LOCUS       NM_014892               5127 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens SR-related CTD associated factor 8 (SCAF8), transcript
            variant 4, mRNA.
ACCESSION   NM_014892
VERSION     NM_014892.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5127)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 5127)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 5127)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5127)
  AUTHORS   Gregersen,L.H., Mitter,R., Ugalde,A.P., Nojima,T., Proudfoot,N.J.,
            Agami,R., Stewart,A. and Svejstrup,J.Q.
  TITLE     SCAF4 and SCAF8, mRNA Anti-Terminator Proteins
  JOURNAL   Cell 177 (7), 1797-1813 (2019)
   PUBMED   31104839
  REMARK    GeneRIF: Together, SCAF4 and SCAF8 coordinate the transition
            between elongation and termination, ensuring correct polyA site
            selection and RNAPII transcriptional termination in human cells.
REFERENCE   5  (bases 1 to 5127)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 5127)
  AUTHORS   Jin,L., Wang,T., Jiang,S., Chen,M., Zhang,R., Hu,C., Jia,W. and
            Liu,Z.
  TITLE     The Association of a Genetic Variant in SCAF8-CNKSR3 with Diabetic
            Kidney Disease and Diabetic Retinopathy in a Chinese Population
  JOURNAL   J Diabetes Res 2017, 6542689 (2017)
   PUBMED   28401168
  REMARK    GeneRIF: SCAF8-CNKSR3 variant rs955333 was not associated with
            diabetic kidney disease but showed association with diabetic
            retinopathy in Chinese type 2 diabetes patients
REFERENCE   7  (bases 1 to 5127)
  AUTHORS   Becker,R., Loll,B. and Meinhart,A.
  TITLE     Snapshots of the RNA processing factor SCAF8 bound to different
            phosphorylated forms of the carboxyl-terminal domain of RNA
            polymerase II
  JOURNAL   J Biol Chem 283 (33), 22659-22669 (2008)
   PUBMED   18550522
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA219101.1, AB029039.1, AK295651.1 and BX090356.1.
            
            On Feb 27, 2020 this sequence version replaced NM_014892.4.
            
            Transcript Variant: This variant (4) contains an alternate 5' exon
            and it thus differs in its 5' UTR and initiates translation at an
            downstream in-frame start codon, compared to variant 1. The encoded
            isoform (d) is shorter at the N-terminus, compared to isoform a.
            Both variants 4 and 5 encode isoform d.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB029039.1, SRR14038192.1570454.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367178.8/ ENSP00000356146.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-300               DA219101.1         2-301
            301-2122            AB029039.1         1-1822
            2123-4689           AK295651.1         1879-4445
            4690-5127           BX090356.1         216-653
FEATURES             Location/Qualifiers
     source          1..5127
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q25.2"
     gene            1..5127
                     /gene="SCAF8"
                     /gene_synonym="RBM16"
                     /note="SR-related CTD associated factor 8"
                     /db_xref="GeneID:22828"
                     /db_xref="HGNC:HGNC:20959"
