LOCUS       NM_138967               3379 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens secretory carrier membrane protein 5 (SCAMP5),
            transcript variant 3, mRNA.
ACCESSION   NM_138967
VERSION     NM_138967.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3379)
  AUTHORS   Pouw,J.N., Olde Nordkamp,M.A.M., O'Toole,T.G., Radstake,T.R.D.J.,
            Leijten,E.F.A. and Boes,M.
  TITLE     Activation-induced colocalisation of SCAMP5 with IFNalpha in human
            plasmacytoid dendritic cells
  JOURNAL   Lupus Sci Med 9 (1) (2022)
   PUBMED   35296555
  REMARK    GeneRIF: Activation-induced colocalisation of SCAMP5 with IFNalpha
            in human plasmacytoid dendritic cells.
REFERENCE   2  (bases 1 to 3379)
  AUTHORS   Ghanem,M.H., Shih,A.J., Vashistha,H., Coke,L.N., Li,W., Kim,S.J.,
            Simpfendorfer,K.R. and Gregersen,P.K.
  TITLE     Investigations into SCAMP5, a candidate lupus risk gene expressed
            in plasmacytoid dendritic cells
  JOURNAL   Lupus Sci Med 8 (1) (2021)
   PUBMED   34728555
  REMARK    GeneRIF: Investigations into SCAMP5, a candidate lupus risk gene
            expressed in plasmacytoid dendritic cells.
REFERENCE   3  (bases 1 to 3379)
  AUTHORS   Yue,C., Xie,S., Zhong,J., Zhao,H., Lin,Z., Zhang,L., Xu,B. and
            Luo,Y.
  TITLE     SCAMP2/5 as diagnostic and prognostic markers for acute myeloid
            leukemia
  JOURNAL   Sci Rep 11 (1), 17012 (2021)
   PUBMED   34426610
  REMARK    GeneRIF: SCAMP2/5 as diagnostic and prognostic markers for acute
            myeloid leukemia.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3379)
  AUTHORS   Lee,U., Choi,C., Ryu,S.H., Park,D., Lee,S.E., Kim,K., Kim,Y. and
            Chang,S.
  TITLE     SCAMP5 plays a critical role in axonal trafficking and synaptic
            localization of NHE6 to adjust quantal size at glutamatergic
            synapses
  JOURNAL   Proc Natl Acad Sci U S A 118 (2) (2021)
   PUBMED   33372133
  REMARK    GeneRIF: SCAMP5 plays a critical role in axonal trafficking and
            synaptic localization of NHE6 to adjust quantal size at
            glutamatergic synapses.
REFERENCE   5  (bases 1 to 3379)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 3379)
  AUTHORS   Castermans,D., Volders,K., Crepel,A., Backx,L., De Vos,R.,
            Freson,K., Meulemans,S., Vermeesch,J.R., Schrander-Stumpel,C.T., De
            Rijk,P., Del-Favero,J., Van Geet,C., Van De Ven,W.J.,
            Steyaert,J.G., Devriendt,K. and Creemers,J.W.
  TITLE     SCAMP5, NBEA and AMISYN: three candidate genes for autism involved
            in secretion of large dense-core vesicles
  JOURNAL   Hum Mol Genet 19 (7), 1368-1378 (2010)
   PUBMED   20071347
  REMARK    GeneRIF: scanp5 is predicted to play a role in neuronal vesicle
            trafficking and be involed in autism
REFERENCE   7  (bases 1 to 3379)
  AUTHORS   Noh,J.Y., Lee,H., Song,S., Kim,N.S., Im,W., Kim,M., Seo,H.,
            Chung,C.W., Chang,J.W., Ferrante,R.J., Yoo,Y.J., Ryu,H. and
            Jung,Y.K.
  TITLE     SCAMP5 links endoplasmic reticulum stress to the accumulation of
            expanded polyglutamine protein aggregates via endocytosis
            inhibition
  JOURNAL   J Biol Chem 284 (17), 11318-11325 (2009)
   PUBMED   19240033
  REMARK    GeneRIF: exposure to ER stress increases SCAMP5 in the striatum,
            which positively regulates mtHTT aggregation via the endocytosis
            pathway
REFERENCE   8  (bases 1 to 3379)
  AUTHORS   Han,C., Chen,T., Yang,M., Li,N., Liu,H. and Cao,X.
  TITLE     Human SCAMP5, a novel secretory carrier membrane protein,
            facilitates calcium-triggered cytokine secretion by interaction
            with SNARE machinery
  JOURNAL   J Immunol 182 (5), 2986-2996 (2009)
   PUBMED   19234194
  REMARK    GeneRIF: SCAMP5 is involved in calcium-regulated exocytosis of
            signal peptide-containing cytokines, in cooperation with the SNARE
            machinery of secretory vesicles.
REFERENCE   9  (bases 1 to 3379)
  AUTHORS   Lin,P.J., Williams,W.P., Luu,Y., Molday,R.S., Orlowski,J. and
            Numata,M.
