LOCUS       NM_020706               4269 bp    mRNA    linear   PRI 29-JUL-2024
DEFINITION  Homo sapiens SR-related CTD associated factor 4 (SCAF4), transcript
            variant 1, mRNA.
ACCESSION   NM_020706
VERSION     NM_020706.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4269)
  AUTHORS   Hu,Y., Zhang,B., Chen,L., He,J., Yang,L. and Chen,X.
  TITLE     SCAF4 variants are associated with epilepsy with neurodevelopmental
            disorders
  JOURNAL   Seizure 116, 113-118 (2024)
   PUBMED   37891035
  REMARK    GeneRIF: SCAF4 variants are associated with epilepsy with
            neurodevelopmental disorders.
REFERENCE   2  (bases 1 to 4269)
  AUTHORS   Lin,H. and Chen,Y.H.
  TITLE     SCAF4 variants associated with focal epilepsy accompanied by
            multisystem disorders
  JOURNAL   Seizure 116, 65-73 (2024)
   PUBMED   37394306
  REMARK    GeneRIF: SCAF4 variants associated with focal epilepsy accompanied
            by multisystem disorders.
REFERENCE   3  (bases 1 to 4269)
  AUTHORS   Zhou,M., Ehsan,F., Gan,L., Dong,A., Li,Y., Liu,K. and Min,J.
  TITLE     Structural basis for the recognition of the S2, S5-phosphorylated
            RNA polymerase II CTD by the mRNA anti-terminator protein hSCAF4
  JOURNAL   FEBS Lett 596 (2), 249-259 (2022)
   PUBMED   34897689
  REMARK    GeneRIF: Structural basis for the recognition of the S2,
            S5-phosphorylated RNA polymerase II CTD by the mRNA anti-terminator
            protein hSCAF4.
REFERENCE   4  (bases 1 to 4269)
  AUTHORS   Fliedner,A., Kirchner,P., Wiesener,A., van de Beek,I., Waisfisz,Q.,
            van Haelst,M., Scott,D.A., Lalani,S.R., Rosenfeld,J.A.,
            Azamian,M.S., Xia,F., Dutra-Clarke,M., Martinez-Agosto,J.A.,
            Lee,H., Noh,G.J., Lippa,N., Alkelai,A., Aggarwal,V., Agre,K.E.,
            Gavrilova,R., Mirzaa,G.M., Straussberg,R., Cohen,R., Horist,B.,
            Krishnamurthy,V., McWalter,K., Juusola,J., Davis-Keppen,L.,
            Ohden,L., van Slegtenhorst,M., de Man,S.A., Ekici,A.B., Gregor,A.,
            van de Laar,I. and Zweier,C.
  CONSRTM   UCLA Clinical Genomics Center
  TITLE     Variants in SCAF4 Cause a Neurodevelopmental Disorder and Are
            Associated with Impaired mRNA Processing
  JOURNAL   Am J Hum Genet 107 (3), 544-554 (2020)
   PUBMED   32730804
  REMARK    GeneRIF: Variants in SCAF4 Cause a Neurodevelopmental Disorder and
            Are Associated with Impaired mRNA Processing.
REFERENCE   5  (bases 1 to 4269)
  AUTHORS   Gregersen,L.H., Mitter,R., Ugalde,A.P., Nojima,T., Proudfoot,N.J.,
            Agami,R., Stewart,A. and Svejstrup,J.Q.
  TITLE     SCAF4 and SCAF8, mRNA Anti-Terminator Proteins
  JOURNAL   Cell 177 (7), 1797-1813 (2019)
   PUBMED   31104839
  REMARK    GeneRIF: Together, SCAF4 and SCAF8 coordinate the transition
            between elongation and termination, ensuring correct polyA site
            selection and RNAPII transcriptional termination in human cells.
REFERENCE   6  (bases 1 to 4269)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 4269)
  AUTHORS   Rajaraman,P., Brenner,A.V., Butler,M.A., Wang,S.S., Pfeiffer,R.M.,
            Ruder,A.M., Linet,M.S., Yeager,M., Wang,Z., Orr,N., Fine,H.A.,
            Kwon,D., Thomas,G., Rothman,N., Inskip,P.D. and Chanock,S.J.
  TITLE     Common variation in genes related to innate immunity and risk of
            adult glioma
  JOURNAL   Cancer Epidemiol Biomarkers Prev 18 (5), 1651-1658 (2009)
   PUBMED   19423540
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 4269)
  AUTHORS   Becker,R., Loll,B. and Meinhart,A.