                     /db_xref="MIM:616024"
     exon            1..515
                     /gene="SCAF8"
                     /gene_synonym="RBM16"
                     /inference="alignment:Splign:2.1.0"
     CDS             486..4301
                     /gene="SCAF8"
                     /gene_synonym="RBM16"
                     /note="isoform d is encoded by transcript variant 4;
                     SR-like CTD-associated factor 8; protein SCAF8;
                     RNA-binding motif protein 16; CDC5L complex-associated
                     protein 7; SR-related and CTD-associated factor 8"
                     /codon_start=1
                     /product="SR-related and CTD-associated factor 8 isoform
                     d"
                     /protein_id="NP_055707.3"
                     /db_xref="CCDS:CCDS5247.1"
                     /db_xref="GeneID:22828"
                     /db_xref="HGNC:HGNC:20959"
                     /db_xref="MIM:616024"
                     /translation="MEAVKTFNSELYSLNDYKPPISKAKMTQITKAAIKAIKFYKHVV
                     QSVEKFIQKCKPEYKVPGLYVIDSIVRQSRHQFGQEKDVFAPRFSNNIISTFQNLYRC
                     PGDDKSKIVRVLNLWQKNNVFKSEIIQPLLDMAAGIPPPVVTPVLASTTTAMSNTPGT
                     PVTPVTPANVVQGLPDPWVSQITNTDTLAAVAQILQSPQGQQLQQLIQTLQIQQQKPQ
                     PSILQALDAGLVVQLQALTAQLTAAAAAANTLTPLEQGVSFNKKLMDRFDFGEDSEHS
                     EEPKKEIPASQLSHVSESVNNSIFHQIAEQLQQQNLEHLRQQLLEQQQPQKATPQDSQ
                     EGTFGSEHSASPSQGSSQQHFLEPEVNLDDSIDIQQQDMDIDEGQDGVEEEVFEQEAK
                     KVAVRSRSRTHSRSRSRSPRKRRSRSRSGSRKRKHRKRSRSRSRERKRKSSRSYSSER
                     RAREREKERQKKGLPPIRSKTLSVCSTTLWVGQVDKKATQQDLTNLFEEFGQIESINM
                     IPPRGCAYVCMVHRQDAFRALQKLSSGSYKIGSKVIKIAWALNKGVKTEYKQFWDVDL
                     GVTYIPWEKVKVDDLEGFAEGGMIDQETVNTEWETVKSSEPVKETVQTTQSPTPVEKE
                     TVVTTQAEVFPPPVAMLQIPVAPAVPTVSLVPPAFPVSMPVPPPGFSPIPPPPFLRAS
                     FNPSQPPPGFMPPPVPPPVVPPPTIPPVVPTSLVQPSLSMTPETVKDVGFGSLVIPGG
                     SVASNLATSALPAGNVFNAPTKQAEPEEKVPHLIDHQISSGENTRSVIPNDISSNAAI
                     LGGQPPNVTSNSGILGVQRPNVSSNSEILGVRPSNVSSSSGIIAAQPPNILNNSGILG
                     IQPPSVSNSSGLLGVLPPNIPNNSGLVGVQPPNVPNTPGLLGTQPPAGPQNLPPLSIP
                     NQRMPTMPMLDIRPGLIPQAPGPRFPLIQPGIPPQRGIPPPSVLDSALHPPPRGPFPP
                     GDIFSQPERPFLAPGRQSVDNVTNPEKRIPLGNDNIQQEGDRDYRFPPIETRESISRP
                     PPVDVRDVVGRPIDPREGPGRPPLDGRDHFGRPPVDIRENLVRPGIDHLGRRDHFGFN
                     PEKPWGHRGDFDEREHRVLPVYGGPKGLHEERGRFRSGNYRFDPRSGPWNRGFGQEVH
                     RDFDDRRRPWERQRDRDDRDFDFCREMNGNRLGRDRIQNTWVPPPHARVFDYFEGATS
                     QRKGDNVPQVNGENTERHAQPPPIPVQNDPELYEKLTSSNEINKEKSDTVADIESEPV
                     VESTETEGT"
     exon            516..599
                     /gene="SCAF8"
                     /gene_synonym="RBM16"
                     /inference="alignment:Splign:2.1.0"
     exon            600..644
                     /gene="SCAF8"
                     /gene_synonym="RBM16"
                     /inference="alignment:Splign:2.1.0"
     exon            645..806
                     /gene="SCAF8"
                     /gene_synonym="RBM16"
                     /inference="alignment:Splign:2.1.0"