  TITLE     Secretory carrier membrane proteins interact and regulate
            trafficking of the organellar (Na+,K+)/H+ exchanger NHE7
  JOURNAL   J Cell Sci 118 (Pt 9), 1885-1897 (2005)
   PUBMED   15840657
REFERENCE   10 (bases 1 to 3379)
  AUTHORS   Fernandez-Chacon,R. and Sudhof,T.C.
  TITLE     Novel SCAMPs lacking NPF repeats: ubiquitous and synaptic
            vesicle-specific forms implicate SCAMPs in multiple
            membrane-trafficking functions
  JOURNAL   J Neurosci 20 (21), 7941-7950 (2000)
   PUBMED   11050114
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA810757.1 and BC024700.1.
            
            On Nov 22, 2018 this sequence version replaced NM_138967.3.
            
            Transcript Variant: This variant (3) lacks an alternate exon in the
            5' UTR, compared to variant 1. Variants 1-3 encode the same
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK126940.1, SRR3476690.367996.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000425597.8/ ENSP00000406547.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-503               DA810757.1         29-531
            504-3379            BC024700.1         375-3250
FEATURES             Location/Qualifiers
     source          1..3379
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q24.2"
     gene            1..3379
                     /gene="SCAMP5"
                     /note="secretory carrier membrane protein 5"
                     /db_xref="GeneID:192683"
                     /db_xref="HGNC:HGNC:30386"
                     /db_xref="MIM:613766"
     exon            1..111
                     /gene="SCAMP5"
                     /inference="alignment:Splign:2.1.0"
     exon            112..166
                     /gene="SCAMP5"
                     /inference="alignment:Splign:2.1.0"
     CDS             160..867
                     /gene="SCAMP5"
                     /note="hSCAMP5"
                     /codon_start=1
                     /product="secretory carrier-associated membrane protein 5"
                     /protein_id="NP_620417.1"
                     /db_xref="CCDS:CCDS45306.1"
                     /db_xref="GeneID:192683"
                     /db_xref="HGNC:HGNC:30386"
                     /db_xref="MIM:613766"
                     /translation="MAEKVNNFPPLPKFIPLKPCFYQDFEADIPPQHVSMTKRLYYLW
                     MLNSVTLAVNLVGCLAWLIGGGGATNFGLAFLWLILFTPCSYVCWFRPIYKAFKTDSS
                     FSFMAFFFTFMAQLVISIIQAVGIPGWGVCGWIATISFFGTNIGSAVVMLIPTVMFTV
                     MAVFSFIALSMVHKFYRGSGGSFSKAQEEWTTGAWKNPHVQQAAQNAAMGAAQGAMNQ
                     PQTQYSATPNYTYSNEM"
     exon            167..295
                     /gene="SCAMP5"
                     /inference="alignment:Splign:2.1.0"
     exon            296..452
                     /gene="SCAMP5"
                     /inference="alignment:Splign:2.1.0"
     exon            453..554
                     /gene="SCAMP5"
                     /inference="alignment:Splign:2.1.0"
     exon            555..672
                     /gene="SCAMP5"
                     /inference="alignment:Splign:2.1.0"
     exon            673..3379
                     /gene="SCAMP5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3354..3359
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCAMP5"
                     /note="hexamer: AATAAA"
     polyA_site      3379
                     /gene="SCAMP5"
                     /note="major polyA site"
ORIGIN      
        1 ccccgccccc agccccggag cggctcgcgg ccggctccgc gccgcatcgc tcgggtgcag
       61 cgcagctcag cgcagcgctg cggcctttcg gcagccgaac ggccgcggca gttcaggaca
      121 aagaggtgtg ggcaggccac tgggccagct ggtaacatca tggcagagaa agtgaacaac
      181 ttcccaccat tgcccaaatt catcccgctg aagccatgtt tctaccaaga cttcgaggca
      241 gatattcctc cccagcatgt cagcatgacc aagcgcctct actacctctg gatgttgaac
