LOCUS       NM_079834               2501 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens secretory carrier membrane protein 4 (SCAMP4),
            transcript variant 1, mRNA.
ACCESSION   NM_079834
VERSION     NM_079834.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2501)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 2501)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2501)
  AUTHORS   Kim,K.M., Noh,J.H., Bodogai,M., Martindale,J.L., Pandey,P.R.,
            Yang,X., Biragyn,A., Abdelmohsen,K. and Gorospe,M.
  TITLE     SCAMP4 enhances the senescent cell secretome
  JOURNAL   Genes Dev 32 (13-14), 909-914 (2018)
   PUBMED   29967290
  REMARK    GeneRIF: secretory carrier membrane protein 4 (SCAMP4) levels were
            strikingly elevated on the surface of senescent cells compared with
            proliferating cells
REFERENCE   4  (bases 1 to 2501)
  AUTHORS   Castle,A. and Castle,D.
  TITLE     Ubiquitously expressed secretory carrier membrane proteins (SCAMPs)
            1-4 mark different pathways and exhibit limited constitutive
            trafficking to and from the cell surface
  JOURNAL   J Cell Sci 118 (Pt 16), 3769-3780 (2005)
   PUBMED   16105885
REFERENCE   5  (bases 1 to 2501)
  AUTHORS   Krebs,C.J. and Pfaff,D.W.
  TITLE     Expression of the SCAMP-4 gene, a new member of the secretory
            carrier membrane protein family, is repressed by progesterone in
            brain regions associated with female sexual behavior
  JOURNAL   Brain Res Mol Brain Res 88 (1-2), 144-154 (2001)
   PUBMED   11295240
REFERENCE   6  (bases 1 to 2501)
  AUTHORS   Fernandez-Chacon,R. and Sudhof,T.C.
  TITLE     Novel SCAMPs lacking NPF repeats: ubiquitous and synaptic
            vesicle-specific forms implicate SCAMPs in multiple
            membrane-trafficking functions
  JOURNAL   J Neurosci 20 (21), 7941-7950 (2000)
   PUBMED   11050114
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK074586.1, BC062598.1, AL832731.1 and CA417608.1.
            
            On Nov 23, 2018 this sequence version replaced NM_079834.3.
            
            Summary: Secretory carrier membrane proteins (SCAMPs) are widely
            distributed integral membrane proteins implicated in membrane
            trafficking. Most SCAMPs (e.g., SCAMP1; MIM 606911) have N-terminal
            cytoplasmic NPF (arg-pro-phe) repeats, 4 central transmembrane
            regions, and a short C-terminal cytoplasmic tail. These SCAMPs
            likely have a role in endocytosis that is mediated by their NPF
            repeats. Other SCAMPs, such as SCAMP4, lack the NPF repeats and are
            therefore unlikely to function in endocytosis (summary by
            Fernandez-Chacon and Sudhof, 2000 [PubMed 11050114]).[supplied by
            OMIM, Feb 2011].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC016509.1, SRR3476690.24849.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000316097.13/ ENSP00000316007.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-375               AK074586.1         28-402
            376-1607            BC062598.1         374-1605
            1608-1882           AL832731.1         1461-1735
            1883-2403           BC062598.1         1880-2400
            2404-2478           AL832731.1         2256-2330
            2479-2501           CA417608.1         22-44               c
FEATURES             Location/Qualifiers
     source          1..2501
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..2501
                     /gene="SCAMP4"
                     /gene_synonym="SCAMP-4"
                     /note="secretory carrier membrane protein 4"
                     /db_xref="GeneID:113178"
                     /db_xref="HGNC:HGNC:30385"
                     /db_xref="MIM:613764"
     exon            1..41
                     /gene="SCAMP4"
                     /gene_synonym="SCAMP-4"
                     /inference="alignment:Splign:2.1.0"
     exon            42..89
                     /gene="SCAMP4"
                     /gene_synonym="SCAMP-4"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..772
                     /gene="SCAMP4"
                     /gene_synonym="SCAMP-4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     secretory carrier-associated membrane protein 4"
                     /codon_start=1
                     /product="secretory carrier-associated membrane protein 4
                     isoform 1"
                     /protein_id="NP_524558.1"
                     /db_xref="CCDS:CCDS45903.1"
                     /db_xref="GeneID:113178"
                     /db_xref="HGNC:HGNC:30385"
                     /db_xref="MIM:613764"
