LOCUS       NM_004866               6143 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens secretory carrier membrane protein 1 (SCAMP1),
            transcript variant 1, mRNA.
ACCESSION   NM_004866
VERSION     NM_004866.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6143)
  AUTHORS   Chevalier,B., Baatallah,N., Najm,M., Castanier,S., Jung,V.,
            Pranke,I., Golec,A., Stoven,V., Marullo,S., Antigny,F.,
            Guerrera,I.C., Sermet-Gaudelus,I., Edelman,A. and Hinzpeter,A.
  TITLE     Differential CFTR-Interactome Proximity Labeling Procedures
            Identify Enrichment in Multiple SLC Transporters
  JOURNAL   Int J Mol Sci 23 (16), 8937 (2022)
   PUBMED   36012204
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6143)
  AUTHORS   Yousaf,T., Sun,Y., Naz,W., Liu,Y., Xu,J., Yuan,S., Wu,K., Wang,M.,
            Wang,J., Guo,M. and Sun,G.
  TITLE     Multiomics Analysis of Endocytosis upon HBV Infection and
            Identification of SCAMP1 as a Novel Host Restriction Factor against
            HBV Replication
  JOURNAL   Int J Mol Sci 23 (4), 2211 (2022)
   PUBMED   35216324
  REMARK    GeneRIF: Multiomics Analysis of Endocytosis upon HBV Infection and
            Identification of SCAMP1 as a Novel Host Restriction Factor against
            HBV Replication.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6143)
  AUTHORS   Lim,S.H., Snider,J., Birimberg-Schwartz,L., Ip,W., Serralha,J.C.,
            Botelho,H.M., Lopes-Pacheco,M., Pinto,M.C., Moutaoufik,M.T.,
            Zilocchi,M., Laselva,O., Esmaeili,M., Kotlyar,M., Lyakisheva,A.,
            Tang,P., Lopez Vazquez,L., Akula,I., Aboualizadeh,F., Wong,V.,
            Grozavu,I., Opacak-Bernardi,T., Yao,Z., Mendoza,M., Babu,M.,
            Jurisica,I., Gonska,T., Bear,C.E., Amaral,M.D. and Stagljar,I.
  TITLE     CFTR interactome mapping using the mammalian membrane two-hybrid
            high-throughput screening system
  JOURNAL   Mol Syst Biol 18 (2), e10629 (2022)
   PUBMED   35156780
REFERENCE   4  (bases 1 to 6143)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 6143)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 6143)
  AUTHORS   Fernandez-Chacon,R., Achiriloaie,M., Janz,R., Albanesi,J.P. and
            Sudhof,T.C.
  TITLE     SCAMP1 function in endocytosis
  JOURNAL   J Biol Chem 275 (17), 12752-12756 (2000)
   PUBMED   10777571
REFERENCE   7  (bases 1 to 6143)
  AUTHORS   Wu,T.T. and Castle,J.D.
  TITLE     Tyrosine phosphorylation of selected secretory carrier membrane
            proteins, SCAMP1 and SCAMP3, and association with the EGF receptor
  JOURNAL   Mol Biol Cell 9 (7), 1661-1674 (1998)
   PUBMED   9658162
REFERENCE   8  (bases 1 to 6143)
  AUTHORS   Singleton,D.R., Wu,T.T. and Castle,J.D.
  TITLE     Three mammalian SCAMPs (secretory carrier membrane proteins) are
            highly related products of distinct genes having similar
            subcellular distributions
  JOURNAL   J Cell Sci 110 (Pt 17), 2099-2107 (1997)
   PUBMED   9378760
REFERENCE   9  (bases 1 to 6143)
  AUTHORS   Wu,T.T. and Castle,J.D.
  TITLE     Evidence for colocalization and interaction between 37 and 39 kDa
            isoforms of secretory carrier membrane proteins (SCAMPs)
  JOURNAL   J Cell Sci 110 (Pt 13), 1533-1541 (1997)
   PUBMED   9224770
REFERENCE   10 (bases 1 to 6143)
  AUTHORS   Brand,S.H. and Castle,J.D.
