LOCUS       NM_001144877           12111 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens suppressor of cancer cell invasion (SCAI), transcript
            variant 2, mRNA.
ACCESSION   NM_001144877
VERSION     NM_001144877.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 12111)
  AUTHORS   Wang,X., Liu,Z., Chu,A., Song,R., Liu,S., Chai,T. and Sun,C.
  TITLE     Hsa_circ_0052611 and mir-767-5p guide the warburg effect,
            migration, and invasion of BRCA cells through modulating SCAI
  JOURNAL   J Bioenerg Biomembr 55 (5), 381-396 (2023)
   PUBMED   37743442
  REMARK    GeneRIF: Hsa_circ_0052611 and mir-767-5p guide the warburg effect,
            migration, and invasion of BRCA cells through modulating SCAI.
REFERENCE   2  (bases 1 to 12111)
  AUTHORS   Anuchina,A.A., Zaynitdinova,M.I., Demchenko,A.G., Evtushenko,N.A.,
            Lavrov,A.V. and Smirnikhina,S.A.
  TITLE     Bridging Gaps in HDR Improvement: The Role of MAD2L2, SCAI, and
            SCR7
  JOURNAL   Int J Mol Sci 24 (7), 6704 (2023)
   PUBMED   37047677
  REMARK    GeneRIF: Bridging Gaps in HDR Improvement: The Role of MAD2L2,
            SCAI, and SCR7.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 12111)
  AUTHORS   Adeyemi,R.O., Willis,N.A., Elia,A.E.H., Clairmont,C., Li,S., Wu,X.,
            D'Andrea,A.D., Scully,R. and Elledge,S.J.
  TITLE     The Protexin complex counters resection on stalled forks to promote
            homologous recombination and crosslink repair
  JOURNAL   Mol Cell 81 (21), 4440-4456 (2021)
   PUBMED   34597596
  REMARK    GeneRIF: The Protexin complex counters resection on stalled forks
            to promote homologous recombination and crosslink repair.
REFERENCE   4  (bases 1 to 12111)
  AUTHORS   Luo,X., Zhang,X., Peng,J., Chen,Y., Zhao,W., Jiang,X., Su,L.,
            Xie,M. and Lin,B.
  TITLE     miR-371b-5p promotes cell proliferation, migration and invasion in
            non-small cell lung cancer via SCAI
  JOURNAL   Biosci Rep 40 (11) (2020)
   PUBMED   33103723
  REMARK    GeneRIF: miR-371b-5p promotes cell proliferation, migration and
            invasion in non-small cell lung cancer via SCAI.
REFERENCE   5  (bases 1 to 12111)
  AUTHORS   Cai,Y., Zhang,K., Cao,L., Sun,H. and Wang,H.
  TITLE     Inhibition of Microrna-766-5p Attenuates the Development of
            Cervical Cancer Through Regulating SCAI
  JOURNAL   Technol Cancer Res Treat 19, 1533033820980081 (2020)
   PUBMED   33327889
  REMARK    GeneRIF: Inhibition of Microrna-766-5p Attenuates the Development
            of Cervical Cancer Through Regulating SCAI.
REFERENCE   6  (bases 1 to 12111)
  AUTHORS   Lin,L., Liu,D., Liang,H., Xue,L., Su,C. and Liu,M.
  TITLE     MiR-1228 promotes breast cancer cell growth and metastasis through
            targeting SCAI protein
  JOURNAL   Int J Clin Exp Pathol 8 (6), 6646-6655 (2015)
   PUBMED   26261546
  REMARK    GeneRIF: miR-1228 promoted breast cancer proliferation, invasion
            and migration was mediated by MOAP1 and SCAI.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 12111)
  AUTHORS   Chen,X., Hu,W., Xie,B., Gao,H., Xu,C. and Chen,J.
  TITLE     Downregulation of SCAI enhances glioma cell invasion and stem cell
            like phenotype by activating Wnt/beta-catenin signaling
  JOURNAL   Biochem Biophys Res Commun 448 (2), 206-211 (2014)
   PUBMED   24785374
  REMARK    GeneRIF: Downregulation of SCAI enhances glioma cell invasion and
            cancer stem cell like phenotype.Downregulation of SCAI activates
            the Wnt/beta-catenin signaling.
