LOCUS       NM_005698               1545 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens secretory carrier membrane protein 3 (SCAMP3),
            transcript variant 1, mRNA.
ACCESSION   NM_005698
VERSION     NM_005698.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1545)
  AUTHORS   Lu,J.Y., Brewer,G., Li,M.L., Lin,K.Z., Huang,C.C., Yen,L.C. and
            Lin,J.Y.
  TITLE     Secretory Carrier Membrane Protein 3 Interacts with 3A Viral
            Protein of Enterovirus and Participates in Viral Replication
  JOURNAL   Microbiol Spectr 9 (1), e0047521 (2021)
   PUBMED   34378951
  REMARK    GeneRIF: Secretory Carrier Membrane Protein 3 Interacts with 3A
            Viral Protein of Enterovirus and Participates in Viral Replication.
REFERENCE   2  (bases 1 to 1545)
  AUTHORS   Kulyte,A., Kwok,K.H.M., de Hoon,M., Carninci,P., Hayashizaki,Y.,
            Arner,P. and Arner,E.
  TITLE     MicroRNA-27a/b-3p and PPARG regulate SCAMP3 through a feed-forward
            loop during adipogenesis
  JOURNAL   Sci Rep 9 (1), 13891 (2019)
   PUBMED   31554889
  REMARK    GeneRIF: MicroRNA-27a/b-3p and PPARG regulate SCAMP3 through a
            feed-forward loop during adipogenesis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1545)
  AUTHORS   Naboulsi,W., Bracht,T., Megger,D.A., Reis,H., Ahrens,M.,
            Turewicz,M., Eisenacher,M., Tautges,S., Canbay,A.E., Meyer,H.E.,
            Weber,F., Baba,H.A. and Sitek,B.
  TITLE     Quantitative proteome analysis reveals the correlation between
            endocytosis-associated proteins and hepatocellular carcinoma
            dedifferentiation
  JOURNAL   Biochim Biophys Acta 1864 (11), 1579-1585 (2016)
   PUBMED   27519163
  REMARK    GeneRIF: The novel association of several endocytosis-associated
            proteins has been demonstrated, in particular, of CLTC and SCAMP3
            with hepatocellular carcinoma progression.
REFERENCE   4  (bases 1 to 1545)
  AUTHORS   Thomas,P., Wohlford,D. and Aoh,Q.L.
  TITLE     SCAMP 3 is a novel regulator of endosomal morphology and
            composition
  JOURNAL   Biochem Biophys Res Commun 478 (3), 1028-1034 (2016)
   PUBMED   27507217
  REMARK    GeneRIF: SCAMP 3 is a novel regulator of endosomal morphology and
            composition.
REFERENCE   5  (bases 1 to 1545)
  AUTHORS   Castle,A. and Castle,D.
  TITLE     Ubiquitously expressed secretory carrier membrane proteins (SCAMPs)
            1-4 mark different pathways and exhibit limited constitutive
            trafficking to and from the cell surface
  JOURNAL   J Cell Sci 118 (Pt 16), 3769-3780 (2005)
   PUBMED   16105885
REFERENCE   6  (bases 1 to 1545)
  AUTHORS   Brill,L.M., Salomon,A.R., Ficarro,S.B., Mukherji,M.,
            Stettler-Gill,M. and Peters,E.C.
  TITLE     Robust phosphoproteomic profiling of tyrosine phosphorylation sites
            from human T cells using immobilized metal affinity chromatography
            and tandem mass spectrometry
  JOURNAL   Anal Chem 76 (10), 2763-2772 (2004)
   PUBMED   15144186
REFERENCE   7  (bases 1 to 1545)
  AUTHORS   Wu,T.T. and Castle,J.D.
  TITLE     Tyrosine phosphorylation of selected secretory carrier membrane
            proteins, SCAMP1 and SCAMP3, and association with the EGF receptor
  JOURNAL   Mol Biol Cell 9 (7), 1661-1674 (1998)
   PUBMED   9658162
REFERENCE   8  (bases 1 to 1545)
  AUTHORS   Winfield,S.L., Tayebi,N., Martin,B.M., Ginns,E.I. and Sidransky,E.