  TITLE     SCAMP 37, a new marker within the general cell surface recycling
            system
  JOURNAL   EMBO J 12 (10), 3753-3761 (1993)
   PUBMED   8404846
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB213762.1, CR542286.1,
            BC034048.1, AK001417.1, AL049223.1 and AW590077.1.
            
            On Nov 23, 2018 this sequence version replaced NM_004866.5.
            
            Summary: This gene product belongs to the SCAMP family of proteins,
            which are secretory carrier membrane proteins. They function as
            carriers to the cell surface in post-golgi recycling pathways.
            Different family members are highly related products of distinct
            genes, and are usually expressed together. These findings suggest
            that these protein family members may function at the same site
            during vesicular transport rather than in separate pathways. A
            pseudogene of this gene has been defined on chromosome 1.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Mar 2014].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.253417.1,
                                           SRR1660807.129470.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000621999.5/ ENSP00000481022.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                DB213762.1         115-169
            56-1069             CR542286.1         1-1014
            1070-2542           BC034048.1         1038-2510
            2543-3391           BC034048.1         2512-3360
            3392-4078           AK001417.1         156-842
            4079-4079           BC034048.1         4048-4048
            4080-4789           AK001417.1         844-1553
            4790-4790           AL049223.1         217-217
            4791-5419           AK001417.1         1555-2183
            5420-5880           AW590077.1         1-461               c
            5881-6143           AL049223.1         1309-1571
FEATURES             Location/Qualifiers
     source          1..6143
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q14.1"
     gene            1..6143
                     /gene="SCAMP1"
                     /gene_synonym="SCAMP; SCAMP37"
                     /note="secretory carrier membrane protein 1"
                     /db_xref="GeneID:9522"
                     /db_xref="HGNC:HGNC:10563"
                     /db_xref="MIM:606911"
     exon            1..112
                     /gene="SCAMP1"
                     /gene_synonym="SCAMP; SCAMP37"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..1072
                     /gene="SCAMP1"
                     /gene_synonym="SCAMP; SCAMP37"
                     /note="isoform 1 is encoded by transcript variant 1;
                     secretory carrier-associated membrane protein 1"
                     /codon_start=1
                     /product="secretory carrier-associated membrane protein 1
                     isoform 1"
                     /protein_id="NP_004857.4"
                     /db_xref="CCDS:CCDS75264.1"
                     /db_xref="GeneID:9522"
                     /db_xref="HGNC:HGNC:10563"
                     /db_xref="MIM:606911"
                     /translation="MSDFDSNPFADPDLNNPFKDPSVTQVTRNVPPGLDEYNPFSDSR
                     TPPPGGVKMPNVPNTQPAIMKPTEEHPAYTQIAKEHALAQAELLKRQEELERKAAELD
                     RREREMQNLSQHGRKNNWPPLPSNFPVGPCFYQDFSVDIPVEFQKTVKLMYYLWMFHA