REFERENCE   8  (bases 1 to 12111)
  AUTHORS   Brauchle,M., Yao,Z., Arora,R., Thigale,S., Clay,I., Inverardi,B.,
            Fletcher,J., Taslimi,P., Acker,M.G., Gerrits,B., Voshol,J.,
            Bauer,A., Schubeler,D., Bouwmeester,T. and Ruffner,H.
  TITLE     Protein complex interactor analysis and differential activity of
            KDM3 subfamily members towards H3K9 methylation
  JOURNAL   PLoS One 8 (4), e60549 (2013)
   PUBMED   23593242
  REMARK    GeneRIF: SCAI is a specific interaction partner for KMD3B.
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 12111)
  AUTHORS   Fintha,A., Gasparics,A., Fang,L., Erdei,Z., Hamar,P., Mozes,M.M.,
            Kokeny,G., Rosivall,L. and Sebe,A.
  TITLE     Characterization and role of SCAI during renal fibrosis and
            epithelial-to-mesenchymal transition
  JOURNAL   Am J Pathol 182 (2), 388-400 (2013)
   PUBMED   23178076
  REMARK    GeneRIF: SCAI is a novel transcriptional cofactor that regulates
            epithelial-to-mesenchymal transition and renal fibrosis.
REFERENCE   10 (bases 1 to 12111)
  AUTHORS   Brandt,D.T., Baarlink,C., Kitzing,T.M., Kremmer,E., Ivaska,J.,
            Nollau,P. and Grosse,R.
  TITLE     SCAI acts as a suppressor of cancer cell invasion through the
            transcriptional control of beta1-integrin
  JOURNAL   Nat Cell Biol 11 (5), 557-568 (2009)
   PUBMED   19350017
  REMARK    GeneRIF: Genome-wide expression analysis surprisingly reveals that
            one of the strongest upregulated genes after suppression of SCAI is
            beta1-integrin
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB048788.1, BC104031.1,
            AL451125.7 and BM873972.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001144877.2.
            
            Summary: This gene encodes a regulator of cell migration. The
            encoded protein appears to function in the RhoA (ras homolog gene
            family, member A)-Dia1 (diaphanous homolog 1) signal transduction
            pathway. Alternatively spliced transcript variants have been
            described. [provided by RefSeq, Feb 2010].
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon compared to variant 1. The resulting isoform (2) has the same
            N- and C-termini but is shorter compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038195.1208117.1,
                                           SRR11853567.30856.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000336505.11/ ENSP00000336756.6
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                DB048788.1         32-72
            42-1931             BC104031.1         1-1890
            1932-11661          AL451125.7         26487-36216         c
            11662-12111         BM873972.1         23-472              c
FEATURES             Location/Qualifiers
     source          1..12111
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q33.3"
     gene            1..12111
                     /gene="SCAI"
                     /gene_synonym="C9orf126; NET40"
                     /note="suppressor of cancer cell invasion"
                     /db_xref="GeneID:286205"
                     /db_xref="HGNC:HGNC:26709"
                     /db_xref="MIM:619222"
     exon            1..144
                     /gene="SCAI"
