQPKQVFNVSHINISALRASYKVALPVAKSKTPYTIAETLVKDCIKEVCLEML
                     GESAAKKVAQVPLSNDTIARRIQELANDMEDQLIEQIKLAKYFSLQLDECRDIANMII
                     LLVYVRFEHDDDIKEEFFFSASLPTNTTSSELYEAVKNYIVNKCGLEFKFCVGVCSDG
                     AASMTGKHSEVVTQIKELAPECKTTHCFIHRESLAMKKISAELNSVLNDIVKIVNYIK
                     SNSLNSRLFSLLCDNMEADHKQLLLHAEIRWLSRGKVLSRMFEIRNELLVFLQGKKPM
                     WSQLFKDVNWTARLAYLSDIFSIFNDLNASMQGKNATYFSMADKVEGQKQKLEAWKNR
                     ISTDCYDMFHNLTTIINEVGNDLDIAHLRKVISEHLTNLLECFEFYFPSKEDPRIGNL
                     WIQNPFLSSKDNLNLTVTLQDKLLKLATDEGLKISFENTASLPSFWIKAKNDYPELAE
                     IALKLLLLFPSTYLCETGFSTLSVIKTKHRNSLNIHYPLRVALSSIQPRLDKLTSKKQ
                     AHLSH"
     exon            1002..1149
                     /gene="SCAND3"
                     /gene_synonym="Buster4; dJ1186N24.3; FAM200D; ZBED9;
                     ZFP38-L; ZNF305P2; ZNF452"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..2642
                     /gene="SCAND3"
                     /gene_synonym="Buster4; dJ1186N24.3; FAM200D; ZBED9;
                     ZFP38-L; ZNF305P2; ZNF452"
                     /inference="alignment:Splign:2.1.0"
     exon            2643..5935
                     /gene="SCAND3"
                     /gene_synonym="Buster4; dJ1186N24.3; FAM200D; ZBED9;
                     ZFP38-L; ZNF305P2; ZNF452"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4822..4827
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCAND3"
                     /gene_synonym="Buster4; dJ1186N24.3; FAM200D; ZBED9;
                     ZFP38-L; ZNF305P2; ZNF452"
                     /note="hexamer: ATTAAA"
     polyA_site      4840
                     /gene="SCAND3"
                     /gene_synonym="Buster4; dJ1186N24.3; FAM200D; ZBED9;
                     ZFP38-L; ZNF305P2; ZNF452"
                     /note="major polyA site"
ORIGIN      
        1 acagctgcgg gtgtgtctgc ggaacctcca cctgagctgt agagtgtttc cctcgaccca
       61 ctagtctggg ttccacaggg tctgagctcc tcagaggtgg gagctgcggc cgagggaagg
      121 gtgcatgtgc gcggcgacaa tcgggcctct tccccaggca gcttgtgagc ccctctccct
      181 ctccgccctc gcccaggctg ctccgatctt cgtttccttg cctaggctca tacacccagg
      241 ctttatttag ggccaaagta tccgtcataa cctcggtttt ctgtctcgca agtatcttgc
      301 cgctcaattt gtgaccctga agctttagtg agtcgctctg tgctcactat ttctggtctt
      361 ttcagaggat ggcttcactt tcaatggaat tgcccgagta actgccctgt gttgtcacgt
      421 aaacaagtcc ttttaaactg agtctgtagt tgtcctgtgt tgagtgtttt cttatatcaa
      481 aaactttcct gaccaagaac aaaaaaggag ctcaagtaaa atcacccatt tgcctagacc
      541 ccaactggag agaacctttg cctgagctgt ctaagctcgg gatggaagca gtctctaggg
      601 tcttcccagc cttggctggc caggctccag aagaacaagg ggagattatc aaagtaaagg
      661 ttaaagaaga agaccacact tgggatcagg aatcagccct acgtaggaat ttgtcttata
      721 ccagggaact ctctcgtcag cgcttcaggc agttctgcta tcaggagaca cctgggccca
      781 gggaggctct gagtcaactg cgggaacttt gccgtcagtg gctgaaccca gagatacata
      841 ccaaggagca gatcctggaa ttgttggtgc tggagcagtt cctgaccatc ctgcctgagg
      901 agctccagtc ttgggtgcgg gagcataatc ctgagagtgg agaagaggtg gtgactttgc