                     VTLFLNIFGCLAWFCVDSARAVDFGLSILWFLLFTPCSFVCWYRPLYGAFRSDSSFRF
                     FVFFFVYICQFAVHVLQAAGFHNWGNCGWISSLTGLNQNIPVGIMMIIIAALFTASAV
                     ISLVMFKKVHGLYRTTGASFEKAQQEFATGVMSNKTVQTAAANAASTAASSAAQNAFK
                     GNQI"
     exon            113..190
                     /gene="SCAMP1"
                     /gene_synonym="SCAMP; SCAMP37"
                     /inference="alignment:Splign:2.1.0"
     exon            191..289
                     /gene="SCAMP1"
                     /gene_synonym="SCAMP; SCAMP37"
                     /inference="alignment:Splign:2.1.0"
     exon            290..398
                     /gene="SCAMP1"
                     /gene_synonym="SCAMP; SCAMP37"
                     /inference="alignment:Splign:2.1.0"
     exon            399..527
                     /gene="SCAMP1"
                     /gene_synonym="SCAMP; SCAMP37"
                     /inference="alignment:Splign:2.1.0"
     exon            528..687
                     /gene="SCAMP1"
                     /gene_synonym="SCAMP; SCAMP37"
                     /inference="alignment:Splign:2.1.0"
     exon            688..789
                     /gene="SCAMP1"
                     /gene_synonym="SCAMP; SCAMP37"
                     /inference="alignment:Splign:2.1.0"
     exon            790..907
                     /gene="SCAMP1"
                     /gene_synonym="SCAMP; SCAMP37"
                     /inference="alignment:Splign:2.1.0"
     exon            908..6143
                     /gene="SCAMP1"
                     /gene_synonym="SCAMP; SCAMP37"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3665..3670
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCAMP1"
                     /gene_synonym="SCAMP; SCAMP37"
                     /note="hexamer: AATAAA"
     polyA_site      3685
                     /gene="SCAMP1"
                     /gene_synonym="SCAMP; SCAMP37"
                     /note="major polyA site"
     regulatory      4210..4215
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCAMP1"
                     /gene_synonym="SCAMP; SCAMP37"
                     /note="hexamer: AATACA"
     polyA_site      4229
                     /gene="SCAMP1"
                     /gene_synonym="SCAMP; SCAMP37"
     regulatory      6117..6122
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCAMP1"
                     /gene_synonym="SCAMP; SCAMP37"
                     /note="hexamer: AATAAA"
     polyA_site      6143
                     /gene="SCAMP1"
                     /gene_synonym="SCAMP; SCAMP37"
ORIGIN      
        1 gcctcgtctc tctctctgcg cctgggtcgg gtgggtgacg ccgagagcca gagagatgtc
       61 ggatttcgac agtaacccgt ttgccgaccc ggatctcaac aatcccttca aggatccatc
      121 agttacacaa gtgacaagaa atgttccacc aggacttgat gaatataatc cattctcgga
      181 ttctagaaca cctccaccag gcggtgtgaa gatgcctaat gtacccaata cacaaccagc
      241 aataatgaaa ccaacagagg aacatccagc ttatacacag attgcaaagg aacatgcatt
      301 ggcccaagct gaacttctta agcgccagga agaactagaa agaaaagccg cagaattaga
      361 tcgtcgggaa cgagaaatgc aaaacctcag tcaacatggt agaaaaaata attggccacc
      421 tcttcctagc aattttcctg tcggaccttg tttctatcag gatttttctg tagacattcc
      481 tgtagaattc caaaagacag taaagcttat gtactacttg tggatgttcc atgcagtaac
      541 actgtttcta aatatcttcg gatgcttggc ttggttttgt gttgattctg caagagcggt
      601 tgattttgga ttgagtatcc tgtggttctt gctttttact ccttgttcat ttgtctgttg
