LOCUS       NM_004719               7552 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens SR-related CTD associated factor 11 (SCAF11), mRNA.
ACCESSION   NM_004719
VERSION     NM_004719.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7552)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7552)
  AUTHORS   Rodrigues,T.S., Caetano,C.C.S., de Sa,K.S.G., Almeida,L.,
            Becerra,A., Goncalves,A.V., Lopes,L.S., Oliveira,S.,
            Mascarenhas,D.P.A., Batah,S.S., Silva,B.M., Gomes,G.F., Castro,R.,
            Martins,R.B., Avila,J., Frantz,F.G., Cunha,T.M., Arruda,E.,
            Cunha,F.Q., Nakaya,H., Cunha,L.D., Fabro,A.T., Louzada-Junior,P.,
            de Oliveira,R.D.R. and Zamboni,D.S.
  TITLE     CASP4/11 Contributes to NLRP3 Activation and COVID-19 Exacerbation
  JOURNAL   J Infect Dis 227 (12), 1364-1375 (2023)
   PUBMED   36763010
  REMARK    GeneRIF: CASP4/11 Contributes to NLRP3 Activation and COVID-19
            Exacerbation.
REFERENCE   3  (bases 1 to 7552)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 7552)
  AUTHORS   Agnew,A., Nulty,C. and Creagh,E.M.
  TITLE     Regulation, Activation and Function of Caspase-11 during Health and
            Disease
  JOURNAL   Int J Mol Sci 22 (4), 1506 (2021)
   PUBMED   33546173
  REMARK    GeneRIF: Regulation, Activation and Function of Caspase-11 during
            Health and Disease.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7552)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   6  (bases 1 to 7552)
  AUTHORS   Scanlan,M.J., Gordan,J.D., Williamson,B., Stockert,E., Bander,N.H.,
            Jongeneel,V., Gure,A.O., Jager,D., Jager,E., Knuth,A., Chen,Y.T.
            and Old,L.J.
  TITLE     Antigens recognized by autologous antibody in patients with
            renal-cell carcinoma
  JOURNAL   Int J Cancer 83 (4), 456-464 (1999)
   PUBMED   10508479
REFERENCE   7  (bases 1 to 7552)
  AUTHORS   van de Craen,M., de Jonghe,C., van den Brande,I., Declercq,W., van
            Gassen,G., van Criekinge,W., Vanderhoeven,I., Fiers,W., van
            Broeckhoven,C., Hendriks,L. and Vandenabeele,P.
  TITLE     Identification of caspases that cleave presenilin-1 and
            presenilin-2. Five presenilin-1 (PS1) mutations do not alter the
            sensitivity of PS1 to caspases
  JOURNAL   FEBS Lett 445 (1), 149-154 (1999)
   PUBMED   10069390
REFERENCE   8  (bases 1 to 7552)
  AUTHORS   Zhang,W.J. and Wu,J.Y.
  TITLE     Sip1, a novel RS domain-containing protein essential for pre-mRNA
            splicing
  JOURNAL   Mol Cell Biol 18 (2), 676-684 (1998)
   PUBMED   9447963
REFERENCE   9  (bases 1 to 7552)
  AUTHORS   Tanner,S., Stagljar,I., Georgiev,O., Schaffner,W. and Bourquin,J.P.
  TITLE     A novel SR-related protein specifically interacts with the
            carboxy-terminal domain (CTD) of RNA polymerase II through a
            conserved interaction domain
  JOURNAL   Biol Chem 378 (6), 565-571 (1997)
   PUBMED   9224939
REFERENCE   10 (bases 1 to 7552)
  AUTHORS   Gui,J.F., Lane,W.S. and Fu,X.D.
  TITLE     A serine kinase regulates intracellular localization of splicing
            factors in the cell cycle
  JOURNAL   Nature 369 (6482), 678-682 (1994)
   PUBMED   8208298
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC084878.12, AF030234.1 and AC000015.2.
