LOCUS       NM_005697               2453 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens secretory carrier membrane protein 2 (SCAMP2),
            transcript variant 2, mRNA.
ACCESSION   NM_005697
VERSION     NM_005697.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2453)
  AUTHORS   Yue,C., Xie,S., Zhong,J., Zhao,H., Lin,Z., Zhang,L., Xu,B. and
            Luo,Y.
  TITLE     SCAMP2/5 as diagnostic and prognostic markers for acute myeloid
            leukemia
  JOURNAL   Sci Rep 11 (1), 17012 (2021)
   PUBMED   34426610
  REMARK    GeneRIF: SCAMP2/5 as diagnostic and prognostic markers for acute
            myeloid leukemia.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2453)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 2453)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2453)
  AUTHORS   Cornelis,M.C., Monda,K.L., Yu,K., Paynter,N., Azzato,E.M.,
            Bennett,S.N., Berndt,S.I., Boerwinkle,E., Chanock,S.,
            Chatterjee,N., Couper,D., Curhan,G., Heiss,G., Hu,F.B.,
            Hunter,D.J., Jacobs,K., Jensen,M.K., Kraft,P., Landi,M.T.,
            Nettleton,J.A., Purdue,M.P., Rajaraman,P., Rimm,E.B., Rose,L.M.,
            Rothman,N., Silverman,D., Stolzenberg-Solomon,R., Subar,A.,
            Yeager,M., Chasman,D.I., van Dam,R.M. and Caporaso,N.E.
  TITLE     Genome-wide meta-analysis identifies regions on 7p21 (AHR) and
            15q24 (CYP1A2) as determinants of habitual caffeine consumption
  JOURNAL   PLoS Genet 7 (4), e1002033 (2011)
   PUBMED   21490707
REFERENCE   5  (bases 1 to 2453)
  AUTHORS   Fjorback,A.W., Muller,H.K., Haase,J., Raarup,M.K. and Wiborg,O.
  TITLE     Modulation of the dopamine transporter by interaction with
            Secretory Carrier Membrane Protein 2
  JOURNAL   Biochem Biophys Res Commun 406 (2), 165-170 (2011)
   PUBMED   21295544
  REMARK    GeneRIF: this finding that SCAMP2 interacts with and regulates the
            subcellular distribution of both DAT and SERT suggests that
            interaction with SCAMP2 may constitute an important mechanism for
            coordinating cell surface expression of monoamine transporters.
REFERENCE   6  (bases 1 to 2453)
  AUTHORS   Lin,P.J., Williams,W.P., Luu,Y., Molday,R.S., Orlowski,J. and
            Numata,M.
  TITLE     Secretory carrier membrane proteins interact and regulate
            trafficking of the organellar (Na+,K+)/H+ exchanger NHE7
  JOURNAL   J Cell Sci 118 (Pt 9), 1885-1897 (2005)
   PUBMED   15840657
REFERENCE   7  (bases 1 to 2453)
  AUTHORS   Liu,L., Guo,Z., Tieu,Q., Castle,A. and Castle,D.
  TITLE     Role of secretory carrier membrane protein SCAMP2 in granule
            exocytosis
  JOURNAL   Mol Biol Cell 13 (12), 4266-4278 (2002)
   PUBMED   12475951
REFERENCE   8  (bases 1 to 2453)
  AUTHORS   Guo,Z., Liu,L., Cafiso,D. and Castle,D.
  TITLE     Perturbation of a very late step of regulated exocytosis by a
            secretory carrier membrane protein (SCAMP2)-derived peptide
  JOURNAL   J Biol Chem 277 (38), 35357-35363 (2002)
   PUBMED   12124380
REFERENCE   9  (bases 1 to 2453)
  AUTHORS   Singleton,D.R., Wu,T.T. and Castle,J.D.
  TITLE     Three mammalian SCAMPs (secretory carrier membrane proteins) are
            highly related products of distinct genes having similar
            subcellular distributions
  JOURNAL   J Cell Sci 110 (Pt 17), 2099-2107 (1997)
   PUBMED   9378760
REFERENCE   10 (bases 1 to 2453)
  AUTHORS   Wu,T.T. and Castle,J.D.