                     /gene_synonym="C9orf126; NET40"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..1912
                     /gene="SCAI"
                     /gene_synonym="C9orf126; NET40"
                     /note="isoform 2 is encoded by transcript variant 2;
                     protein SCAI; suppressor of cancer cell invasion protein"
                     /codon_start=1
                     /product="protein SCAI isoform 2"
                     /protein_id="NP_001138349.1"
                     /db_xref="CCDS:CCDS48017.1"
                     /db_xref="GeneID:286205"
                     /db_xref="HGNC:HGNC:26709"
                     /db_xref="MIM:619222"
                     /translation="MVRGARQPQQPRSRLAPRLTGTVEKPPRKRRSRTEFALKEIMSS
                     GGAEDDIPQGERKTVTDFCYLLDKSKQLFNGLRDLPQYGQKQWQSYFGRTFDVYTKLW
                     KFQQQHRQVLDNRYGLKRWQIGEIASKIGQLYYHYYLRTSETSYLNEAFSFYSAIRQR
                     SYYSQVNKEDRPELVVKKLRYYARFIVVCLLLNKMDVVKDLVKELSDEIEDYTHRFNT
                     EDQVEWNLVLQEVAAFIEADPVMVLNDDNTIVITSNRLAETGAPLLEQGMIVGQLSLA
                     DALIIGNCNNQVKFSELTVDMFRMLQALEREPMNLASQMNKPGMQESADKPTRRENPH
                     KYLLYKPTFSQLYTFLAASFKELPANSVLLIYLSATGVFPTGRSDSEGPYDFGGVLTN
                     SNRDIINGDAIHKRNQSHKEMHCLHPGDLYPFTRKPLFIIVDSSNSVAYKNFTNLFGQ
                     PLVCLLSPTAYPKALQDQSQRGSLFTLFLNNPLMAFLFVSGLSSMRRGLWEKCQEYLR
                     KINRDIAQLLTHSRSIDQAFLQFFGDEFLRLLLTRFIFCSATMRMHKIFRETRNYPES
                     YPQLPRDETVENPHLQKHILELASILDVRNVFFENTIDDY"
     exon            145..189
                     /gene="SCAI"
                     /gene_synonym="C9orf126; NET40"
                     /inference="alignment:Splign:2.1.0"
     exon            190..321
                     /gene="SCAI"
                     /gene_synonym="C9orf126; NET40"
                     /inference="alignment:Splign:2.1.0"
     exon            322..417
                     /gene="SCAI"
                     /gene_synonym="C9orf126; NET40"
                     /inference="alignment:Splign:2.1.0"
     exon            418..504
                     /gene="SCAI"
                     /gene_synonym="C9orf126; NET40"
                     /inference="alignment:Splign:2.1.0"
     exon            505..603
                     /gene="SCAI"
                     /gene_synonym="C9orf126; NET40"
                     /inference="alignment:Splign:2.1.0"
     exon            604..700
                     /gene="SCAI"
                     /gene_synonym="C9orf126; NET40"
                     /inference="alignment:Splign:2.1.0"
     exon            701..799
                     /gene="SCAI"
                     /gene_synonym="C9orf126; NET40"
                     /inference="alignment:Splign:2.1.0"
     exon            800..952
                     /gene="SCAI"
                     /gene_synonym="C9orf126; NET40"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1054
                     /gene="SCAI"
                     /gene_synonym="C9orf126; NET40"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1156
                     /gene="SCAI"
                     /gene_synonym="C9orf126; NET40"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1235
                     /gene="SCAI"
                     /gene_synonym="C9orf126; NET40"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1335