            
            On Nov 23, 2018 this sequence version replaced NM_004719.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF030234.1, SRR1660803.223614.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369367.8/ ENSP00000358374.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 AC084878.12        64176-64184         c
            10-428              AF030234.1         1-419
            429-4968            AF030234.1         421-4960
            4969-7552           AC000015.2         12286-14869         c
FEATURES             Location/Qualifiers
     source          1..7552
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q12"
     gene            1..7552
                     /gene="SCAF11"
                     /gene_synonym="CASP11; SFRS2IP; SIP1; SRRP129; SRSF2IP"
                     /note="SR-related CTD associated factor 11"
                     /db_xref="GeneID:9169"
                     /db_xref="HGNC:HGNC:10784"
                     /db_xref="MIM:603668"
     exon            1..222
                     /gene="SCAF11"
                     /gene_synonym="CASP11; SFRS2IP; SIP1; SRRP129; SRSF2IP"
                     /inference="alignment:Splign:2.1.0"
     exon            223..304
                     /gene="SCAF11"
                     /gene_synonym="CASP11; SFRS2IP; SIP1; SRRP129; SRSF2IP"
                     /inference="alignment:Splign:2.1.0"
     CDS             244..4635
                     /gene="SCAF11"
                     /gene_synonym="CASP11; SFRS2IP; SIP1; SRRP129; SRSF2IP"
                     /note="SC35-interacting protein 1; SRSF2-interacting
                     protein; SFRS2-interacting protein; serine/arginine-rich
                     splicing factor 2-interacting protein; CTD-associated SR
                     protein 11; splicing regulatory protein 129; renal
                     carcinoma antigen NY-REN-40; splicing factor,
                     arginine/serine-rich 2-interacting protein; SR-related and
                     CTD-associated factor 11"
                     /codon_start=1
                     /product="protein SCAF11"
                     /protein_id="NP_004710.2"
                     /db_xref="CCDS:CCDS8748.2"
                     /db_xref="GeneID:9169"
                     /db_xref="HGNC:HGNC:10784"
                     /db_xref="MIM:603668"
                     /translation="MKKKTVCTLNMGDKKYEDMEGEENGDNTISTGLLYSEADRCPIC
                     LNCLLEKEVGFPESCNHVFCMTCILKWAETLASCPIDRKPFQAVFKFSALEGYVKVQV
                     KKQLRETKDKKNENSFEKQVSCHENSKSCIRRKAIVREDLLSAKVCDLKWIHRNSLYS
                     ETGGKKNAAIKINKPQRSNWSTNQCFRNFFSNMFSSVSHSGESSFTYRAYCTEFIEAS
                     EISALIRQKRHELELSWFPDTLPGIGRIGFIPWNVETEVLPLISSVLPRTIFPTSTIS
                     FEHFGTSCKGYALAHTQEGEEKKQTSGTSNTRGSRRKPAMTTPTRRSTRNTRAETASQ
                     SQRSPISDNSGCDAPGNSNPSLSVPSSAESEKQTRQAPKRKSVRRGRKPPLLKKKLRS
                     SVAAPEKSSSNDSVDEETAESDTSPVLEKEHQPDVDSSNICTVQTHVENQSANCLKSC
                     NEQIEESEKHTANYDTEERVGSSSSESCAQDLPVLVGEEGEVKKLENTGIEANVLCLE
                     SEISENILEKGGDPLEKQDQISGLSQSEVKTDVCTVHLPNDFPTCLTSESKVYQPVSC
                     PLSDLSENVESVVNEEKITESSLVEITEHKDFTLKTEELIESPKLESSEGEIIQTVDR
                     QSVKSPEVQLLGHVETEDVEIIATCDTFGNEDFNNIQDSENNLLKNNLLNTKLEKSLE
                     EKNESLTEHPRSTELPKTHIEQIQKHFSEDNNEMIPMECDSFCSDQNESEVEPSVNAD