      661 gtacagacca ctttatggag ctttcaggag tgacagttca tttagattct ttgtattctt
      721 cttcgtctat atttgtcagt ttgctgtaca tgtactccaa gctgcaggat ttcataactg
      781 gggcaattgt ggttggattt catcccttac tggtctcaac caaaatattc ctgttggaat
      841 catgatgata atcatagcag cacttttcac agcatcagca gtcatctcac tagttatgtt
      901 caaaaaagta catggactat atcgcacaac aggtgctagt tttgagaagg cccaacagga
      961 gtttgcaaca ggtgtgatgt ccaacaaaac tgtccagacc gcagctgcaa atgcagcttc
     1021 aactgcagca tctagtgcag ctcagaatgc tttcaagggt aaccagattt aagaatcttc
     1081 aaacaataca ctgttacctt ttgactgtac ctttttctcc agttactgta ttctacaaat
     1141 atttttatgt tcaaaacaca cagtacagac agcatggata tttcctgttc acttgtgcat
     1201 gggctaaaac caggaaaact tccttgtctt attactttac ctaatagttt cttaatattt
     1261 cagtgcccct tgcagaaaaa atattacatg ctaaataaat attctccata tttttggggg
     1321 atgacattca gtgaattatt tcagtggtga cccactgaaa attaataatg gtacttatga
     1381 ttaaaaacgc atttaatact aactgcagta gttctttcaa gaatctttag agataaggat
     1441 tgcacattgg aaaagtaaac catgtttcat tcctttttcc ctatttatat tgaaagaaat
     1501 aggccagcag agacttaggg attttaaatt ggcttgcttt ttagctgttt cagtcaccag
     1561 tgaagagcct atgtgcattt tgtagtagat aatgtaaaat ttgtcatctt tttcttttct
     1621 tttttttaga atagctgata ttttgataac aatctctaat ttgcatgggc accacatttc
     1681 ttatattaaa agaattagtg ttttggcttc tgtactgctt atggttgtag gattcagggg
     1741 ttaatggaat cacagaaatg atattctgca agaatttctt ttaaataaaa agtttggggg
     1801 tgcaatataa gaagtttata taatatgcag tacattatcc aaaagagaag gtagttaatg
     1861 cagtagaaag tagtggtaat aattcctttt taaaaaaatt tcggtagtca tatagtaaca
     1921 ttttgctata tgaaaacttt ggtatattct gtggttacaa ctaagattgt gtctggcagc
     1981 tcttttttgg ggatgtgtgt gtgtgatttt taacagaggt attaaaggct agcctaactg
     2041 ttgtctaaaa agattgtaca gtatttaagg gattttcctt ttagcttttc atctccagtg
     2101 gcattaaaca taaaaagacc ctggcatttt ttcacatact tgaatcccta aatgcacctg
     2161 tctttcactt tttgagacag actgaatata tctaaaattt ccagcaataa aaaaaaaagc
     2221 atttaacttg caccaagcaa gaaaatataa atacagttaa ctgcattaag ataatcacgt
     2281 taaaattgtt actatgcagc acagaacttc attcttatag tattcttggg ttcaaccttt
     2341 gaatcaattt taccactgat taaataaatg actcaaagac atctgtaagt catgctgctg
     2401 tgttttgaaa gtctttaact aaattaagat tgcagaatga tagtgattat tcaattagat
     2461 tttaagtaag gattgtgata ttagaggctg gaaatcctta ttttttaaaa aatcagatag
     2521 gcataaatag ttaaatcact ttcattctcc ccaaacctgt agttacagaa aaagttttat
     2581 gctagaggtg ggatgccaag ttttcactat ccatgaagca gcgctgcatg tcactaggta
     2641 acacagatcc atccagatgg tgtttacatt tgatttattt gggatcttat tgacatcagg
     2701 tatacttgga agacatttct tttattcttc agcgtatgaa tttaaagcta ttttttgtaa
     2761 atatttctaa tcagcgataa tttctaccta tgttctcaac caacttagcc agtttgtttt
     2821 tcagagcctg tagtcttatt ggaaatctat tttatcagtg tgctttattg agtgtggatt
     2881 ttgcatacat tcaaaacatt aaccacaaaa tacagcaagt gcacctatat tcaccattaa
     2941 cttatatccc aagtccattt tttcctgtac actacaaaca aaagatatat tagagacttt
     3001 tgaaaaatgc tgaaatactt tgcttcagaa ttggaatgtt tatattatgt agaaatcttc
     3061 aaaggtagca ttattaaata gcaaagaata attagaaccc acatatcttt ttttgtgtgg
     3121 atggggaaaa tgttttaaaa tccagttatt taatatgagt ttgagagaga aaattgtttt
     3181 ttaaaaatat atgtgcattg aaatgatggc aatgcttata gtatgatcaa gtatgaaagg
     3241 aactttaaat tcttatattt acttttctct cagtaaattg ttaaattttc actcagcaaa
     3301 agattggcat ttgttaagtg ttctatattt agtactaaaa tcacagtcat gaaatcatag
     3361 tcataaaatg gtcttcacac agcagtcatc cgtgtcattt atcattttgt aatattaaat