                     /gene="SCAI"
                     /gene_synonym="C9orf126; NET40"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1417
                     /gene="SCAI"
                     /gene_synonym="C9orf126; NET40"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..1490
                     /gene="SCAI"
                     /gene_synonym="C9orf126; NET40"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..1664
                     /gene="SCAI"
                     /gene_synonym="C9orf126; NET40"
                     /inference="alignment:Splign:2.1.0"
     exon            1665..1765
                     /gene="SCAI"
                     /gene_synonym="C9orf126; NET40"
                     /inference="alignment:Splign:2.1.0"
     exon            1766..12111
                     /gene="SCAI"
                     /gene_synonym="C9orf126; NET40"
                     /inference="alignment:Splign:2.1.0"
     regulatory      12091..12096
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCAI"
                     /gene_synonym="C9orf126; NET40"
                     /note="hexamer: AATAAA"
     polyA_site      12111
                     /gene="SCAI"
                     /gene_synonym="C9orf126; NET40"
                     /note="major polyA site"
ORIGIN      
        1 gcctctccgc ctactccagc ctccgccgcc tcagcttccc gagcgagccc tgcggccgcc
       61 ggagcagctc ccgcggcgga gcaggagccg gatggtcaga ggagcccggc agccccagca
      121 gccgcggagt cgcctggccc ccagactgac tggcacagtg gagaaaccgc ctcgaaaacg
      181 gagaagcagg actgaatttg ctcttaaaga aatcatgtcc tctggaggtg ctgaagatga
      241 tatcccacag ggagagagga aaacagttac agatttttgt tatcttctgg ataaatctaa
      301 gcaactgttc aatgggttaa gagatttgcc acaatatgga cagaagcagt ggcagtccta
      361 ttttggaaga acttttgatg tttacaccaa actctggaag ttccagcagc agcatcgaca
      421 agtcttggat aatcggtatg gcttgaagcg ctggcaaata ggagaaattg cttccaagat
      481 tgggcagcta tactatcatt attacttacg cacatcggaa accagctatc tgaatgaggc
      541 tttttccttc tattctgcaa tcagacagag atcatattat tctcaagtca ataaagagga
      601 cagacctgaa ttggtagtta agaagttacg atattatgca agatttatag tagtttgtct
      661 tcttctcaac aaaatggatg ttgtaaagga tctggtaaag gaattgtcag atgaaattga
      721 agattatact caccgattta atactgaaga tcaagtggaa tggaacttgg tgcttcaaga
      781 agtagcagct ttcattgagg cggatcctgt aatggtatta aatgatgata ataccattgt
      841 tatcacatcg aatcgccttg ctgaaacagg agccccattg ctggaacagg gcatgattgt
      901 gggacagttg tctctggctg acgcactcat tattggtaat tgtaataatc aggttaagtt
      961 cagtgaacta actgttgaca tgttccggat gttacaagct ctggaaaggg agccaatgaa
     1021 tttagcttcc cagatgaata aaccaggaat gcaggaatca gctgacaagc ctactagacg
     1081 agaaaacccc cacaagtatc tgctctacaa accaaccttc agccagctat ataccttctt
     1141 agcagcgtct tttaaggagc tgcctgccaa tagcgtgctt ctgatttacc tgtcggccac
     1201 tggcgttttc cccacaggtc gttctgatag tgaaggtcct tatgattttg gaggtgtact
     1261 tactaatagt aaccgggata ttattaatgg agatgccatc cacaaacgaa atcagtccca
     1321 caaggaaatg cactgccttc atcccgggga tctctatcct ttcaccagga agccactgtt
     1381 catcattgtg gattcgtcta atagtgttgc gtataagaat ttcacaaact tgtttggaca
     1441 gccactagtc tgcttgcttt ctcctacagc atatccaaaa gctttacaag atcaatctca
     1501 gcgaggtagc ctcttcactc tctttttgaa caatcctcta atggccttcc tatttgtctc
     1561 tggattgtca agcatgcgca gaggcctatg ggaaaagtgt caagaatatc ttcgaaaaat