                     LKQMNENSVTHCSENNMPSSDLADEKVETVSQPSESPKDTIDKTKKPRTRRSRFHSPS
                     TTWSPNKDTPQEKKRPQSPSPRRETGKESRKSQSPSPKNESARGRKKSRSQSPKKDIA
                     RERRQSQSRSPKRDTTRESRRSESLSPRRETSRENKRSQPRVKDSSPGEKSRSQSRER
                     ESDRDGQRRERERRTRKWSRSRSHSRSPSRCRTKSKSSSFGRIDRDSYSPRWKGRWAN
                     DGWRCPRGNDRYRKNDPEKQNENTRKEKNDIHLDADDPNSADKHRNDCPNWITEKINS
                     GPDPRTRNPEKLKESHWEENRNENSGNSWNKNFGSGWVSNRGRGRGNRGRGTYRSSFA
                     YKDQNENRWQNRKPLSGNSNSSGSESFKFVEQQSYKRKSEQEFSFDTPADRSGWTSAS
                     SWAVRKTLPADVQNYYSRRGRNSSGPQSGWMKQEEETSGQDSSLKDQTNQQVDGSQLP
                     INMMQPQMNVMQQQMNAQHQPMNIFPYPVGVHAPLMNIQRNPFNIHPQLPLHLHTGVP
                     LMQVATPTSVSQGLPPPPPPPPPSQQVNYIASQPDGKQLQGIPSSSHVSNNMSTPVLP
                     APTAAPGNTGMVQGPSSGNTSSSSHSKASNAAVKLAESKVSVAVEASADSSKTDKKLQ
                     IQEKAAQEVKLAIKPFYQNKDITKEEYKEIVRKAVDKVCHSKSGEVNSTKVANLVKAY
                     VDKYKYSRKGSQKKTLEEPVSTEKNIG"
     exon            305..462
                     /gene="SCAF11"
                     /gene_synonym="CASP11; SFRS2IP; SIP1; SRRP129; SRSF2IP"
                     /inference="alignment:Splign:2.1.0"
     exon            463..540
                     /gene="SCAF11"
                     /gene_synonym="CASP11; SFRS2IP; SIP1; SRRP129; SRSF2IP"
                     /inference="alignment:Splign:2.1.0"
     exon            541..641
                     /gene="SCAF11"
                     /gene_synonym="CASP11; SFRS2IP; SIP1; SRRP129; SRSF2IP"
                     /inference="alignment:Splign:2.1.0"
     exon            642..706
                     /gene="SCAF11"
                     /gene_synonym="CASP11; SFRS2IP; SIP1; SRRP129; SRSF2IP"
                     /inference="alignment:Splign:2.1.0"
     exon            707..765
                     /gene="SCAF11"
                     /gene_synonym="CASP11; SFRS2IP; SIP1; SRRP129; SRSF2IP"
                     /inference="alignment:Splign:2.1.0"
     exon            766..875
                     /gene="SCAF11"
                     /gene_synonym="CASP11; SFRS2IP; SIP1; SRRP129; SRSF2IP"
                     /inference="alignment:Splign:2.1.0"
     exon            876..977
                     /gene="SCAF11"
                     /gene_synonym="CASP11; SFRS2IP; SIP1; SRRP129; SRSF2IP"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1084
                     /gene="SCAF11"
                     /gene_synonym="CASP11; SFRS2IP; SIP1; SRRP129; SRSF2IP"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..3802
                     /gene="SCAF11"
                     /gene_synonym="CASP11; SFRS2IP; SIP1; SRRP129; SRSF2IP"
                     /inference="alignment:Splign:2.1.0"
     exon            3803..4149
                     /gene="SCAF11"
                     /gene_synonym="CASP11; SFRS2IP; SIP1; SRRP129; SRSF2IP"
                     /inference="alignment:Splign:2.1.0"
     exon            4150..4368
                     /gene="SCAF11"
                     /gene_synonym="CASP11; SFRS2IP; SIP1; SRRP129; SRSF2IP"
                     /inference="alignment:Splign:2.1.0"
     exon            4369..4488
                     /gene="SCAF11"
                     /gene_synonym="CASP11; SFRS2IP; SIP1; SRRP129; SRSF2IP"
                     /inference="alignment:Splign:2.1.0"