      301 agcgtcacgc tggccgtgaa cctggtgggc tgtctcgcgt ggctgatcgg aggcggggga
      361 gccaccaact ttggcctcgc ctttctctgg ctcatcctct tcacaccctg ctcctacgtc
      421 tgctggtttc ggcccattta caaggccttc aagactgaca gctccttcag tttcatggca
      481 ttcttcttta ccttcatggc tcagttggtc atcagcatca tccaggccgt gggcatccca
      541 ggctggggcg tctgcggctg gattgctacc atctccttct tcggaacgaa cattggctcg
      601 gcggtggtga tgctaattcc cactgtcatg ttcacagtga tggccgtctt ttccttcatc
      661 gccctcagca tggttcataa attttaccgg ggaagtgggg ggagtttcag caaagctcag
      721 gaggagtgga ccacaggggc ctggaagaat ccacatgtgc agcaggcagc ccagaacgca
      781 gccatggggg cagcccaggg tgccatgaat cagcctcaga ctcagtattc cgccaccccc
      841 aattacacgt actccaatga gatgtgaacc agccacgcct accaggtggc agagctgggg
      901 ccattgggac agggggctca agccacatcg tcatttgtgg ttaccaagca gggttccccc
      961 ttcccttttc tccttcccta ctttgtacaa aggaccagag ttatatatat atatatatgt
     1021 atatgtctgt accccagccc ccacctttca gattctgctc ttggcactca gctgtgggct
     1081 gcacgtggag ctgtcccgtg cggtagtagc tgtgtctgtg tcccctcgtg aaatagtgtg
     1141 cagtggaggt ctcttgtggt gctagatgtg tgtttagagc taaaccagcc cccaccccca
     1201 ccctccacct gcccctcttg cctctggccc ctctgaccct ggcccaggga cccctcacgg
     1261 ggccagggga ggcatagcag aaagactggc cccttcctag ggttatgagc tggaactgtt
     1321 tctactttca gtcttcctgg gaagtaacag tacttagcac tcttggtggt gggtgggagg
     1381 gtgggtacag gccagggata ttcccttgct cttttgatcc ctccaggcct cgcctccttc
     1441 agcctcctcc tccctcatct gttccctgat gtcacattcc ctgtgcaatc ttcccttgcc
     1501 catggtctgt ctatctcttt cctatgtggc ttttctttgt cttccccaag gctgagtgtc
     1561 ccagttttat ctgctcctga gactgagccc agatccccaa atctaatctg atttacagtt
     1621 caaggaagct gatggggagc tgggccttac ccctgatgta ggaggggcac acagctgggg
     1681 gtgcagagcc cacctgggta cctgaccccc aggggatgaa aatgcaagga tgagtctgct
     1741 tgggcctgag agtttgatct gcaggggcag gctcatcttt tctctcccct gccttctcct
     1801 ccttctctcc ccagagcccc cttgagcccc tctgcctatg tccctctgcc tcctccccat
     1861 gcccccagtt gctgtggctt gattctgcta ccctgacccc accatgtgcc aggtggcatc
     1921 tgccttactg ccttccctga ggagctggga catgctgggc agttgtcaga tgtaaaggca
     1981 cagctggagc agagggcatg tcagtaatga ttggtccctg gggaaggtct ggctggctcc
     2041 agcacagtga ggcatttagg tatctctcgg tgaccgttgg attcctggaa gcagtagctg
     2101 ttctgtttgg atctggtagg acagggctca gagggctagg cacggaggga aggtcagagg
     2161 agaaggcagg cagggcccag tgagagggga gcatgccttc ccccaccctg gcttgctctt
     2221 ggtcacaggg cggttctggg cacttgaact cagggcccaa gcagaagcac aggcccagtc
     2281 ctggctgcaa gcacaatagc ctgaatggga tttcaggtta ggcagggtgg gaggggaggc
     2341 tctctggctt tagttttgtt ttgttttcca aatcaaggta acttgctccc ttctgcctac
     2401 aggccttggt cttggcttgt cctcacccag tcggaactcc ctaccacttt caggagagtg
     2461 gttttaggcc cgtggggctg ttctgttcca agcagtgtga gaacatggct ggtagaggct
     2521 ctagctgtgt gcggggcctg aaggggagtg ggttctcgcc caaagagcat ctgcccattt
     2581 cccaccttcc cttctcccac cagaagcttg cctgagctgt ttggacaaaa atccaaaccc
     2641 cacttggcta ctctggcctg gcttcagctt ggaacccaat acctaggctt acaggccatc
     2701 ctgagccagg ggcctctgga aattctcttc ctgatggtcc tttaggtttg ggcacaaaat
     2761 ataattgcct ctcccctctc ccattttctc tcttgggagc aatggtcaca gtccctggta
     2821 cctgaaaagg tacctaggtc taggcccttc ttccctttcc cttcctctcc cctaccccag
     2881 aactttggct ccctttccct tctctctctg gtagctccag gaggcctgtg atccagctcc
     2941 ctgcctagca tccatgacct gttggatgtt acctccaatc agtttcctgt cctacctgcc
     3001 tctttggctt ggacctatat ggccatgctc tggctctacc cttgggaagc ctgatcccgg
     3061 tgtgtggccc agcttgttca ggccctggga tgctgcatct ccaggcaact atgcactttc
     3121 ccggggagag aaccagtatg agaagtgggg gcagggcaca cattcatctt tgtaggaagg
     3181 tctggcctgg ggtcgggtga aggagggccc aggtcagttc tggggtccca gtgacctgct
     3241 ttgccattct cctggtgccg ctgctgctcc ctgtttctgg agctggatgt tccccagctg
     3301 gcagttgagc tgcctgagcc aatgtgtctg tctttggtaa ctgagtgaac cataataaag
     3361 gggaacattt ggccctgtg
//