     3421 tatggcaatt ttatttcaaa ctaaagtttg aacaccggaa agtcattact cagtgatttg
     3481 taatttggga cttggattat ttatctagag atgtttgtat attttgtcag taactaatac
     3541 tgcgctgcca tcatggtgac tgtcatggtt ctacagaaat gccctccatg tgtccctcta
     3601 atgttgcatg tttcagtggg ttggaagttt tgtatattta ttgtattaac acagagtgtc
     3661 ataaaataaa atgctgttta ctggatgttt gtttgtataa ttttgaacac tataatagca
     3721 attcagagac agacattgtt aaaggtttga tgtatataga aattccatgt ttgatttttt
     3781 aaaatatgtg tataagtctg tcatgtgcta aacaaaataa tatgaaagac ctagttaaaa
     3841 attctaacca atgtaaaatg accatttttc tgttgcatta gacctttaca ggtaatggaa
     3901 catgagcttc acccatatta aatattttgg cccctttaag gtcaaaatac agatcatcta
     3961 gaagttagat tcaaaatgga aaacctattc atggctcaga tttttcattg tgggttaaaa
     4021 atgggtgtct ctgtactagt attgtattta ttcaattgaa cttgtattct gatttctatc
     4081 cttgctacct attgctgttt tatgtactga tgaaagtacc tatttgtgta tattggattt
     4141 ttcacttggt tagctaaaga agatgtaaaa atatctaaaa taatgttcat ggtgaatctt
     4201 attttgagaa atacatgtta aaaaaggaac agtattcttt attttctggg tgttatattt
     4261 aaaaaagcaa gtttggattt ttacacctaa tttactagga aaatatttta ttctgtaatt
     4321 catgttaaga ttatgtatgg tttgcatttt aaggggattt atgttaggtt aattagttgt
     4381 ttctgtaaat catttgtaat agcatagtgc tttttactca ttgctgtatc tttttctgaa
     4441 aacactgttg ttaacatcta attcagtatc cttattggta caaatctgtg tttggcatga
     4501 ctgtttatat acagaatttg ttacattttg agcatttttt cccctgctta tgtatacctt
     4561 agagttacca tggctgtcat ataccatttc actatatctc ctttcagttt ttccttaagg
     4621 aaaatgttta gaggaatttg ttcatttcat gtgattaagc cctttagaga tgaaataaga
     4681 ttggttaatt ttaaaaaaat tgaggatggt taaaaaatag aaaacacctt actttgatac
     4741 attttaaagt acaatagtat acatttattt agagtagact aatgtgttta aaacatgagt
     4801 tgttttaaat acttttttat tgagctaaaa agttttatct cacatattaa gtattacaga
     4861 aagtgaagta ttttggctag aattttaggg catattttat aaagcagcat gcctgtaata
     4921 ttggtgggta tttttaaact ttaggacttt atcacagtat gtagagagct agaaataaat
     4981 ctagaaactt tctaagccag gtattgccac taacctgtct tatataagca gatacctctt
     5041 atttgaagat tgtaggaaaa tagagaaaga ctgttctcca gttttctcac ccccgctgtg
     5101 ggttttatat ttacaattta actttggggt ttgggtaaga caaacattta atgtatagga
     5161 ttttggccag gtgtggtggc tcacgcctgt aatcccagca ctttgggagg ccaaggtggg
     5221 cggatcacga ggtcaggaga tcgaaaccat cctggctaac atggtgaaac cccatctcta
     5281 ctaaaaatac aaaaaaaaaa ttagctgagc atggtggcgg gcgcctgtag tcccagctac
     5341 ttgggaggct gaggcaggag aatgacgtga acctgggagg cggagcttgc agtgagccga
     5401 gatctctcca ctgcactcca gcctgggcga cagagcgaga ctccatctca agaaaaaaaa
     5461 aaaagaattt tcattagtgc tggccgtgtt tcaaatggca agggaacatg ggaactatca
     5521 tgtggcaatg tagtgagtgt taaactttgt gtttgtccaa atcctgattt atttttcagt
     5581 tcatatcttt ctgggcttga catggctgat ggtgtagctg aaaccctcct aacactaaaa
     5641 gccatttaat cttttctgta ataggagcag aaaatagtta atcatccacc tagtaatata
     5701 agattactgt gaatattatc ttctatacat taaaacagtt ctagtttgta gaataatacc
     5761 atacaagttt tatttttaaa ttctagttat tttcagtgct tacttaaatg taattctaga
     5821 attcctccac aacttttaat attttgtatg ccagtgattc tcaagataaa tcatgattgt
     5881 agtagttgtt actgttggca gtttgtagta gtattcaggt attttgggga tgggggaaaa
     5941 caccaaaaat cagtgtcttt tatctggtga tcactgtggt atctacagta ttctagtctc
     6001 ctgcacaaaa actgaaccca ctgggcctat gcatccctca cacttttttt ctagtataaa
     6061 agcaatacat aatgtgttgt agaacaatta aaaattcaga aagtgataca tgagaaaata
     6121 aaaataaatc cttaattctg tca
//