  TITLE     Snapshots of the RNA processing factor SCAF8 bound to different
            phosphorylated forms of the carboxyl-terminal domain of RNA
            polymerase II
  JOURNAL   J Biol Chem 283 (33), 22659-22669 (2008)
   PUBMED   18550522
  REMARK    GeneRIF: Describes function of the CTD-interacting domain of human
            SCAF8, human SCAF4, and similar proteins in S. cerevisiae.
REFERENCE   9  (bases 1 to 4269)
  AUTHORS   Al-Kateb,H., Boright,A.P., Mirea,L., Xie,X., Sutradhar,R.,
            Mowjoodi,A., Bharaj,B., Liu,M., Bucksa,J.M., Arends,V.L.,
            Steffes,M.W., Cleary,P.A., Sun,W., Lachin,J.M., Thorner,P.S.,
            Ho,M., McKnight,A.J., Maxwell,A.P., Savage,D.A., Kidd,K.K.,
            Kidd,J.R., Speed,W.C., Orchard,T.J., Miller,R.G., Sun,L., Bull,S.B.
            and Paterson,A.D.
  CONSRTM   Diabetes Control and Complications Trial/Epidemiology of Diabetes
            Interventions and Complications Research Group
  TITLE     Multiple superoxide dismutase 1/splicing factor serine alanine 15
            variants are associated with the development and progression of
            diabetic nephropathy: the Diabetes Control and Complications
            Trial/Epidemiology of Diabetes Interventions and Complications
            Genetics study
  JOURNAL   Diabetes 57 (1), 218-228 (2008)
   PUBMED   17914031
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   10 (bases 1 to 4269)
  AUTHORS   Yuryev,A., Patturajan,M., Litingtung,Y., Joshi,R.V., Gentile,C.,
            Gebara,M. and Corden,J.L.
  TITLE     The C-terminal domain of the largest subunit of RNA polymerase II
            interacts with a novel set of serine/arginine-rich proteins
  JOURNAL   Proc Natl Acad Sci U S A 93 (14), 6975-6980 (1996)
   PUBMED   8692929
  REMARK    GeneRIF: Describes identification of rat serine/arginine-rich
            splicing factors that interact with RNA polymerase II, including
            rA1, rA4, rA8, and rA9.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA016102.1, BC014921.1,
            BC031898.1 and AF023142.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Feb 28, 2009 this sequence version replaced NM_020706.1.
            
            Summary: This gene likely encodes a member of the
            arginine/serine-rich splicing factor family. A similar protein in
            Rat appears to bind the large subunit of RNA polymerase II and
            provide a link between transcription and pre-mRNA splicing.
            Alternatively spliced transcript variants have been described.
            [provided by RefSeq, Feb 2009].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF023142.1, BC043353.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000286835.12/ ENSP00000286835.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                DA016102.1         1-24
            25-4086             BC014921.1         2-4063
            4087-4123           BC031898.1         1126-1162
            4124-4269           AF023142.1         3724-3869
FEATURES             Location/Qualifiers
     source          1..4269
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.11"
     gene            1..4269
                     /gene="SCAF4"
                     /gene_synonym="FZS; SFRS15; SRA4"
                     /note="SR-related CTD associated factor 4"
                     /db_xref="GeneID:57466"
                     /db_xref="HGNC:HGNC:19304"
                     /db_xref="MIM:616023"
     exon            1..456
                     /gene="SCAF4"
                     /gene_synonym="FZS; SFRS15; SRA4"
                     /inference="alignment:Splign:2.1.0"
     CDS             427..3870
                     /gene="SCAF4"