  TITLE     Identification of three additional genes contiguous to the
            glucocerebrosidase locus on chromosome 1q21: implications for
            Gaucher disease
  JOURNAL   Genome Res 7 (10), 1020-1026 (1997)
   PUBMED   9331372
REFERENCE   9  (bases 1 to 1545)
  AUTHORS   Singleton,D.R., Wu,T.T. and Castle,J.D.
  TITLE     Three mammalian SCAMPs (secretory carrier membrane proteins) are
            highly related products of distinct genes having similar
            subcellular distributions
  JOURNAL   J Cell Sci 110 (Pt 17), 2099-2107 (1997)
   PUBMED   9378760
  REMARK    GeneRIF: the SCAMPs may largely function at the same sites during
            vesicular transport rather than in separate post-Golgi recycling
            pathways.
REFERENCE   10 (bases 1 to 1545)
  AUTHORS   Wu,T.T. and Castle,J.D.
  TITLE     Evidence for colocalization and interaction between 37 and 39 kDa
            isoforms of secretory carrier membrane proteins (SCAMPs)
  JOURNAL   J Cell Sci 110 (Pt 13), 1533-1541 (1997)
   PUBMED   9224770
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BU193466.1, AL713999.28 and
            BC000161.2.
            
            On Nov 23, 2018 this sequence version replaced NM_005698.3.
            
            Summary: This gene encodes an integral membrane protein that
            belongs to the secretory carrier membrane protein family. The
            encoded protein functions as a carrier to the cell surface in
            post-golgi recycling pathways. This protein is also involved in
            protein trafficking in endosomal pathways. Two transcript variants
            encoding different isoforms have been found for this gene.[provided
            by RefSeq, May 2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189661.128903.1,
                                           SRR3476690.370013.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000302631.8/ ENSP00000307275.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-77                BU193466.1         26-102
            78-101              AL713999.28        90540-90563         c
            102-1545            BC000161.2         1-1444
FEATURES             Location/Qualifiers
     source          1..1545
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1545
                     /gene="SCAMP3"
                     /gene_synonym="C1orf3"
                     /note="secretory carrier membrane protein 3"
                     /db_xref="GeneID:10067"
                     /db_xref="HGNC:HGNC:10565"
                     /db_xref="MIM:606913"
     exon            1..275
                     /gene="SCAMP3"
                     /gene_synonym="C1orf3"
                     /inference="alignment:Splign:2.1.0"
     CDS             210..1253
                     /gene="SCAMP3"
                     /gene_synonym="C1orf3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     propin 1; secretory carrier-associated membrane protein 3"
                     /codon_start=1
                     /product="secretory carrier-associated membrane protein 3
                     isoform 1"
                     /protein_id="NP_005689.2"
                     /db_xref="CCDS:CCDS1105.1"
                     /db_xref="GeneID:10067"
                     /db_xref="HGNC:HGNC:10565"
                     /db_xref="MIM:606913"
                     /translation="MAQSRDGGNPFAEPSELDNPFQDPAVIQHRPSRQYATLDVYNPF
                     ETREPPPAYEPPAPAPLPPPSAPSLQPSRKLSPTEPKNYGSYSTQASAAAATAELLKK
                     QEELNRKAEELDRRERELQHAALGGTATRQNNWPPLPSFCPVQPCFFQDISMEIPQEF
                     QKTVSTMYYLWMCSTLALLLNFLACLASFCVETNNGAGFGLSILWVLLFTPCSFVCWY