  TITLE     Evidence for colocalization and interaction between 37 and 39 kDa
            isoforms of secretory carrier membrane proteins (SCAMPs)
  JOURNAL   J Cell Sci 110 (Pt 13), 1533-1541 (1997)
   PUBMED   9224770
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC091230.23, BC004385.1 and
            R59393.1.
            
            On Nov 23, 2018 this sequence version replaced NM_005697.4.
            
            Summary: This gene product belongs to the SCAMP family of proteins
            which are secretory carrier membrane proteins. They function as
            carriers to the cell surface in post-golgi recycling pathways.
            Different family members are highly related products of distinct
            genes, and are usually expressed together. These findings suggest
            that the SCAMPs may function at the same site during vesicular
            transport rather than in separate pathways. Alternate splicing
            results in multiple transcript variants. [provided by RefSeq, Mar
            2016].
            
            Transcript Variant: This variant (2) lacks a exon in the central
            coding region compared to variant 1. The encoded isoform (2) is
            sorter than isoform 2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.8622.1,
                                           SRR3476690.142249.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000268099.13/ ENSP00000268099.9
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                AC091230.23        602-637
            37-1327             BC004385.1         1-1291
            1328-2311           AC091230.23        29112-30095
            2312-2453           R59393.1           12-153              c
FEATURES             Location/Qualifiers
     source          1..2453
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q24.1"
     gene            1..2453
                     /gene="SCAMP2"
                     /note="secretory carrier membrane protein 2"
                     /db_xref="GeneID:10066"
                     /db_xref="HGNC:HGNC:10564"
                     /db_xref="MIM:606912"
     exon            1..167
                     /gene="SCAMP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..1100
                     /gene="SCAMP2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     secretory carrier-associated membrane protein 2; testis
                     secretory sperm-binding protein Li 219p"
                     /codon_start=1
                     /product="secretory carrier-associated membrane protein 2
                     isoform 2"
                     /protein_id="NP_005688.2"
                     /db_xref="CCDS:CCDS10271.1"
                     /db_xref="GeneID:10066"
                     /db_xref="HGNC:HGNC:10564"
                     /db_xref="MIM:606912"
                     /translation="MSAFDTNPFADPVDVNPFQDPSVTQLTNAPQGGLAEFNPFSETN
                     AATTVPVTQLPGSSQPAVLQPSVEPTQPTPQAVVSAAQAGLLRQQEELDRKAAELERK
                     ERELQNTVANLHVRQNNWPPLPSWCPVKPCFYQDFSTEIPADYQRICKMLYYLWMLHS
                     VTLFLNLLACLAWFSGNSSKGVDFGLSILWFLIFTPCAFLCWYRPIYKAFRSDNSFSF
                     FVFFFVFFCQIGIYIIQLVGIPGLGDSGWIAALSTLDNHSLAISVIMMVVAGFFTLCA
                     VLSVFLLQRVHSLYRRTGASFQQAQEEFSQGIFSSRTFHRAASSAAQGAFQGN"
     exon            168..236
                     /gene="SCAMP2"
                     /inference="alignment:Splign:2.1.0"
     exon            237..335
                     /gene="SCAMP2"
                     /inference="alignment:Splign:2.1.0"
     exon            336..453
                     /gene="SCAMP2"
                     /inference="alignment:Splign:2.1.0"
     exon            454..582
                     /gene="SCAMP2"
                     /inference="alignment:Splign:2.1.0"