     exon            4489..7552
                     /gene="SCAF11"
                     /gene_synonym="CASP11; SFRS2IP; SIP1; SRRP129; SRSF2IP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7530..7535
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCAF11"
                     /gene_synonym="CASP11; SFRS2IP; SIP1; SRRP129; SRSF2IP"
                     /note="hexamer: AATAAA"
     polyA_site      7552
                     /gene="SCAF11"
                     /gene_synonym="CASP11; SFRS2IP; SIP1; SRRP129; SRSF2IP"
                     /note="major polyA site"
ORIGIN      
        1 gagtagcggt ggcttaagcc gcgcggagca gcgcaacctg ggtcgctccc tgcttcgccg
       61 ccgcctccgg accgagccag cggagtcagt gtcctagaga ccctgtaaca ccacaaagcg
      121 gacgaaggag tccatgttgg ggaacttggc agcggagtga ctgggacctg ggaacctact
      181 gtggggccgc ggccggaccg agcgcctcga cctcggtctg aggaaaccct tttccaaaga
      241 gaaatgaaga agaaaactgt atgtacccta aatatgggag ataagaagta tgaagacatg
      301 gaaggtgaag aaaacggaga taatactatt tccactggtc tgttgtacag tgaggctgac
      361 agatgcccaa tatgtcttaa ttgtctatta gaaaaggaag ttggttttcc agaaagctgt
      421 aatcatgtct tctgtatgac ttgtattctt aaatgggcag agacactggc ttcatgtcct
      481 attgaccgta aaccttttca ggcagtgttt aaattcagtg cattggaagg ttatgttaag
      541 gttcaagtaa aaaaacagct gagagaaaca aaagacaaga aaaatgaaaa ctcatttgag
      601 aaacaggtct cctgtcatga aaattctaaa agctgtataa gaagaaaagc catcgtaaga
      661 gaagatctat taagtgcaaa agtttgtgac ttgaagtgga tacatagaaa ctctttatac
      721 agtgaaacag gaggaaagaa aaatgcagca ataaagataa ataagcctca gagatcaaat
      781 tggagtacaa atcagtgctt cagaaatttt ttctccaata tgttttcttc tgttagccac
      841 tctggagaat cttcctttac ctatagagct tattgtacag aatttataga agccagtgaa
      901 atcagtgcat tgattaggca gaagagacat gaactggaat tgtcatggtt tcctgataca
      961 ttacctggaa ttggaagaat tggttttata ccctggaatg ttgaaacaga agtccttcct
     1021 ctcatttctt ctgtgttgcc aagaactatt tttccaacaa gtaccatatc tttcgaacat
     1081 tttggtactt cttgcaaggg atatgcatta gcacatactc aagaagggga agaaaagaag
     1141 caaacttctg gtacatcaaa taccagagga tcaagacgaa aacctgcaat gacaactcct
     1201 acaaggaggt ctacacgtaa cacaagagct gaaacagcca gtcagtctca gagatcccca
     1261 atatcagaca attctgggtg tgatgcccca ggtaacagta atccatcttt aagtgttccc
     1321 tcttcagctg agtcagaaaa gcaaacaaga caggctccaa aacggaagtc tgtaagaaga
     1381 ggaagaaaac cacctttact gaaaaagaaa cttcggagct ctgtagctgc ccctgaaaaa
     1441 tcatcttcca atgattcagt agatgaagaa acagcagaat ctgacacatc acctgtgtta
     1501 gaaaaagagc accaaccaga tgtagacagt agtaacattt gtactgtgca gactcatgta
     1561 gaaaaccagt ctgctaattg cttgaaaagt tgcaatgagc aaatagaaga aagtgagaag
     1621 catactgcaa attatgatac agaggaaaga gtaggatctt catcttctga gtcttgtgct
     1681 caagatcttc ctgtgctagt tggtgaggaa ggggaagtta aaaaactcga gaatacaggt
     1741 atagaggcta atgttttgtg tttggaaagt gagatttctg aaaatattct tgaaaaagga
     1801 ggtgatccat tggaaaagca agaccagata tctggacttt cacaatcaga ggtaaagaca
     1861 gatgtatgta cagttcatct tccaaatgat tttcctacat gtttaacatc tgaaagcaaa
     1921 gtgtaccaac ctgtatcttg tcccctaagt gacttatctg agaatgtaga gtcagtggtt
     1981 aatgaagaaa aaataacaga gagttcccta gtagaaatta ctgaacataa agattttaca
     2041 ctaaaaacag aggagcttat agagagcccc aagttagaat cttctgaggg tgaaattata
     2101 cagacagtgg acagacaatc tgttaagagc ccagaggttc aattgcttgg gcatgttgaa
     2161 actgaagatg tagaaataat tgcaacatgt gatacttttg ggaatgaaga tttcaataat
