LOCUS       NM_001329540            2399 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens secretory carrier membrane protein 4 (SCAMP4),
            transcript variant 3, mRNA.
ACCESSION   NM_001329540
VERSION     NM_001329540.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2399)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 2399)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2399)
  AUTHORS   Kim,K.M., Noh,J.H., Bodogai,M., Martindale,J.L., Pandey,P.R.,
            Yang,X., Biragyn,A., Abdelmohsen,K. and Gorospe,M.
  TITLE     SCAMP4 enhances the senescent cell secretome
  JOURNAL   Genes Dev 32 (13-14), 909-914 (2018)
   PUBMED   29967290
  REMARK    GeneRIF: secretory carrier membrane protein 4 (SCAMP4) levels were
            strikingly elevated on the surface of senescent cells compared with
            proliferating cells
REFERENCE   4  (bases 1 to 2399)
  AUTHORS   Castle,A. and Castle,D.
  TITLE     Ubiquitously expressed secretory carrier membrane proteins (SCAMPs)
            1-4 mark different pathways and exhibit limited constitutive
            trafficking to and from the cell surface
  JOURNAL   J Cell Sci 118 (Pt 16), 3769-3780 (2005)
   PUBMED   16105885
REFERENCE   5  (bases 1 to 2399)
  AUTHORS   Krebs,C.J. and Pfaff,D.W.
  TITLE     Expression of the SCAMP-4 gene, a new member of the secretory
            carrier membrane protein family, is repressed by progesterone in
            brain regions associated with female sexual behavior
  JOURNAL   Brain Res Mol Brain Res 88 (1-2), 144-154 (2001)
   PUBMED   11295240
REFERENCE   6  (bases 1 to 2399)
  AUTHORS   Fernandez-Chacon,R. and Sudhof,T.C.
  TITLE     Novel SCAMPs lacking NPF repeats: ubiquitous and synaptic
            vesicle-specific forms implicate SCAMPs in multiple
            membrane-trafficking functions
  JOURNAL   J Neurosci 20 (21), 7941-7950 (2000)
   PUBMED   11050114
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC012615.4, AK092056.1, BC062598.1 and CA417608.1.
            
            On Jun 1, 2019 this sequence version replaced NM_001329540.1.
            
            Summary: Secretory carrier membrane proteins (SCAMPs) are widely
            distributed integral membrane proteins implicated in membrane
            trafficking. Most SCAMPs (e.g., SCAMP1; MIM 606911) have N-terminal
            cytoplasmic NPF (arg-pro-phe) repeats, 4 central transmembrane
            regions, and a short C-terminal cytoplasmic tail. These SCAMPs
            likely have a role in endocytosis that is mediated by their NPF
            repeats. Other SCAMPs, such as SCAMP4, lack the NPF repeats and are
            therefore unlikely to function in endocytosis (summary by
            Fernandez-Chacon and Sudhof, 2000 [PubMed 11050114]).[supplied by
            OMIM, Feb 2011].
            