     exon            807..960
                     /gene="SCAF8"
                     /gene_synonym="RBM16"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1091
                     /gene="SCAF8"
                     /gene_synonym="RBM16"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1268
                     /gene="SCAF8"
                     /gene_synonym="RBM16"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1348
                     /gene="SCAF8"
                     /gene_synonym="RBM16"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1466
                     /gene="SCAF8"
                     /gene_synonym="RBM16"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..1598
                     /gene="SCAF8"
                     /gene_synonym="RBM16"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1711
                     /gene="SCAF8"
                     /gene_synonym="RBM16"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..1905
                     /gene="SCAF8"
                     /gene_synonym="RBM16"
                     /inference="alignment:Splign:2.1.0"
     exon            1906..2006
                     /gene="SCAF8"
                     /gene_synonym="RBM16"
                     /inference="alignment:Splign:2.1.0"
     exon            2007..2120
                     /gene="SCAF8"
                     /gene_synonym="RBM16"
                     /inference="alignment:Splign:2.1.0"
     exon            2121..2277
                     /gene="SCAF8"
                     /gene_synonym="RBM16"
                     /inference="alignment:Splign:2.1.0"
     exon            2278..2411
                     /gene="SCAF8"
                     /gene_synonym="RBM16"
                     /inference="alignment:Splign:2.1.0"
     exon            2412..2556
                     /gene="SCAF8"
                     /gene_synonym="RBM16"
                     /inference="alignment:Splign:2.1.0"
     exon            2557..2625
                     /gene="SCAF8"
                     /gene_synonym="RBM16"
                     /inference="alignment:Splign:2.1.0"
     exon            2626..2844
                     /gene="SCAF8"
                     /gene_synonym="RBM16"
                     /inference="alignment:Splign:2.1.0"
     exon            2845..5127
                     /gene="SCAF8"
                     /gene_synonym="RBM16"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4944..4949
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCAF8"
                     /gene_synonym="RBM16"
                     /note="hexamer: AATAAA"
     polyA_site      4966
                     /gene="SCAF8"
                     /gene_synonym="RBM16"
                     /note="major polyA site"
     regulatory      4997..5002
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCAF8"
                     /gene_synonym="RBM16"
                     /note="hexamer: TATAAA"
     polyA_site      5018
                     /gene="SCAF8"
                     /gene_synonym="RBM16"
     regulatory      5104..5109
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCAF8"
                     /gene_synonym="RBM16"
                     /note="hexamer: TATAAA"
     polyA_site      5127
                     /gene="SCAF8"
