LOCUS       NM_033630                771 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens SCAN domain containing 1 (SCAND1), transcript variant
            2, mRNA.
ACCESSION   NM_033630
VERSION     NM_033630.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 771)
  AUTHORS   Eguchi,T., Csizmadia,E., Kawai,H., Sheta,M., Yoshida,K.,
            Prince,T.L., Wegiel,B. and Calderwood,S.K.
  TITLE     SCAND1 Reverses Epithelial-to-Mesenchymal Transition (EMT) and
            Suppresses Prostate Cancer Growth and Migration
  JOURNAL   Cells 11 (24), 3993 (2022)
   PUBMED   36552758
  REMARK    GeneRIF: SCAND1 Reverses Epithelial-to-Mesenchymal Transition (EMT)
            and Suppresses Prostate Cancer Growth and Migration.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 771)
  AUTHORS   Qin,Y., Huttlin,E.L., Winsnes,C.F., Gosztyla,M.L., Wacheul,L.,
            Kelly,M.R., Blue,S.M., Zheng,F., Chen,M., Schaffer,L.V., Licon,K.,
            Backstrom,A., Vaites,L.P., Lee,J.J., Ouyang,W., Liu,S.N., Zhang,T.,
            Silva,E., Park,J., Pitea,A., Kreisberg,J.F., Gygi,S.P., Ma,J.,
            Harper,J.W., Yeo,G.W., Lafontaine,D.L.J., Lundberg,E. and Ideker,T.
  TITLE     A multi-scale map of cell structure fusing protein images and
            interactions
  JOURNAL   Nature 600 (7889), 536-542 (2021)
   PUBMED   34819669
REFERENCE   3  (bases 1 to 771)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 771)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 771)
  AUTHORS   Carneiro,F.R., Silva,T.C., Alves,A.C., Haline-Vaz,T., Gozzo,F.C.
            and Zanchin,N.I.
  TITLE     Spectroscopic characterization of the tumor antigen NY-REN-21 and
            identification of heterodimer formation with SCAND1
  JOURNAL   Biochem Biophys Res Commun 343 (1), 260-268 (2006)
   PUBMED   16540086
  REMARK    GeneRIF: This result indicates that NY-REN-21 can function either
            as a homodimer or as a heterodimer with SCAND1.
REFERENCE   6  (bases 1 to 771)
  AUTHORS   Babb,R. and Bowen,B.R.
  TITLE     SDP1 is a peroxisome-proliferator-activated receptor gamma 2
            co-activator that binds through its SCAN domain
  JOURNAL   Biochem J 370 (Pt 2), 719-727 (2003)
   PUBMED   12444922
REFERENCE   7  (bases 1 to 771)
  AUTHORS   Sander,T.L. and Morris,J.F.
  TITLE     Characterization of the SCAN box encoding RAZ1 gene: analysis of
            cDNA transcripts, expression, and cellular localization
  JOURNAL   Gene 296 (1-2), 53-64 (2002)
   PUBMED   12383503
REFERENCE   8  (bases 1 to 771)
  AUTHORS   Schumacher,C., Wang,H., Honer,C., Ding,W., Koehn,J., Lawrence,Q.,
            Coulis,C.M., Wang,L.L., Ballinger,D., Bowen,B.R. and Wagner,S.
  TITLE     The SCAN domain mediates selective oligomerization
  JOURNAL   J Biol Chem 275 (22), 17173-17179 (2000)
   PUBMED   10747874
REFERENCE   9  (bases 1 to 771)
  AUTHORS   Sander,T.L., Haas,A.L., Peterson,M.J. and Morris,J.F.
  TITLE     Identification of a novel SCAN box-related protein that interacts
            with MZF1B. The leucine-rich SCAN box mediates hetero- and
            homoprotein associations
  JOURNAL   J Biol Chem 275 (17), 12857-12867 (2000)
   PUBMED   10777584
REFERENCE   10 (bases 1 to 771)
  AUTHORS   Williams,A.J., Blacklow,S.C. and Collins,T.
  TITLE     The zinc finger-associated SCAN box is a conserved oligomerization
            domain
  JOURNAL   Mol Cell Biol 19 (12), 8526-8535 (1999)
   PUBMED   10567577
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL109965.34.