            Transcript Variant: This variant (3) lacks an alternate in-frame
            exon in the central coding region compared to variant 1. The
            encoded isoform (3) is shorter than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK092056.1, SRR3476690.36831.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 AC012615.4         97846-97850
            6-1039              AK092056.1         1-1034
            1040-1505           BC062598.1         1140-1605
            1506-2329           AC012615.4         117567-118390
            2330-2399           CA417608.1         22-91               c
FEATURES             Location/Qualifiers
     source          1..2399
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..2399
                     /gene="SCAMP4"
                     /gene_synonym="SCAMP-4"
                     /note="secretory carrier membrane protein 4"
                     /db_xref="GeneID:113178"
                     /db_xref="HGNC:HGNC:30385"
                     /db_xref="MIM:613764"
     exon            1..41
                     /gene="SCAMP4"
                     /gene_synonym="SCAMP-4"
                     /inference="alignment:Splign:2.1.0"
     exon            42..89
                     /gene="SCAMP4"
                     /gene_synonym="SCAMP-4"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..670
                     /gene="SCAMP4"
                     /gene_synonym="SCAMP-4"
                     /note="isoform 3 is encoded by transcript variant 3;
                     secretory carrier-associated membrane protein 4"
                     /codon_start=1
                     /product="secretory carrier-associated membrane protein 4
                     isoform 3"
                     /protein_id="NP_001316469.1"
                     /db_xref="CCDS:CCDS86689.1"
                     /db_xref="GeneID:113178"
                     /db_xref="HGNC:HGNC:30385"
                     /db_xref="MIM:613764"
                     /translation="MSEKENNFPPLPKFIPVKPCFYQNFSDEIPVEHQVLVKRIYRLW
                     MFYCATLGVNLIACLAWWIGGGSGTNFGLAFVWLLLFTPCGYVCWFRPVYKAFRGWLS
                     AIGFFQYSPGAAVVMLLPAIMFSVSAAMMAIAIMKVHRIYRGAGGSFQKAQTEWNTGT
                     WRNPPSREAQYNNFSGNSLPEYPTVPSYPGSGQWP"
     exon            90..218
                     /gene="SCAMP4"
                     /gene_synonym="SCAMP-4"
                     /inference="alignment:Splign:2.1.0"
     exon            219..375
                     /gene="SCAMP4"
                     /gene_synonym="SCAMP-4"
                     /inference="alignment:Splign:2.1.0"
     exon            376..493
                     /gene="SCAMP4"
                     /gene_synonym="SCAMP-4"
                     /inference="alignment:Splign:2.1.0"
     exon            494..2399
                     /gene="SCAMP4"
                     /gene_synonym="SCAMP-4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2374..2379
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCAMP4"
                     /gene_synonym="SCAMP-4"
                     /note="hexamer: AATAAA"
     polyA_site      2399
                     /gene="SCAMP4"
                     /gene_synonym="SCAMP-4"
                     /note="major polyA site"
ORIGIN      
        1 aagacttggc gaagcgctgc gctcgcgccc ggatccctca ggcggctgca ggcttcagcc
       61 tgcgctggtt ggtgaaacag agatgtcaga aaaggagaac aacttcccgc cactgcccaa
      121 gttcatccct gtgaagccct gcttctacca gaacttctcc gacgagatcc cagtggagca
      181 ccaggtcctg gtgaagagga tctaccggct gtggatgttt tactgcgcca ccctcggcgt
      241 caacctcatt gcctgcctgg cctggtggat cggcggaggc tcggggacca acttcggcct
      301 ggccttcgtg tggctgctcc tgttcacgcc ttgcggctac gtgtgctggt tccggcctgt
      361 ctacaaggcc ttccgcggct ggctgtcggc aattggattc ttccagtaca gcccgggcgc
      421 tgccgtggtc atgctgcttc cagccatcat gttctccgtg tcggctgcca tgatggccat
      481 cgcgatcatg aaggtgcaca ggatctaccg aggggctggc ggaagcttcc agaaggcaca
      541 gacggagtgg aacacgggca cttggcggaa cccaccgtcg agggaggccc agtacaacaa
      601 cttctcaggc aacagcctgc ccgagtaccc cactgtgccc agctacccgg gcagtggcca
      661 gtggccttag agggagcctg ccctgccccc accgcccacc acctcctccc cttcattcct
      721 gctgctaccc ctggtcccga gggctgggag tacctggggc cccatccccc cagctgggat
      781 ggtggaagcc ggtggtggcc acggaccgcc cccctcctgc cagggccaca gaacccgtgt
      841 tcatctcatc cgagagcgga gttcctcaca agcactcccc agcagccctt ggcctctgcc
      901 gtccacagga cgccctcttg ctcccggaaa cgtgtggtca cccgccgtcc actgcacggc
      961 tggtacggcc ttgtcttcag gtctcgaggc ctgactccgg gggacaggtg gcagcaggtc
     1021 ggccgccctc ccgtcctccc agagctgctg gcgctgaggt cagagcgggt ctgatgggga
     1081 gctccgtctc accggccacc cgccgtcacc atggcagatg cccttggccg gaactaataa
     1141 gaggcgtcgg ggccagcttc cggtcccctg cagtgataga gggcttggtg cctagctgag
     1201 tcctcgctgt ccccgccatc ccctgatctg tgcggctcca gcctcgcccc ctccccacgt
     1261 gcaccatacc tggggagttc ctggtccagg gtatcctggg gccaccctcc ctgcctccaa
     1321 aacagggatc cctggcaggc tgtctttcca cgcccctgag ttcagagtcg gggacccagg
     1381 ccaggtcggg agcacagccg ctccccaaac ccagcaaacc ggcagagagc cggtttccca
     1441 gcagccggag ccctgcagga gaggcctttg tgttttgttt tgttttgttt tttctctttt
     1501 gagacaagag tttcactctg tcgcccaggc tggagtgcag tggtgtgatc tcggctcact
     1561 gcaacctctg cctcccgtgt tcaagcagtt ctcctgcctc agcctcccaa atagctggga
     1621 ttacagttgc ctgccaccac gcccagctaa tttttatatt tttagtacag atggggtttc
     1681 accatgttgg ccaggctggt ctcgaactcc tgacctcaag tgatccaccc gccttggcct
     1741 cccaaagtgc tgggataata ggtgtcagcc accgcgccca gcctggagtg gccttttatg
     1801 agaggggacc cgtcaaatct gtgccttatg gaggggtccg gcagcggcca caattgtctt
     1861 gtcccctcac cccccaactc cccctggaac acctctccca ggcaagacat tttcacagca
     1921 ccattcacaa cggttgggcc aaaaagaaac ttttccttca tcatttcctg cactcgctga
     1981 ccacaacttt ggacacccca ggctgccacc cctccccacc cgttcacccc caggatgctg
     2041 ttgctgtagg acgcctgctg ccctggagcc ctccccagga tgtgagccag tcccctcgct
     2101 ggtacggaat gccgctgggt gcccggaggc ggccatggtg tctcgatgga cggcagccag
     2161 gatggagcac ccatgggtct cacggccatg cttcagggtc ttcaggtcct gcccccggcc
     2221 agtctgccaa gaggcacccc cttccccagc ctctcgcctg cactgatgca gacaaaatct
     2281 cacctggcag gcccaacccc cccccacccc tcccccgccg tgtgtggccc ctcgccgcat
     2341 cgttggggtt ttgttatgtg aaaatatcct ggaaataaat acatgtttct gcacttaga
//