      961 tggaagattt ggagagggag cttgatgaac ctagacagca ggtctcacag ggcacatatg
     1021 ggcaggaagt ttctatggaa gaaatgatcc ctctggattc tgcaaaggag tctttaggca
     1081 cccagcttca gtctatggaa gatagaatgg aatgtgaatc tccagagcca cacccacttc
     1141 aagataatgg gtcatttttg tggttttcca tgatgtctca aagcatgggt ggtgataacc
     1201 tcagtagctt agatactaat gaagcagaaa ttgaaccaga aaacatgaga gaaaagttct
     1261 tcagaagctt agcaaggtta ctggaaaaca aaagtaataa tactaagata ttttctaaag
     1321 caaagtactg tcagttgata aaggaagtga aagaagctaa agctaaggcg aaaaaggaat
     1381 cagttgacta ccgtcgcttg gctagatttg atgttatcct tgtacaagga aatgagaagc
     1441 taattgaggc tgtaaatggg gaaacagata aaatacggta ttacttacac agtgaggact
     1501 tatttgacat tctgcataat acacatctca gcattggaca tggtggacgt actcgcatgg
     1561 agaaagagtt acaagcgaaa tacaagaaca tcacaaaaga agttataatg ctgtatctga
     1621 ccctctgtaa accatgccaa cagaaaaatt caaaactcaa gaaggttcta acatcaaaat
     1681 caattaagga agttagttca agatgccaag tagatcttat agacatgcag ttgaatcctg
     1741 atggggagta cagatttatt ttgcattatc aagatctctg tacaaagtta acttttttgc
     1801 ggtcattaaa gtctaaaagg cctacggaag ttgcacatgc tcttttagat atatttacaa
     1861 ttattggagc acccagtgtc ctacaatctg acaatgggag ggaattttca agccaggttg
     1921 tcagtgaact cagtaatatt tggccagaat tgaaaattgt ccatgggaag tctcagacct
     1981 gccaaagcca gagttctgca gaacaaactg aggatatccg aaagaggatt ttctcctgga
     2041 tgcaaactaa caactcatca cactggactg aatttttgtg gttcattcag atgtcccaaa
     2101 atcagcccta tcacagaagc atgcaacaga ctccatgtga aagtgcattt agctctgaag
     2161 ctaaactggg cttgtcccat tctcagctaa ctgaagaact tgttgccagc ttgcatacag
     2221 aaaatgaatt agatcaggct gacaaagagt tagaaaatac tttaagagcc cagtatgaag
     2281 aaaacattga gactggaaca gacagtagtg atattgaaga gaatctttct gtcactccta
     2341 aggtggctga aaaaagccct cctgagagca gactaagatt tttatcctgt gtagtttgtg
     2401 aaaaagaatg cacaggtgtt aatagttgta tatcatgtga tggaaatatc catgcaattt
     2461 gtggagtgcc ctctcaacat gggactgagg gctgtggtcg gcaaataact tgtagccttt
     2521 gctatgaaac cagcacaatg aagaggaaac atgatgagat tcaaagaagt ttgcctgtta
     2581 aaccttccaa aatgctaaag ccatcaggga caccattttc accagacaaa gtaggagact
     2641 ggatggcgaa acaagcttca ctggactttt ttgtcaagaa aagacatgcc ttttctgaac
     2701 acagtagtag taataaaaga aatgttaaca atagaagtta tcctgaagaa gggaaaacca
     2761 aaagagttca tgctagtttc actcggaaat atgatccttc atatattgag tttggttttg
     2821 tagctgtaat tgatggtgaa gtactaaaac cacagtgtat tatttgtgga gatgtactgg
     2881 ctaatgaagc aatgaaacca tcaaaactta agcgacattt atattcaaaa cataaagaaa
     2941 taagttcaca accaaaagaa ttctttgaaa gaaagagtag tgaattgaaa agccaaccaa
     3001 agcaggtgtt caacgtttct catataaaca ttagtgcttt gcgggcttca tataaagtag
     3061 cacttccggt tgccaagtct aaaacaccat acacaattgc tgagacacta gtgaaagact
     3121 gcatcaaaga agtttgcttg gaaatgttgg gtgaatctgc agcaaagaag gtagctcagg
     3181 taccactttc caatgacacc atagctcgac gtattcagga actggctaat gatatggaag
     3241 atcaactcat agaacaaata aaactagcaa agtatttttc attgcaactt gatgaatgca
     3301 gagatattgc taacatgata attcttttag tctatgtgag gtttgaacat gatgatgata
     3361 taaaggaaga gttctttttt tcagcctctt tgcctacaaa cacaactagc tcagaactgt
     3421 atgaagctgt aaagaattat attgttaaca aatgtggttt ggaatttaaa ttttgtgtag