     1621 caaccgtgat attgcccagc tactgactca ttcacgttca atagatcagg catttctcca
     1681 gttttttgga gatgaatttc ttcgcttgct cctcacaaga tttatctttt gttcagccac
     1741 catgaggatg cacaagattt ttcgggaaac acgaaattat ccagaatcat atccacaact
     1801 gccaagggat gaaacagtgg agaatcctca tctccagaag cacattttgg aattagcatc
     1861 cattctggat gttcgaaacg tgttctttga gaataccatt gatgactatt aaaacaaaaa
     1921 ccctgttgtc gaaacaagtt ttcattttcc acaaatttta aatggtgcag ttttctaacg
     1981 tgataagaca catagtggtg ttacttagtt tttatttttt aatttagggc caccatttta
     2041 aaaacaaaca aaaaaatgtt cacactttta gggtaactgt tttaaaatgc aacctttcag
     2101 gtcttttaaa atcttaacct tggaattttt attttttgat tttgagggat ggatatttac
     2161 ctccaacttc taatcctaca ctcaaatagt cactattctc accctgagaa gagtaaatca
     2221 tttatttttg tataatgagg taaatccaac tcttatactt ggacctaagt taaatgtctg
     2281 gatttggaaa tatgtaatgg ttcataatga tgaagctagc caccatggac tactgaaaat
     2341 caagaacaga gtccctccat aatatatttt ttctcattcc aacttagctg gtagaaaaat
     2401 gtttgatcct ttgaaacatg atcaagccag ttttttgaaa tcatttaatt tctttcaata
     2461 ctgtcataat ttcagaaatt ggattgaatt gcatctgaaa gctacatctt gattgaggac
     2521 ttgaggtggt aatattactt ggaatgtatg agtattatga gatttatttg catattttct
     2581 ttgtagtctg tgaatgctgg aaatgaaaaa ggaaacaact ttgaaatatt ttagtcaaaa
     2641 aaccatgtca ttggtttcat aatacaatgt ctccaatagg aattctattt aaactcttgg
     2701 tttatgagat cacatttaaa gactggattg atgtctgtga cataaagttt taattttttg
     2761 cctcattcaa atttatgaga cttcaaagtc atagatgttt taaattttgg taaggggtaa
     2821 ctgggtgtta tgaaacctaa aatgtaagtt gattttgcat tggtaatttg gaaataagat
     2881 ttattaacat tccctgtatt tagtatttta tattcatgca caaaattttt attatcttaa
     2941 ataggactca gtgtatatta taaagatttt tcttttttgt gttttccttc cctgtcattc
     3001 cctttataat ttcacagtca cttgctatga agtcctccct cctttttgat tatgcagcat
     3061 tcaatttcag aaatctatga atgagaaggc cttataccta attttctgta caggatcaca
     3121 tctggcagtc ccaggagaag tgagctgatt gcttttgata tctctttccc atggccctag
     3181 gtaaattata ctctaaattt atttattttt tttgaaacag agtcttgctt ttgttgccca
     3241 ggttggagtg cagtggggct atctcggctc actgcaacct ccgcctccca ggttcaagca
     3301 attttcctgc ctcagcctcc cgagtagctg ggattacagg tgcccgccac catgcctggc
     3361 taatttttgt atttttagta gagacggggt ttcaccatgt tggtcaggct ggtctcaaac
     3421 tcctgacctt gtgatctgcc tgcctcagcc tcccaaagtg ctgggattac aggcgtgagc
     3481 caccgcacct ggctattatt tttaacttgg ttttcatttc tggcatagag actaatttgg
     3541 gtctaagtta ttcccattcc tgctttgatt tgctgatttt tcaaacctga agtccaaagt
     3601 tactgttttt ggggtttggg gacttgggga gtattttact tttttttttt ttttttttta
     3661 agagacagag tcttgctttg ttgcccaggt tggggtgcag cggtacattc atggctcact
     3721 gcagcctcaa attcctggat tcaggcaatc ttctcacctc agcctcccaa gtagctggga
     3781 ctacaggcat gcgccaccat gcctggctaa ttttctttat tttttaattt tttgtagaga
     3841 catggtctca ctttgttgag caggctggcc tcaaactcct gggctcaagt gatcctcctg
     3901 cctcaacctc ccaaagtgct aggattacag gtgtgagcca ctgtacctgg cctgtttact
     3961 ttttaaaaat ttttttgttt gttctttcaa acagtatttc agaaagcttg ggaaaagtta
     4021 ccctggaaag atttcctttg ctagtgggtt ttcattttca ggtaaagact gctttccttt
     4081 tttttcagta tcttaataaa cttcatagct ttcctttagt aacagtgttc attgaactac
     4141 agcaatagac tatcttcggt tttctgacct cttgtttcaa ttccccttaa gtcctgtgcc