                     /gene_synonym="FZS; SFRS15; SRA4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     SR-like CTD-associated factor 4; pre-mRNA splicing SR
                     protein rA4; splicing factor, arginine/serine-rich 15;
                     CTD-binding SR-like protein rA4; splicing factor serine
                     alanine 15"
                     /codon_start=1
                     /product="SR-related and CTD-associated factor 4 isoform
                     1"
                     /protein_id="NP_065757.1"
                     /db_xref="CCDS:CCDS33537.1"
                     /db_xref="GeneID:57466"
                     /db_xref="HGNC:HGNC:19304"
                     /db_xref="MIM:616023"
                     /translation="MDAVNAFNQELFSLMDMKPPISRAKMILITKAAIKAIKLYKHVV
                     QIVEKFIKKCKPEYKVPGLYVIDSIVRQSRHQFGTDKDVFGPRFSKNITATFQYLYLC
                     PSEDKSKIVRVLNLWQKNGVFKIEIIQPLLDMAAGTSNAAPVAENVTNNEGSPPPPVK
                     VSSEPPTQATPNSVPAVPQLPSSDAFAAVAQLFQTTQGQQLQQILQTFQQPPKPQSPA
                     LDNAVMAQVQAITAQLKTTPTQPSEQKAAFPPPEQKTAFDKKLLDRFDYDDEPEAVEE
                     SKKEDTTAVTTTAPAAAVPPAPTATVPAAAAPAAASPPPPQAPFGFPGDGMQQPAYTQ
                     HQNMDQFQPRMMGIQQDPMHHQVPLPPNGQMPGFGLLPTPPFPPMAQPVIPPTPPVQQ
                     PFQASFQAQNEPLTQKPHQQEMEVEQPCIQEVKRHMSDNRKSRSRSASRSPKRRRSRS
                     GSRSRRSRHRRSRSRSRDRRRHSPRSRSQERRDREKERERRQKGLPQVKPETASVCST
                     TLWVGQLDKRTTQQDVASLLEEFGPIESINMIPPRGCAYIVMVHRQDAYRALQKLSRG
                     NYKVNQKSIKIAWALNKGIKADYKQYWDVELGVTYIPWDKVKPEELESFCEGGMLDSD
                     TLNPDWKGIPKKPENEVAQNGGAETSHTEPVSPIPKPLPVPVPPIPVPAPITVPPPQV
                     PPHQPGPPVVGALQPPAFTPPLGIPPPGFGPGVPPPPPPPPFLRPGFNPMHLPPGFLP
                     PGPPPPITPPVSIPPPHTPPISIPNSTIAGINEDTTKDLSIGNPIPTVVSGARGNAES
                     GDSVKMYGSAVPPAAPTNLPTPPVTQPVSLLGTQGVAPGPVIGLQAPSTGLLGARPGL
                     IPLQRPPGMPPPHLQRFPLMPPRPMPPHMMHRGPPPGPGGFAMPPPHGMKGPFPPHGP
                     FVRPGGMPGLGGPGPGPGGPEDRDGRQQPPQQPQQQPQPQAPQQPQQQQQQQPPPSQQ
                     PPPTQQQPQQFRNDNRQQFNSGRDQERFGRRSFGNRVENDRERYGNRNDDRDNSNRDR
                     REWGRRSPDRDRHRDLEERNRRSSGHRDRERDSRDRESRREKEEARGKEKPEVTDRAG
                     GNKTVEPPISQVGNVDTASELEKGVSEAAVLKPSEELPAEATSSVEPEKDSGSAAEAP
                     R"
     exon            457..540
                     /gene="SCAF4"
                     /gene_synonym="FZS; SFRS15; SRA4"
                     /inference="alignment:Splign:2.1.0"
     exon            541..585
                     /gene="SCAF4"
                     /gene_synonym="FZS; SFRS15; SRA4"
                     /inference="alignment:Splign:2.1.0"
     exon            586..747
                     /gene="SCAF4"
                     /gene_synonym="FZS; SFRS15; SRA4"
                     /inference="alignment:Splign:2.1.0"
     exon            748..883
                     /gene="SCAF4"
                     /gene_synonym="FZS; SFRS15; SRA4"
                     /inference="alignment:Splign:2.1.0"
     exon            884..1026
                     /gene="SCAF4"
                     /gene_synonym="FZS; SFRS15; SRA4"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1203
                     /gene="SCAF4"
                     /gene_synonym="FZS; SFRS15; SRA4"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1385
                     /gene="SCAF4"
                     /gene_synonym="FZS; SFRS15; SRA4"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1494
                     /gene="SCAF4"
                     /gene_synonym="FZS; SFRS15; SRA4"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..1662
                     /gene="SCAF4"
                     /gene_synonym="FZS; SFRS15; SRA4"
                     /inference="alignment:Splign:2.1.0"