     3481 gagtatgttc tgatggtgca gcttcaatga caggaaaaca ttctgaagtg gtaacccaga
     3541 ttaaggaact tgcgccagaa tgtaaaacaa cacattgctt cattcatcga gaaagtcttg
     3601 ccatgaaaaa aatatcagct gaactaaata gtgtacttaa tgatatagta aaaattgtga
     3661 attatataaa atctaattca ttgaattcaa gattattctc tttattatgt gataatatgg
     3721 aagctgatca taagcaactg ttactgcatg ctgagatacg gtggttatca cggggaaaag
     3781 ttctgtcaag aatgtttgaa atacgaaatg aactcttagt gtttctgcaa ggcaagaaac
     3841 ccatgtggtc ccaacttttt aaagatgtga attggacagc cagacttgct tatttgtctg
     3901 atatcttcag tatttttaat gatcttaatg cttctatgca agggaagaat gcaacttatt
     3961 tttcaatggc agataaagtt gaaggacaaa aacagaagtt agaagcttgg aaaaacagaa
     4021 tttctacaga ttgttatgac atgtttcata atttaacaac aattatcaat gaagtaggta
     4081 atgatcttga tattgcacat ctgcgaaaag ttatcagtga acatcttaca aatttgttag
     4141 aatgttttga attttatttt ccatcaaaag aagatccacg cataggaaat ttgtggatcc
     4201 aaaatccatt tctttcatca aaagataact taaatttaac tgtaactcta caggataagt
     4261 tgttgaagct ggctaccgac gaaggattga aaatcagttt tgaaaataca gcatcacttc
     4321 cttcattttg gataaaagct aaaaatgact atcctgagct tgctgagatt gctttaaaat
     4381 tgctgcttct tttcccctca acatacctct gtgagaccgg attctctact ttaagtgtta
     4441 ttaaaacaaa acatagaaac agtttaaata tacattatcc cctgagggta gcattgtcat
     4501 caatccaacc tagattagac aaattaacaa gcaagaagca agctcactta tcacattaaa
     4561 agctttaaat attgatatgt aaggtattgg ttcaaagtat gcatataagc attgagtgtg
     4621 aggaatttgc tatttcactt taaactttct gtctagttac agttatggaa gtatgagaag
     4681 ttatgagtga aacagcaatt ttctatataa attgcctata tgtatatttt caattaagaa
     4741 tgtgtacagt ttttataatt ctatttttcc tcatatttgt cgtatttatt aaaatataat
     4801 tttaaatctg ttgattctaa tattaaaaca tttgatctta tattttgtgt cttcttcttg
     4861 tatttcatta gcatgttaag attgtaggac aacttcagga tgggagatgg tttctttgaa
     4921 atagacaagg tcagtgaaag gaagtgaatt caaaggggta ggcttagaat tcaaatgcag
     4981 gggacaggtc agtagggtat gaagtttgtt aaactgatcc agagtggtta ggttggaagt
     5041 tgatgttgtt tgttttgtag gtgcatgttt agacaaagat ggaagggaac acttattttg
     5101 taatggtgtt atggccttgg attcatattg ataaatttat ttacttattt atttttgagg
     5161 cagggtcttg ctctgttgcc caggctggag tgcattggtg caatctctgc tcactgcaac
     5221 ctgtacctcc tgggttcaag tgattctctt gcctcagtct tccgagtaac tgagattaca
     5281 ggcacccacc accatgcctg gctaattttt gtatttatag tagagatggg gtttcaccat
     5341 gttggccagg ctcatcttga actcctgaca tcagatgacc ctcccacctc ggcctctcaa
     5401 agtgctggga ttacaggcgt gacctgctgc gcccggccga taaattctga tttcataagg
     5461 atgggcgatt gggccatact gacaagttta tgttaggtgg tttctagatt ttgctagaac
     5521 tgattgcctt taaggtgctc tgggacaaag tcagaaatta ttggcacctc aattagattt
     5581 aacaacctct attttgtttg gagatgattc agaaaaatgc cacaaatatc tgctcttgtg
     5641 tctgtgaact catttagaat aatcgaaagc aaattagtcc gataaaacag gttctttagc
     5701 atcaaaacat gacagaatcc atgaagaaaa tatcttttcc tagacagggt agcaatttac
     5761 agtaagtgct tcgtttcaaa taaatgtgat attcaaagtt aaggaaagga aggctattta
     5821 gtgattcaga atgttactaa taatttaacc ttttggtaat ggaagtttca aggatcctcc
     5881 aaacctttga aagtagagga aaggttcata tttagtcctg aaaccttaat tggat
//