            
            On Jul 27, 2020 this sequence version replaced NM_033630.2.
            
            Summary: This gene encodes a SCAN box domain-containing protein.
            The SCAN domain is a highly conserved, leucine-rich motif of
            approximately 60 aa originally found within a subfamily of zinc
            finger proteins. This gene belongs to a family of genes that encode
            an isolated SCAN domain, but no zinc finger motif. This protein
            binds to and may regulate the function of the transcription factor
            myeloid zinc finger 1B. Alternate splicing results in multiple
            transcript variants.[provided by RefSeq, Jan 2011].
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            contains an extra segment in the 5' coding region, compared to
            variant 1. These differences cause translation initiation at an
            upstream start codon, compared to variant 1. The encoded protein
            (isoform 2) has a longer N-terminus, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF207829.1, BM923953.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000305978.7/ ENSP00000301995.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                AL109965.34        64578-64632         c
            56-771              AL109965.34        63754-64469         c
FEATURES             Location/Qualifiers
     source          1..771
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q11.23"
     gene            1..771
                     /gene="SCAND1"
                     /gene_synonym="RAZ1; SDP1"
                     /note="SCAN domain containing 1"
                     /db_xref="GeneID:51282"
                     /db_xref="HGNC:HGNC:10566"
                     /db_xref="MIM:610416"
     exon            1..55
                     /gene="SCAND1"
                     /gene_synonym="RAZ1; SDP1"
                     /inference="alignment:Splign:2.1.0"
     exon            56..771
                     /gene="SCAND1"
                     /gene_synonym="RAZ1; SDP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..650
                     /gene="SCAND1"
                     /gene_synonym="RAZ1; SDP1"
                     /note="SCAN-related protein RAZ1"
                     /codon_start=1
                     /product="SCAN domain-containing protein 1"
                     /protein_id="NP_361012.3"
                     /db_xref="GeneID:51282"
                     /db_xref="HGNC:HGNC:10566"
                     /db_xref="MIM:610416"
                     /translation="MAATEPILAATGSPAAVPPEKLEGAGSSSAPERNCVGSSLPEAS
                     PPAPEPSSPNAAVPEAIPTPRAAASAALELPLGPAPVSVAPQAEAEARSTPGPAGSRL
                     GPETFRQRFRQFRYQDAAGPREAFRQLRELSRQWLRPDIRTKEQIVEMLVQEQLLAIL
                     PEAARARRIRRRTDVRITG"
     regulatory      746..751
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCAND1"
                     /gene_synonym="RAZ1; SDP1"
                     /note="hexamer: AATGAA"
     polyA_site      771
                     /gene="SCAND1"
                     /gene_synonym="RAZ1; SDP1"
                     /note="major polyA site"
ORIGIN      
        1 gcagagaagc cagagacttt cgcttccggc tgccgcaggc gcttcgctgg tgcagacgca
       61 gtgctgagca cacagctacc ggacaaagag tgacgcccgg agctggagtt atggcggcta
      121 cggagccgat cttggcggcc actgggagtc ccgcggcggt gccaccggag aaactggaag
      181 gagccggttc gagctcagcc cctgagcgta actgtgtggg ctcctcgctg ccagaggcct
      241 caccgcctgc ccctgagcct tccagtccca acgccgcggt ccctgaagcc atccctacgc
      301 cccgagctgc ggcctccgcg gccctggagc tgcctctcgg gcccgcaccc gtgagcgtag
      361 cgcctcaggc cgaagctgaa gcgcgctcca caccaggccc cgccggctct agactcggtc
      421 ccgagacgtt ccgccagcgt ttccggcagt tccgctacca ggatgcggcg ggtccccggg
      481 aggctttccg gcagctgcgg gagctgtccc gccagtggct gcggcctgac atccgcacca
      541 aggagcagat cgtggagatg ctggtgcaag agcagctgct cgccatcctg cccgaggcgg
      601 ctcgggcccg gcggatccgc cgccgcacgg atgtgcgcat cactggctga gcggtggagc
      661 tgcgggcggc cagggccggg cgctctgtgc ggactggggc catgatcggg cccgggggcc
      721 tgagcctggg accccacccc gtgttaatga aaaatgagtt ttggcagcgc c
//