     exon            1663..1748
                     /gene="SCAF4"
                     /gene_synonym="FZS; SFRS15; SRA4"
                     /inference="alignment:Splign:2.1.0"
     exon            1749..1939
                     /gene="SCAF4"
                     /gene_synonym="FZS; SFRS15; SRA4"
                     /inference="alignment:Splign:2.1.0"
     exon            1940..2040
                     /gene="SCAF4"
                     /gene_synonym="FZS; SFRS15; SRA4"
                     /inference="alignment:Splign:2.1.0"
     exon            2041..2154
                     /gene="SCAF4"
                     /gene_synonym="FZS; SFRS15; SRA4"
                     /inference="alignment:Splign:2.1.0"
     exon            2155..2311
                     /gene="SCAF4"
                     /gene_synonym="FZS; SFRS15; SRA4"
                     /inference="alignment:Splign:2.1.0"
     exon            2312..2469
                     /gene="SCAF4"
                     /gene_synonym="FZS; SFRS15; SRA4"
                     /inference="alignment:Splign:2.1.0"
     exon            2470..2635
                     /gene="SCAF4"
                     /gene_synonym="FZS; SFRS15; SRA4"
                     /inference="alignment:Splign:2.1.0"
     exon            2636..2722
                     /gene="SCAF4"
                     /gene_synonym="FZS; SFRS15; SRA4"
                     /inference="alignment:Splign:2.1.0"
     exon            2723..2914
                     /gene="SCAF4"
                     /gene_synonym="FZS; SFRS15; SRA4"
                     /inference="alignment:Splign:2.1.0"
     exon            2915..4269
                     /gene="SCAF4"
                     /gene_synonym="FZS; SFRS15; SRA4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4213..4218
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCAF4"
                     /gene_synonym="FZS; SFRS15; SRA4"
                     /note="hexamer: AATAAA"
     polyA_site      4236
                     /gene="SCAF4"
                     /gene_synonym="FZS; SFRS15; SRA4"
                     /note="major polyA site"
ORIGIN      
        1 agggtgcccc gcgcggcgtg gactcgggcc gctgccgcca tcccgctgga gagagggaga
       61 gagaggcccg cccgctcgcc ggccgggcca gtgtgagcca gtgcgtgagg gcgcgggggg
      121 ccgtgtcagc gagacgcaga gcgcagccgc caccaccaaa cggacatgtt gaagaccagc
      181 gctgccgccg cctccttttc ctcatcctgc gaacgggact gagagggggc ccgccacctc
      241 tccgcctctg cctcggccgc ccgcctcgcc gcttcgggcg cagcctcttc ctgcccgggc
      301 ctcggactcc gccgctcgtc gcctcccccc ggccaccagg cccggctggt ttcccagccc
      361 cgctccgccg cggcgcgagg tctatgtgac cggcgggccc ggagcagccg ccgccgcagc
      421 gcgaacatgg acgccgtcaa cgccttcaac caggagctct tttcgcttat ggatatgaaa
      481 cctcccatct ctagagccaa gatgattctc atcactaaag ctgctattaa agctattaag
      541 ctttataagc atgtagttca aatagtagaa aagttcatca aaaagtgtaa accagaatac
      601 aaggttccgg gattatatgt aattgactca attgtgcgac agtctcgtca tcagtttgga
      661 actgataaag atgtttttgg gccaagattc tctaaaaaca taactgccac attccaatat
      721 ttatatcttt gtccatctga agataagagt aaaatagttc gtgtgctgaa cctttggcaa
      781 aaaaatggag tgttcaaaat tgaaattatt caacctcttt tggacatggc agcgggaacc
      841 agtaatgcag ccccagtagc agaaaatgtt accaataatg aaggctcacc tccacctcca
      901 gtaaaagttt cttctgaacc tcccacacaa gccactccaa actccgtccc agctgtacca
      961 cagttgccca gctctgatgc ttttgctgct gtggctcagc tgtttcagac aactcaaggc
     1021 caacagcttc agcagatcct tcagactttt caacagcctc caaaaccaca gtctcctgcc
     1081 cttgacaatg ctgtgatggc tcaggttcag gctatcacag ctcagttaaa gacaactcct
     1141 acacaaccat ctgaacaaaa agctgctttc cccccacctg aacagaaaac tgcatttgac
     1201 aagaagttgc ttgatagatt tgactatgat gatgagccag aagctgtgga agaatcaaag
     1261 aaagaggata ccactgccgt caccacgaca gcacctgctg ccgcagtacc ccctgcaccc