                     /gene_synonym="RBM16"
ORIGIN      
        1 atattggatg ccgcagccgc tgctgccagc gcttcctcct ctgtcttcgc cgagcggggc
       61 tggttcctgc ggcccgagcg gcggggaggt gaaacaggag cccgtcggag gaaggggcag
      121 aagggagtgg agagtgtagg ggaaggggct agagggaggg ggaccgaaac ggagcggggc
      181 agagaagaga aggcgccgcg gcccagcccc tcccccgccc gccgccgacc cgccccggca
      241 gcgcctctgt tccctagaac ggcgctcccc ccgccctagc ggccatgccg gtgccgctct
      301 gccgctgagg gagcccttcc ccgccagcgc gtgcccttcc actccgcccc gaggtcgcag
      361 cggcccgctc tcccgccagc gccccctcct cgcggccacg cagcagcccg cgtctcgctc
      421 tccccaccca gtgcagtggc cgccgcctct tccgccgccg ggctcggggc ctccgcagcg
      481 acaacatgga ggccgtgaag accttcaata gcgagttgta ttccctgaat gactataaac
      541 cacccatttc gaaagcgaaa atgacccaaa ttactaaggc agccatcaaa gctattaagt
      601 tctataaaca tgtggtacag agtgttgaga agtttattca gaaatgtaaa ccagaataca
      661 aagtacctgg actttatgtt attgactcca ttgtgcgaca atcccgacat cagtttggtc
      721 aagaaaagga tgtgtttgca cccagattta gtaataacat cattagcact ttccagaatt
      781 tatatcgttg ccctggggat gacaagagta aaatagtgag agtactaaac ttatggcaga
      841 agaataatgt atttaagagt gagattattc agcccctttt ggatatggca gccgggattc
      901 cgcctccagt tgtcacacct gttttggcca gcactaccac tgctatgagc aatactccag
      961 gaactcctgt gacacctgtt actccggcca atgtggtcca aggcttacct gatccgtggg
     1021 tatctcagat aacaaataca gatacacttg cggctgtagc tcagatcttg caaagtcctc
     1081 aaggccagca gcttcaacaa ttaatacaaa ccttacagat acaacaacag aagccccagc
     1141 cttccattct gcaggcccta gatgctggtc ttgttgttca gttgcaagct cttacggcac
     1201 aacttacagc tgcagctgca gctgccaaca ctcttactcc cttagaacag ggagtctcct
     1261 ttaacaagaa gttgatggat aggtttgatt ttggggaaga ctctgagcat agtgaagaac
     1321 ccaaaaagga aattccagct tcacaacttt ctcacgtttc agaatctgtg aacaattcca
     1381 tttttcatca gatagcagaa caactacaac agcaaaacct agaacatctc agacagcagc
     1441 tcttggagca gcaacagcct caaaaggcca ctcctcagga tagtcaggaa ggaacctttg
     1501 ggtcagagca ttcagcgtca ccatcacaag ggagtagtca gcagcatttt cttgaacctg
     1561 aagtcaattt ggatgattcc atagatattc agcaacagga tatggatata gatgaagggc
     1621 aagatggagt ggaagaggag gtctttgaac aagaagctaa gaaagtggcg gttcgctcaa
     1681 gatcaagaac acattcacga tctcgttcaa gatcaccaag aaaacgaagg tctaggtcac
     1741 ggtctggctc tagaaagcgt aaacacagaa agcgatcacg ctcccgctca agagaaagaa
     1801 agaggaaatc atcacggtcg tattcaagtg aaaggagagc cagagaaagg gagaaagaac
     1861 gacagaaaaa gggattacct ccaattagat ctaaaacact aagtgtatgt agtactactc
     1921 tctgggttgg gcaagtggac aagaaggcaa cacagcaaga cttaaccaac ctgtttgaag
     1981 agtttggaca gattgaatcc attaatatga ttcctccccg gggctgtgct tatgtctgca
     2041 tggttcatcg acaagatgca tttcgagctc ttcagaaact cagttctgga tcatataaaa
     2101 ttgggtccaa ggtcattaag atcgcttggg ctttaaacaa aggtgtaaaa acagaataca
     2161 aacaattctg ggatgtggat cttggagtta catatatacc atgggaaaaa gttaaagtgg
     2221 atgacttgga aggttttgca gaaggaggca tgattgatca ggagactgta aatactgagt
     2281 gggaaactgt gaaaagctca gaacctgtta aagagacggt ccagacaact cagagcccaa
     2341 ctccagttga aaaggagaca gtggtcacaa cccaggcaga ggttttccct cctcctgttg
     2401 ctatgttgca gattccagtg gcgccagccg tgcctacagt tagtttagtc ccaccagcat
     2461 ttcctgtgtc gatgccggtt cctcctcctg gattcagtcc aatccctcca cctccttttt