     2221 attcaagact ctgaaaataa cttactaaaa aataatcttc tgaacaccaa attggaaaaa
     2281 tctttagaag aaaagaatga atcgctgacc gaacatccta gatctacaga gttgcctaaa
     2341 acacacattg aacagattca gaagcatttt agtgaggaca acaatgaaat gatacctatg
     2401 gagtgtgatt cattttgcag tgaccaaaat gaatctgaag ttgaaccatc tgtaaatgct
     2461 gatcttaaac aaatgaatga aaattctgtg acacactgtt ctgaaaataa tatgccgtct
     2521 tctgatcttg cggatgaaaa ggttgaaact gtttctcaac catctgaaag cccaaaagat
     2581 accatagata aaaccaaaaa gcctcgtact cgaagatcta gatttcattc tccatctaca
     2641 acttggtcac ccaacaaaga cactccacaa gaaaagaagc ggccccagtc tccatctccc
     2701 agaagagaaa ctgggaaaga aagcaggaag tctcaatcac catctcctaa gaatgagtca
     2761 gccagaggcc ggaaaaaatc ccgttctcag tccccaaaaa aggatattgc aagagaaagg
     2821 aggcaatctc agtctcggtc tccaaaaagg gatactacta gggaaagcag aagatctgaa
     2881 tcactgtccc caagaagaga aacttctaga gagaacaaaa gatctcagcc aagagtgaaa
     2941 gattcttccc caggagaaaa atccaggtcc cagagcagag aacgagaaag tgatagagat
     3001 gggcagagga gagagagaga aaggagaacc agaaagtggt ctaggtccag atctcattct
     3061 aggtccccct caagatgtag aacaaaaagt aagagttcat catttggtag aattgacaga
     3121 gatagttact ctccccggtg gaagggaaga tgggcaaatg atggttggag atgtccacga
     3181 ggaaatgatc ggtacagaaa gaatgaccca gagaaacaga atgaaaatac aagaaaagaa
     3241 aaaaatgaca tccatctaga tgctgatgat ccaaattctg ctgacaaaca tagaaatgac
     3301 tgtcccaatt ggataacaga aaaaataaac tctgggcctg atccaagaac cagaaatcca
     3361 gaaaagttga aagagtctca ttgggaagaa aatagaaatg aaaattcagg aaattcttgg
     3421 aataaaaact ttggttctgg ttgggtatct aaccgtggta gaggcagagg caaccgtggc
     3481 agaggcactt acagaagtag ttttgcctat aaagatcaga atgaaaatcg gtggcaaaat
     3541 cgaaaacccc tctcagggaa ttcaaacagt tcagggagtg aatctttcaa gtttgtggaa
     3601 cagcaatcct ataagcgaaa aagtgaacag gagttctcat ttgatacacc agcagataga
     3661 tctggatgga catctgcatc cagctgggcc gtgagaaaga ctttgccagc agatgtacaa
     3721 aactactact cacgacgagg cagaaattct tcaggtccac agtctggatg gatgaaacaa
     3781 gaggaggaaa catctggaca ggattctagc ctaaaagacc aaacaaacca gcaagttgat
     3841 ggttctcagc tacctataaa tatgatgcaa ccgcaaatga atgtaatgca gcaacaaatg
     3901 aatgcacaac accagcctat gaatatcttc ccatatccag tgggtgttca tgctcctttg
     3961 atgaacatcc aacgcaatcc atttaacatt catcctcagc tacccttgca tctccacaca
     4021 ggagtgcccc tcatgcaggt agccactcct accagtgtat ctcagggact accaccacca
     4081 ccaccccctc ccccaccatc ccaacaagtc aactacattg cttcacaacc agatggaaag
     4141 caattgcagg gtattcctag ttcttctcat gtaagtaata acatgagtac accagttttg
     4201 cctgctccga cagcagcccc aggaaatacg ggaatggttc agggaccaag ttctggtaat
     4261 acttcgtcat caagtcacag caaagcctct aatgctgctg taaaattggc agaaagcaaa
     4321 gtaagtgttg cagtggaagc cagcgcagat agctcgaaga cagacaagaa attgcaaatt
     4381 caagaaaaag cagcacaaga ggtaaaattg gccatcaagc cattttacca aaataaagat
     4441 atcaccaagg aagaatataa agaaattgta cggaaagcag tagataaagt ttgtcatagt
     4501 aagagtggag aagtaaattc tactaaagtg gcaaatctgg ttaaagccta tgtagacaaa
     4561 tacaaatatt cacggaaggg gagccaaaag aaaactctgg aagaacctgt gtctactgaa
     4621 aaaaacatag gctgaaatgg ggaacgctgt caaggacatt atcaggatat ctgcaaagtg
     4681 caatttcaac atgtaccatt aactgaaaat catacataac tgtgattgaa atttggtttt
     4741 gataaaatta tttttttaac ataggatatg atgttttgtt ctaaataaat ataggtctgc
     4801 actgcaactt ctgtatcctt ccttcccctc caccctcccc cacaaaattc aagggaaagt