     4201 agttatgctc ctaccaacac agagtttcct gtcctctaat gtttaaaata gtatttactg
     4261 ttctgagctt tatcctcccc cgttaagcat aaagaacact ggtctgagaa ctaggagacc
     4321 taagttctag tcctggcttt cctggtaact taagcgttat gccctttgac aactgtcttc
     4381 atgtctctgc ttgttagcac tctcatctgt aaaatgaaga ggttggccca ggtcttctcc
     4441 aactctgatt ctgtaatttg gactcttggt tccaaaaata ttgatttccc cactccaacc
     4501 accaagagaa ctatttaccc tgtttgtagt gtacacaacc ttttcttttg taagtcatat
     4561 ttacctagat tttgttcaag aaaatctggg tcccacttag ctgttttaga aactagtaca
     4621 gacagagact ctcctgagga aattagagct tttatgatta gaaacatgct tgtctaaaaa
     4681 tgagggtctt agaaatcaca acattgaccc ttatgatgtt gccccttaag ctaatagtgt
     4741 aattccttac tggtagttaa aaatctaaag tggactgaag tgatcttgaa tcttcaaaga
     4801 gaggaaaact gtgctggaaa atgttattgt ttcattgatg ccttcaaaaa aatgcgtatt
     4861 aaacaaagac tatactccag attttcttct gggcattggg gaagcaaaca aaatagactt
     4921 aaaaatcctc atgttcatga agcttacatt ctagtagaag gagtaaggca ataaacataa
     4981 gtaatttatg ttagaaaatg ttaagtagga tggaaaagtg tagattatgg taaggtaaat
     5041 cttttgtttg ttttcttaag agaagaacaa tgtttaaaag agtgatcaag cagggcatgg
     5101 tggcatgacc ctattagtcc cagctacctg ggaggccgag gtgggagggt cacttgagcc
     5161 caggagtttg tggctgcagt gagctgtgat tgcaccactg cactccagcc tggatggcaa
     5221 agcaagacct cgtctctgga aaaaaagaaa agaaaaagtg atgatcaggg taggcttcat
     5281 taggaaggtc acatttgcat gaacactttg ccttttcttt ctttttatga aagttttaaa
     5341 catagttttt ttgttttttg tttttgagac ggagtttcac tcttgttact caggctgcag
     5401 tgtggtggca ggatctcagc tcactgcaac ctccaccttc cagtttcaag tgattctcct
     5461 gcctcagcct ccccagtagc tgggattaca ggcatgtgcc accacaccca gctaattttg
     5521 tgttttgaga tggggtttca ccatgttggt caggctggtc tcgaactcct gatttgaggt
     5581 gatccgttgg cctcggcctc ccaaagtgct gggattacag gcatgagcca ccacgcccag
     5641 cctaaacata cagtttaata aatcctcctt gtaccttacc cagcttctgt atttctttaa
     5701 tcaagggaga agaattatct aaaaggacag ttgcccaatg ggcttgagct gatgatagtg
     5761 gcaaagaatt tcatttttta aaaatgcata ccacctgccc tttataaaaa aatttaaacc
     5821 ctaatgtatt taattttata attcataaaa atttaaatat tggaactaag aacagagcaa
     5881 agcaaaggga aaaagcactc ctttgttttc aaattgcaca aactgtccct ggagattctg
     5941 atagtctctc atctctctta actatcactg taaacaacat agaaagcata agactgcaag
     6001 aagtcagtta tacacaaaac aaaatgaagc acagtggaat tttctctttc tttatctgta
     6061 tatttctgaa gttggtaaag caactatctt ctctatttta cagaagagaa agctgagacc
     6121 caaaaagcta ttcatagtga tagagctaga actaaaactc agatctcctc atctcagccc
     6181 agtcttctca gtagctcaga ctgctttcta taatgaacaa gaaagaataa ttagggattt
     6241 gtattttggc acaaaacagt atcaaatttt tattgtaaaa atccacaaat ctgacatttt
     6301 atcttttatt ctagccagga tgtattcttc atttgcatgt gtgtgtttct cttagaaagt
     6361 ggtgctctca aacctttcaa agcacagaat ttattgtacc ctctttattt ttaccaaatt
     6421 gaaacgtttc aggatttcag aagcaaagtg caatccaatt gtggctggag ttttcctgat
     6481 agaggatccg ggtggttccc tcccctccaa cttctggcta ctgcccttta tttcctttgt
     6541 gcaatagaat tccctgaaac agattatgtc gtaattatac tgatttagtc aggataatgg
     6601 gaaaagcgac aaatcggatt tatgtattag gtattatgga gctttcttta gcactctcct
     6661 ccaagtttaa tctctgacat gtgtgatata gtaactttct gtctctgaga agcagtttgg
     6721 acccagctga aaaattttat ttatggagac ttgtaatcag cctgatatac agagaacact
     6781 ctggactgga aatatagtca ggtaccaagg tctgctaatt tggccattgc cagtgattca