                     /translation="MSEKENNFPPLPKFIPVKPCFYQNFSDEIPVEHQVLVKRIYRLW
                     MFYCATLGVNLIACLAWWIGGGSGTNFGLAFVWLLLFTPCGYVCWFRPVYKAFRADSS
                     FNFMAFFFIFGAQFVLTVIQAIGFSGWGACGWLSAIGFFQYSPGAAVVMLLPAIMFSV
                     SAAMMAIAIMKVHRIYRGAGGSFQKAQTEWNTGTWRNPPSREAQYNNFSGNSLPEYPT
                     VPSYPGSGQWP"
     exon            90..218
                     /gene="SCAMP4"
                     /gene_synonym="SCAMP-4"
                     /inference="alignment:Splign:2.1.0"
     exon            219..375
                     /gene="SCAMP4"
                     /gene_synonym="SCAMP-4"
                     /inference="alignment:Splign:2.1.0"
     exon            376..477
                     /gene="SCAMP4"
                     /gene_synonym="SCAMP-4"
                     /inference="alignment:Splign:2.1.0"
     exon            478..595
                     /gene="SCAMP4"
                     /gene_synonym="SCAMP-4"
                     /inference="alignment:Splign:2.1.0"
     exon            596..2501
                     /gene="SCAMP4"
                     /gene_synonym="SCAMP-4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2476..2481
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCAMP4"
                     /gene_synonym="SCAMP-4"
                     /note="hexamer: AATAAA"
     polyA_site      2501
                     /gene="SCAMP4"
                     /gene_synonym="SCAMP-4"
                     /note="major polyA site"
ORIGIN      
        1 aagacttggc gaagcgctgc gctcgcgccc ggatccctca ggcggctgca ggcttcagcc
       61 tgcgctggtt ggtgaaacag agatgtcaga aaaggagaac aacttcccgc cactgcccaa
      121 gttcatccct gtgaagccct gcttctacca gaacttctcc gacgagatcc cagtggagca
      181 ccaggtcctg gtgaagagga tctaccggct gtggatgttt tactgcgcca ccctcggcgt
      241 caacctcatt gcctgcctgg cctggtggat cggcggaggc tcggggacca acttcggcct
      301 ggccttcgtg tggctgctcc tgttcacgcc ttgcggctac gtgtgctggt tccggcctgt
      361 ctacaaggcc ttccgagccg acagctcctt taatttcatg gcgtttttct tcatcttcgg
      421 agcccagttt gtcctgaccg tcatccaggc gattggcttc tccggctggg gcgcgtgcgg
      481 ctggctgtcg gcaattggat tcttccagta cagcccgggc gctgccgtgg tcatgctgct
      541 tccagccatc atgttctccg tgtcggctgc catgatggcc atcgcgatca tgaaggtgca
      601 caggatctac cgaggggctg gcggaagctt ccagaaggca cagacggagt ggaacacggg
      661 cacttggcgg aacccaccgt cgagggaggc ccagtacaac aacttctcag gcaacagcct
      721 gcccgagtac cccactgtgc ccagctaccc gggcagtggc cagtggcctt agagggagcc
      781 tgccctgccc ccaccgccca ccacctcctc cccttcattc ctgctgctac ccctggtccc
      841 gagggctggg agtacctggg gccccatccc cccagctggg atggtggaag ccggtggtgg
      901 ccacggaccg cccccctcct gccagggcca cagaacccgt gttcatctca tccgagagcg
      961 gagttcctca caagcactcc ccagcagccc ttggcctctg ccgtccacag gacgccctct
     1021 tgctcccgga aacgtgtggt cacccgccgt ccactgcacg gctggtacgg ccttgtcttc
     1081 aggtctcgag gcctgactcc gggggacagg tggcagcagg tcggccgccc tcccgtcctc
     1141 ccagagctgc tggcgctgag gtcagagcgg gtctgatggg gagctccgtc tcaccggcca
     1201 cccgccgtca ccatggcaga tgcccttggc cggaactaat aagaggcgtc ggggccagct
     1261 tccggtcccc tgcagtgata gagggcttgg tgcctagctg agtcctcgct gtccccgcca
     1321 tcccctgatc tgtgcggctc cagcctcgcc ccctccccac gtgcaccata cctggggagt
     1381 tcctggtcca gggtatcctg gggccaccct ccctgcctcc aaaacaggga tccctggcag
     1441 gctgtctttc cacgcccctg agttcagagt cggggaccca ggccaggtcg ggagcacagc
     1501 cgctccccaa acccagcaaa ccggcagaga gccggtttcc cagcagccgg agccctgcag
     1561 gagaggcctt tgtgttttgt tttgttttgt tttttctctt ttgagacaag agtttcactc
     1621 tgtcgcccag gctggagtgc agtggtgtga tctcggctca ctgcaacctc tgcctcccgt
     1681 gttcaagcag ttctcctgcc tcagcctccc aaatagctgg gattacagtt gcctgccacc
     1741 acgcccagct aatttttata tttttagtac agatggggtt tcaccatgtt ggccaggctg
     1801 gtctcgaact cctgacctca agtgatccac ccgccttggc ctcccaaagt gctgggataa
     1861 taggtgtcag ccaccgcgcc cagcctggag tggcctttta tgagagggga cccgtcaaat
     1921 ctgtgcctta tggaggggtc cggcagcggc cacaattgtc ttgtcccctc accccccaac
     1981 tccccctgga acacctctcc caggcaagac attttcacag caccattcac aacggttggg
     2041 ccaaaaagaa acttttcctt catcatttcc tgcactcgct gaccacaact ttggacaccc
     2101 caggctgcca cccctcccca cccgttcacc cccaggatgc tgttgctgta ggacgcctgc
     2161 tgccctggag ccctccccag gatgtgagcc agtcccctcg ctggtacgga atgccgctgg
     2221 gtgcccggag gcggccatgg tgtctcgatg gacggcagcc aggatggagc acccatgggt
     2281 ctcacggcca tgcttcaggg tcttcaggtc ctgcccccgg ccagtctgcc aagaggcacc
     2341 cccttcccca gcctctcgcc tgcactgatg cagacaaaat ctcacctggc aggcccaacc
     2401 cccccccacc cctcccccgc cgtgtgtggc ccctcgccgc atcgttgggg ttttgttatg
     2461 tgaaaatatc ctggaaataa atacatgttt ctgcacttag a
//