     4861 aaagggttta aaggaatgtg catctttact aggactgtgt tatagtgtgg atactggaaa
     4921 atgtatagct ttttgattag ggcaatggag tgcataaatt agaaacttct aagtgcactg
     4981 gttttcaaag agatatatat aatgcattta ttctgtcagg ttaaaatgta aagtatgatc
     5041 tttatgattt tttccctcta attatagaaa gttaaataat gtattaccat gaaaaatgtt
     5101 tctaatatta aatagaacat atcagttgca aagttcctaa tgtgtatttt taaagcacat
     5161 atctgaataa attgcctaga tagaaaaaaa attatcacga gtaaaattta gtgttcaaaa
     5221 cattgagaca ctcttcacct attgtatgac caaataaagg ttatgctgct tgtttttctt
     5281 ttgtgccttt gtttacccct aattgagata agcagtttga cttactagat tacaactttg
     5341 gcagttcaaa gtctttgttg aagactttga ggaaaaagat ttggaaaaat tgttgacttt
     5401 cggccgggca tgatggctca cgcctgtaat cccagcactt tgggaggccg aggtggcgga
     5461 tcacctgagg tcaggagttc gagaccagcc tggccaacat ggtgaaatcc cgtctctact
     5521 aaaaatacaa aaattagcca ggcgtggtgg tgggcgcctg taatcccagc tatgcgagag
     5581 gctgaggcag gagaatcagt tgaacccggg aggcggggat tgcagtgagc cgagaccatg
     5641 ccattgcact ccagcctggg caacaggagc aaatctccgt ctcaaaaaaa agaaaaaaaa
     5701 aagtgttgac tttgtagaaa ttatgttctt tcatagtatc ttcttctacc cgttgcagac
     5761 gataaattat ttgtgccaat tcgagaattg ctgttaggct gttatcctcc cttccttggg
     5821 gctaagaatt acaagactca tggcactggc gtaaagttgt tgtttatcta atcactgatg
     5881 aaatattttc acacttgaaa atccccaaat gctttacaat gaatgaagtg ttaatttggt
     5941 gaccaggtgg tagccattag ccatgttgca aaattctaga cagtaaaacc tgtgttttag
     6001 aaacagaggg gaaatttaaa taatggagtc ctggttagcc tttcagggat tagggatttg
     6061 ggtttttttt tttttctctt tttaatacta gaatatctca gtttttataa aaggtaagtt
     6121 taaaatgttt attgtgccat tattttaact ggcatcttga aagaacagta ggttttctcc
     6181 atgataaact gattccagta agaattttca gtacatacca agtacctgga aagttcttca
     6241 gataagttaa tagatccaag gagatacatg cctcagtgag ataaactgac ctttttacta
     6301 gctaaactat ttagccagag caatactctg tagaactgtg cttttctaaa gtaaagatta
     6361 tctgtttctc aattttatgt gcataatact tttcctggtg ctagctttga taggcaaaat
     6421 attttgaaat gttggtccca taatgattgt gctagttcat aagctttgtt gttatgagtg
     6481 taatcataaa aatatttcca agcagttttt gacctttatt ctacatttct gggcatttgt
     6541 aatatggtat tctactggta tatattttta aagtttgcgt ttagattatg gtaaagaaat
     6601 ttcaagcata tttcttctaa taaagtatta agacagtgtt tcagaatatc aaggcacacc
     6661 tccttagttg ttttagatta gaactctaga aacaattttg tgaacattga aagtattttg
     6721 agttaagcct aagctgatta atcacacaat acatactttt cctgcatttt ctttcagtga
     6781 catttgagaa ttgggtgaca ttttaaaatg tgttttatac catttagctt ttgcaaacaa
     6841 gttctaaagt tttggagaaa aagtgatgtg gtcaagagtt gaagtctcat atatctttag
     6901 tagcactccc atgaattatt tccgtgacag taacaagtgt gtgttccatg tctgatttgg
     6961 ggcactggtt agactgcatt aatagctact tgattagaat tcgaactttt aaaattttga
     7021 aatgtttaag aatgtattag aaaatgcatg ctttatgttg aaaaaataca ttgctttaat
     7081 attcctcatt cttgagttaa gaaatttatg ttaattttgc atgggcacaa acttaatcag
     7141 aaacattttg tggagttaca tttcctctta ttatttatca aggttcagta ttgatctttg
     7201 aaaccttggt cccgttaact tactagtcac attgaccaat gttttataga aatgcctaga
     7261 attttgagac taatagtagt tatccattaa cattccaaaa gttttgtgct ttttaaaatt
     7321 tgttttggta attatcacat ttttttctct taccttcctt taaatggcca cagtgtgtac
     7381 tgctggaatg ttccatccaa aagatgtagc ttcagaagca cagtgattgc cccagggtcc
     7441 atgagatatt gtttgtatta tgaagttgga gtgctgtcta ctgaaattat actcttaaat
     7501 aaatatgtat gtagtgtgta atattttcta ataaattctt ttgataaact aa
//