     1321 accgccaccg tgcctgctgc tgctgcaccc gctgctgcct ctcctcctcc tccacaggca
     1381 ccatttggct ttcctggaga tggcatgcag cagccagcat acacacagca tcaaaatatg
     1441 gatcagtttc agccacgaat gatgggaata caacaggatc caatgcacca tcaggttcca
     1501 cttcctccta atggacaaat gccaggattt ggacttcttc ctacacctcc atttcctccc
     1561 atggctcagc ctgtgattcc tccaactcca ccagtgcagc agcctttcca agcttctttt
     1621 caggcacaaa atgaaccact tacacagaag ccgcatcagc aggaaatgga agtagaacaa
     1681 ccttgtattc aagaggttaa gcgacatatg tctgataaca gaaagtcaag atctaggtca
     1741 gcatccaggt caccaaaaag gaggcgatct agatctggtt ctagatctcg aaggtctcgg
     1801 catcgacgtt ctcgatctcg gtccagggat agacgccgac attctccccg atctcgatct
     1861 caagaaagac gggatcgaga aaaagagaga gaacgtcgac aaaaaggcct ccctcaagtg
     1921 aaaccggaaa ctgcaagtgt ttgcagtact accctctggg tggggcagct ggacaaaaga
     1981 actactcagc aggatgttgc cagtctcttg gaagagtttg gtccaattga atcaattaat
     2041 atgattcctc ccaggggttg tgcctatatt gttatggttc ataggcaaga tgcctatcgt
     2101 gccctgcaga aactgagccg aggaaactat aaagtgaacc agaaatccat aaagattgcc
     2161 tgggccttaa acaaaggaat aaaggcagat tataagcagt attgggatgt agaacttggt
     2221 gttacttata ttccatggga caaagtcaag cctgaggaac tggagagttt ttgtgaagga
     2281 ggaatgttgg acagtgacac acttaaccca gattggaaag gaattcctaa gaagcctgaa
     2341 aatgaagttg ctcaaaatgg aggtgctgaa acctcacaca cagaaccagt atcacccata
     2401 cctaaaccat tacctgtgcc tgtccctcct attcctgttc ctgcacctat aacagtgcca
     2461 cctccacagg tcccaccaca tcaaccgggt ccacctgtag ttggtgctct ccagccgcct
     2521 gctttcacgc ctcctctggg aataccgcct ccaggctttg gtcctggtgt tcctcctccc
     2581 cctcctcctc caccattttt gcgcccagga ttcaacccaa tgcatttacc accaggtttt
     2641 ctgcctcctg gacccccacc tcctataact ccaccagtat ccattcctcc tcctcacact
     2701 ccaccaataa gcatcccaaa ctctactatc gctggtataa atgaagacac tacaaaagac
     2761 ttatctattg gaaatcccat tccaacagtg gtgtctgggg ctagaggaaa cgccgagtct
     2821 ggtgacagcg tgaaaatgta tggctctgcc gtgccacctg ctgcacccac gaatctgccc
     2881 acccctcctg taacccagcc tgtttcactt cttggcactc aaggagttgc ccctggtcct
     2941 gtaattggac ttcaggcacc atctactggt cttcttggcg cccggcccgg tctcatccca
     3001 ctccagcgcc ctccaggaat gcccccacct cacttacagc ggttcccttt gatgccgccc
     3061 cgtcccatgc caccgcacat gatgcacaga ggcccaccgc caggaccagg gggctttgcg
     3121 atgcctccac ctcatggaat gaaaggtccc ttcccaccgc atggcccctt tgttaggcct
     3181 ggtggaatgc cagggctcgg gggcccaggg ccaggcccag ggggtcctga agacagagac
     3241 ggaaggcaac agccgccgca gcagccacag cagcagccac agccgcaggc gccccagcaa
     3301 ccacagcagc agcagcagca gcagccacca ccatcacaac agcctccacc aacacagcag
     3361 cagccacagc agtttagaaa tgataacagg cagcagttca attcaggtag agaccaagaa
     3421 aggtttggaa gaagatcttt tggaaatagg gtggaaaatg accgggaacg gtatgggaac
     3481 cgtaatgatg atagagataa tagtaaccgt gacaggagag agtggggaag gaggagccct
     3541 gaccgggaca ggcacagaga cttggaagag agaaatagac gctctagtgg gcatcgagac
     3601 agagagagag attctagaga tagagagtct cgtagagaga aggaagaagc ccgaggaaag
     3661 gaaaagcctg aggtgacaga cagggcaggt ggtaacaaaa ccgttgaacc tcccattagc
     3721 caagtgggaa atgtagacac tgcttcagaa cttgagaagg gggtgtctga ggctgcagtc
     3781 ctaaagcctt ctgaagagtt acctgctgag gctacctcat ccgttgaacc cgaaaaggat
     3841 tctggctcag cagcagaggc tcctcgttag agactggaat ttgtgaaaat gtgacagtga
     3901 cacttcctgg agtgtagagc ttgaggtgta cagatgctgt attatatccg ctcccgctgt
     3961 actgcagccc cgcgccagct ggtggggaac tgtaagcaat ttgattgctt cccttctatt
     4021 taaaaatagc cacaaaataa caaaaaatac tgaaaatatg aataaatatt accctttttg
     4081 ctgtaacttt ttaaaagttt tgactttaaa aagtttacaa atcgtaatta gaagtgctct
     4141 ctattttttt tttttttttt aatttaagac aaggtaacgg tgaaagctcc tcaaaacaat
     4201 agggatgttt ttaataaact ctattttcgt aacaaacttt aatgtgtgct attcttccta
     4261 cactgcatt
//