                     RPMYKAFRSDSSFNFFVFFFIFFVQDVLFVLQAIGIPGWGFSGWISALVVPKGNTAVS
                     VLMLLVALLFTGIAVLGIVMLKRIHSLYRRTGASFQKAQQEFAAGVFSNPAVRTAAAN
                     AAAGAAENAFRAP"
     exon            276..353
                     /gene="SCAMP3"
                     /gene_synonym="C1orf3"
                     /inference="alignment:Splign:2.1.0"
     exon            354..476
                     /gene="SCAMP3"
                     /gene_synonym="C1orf3"
                     /inference="alignment:Splign:2.1.0"
     exon            477..597
                     /gene="SCAMP3"
                     /gene_synonym="C1orf3"
                     /inference="alignment:Splign:2.1.0"
     exon            598..726
                     /gene="SCAMP3"
                     /gene_synonym="C1orf3"
                     /inference="alignment:Splign:2.1.0"
     exon            727..886
                     /gene="SCAMP3"
                     /gene_synonym="C1orf3"
                     /inference="alignment:Splign:2.1.0"
     exon            887..988
                     /gene="SCAMP3"
                     /gene_synonym="C1orf3"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1106
                     /gene="SCAMP3"
                     /gene_synonym="C1orf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1545
                     /gene="SCAMP3"
                     /gene_synonym="C1orf3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1524..1529
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCAMP3"
                     /gene_synonym="C1orf3"
                     /note="hexamer: AAGAAA"
     polyA_site      1545
                     /gene="SCAMP3"
                     /gene_synonym="C1orf3"
                     /note="major polyA site"
ORIGIN      
        1 actttcgtct tagcttttgg acaagacgca ggcgcaaccc acggctgctg cggggatcct
       61 tgtggccctt ccggtcggtg gaaccaatcc gtgcacagag aagcggggcg aactgaggcg
      121 agtgaagtgg actctgaggg ctaccgctac cgccactgct gcggcagggg cgtggagggc
      181 agagggccgc ggaggccgca gttgcaaaca tggctcagag cagagacggc ggaaacccgt
      241 tcgccgagcc cagcgagctt gacaacccct ttcaggaccc agctgtgatc cagcaccgac
      301 ccagccggca gtatgccacg cttgacgtct acaacccttt tgagacccgg gagccaccac
      361 cagcctatga gcctccagcc cctgccccat tgcctccacc ctcagctccc tccttgcagc
      421 cctcgagaaa gctcagcccc acagaaccta agaactatgg ctcatacagc actcaggcct
      481 cagctgcagc agccacagct gagctgctga agaaacagga ggagctcaac cggaaggcag
      541 aggagttgga ccgaagggag cgagagctgc agcatgctgc cctggggggc acagctactc
      601 gacagaacaa ttggccccct ctaccttctt tttgtccagt tcagccctgc tttttccagg
      661 acatctccat ggagatcccc caagaatttc agaagactgt atccaccatg tactacctct
      721 ggatgtgcag cacgctggct cttctcctga acttcctcgc ctgcctggcc agcttctgtg
      781 tggaaaccaa caatggcgca ggctttgggc tttctatcct ctgggtcctc cttttcactc
      841 cctgctcctt tgtctgctgg taccgcccca tgtataaggc tttccggagt gacagttcat
      901 tcaatttctt cgttttcttc ttcattttct tcgtccagga tgtgctcttt gtcctccagg
      961 ccattggtat cccaggttgg ggattcagtg gctggatctc tgctctggtg gtgccgaagg
     1021 gcaacacagc agtatccgtg ctcatgctgc tggtcgccct gctcttcact ggcattgctg
     1081 tgctaggaat tgtcatgctg aaacggatcc actccttata ccgccgcaca ggtgccagct
     1141 ttcagaaggc ccagcaagaa tttgctgctg gtgtcttctc caaccctgcg gtgcgaaccg
     1201 cagctgccaa tgcagccgct ggggctgctg aaaatgcctt ccgggccccg tgacccctga
     1261 ctgggatgcc ctggccctgc tacttgaggg agctgactta gctcccgtcc ctaaggtctc
     1321 tgggacttgg agagacatca ctaactgatg gctcctccgt agtgctccca atcctatggc
     1381 catgactgct gaacctgaca ggcgtgtggg gagttcactg tgacctagtc cccccatcag
     1441 gccacactgc tgccacctct cacacgcccc aacccagctt ccctctgctg tgccacggct
     1501 gttgcttcgg ttatttaaat aaaaagaaag tggaactgga actga
//