     6841 aaaccacctc cccaccctga gtaaaagatt tgatatgaat atgaatgcta tgagtctcct
     6901 ggtgatgttt tgggtgtata tgttcctgtg tgtgtttgga aatcatagag ggtatttacc
     6961 ttgagggctc ttttgttgac cttatttatt tgaaattctt attttatttg taatggcata
     7021 tgtatatttt tgtgatgcta catgcaatct ctgtgtatac tttttgtata tatgtataca
     7081 tatttgtaaa tatattggta tgcagtgata cagtatgtgt atattatgta cccataccca
     7141 ttgtgggctg aatttattta agttctgtga ggacatccta gtggcattgt tcatgctgct
     7201 gtaattaggt tgtggctgta tctcattcat aagcctctat tttgagaggc ttgtgtttgg
     7261 ataaaatggg ctaatttgga gttgaaatta ggatatgaag atcttaacag aaagctagat
     7321 atttattctt agctttaaaa tcacctgcaa atttttattt aaactgatga taaattagtg
     7381 atataacctg aaaaacctaa gtatgtgaaa ctgagacacc agcagattct taggctgtag
     7441 tagtccttta ttttcttgat ccatatttaa gtattattac tgagtagtaa attatgtata
     7501 ttggggctta atagagaggc tgtggaaaaa aattgcttta atcacattta aaaacatagg
     7561 aaaatgtcca ttaaataggg gaaatatatt cccagttgtc atttttatgc ctcatactga
     7621 attttgattt tggaacaatt cttttttcat cagtgtttta tgtgtctcta tgaggcagaa
     7681 aagggggcat tagctaaggg atggcctaac ctaagtagga taggatttag tgaggaacgg
     7741 gaggttgtta atttgtatat ttgcagcagc tatgattaat ttagtcctgt cttggcattt
     7801 ccggctacag attttttctt actggacttg catatcaaag gtgagtaggc tcatctgaga
     7861 aaatgcttcc actgaataaa atgccttcac tcgtattgct gtgtctctat gagaccactt
     7921 gtgttctgca agttgatgat atattcgcac atgaagtaga gtttttaata ttagatgcat
     7981 ggtgtgctat aaaaatctgg gccttcaaac ctctcccaag gatgataggg ttggggagga
     8041 taagaggata gtaaatacgt gcaatgccaa tttgtgaacc tatagaatgt tgccaagtat
     8101 caatgtttgg ttacttcagt tgacatattt atttgcatga aagagtgtag gagatgttta
     8161 atatacactt aaatacattc actgcagaaa ttaagtagag gttatttttg catgataaaa
     8221 tataactgca aagcaacttt ttacaccgta ttctttggaa gattaaatct atctgatcca
     8281 atattatctt aaaatagaga aattatctca ggagtctgtt ttaccaccca aaaaaatgtt
     8341 acatttgctg attcattata ttttaaataa aacagccaac tattcataag acttttcaat
     8401 tatagtatta aattcagaaa taattataac agcatttttc ttgaataaat attaaaattt
     8461 ggtaatttat tatttctgaa aaatcagtga aaacatccat aggatctgat ggtttgttgt
     8521 ttgaataacc aaatcattgt ttttgcactg gagagtagta gagcagatat tataccattt
     8581 aaaattcatg gaactgactc aggctccttg tggatattaa tttgaggaca gtagtggtaa
     8641 tcaaaagtac agtagaaaac acttgacatt gtgaatgtga cctctgaccc caaccgttgt
     8701 aaagccaata actttgaggg tgaataaggt aacacttgct tagaaaaccc agccctttcc
     8761 cccagtctcc tgcgctctta tacattgata ctttacaact atttttgctg tacctctcag
     8821 tctttcctgg ataatgggac cacttaaaaa aaaaagtgat tcatcttcct caaactagaa
     8881 tttcaaagcc taatactaca ctatgttcca gcttcactga gttttgaaca aaaagactta
     8941 agcatgcctt gtgtttaagg aaaaataatt gatgtgtgaa tggaatcaat cacctattga
     9001 cgggaagggt gtcaggatga tgtagggtga tatgccttta attggataaa gagaactgta
     9061 ttaagtataa ctaatttaat aactgattga agcaccattc ttaattttaa aatatttttg
     9121 ttaatttctt ttgtggtttt aaaaattaat aatttttttt tttttgagat ggagttttgc
     9181 tcgttgccca ggctggaatg caatggcgcg atctcagctc actgcaacct ccgcctcctg
     9241 ggttcaagag attctcctgc ctcagcctcc caagtagctg ggattacagg cgtgtgccac
     9301 cacgaccagc taattttgta tttttagtag agatggggtt tcaccatgtt ggccaggttg
     9361 gtctcgaact cctgacctca agtgatccac ccgcctcggc ctcccaaagt gctgggatta
     9421 caggtgtgag ccactgtggc cggcctaaaa aaaattcttt ttaatagtta tcagactact