     2521 taagagcaag ttttaaccct tcacaaccac cacctggttt catgccgcct ccagttcccc
     2581 cacctgttgt gccaccccct acgattccac cagtagtacc aacatcttta gtgcagccgt
     2641 cattatccat gacaccggaa actgtgaaag atgttggatt tggtagcctt gttataccag
     2701 gcggttctgt tgccagcaat cttgctactt ccgctctgcc agctggaaat gtttttaatg
     2761 ctccaactaa acaggcagag cctgaagaaa aagtacctca tcttatagac caccagattt
     2821 cttctggtga aaacaccaga tcagtgattc caaatgatat ttcaagtaat gctgcaattt
     2881 taggaggaca gccgccaaat gtgacaagca attctggaat tctgggagtc caaagaccaa
     2941 atgtatcaag taattctgaa attcttgggg tccggccatc taatgtttcc agtagttctg
     3001 ggattattgc agcccaacca ccaaatattc taaataactc tggaatattg ggaatacagc
     3061 cacccagtgt gtcaaatagt tctggacttt tgggagtgct acccccaaat atacctaaca
     3121 attctggact tgtaggagta cagccaccaa atgttccaaa tactcctgga cttctgggaa
     3181 cacagccacc agctggacct caaaacttac cccctttaag tatccctaat caaaggatgc
     3241 ccacaatgcc aatgttagac attcgtccgg gactaatacc acaggcacct gggccaagat
     3301 tccctttaat acagcctgga attccacccc aacggggaat cccaccccca tcggtacttg
     3361 attcagctct tcatccacca ccccgtggac cttttcctcc aggagatatt tttagtcaac
     3421 cagaaagacc ttttttagct cctggaagac aaagcgtaga caatgttact aacccagaaa
     3481 aaaggatacc acttgggaat gataacattc aacaggaagg agatagagat taccggtttc
     3541 ctcctataga aaccagggaa agcattagta gacctccccc tgtggatgtt agagatgtgg
     3601 ttgggcggcc tatagatcca agagaaggtc ctggacggcc tccactagat ggtagggatc
     3661 attttggaag acctcctgta gatataagag agaatcttgt gaggccaggt atagatcatc
     3721 ttggtcgaag agaccacttt ggctttaatc cagagaagcc ctgggggcat agaggagatt
     3781 ttgatgagag agagcatcgg gttctaccgg tctatggtgg tccaaaaggc ttacatgaag
     3841 aaagaggtag atttcggtct ggaaactatc gatttgatcc tagaagtggt ccttggaacc
     3901 gaggatttgg acaagaagtt cacagagatt ttgatgaccg cagaagaccc tgggagaggc
     3961 aaagggatag ggatgacaga gattttgatt tctgcagaga aatgaatgga aatcgtcttg
     4021 gacgagacag aattcaaaac acttgggttc cccctcctca tgctcgggtt tttgattatt
     4081 ttgaaggggc cacttctcaa cgaaaaggtg ataatgtgcc tcaggttaat ggtgaaaata
     4141 cagagagaca tgctcagcca ccacctatac cagtacagaa tgatcctgaa ctttatgaaa
     4201 aactgacatc ttcaaatgaa ataaacaagg agaagagtga cacagttgct gatatagaaa
     4261 gtgaaccagt ggtagaaagc acagaaactg aggggacata atcatcactc agtaggtaaa
     4321 agataccttt tgtaaagttg tcatctctct gtaatagata atggctgact ggaccatagt
     4381 tgttcacttt tgtctgccag aattaagtta atctgatgtt catgttcacc tttctcttaa
     4441 aataattgta caactgactt gtatagacat tgttcttaat atgaacatgg taggtaaact
     4501 ttttttttat ttttttctga taaaatacaa atgttggccc cagattcttt taacgtcaag
     4561 gaaatgaata acagcttgtc agagacttcc tatggaagaa agaatttttt agatactatc
     4621 attaggttgg atatggtaat agatatattt cagaatagca agtggtggta tatcttatcc
     4681 atatctttag gctgctgcag aattttaagg ttatagataa agctgtgata ttttatgcaa
     4741 agactggctc taggtatttg aggagcacaa tacagagatt ttaaaaagtg attttgtaaa
     4801 atctacacta cggtctctgt ttctccaaag taagtgtttg tgatttgttc ctcatactgc
     4861 agtgagtaaa aaagaaacaa gaaaacaaca acataaatat taaagtacgt ttcaatgttg
     4921 ggtgaatttt gtttttagat gccaataaaa cttatttgtt tgataacagt gttctaggaa
     4981 ttgtattttt ttaacctata aattcttaaa accttgaatt attattagca tgtgcttatt
     5041 ttttgcaaaa gctttctatc ataacaacaa tgaactatgt ggtggaaaaa gcatgtactt
     5101 tgatataaaa atcatgcagc ctcctca
//