     exon            583..742
                     /gene="SCAMP2"
                     /inference="alignment:Splign:2.1.0"
     exon            743..844
                     /gene="SCAMP2"
                     /inference="alignment:Splign:2.1.0"
     exon            845..965
                     /gene="SCAMP2"
                     /inference="alignment:Splign:2.1.0"
     exon            966..2453
                     /gene="SCAMP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2433..2438
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCAMP2"
                     /note="hexamer: AATAAA"
     polyA_site      2453
                     /gene="SCAMP2"
                     /note="major polyA site"
ORIGIN      
        1 agaaccgctg cctcgctccc ggaagtggag ggtctacacg aagcgccgct gggtctgggt
       61 gcccggaggc agcagcgttc gcggagttcg cccgctggcc cccgatcacc atgtcggctt
      121 tcgacaccaa ccccttcgcg gacccagtgg atgtaaaccc cttccaggat ccctctgtga
      181 cccagctgac caacgccccg cagggcggcc tggcggaatt caaccccttc tcagagacaa
      241 atgcagcgac aacagttcct gtcacccaac tccctgggtc ctcacagcca gcggttctcc
      301 agccatcagt ggaaccaacc cagccgaccc cccaggccgt ggtgtctgca gcccaggcag
      361 gcctgctccg gcagcaggaa gaactggaca ggaaagctgc cgagctggaa cgcaaggagc
      421 gggagctgca gaacactgta gccaacttgc atgtgagaca gaacaactgg ccccctctgc
      481 cctcgtggtg ccctgtgaag ccctgcttct atcaggattt ctccacagag atccctgccg
      541 actaccagcg gatatgcaag atgctctact atctgtggat gttgcattca gtgactctgt
      601 ttctgaacct gcttgcctgc ctggcctggt tctcgggcaa cagctccaag ggagtggact
      661 ttggcctctc catcctgtgg tttctgatct tcactccctg tgccttcctt tgttggtacc
      721 gacccatcta taaggccttt aggtccgaca actctttcag cttctttgtg ttcttctttg
      781 tatttttttg tcaaataggg atctacatca tccagttggt tggcatccct ggcctggggg
      841 acagcggttg gattgcagcc ctgtctacac tggataatca ttccctggcc atatcagtca
      901 tcatgatggt ggtggctggc ttcttcaccc tctgtgccgt gctctcagtc ttcctcctgc
      961 agcgggtgca ctccctctac cgacggacag gggccagctt ccagcaggcc caggaggagt
     1021 tttcccaggg catcttcagc agcagaacct tccacagagc tgcttcatct gctgcccaag
     1081 gagccttcca ggggaattag tcctcctctc ttctctcccc ctcagccttt ctctcgcctg
     1141 ccttctgagc tgcactttcc gtgggtgcct tatgtggtgg tggttgtgcc cagcacagac
     1201 ctggcagggt tcttgccgtg gctcttcctc ctccctcagc gaccagctct ccctggaacg
     1261 ggagggacag ggaatttttt ccccctctat gtacaaaaaa aaacaaagct ctctttcctt
     1321 ctctggtgat ggtttggtag gattcttttg tctctggaag cagtgggact gaagttctct
     1381 tcgtcctgtg cacacacaga cacccccaca cagttgggat cacaggctga cctgggccca
     1441 tcccagctgg agctttctgc cagggtcctg ggccttgact cccccaccct gcaggcctgg
     1501 cctgaatctg gcttcttaga cacagcccag tccttcctgc ctgggctggg aataagcctc
     1561 tcacaggttc tggtggacag atctgttccc caggtcactc cagtggtctc caggcttcca
     1621 gagaaggctg gttgcctcaa gctcttctct gcctcataaa cggatccaga gaaggctggt
     1681 tgccttaagc tcttccctgc ctcgtgttcc tgagaaacgg attaatagcc ctttatcccc
     1741 ctgcaccctc ctgcagggga tggcactttg agccctctgg agccctcccc ttgctgagcc
     1801 ttactctctt cagactttct gaatgtacaa tgccgttggt tgggatttgg ggactggaag
     1861 ggaccaagga cactgacccc aagctgtcct gcctagcgtc cagcgtcttc taggagggtg
     1921 gggtctgcct gtcctggtgt ggttggtttg gccctgtttg ctgtgactac ccccccccct
     1981 ccccgaaccg agggacggct gcctttgtct ctgcctcaga tgccacctgc cccgcccatg
     2041 ctccccatca gcagcatcca gactttcagg aagggcaggg ccagccagtc cagaaccgca
     2101 tccctcagca gggactgata agccatctct cggagggccc cctaataccc agtggagtct
     2161 ggttcacacc ctggggggtg tgtcactgtg atgggacacg taggagtcca cccttaaaac
     2221 cagcaccctg tccctcgagg ctgccgagtg ggtgtgtgga ctggggtgcc ttcccacaaa
     2281 actagcctcc ggctctgggc ccgagacagc cgcaggcccc agccactgaa tgatactggc
     2341 agcggctggg gttttatgaa ctcctttctg gtattttttc ccctctatgt acaaatgtat
     2401 atgttacgtc tcaatttttg tgcttaagta aaaataaaaa cattttcaga caa
//