     9481 ttaaccagtg ccatgtttaa acatacttgg acaatagact cagttttttt aatagtttga
     9541 agtacattat attaaaacta caaactcact tattcaagcc taaatttcat catagactat
     9601 aaattgggta tcaatttcct attttggtgg acaattccag tctgtctact acgacaatca
     9661 tctttttagg tgtaatattg tttaagacat aggtaatttt aggttttata cttttctcct
     9721 aggcttatgg aatgaaagct aataggatat cactttcaga atgaaatagg gaattatggc
     9781 tagccttctt atagggctgc cgtaaatgat acttaaatgt ttgttatatc actgattttc
     9841 ttttctcttc tgaagctgtt gtgaatgtcc actttgccat gattaaaagt tgagatttgt
     9901 aaacattaca atttgaacca taaattttct caaacatgaa atcagtatga ataagtataa
     9961 aatttgaaat gatcatacat gagaatccca aaagtaaata cttccaaacc atagagggat
    10021 aaccactgta tttttaaaaa gcttatttcc acccttaaag aagcatgcta ctaattgctt
    10081 tttttctaaa ttaaaactat gtactgtggt aaattaaaaa tctgcaggaa aaattgctta
    10141 gtgttttagc acaataagaa tttttattac tcaggagttg gagaccagtc tgggcaatac
    10201 agtgaaaccc tgtcgctact aaaatacaaa aaaaaaaaaa aaaaaaaaaa aattagccag
    10261 gcatggtggt gtgcgcctgt aatcccagct acttgggagg ctgaggcagg agaactgctt
    10321 gtaacctggg aggcggaggt tgcagtgagc cgagatcgtg ccattgcact ccagtctggg
    10381 tgacagagca agactcattc tcaaaaaaaa aaaaaaaagg aatttttatt actatttcct
    10441 gaagaatggt ttttgttaac ttgttactgt atcattaaaa agaccttcta atggttcagt
    10501 acaataatct agaacttgat ttatgtggct ttttatagtt atctgaatgc attccttttg
    10561 ccacatagac catatggcta gttctccaac ttttttgctt atttttaata aaccttgctg
    10621 ttcaacaatc agagaaacct ttagattttg gatgattctt ccagttgagg tagaaacatc
    10681 ttagataata ggaaaggcaa atacaaagtc ctaacatttt catagtagag tttacaagta
    10741 aaataactta tccatatagg ttatcttcgt tgtgtagcac cagtataaat agtgatttca
    10801 ttaatcattg aatcagatga agcagttata aatcactttt tactttgtgc taagaattat
    10861 tgtaatttca ggacacttta ttatttcctc tgagcagttt ccattggaag gttgagtttc
    10921 ccttttttaa gttctaatca tcactaaagg ttaagataat caaataggag ttaaaataag
    10981 ttatgtttga tctttttccc ttgaaaataa tgctgaactt attgtctaca ttctgattat
    11041 taggcagaaa tgcacttgtt taaatcatag aagtaattca tttggaggat ataattactc
    11101 gattttctag tggtgtgaaa tactttttaa caattgtgct tgtctgtaac tgaaatgtta
    11161 tagaatttta acactatagg gattatagag ttatattagc tctcctcaag agactgaagc
    11221 acaatatttt tcatgtaaca attcttatcc aagtgctgct aatctgtcgt gcaaataatg
    11281 aagctatttg gttgcctatt tagctattca caaatcactg taatctttga aacaatcttg
    11341 tcgttcattt gtattaatat ttggatattg tgagttaata ctttagaaaa aaatccatca
    11401 actcagcccc gttagcaaaa ctgtttggat tcatagtttt tatatgtgtt aacagtagaa
    11461 taaattttga aggggctatt tactaccaat gactaagggg aaaattatac tgtcactatc
    11521 atttgacttg aacatttgtg gtattgtaaa agtcttgtca gttgtgttct aaattgctta
    11581 agccatacgt tctcttaaac aggatgtttt tttcttcctt tccagcagcc tttttcttct
    11641 ttgtctgtta tggttaatac tccatagatt ttagaaattg agaagttctt gaaacatttt
    11701 attttcttga gttcatcact tttgactctt gtatgagatg tgatttgtca taaaagatag
    11761 ccttccacta cttcactaaa tgaatttcag agtaaacact gtgattctgc agagcggatt
    11821 cagtaggctt tccaatgttt tctcctgcta tacagtgcct accaccttga gggcacttca
    11881 gtactagagg atgaaaactg aaacgttgtt ttgatgttta ttgaataacg agattagaga
    11941 atatttgatt tttgttgtca gtgtattaaa gaaattttca cattgataaa tgttctctag
    12001 gaatgtgtct acattcatca ggtgtgaact cttgtacatg aattttgtac cttgaatcca
    12061 catatatatt aagtgtatca tcaatataaa aataaacatt atttgcttaa a
//
