LOCUS       NM_001024956            7035 bp    mRNA    linear   PRI 13-OCT-2024
DEFINITION  Homo sapiens sterol-C5-desaturase (SC5D), transcript variant 2,
            mRNA.
ACCESSION   NM_001024956
VERSION     NM_001024956.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7035)
  AUTHORS   Li,Y., Ran,Q., Duan,Q., Jin,J., Wang,Y., Yu,L., Wang,C., Zhu,Z.,
            Chen,X., Weng,L., Li,Z., Wang,J., Wu,Q., Wang,H., Tian,H., Song,S.,
            Shan,Z., Zhai,Q., Qin,H., Chen,S., Fang,L., Yin,H., Zhou,H.,
            Jiang,X. and Wang,P.
  TITLE     7-Dehydrocholesterol dictates ferroptosis sensitivity
  JOURNAL   Nature 626 (7998), 411-418 (2024)
   PUBMED   38297130
REFERENCE   2  (bases 1 to 7035)
  AUTHORS   Freitas,F.P., Alborzinia,H., Dos Santos,A.F., Nepachalovich,P.,
            Pedrera,L., Zilka,O., Inague,A., Klein,C., Aroua,N., Kaushal,K.,
            Kast,B., Lorenz,S.M., Kunz,V., Nehring,H., Xavier da Silva,T.N.,
            Chen,Z., Atici,S., Doll,S.G., Schaefer,E.L., Ekpo,I., Schmitz,W.,
            Horling,A., Imming,P., Miyamoto,S., Wehman,A.M.,
            Genaro-Mattos,T.C., Mirnics,K., Kumar,L., Klein-Seetharaman,J.,
            Meierjohann,S., Weigand,I., Kroiss,M., Bornkamm,G.W., Gomes,F.,
            Netto,L.E.S., Sathian,M.B., Konrad,D.B., Covey,D.F., Michalke,B.,
            Bommert,K., Bargou,R.C., Garcia-Saez,A., Pratt,D.A., Fedorova,M.,
            Trumpp,A., Conrad,M. and Friedmann Angeli,J.P.
  TITLE     7-Dehydrocholesterol is an endogenous suppressor of ferroptosis
  JOURNAL   Nature 626 (7998), 401-410 (2024)
   PUBMED   38297129
REFERENCE   3  (bases 1 to 7035)
  AUTHORS   Pickens,C.A., Matsuo,K.H. and Fenton,J.I.
  TITLE     Relationship between Body Mass Index, C-Peptide, and
            Delta-5-Desaturase Enzyme Activity Estimates in Adult Males
  JOURNAL   PLoS One 11 (3), e0149305 (2016)
   PUBMED   27023786
  REMARK    GeneRIF: The relationship between C-peptide concentrations and D5D
            enzyme activity estimates remained significant after adjusting for
            body mass index, waist circumference, and TNF-alpha.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7035)
  AUTHORS   Jugessur,A., Shi,M., Gjessing,H.K., Lie,R.T., Wilcox,A.J.,
            Weinberg,C.R., Christensen,K., Boyles,A.L., Daack-Hirsch,S.,
            Nguyen,T.T., Christiansen,L., Lidral,A.C. and Murray,J.C.
  TITLE     Maternal genes and facial clefts in offspring: a comprehensive
            search for genetic associations in two population-based cleft
            studies from Scandinavia
  JOURNAL   PLoS One 5 (7), e11493 (2010)
   PUBMED   20634891
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7035)
  AUTHORS   Liu,B.C., Zhang,J., Wang,L., Li,X.W., Wang,Y., Ji,J., Yang,F.P.,
            Wan,C.L., Gao,L.H., Xu,Y.F., Feng,G.Y., He,L., Zhao,X.Z. and He,G.
  TITLE     No association between EGR gene family polymorphisms and
            schizophrenia in the Chinese population
  JOURNAL   Prog Neuropsychopharmacol Biol Psychiatry 34 (3), 506-509 (2010)
   PUBMED   20144677
  REMARK    GeneRIF: The EGR3 may not play a major role in schizophrenia
            susceptibility in the Chinese Han population.
REFERENCE   6  (bases 1 to 7035)
  AUTHORS   Shefer,S., Salen,G., Batta,A.K., Honda,A., Tint,G.S., Irons,M.,
            Elias,E.R., Chen,T.C. and Holick,M.F.
  TITLE     Markedly inhibited 7-dehydrocholesterol-delta 7-reductase activity
            in liver microsomes from Smith-Lemli-Opitz homozygotes
  JOURNAL   J Clin Invest 96 (4), 1779-1785 (1995)
   PUBMED   7560069
REFERENCE   7  (bases 1 to 7035)
  AUTHORS   Ves-Losada,A. and Brenner,R.R.
  TITLE     Fatty acid delta 5 desaturation in rat liver cell nuclei
  JOURNAL   Mol Cell Biochem 142 (2), 163-170 (1995)
   PUBMED   7770068
REFERENCE   8  (bases 1 to 7035)
  AUTHORS   Takakuwa,Y., Nishino,H., Ishibe,Y. and Ishibashi,T.
  TITLE     Properties and kinetics of membrane-bound enzymes when both the
            enzyme and substrate are components of the same microsomal
            membrane. Studies on lathosterol 5-desaturase
  JOURNAL   J Biol Chem 269 (45), 27889-27893 (1994)
   PUBMED   7961720
  REMARK    Erratum:[J Biol Chem 1995 Feb 24;270(8):4180]
REFERENCE   9  (bases 1 to 7035)
  AUTHORS   Poisson,J.P., Dupuy,R.P., Sarda,P., Descomps,B., Narce,M., Rieu,D.
            and Crastes de Paulet,A.
  TITLE     Evidence that liver microsomes of human neonates desaturate
            essential fatty acids
  JOURNAL   Biochim Biophys Acta 1167 (2), 109-113 (1993)
   PUBMED   8466936
REFERENCE   10 (bases 1 to 7035)
  AUTHORS   Prasun,P. and Ganesh,J.
  TITLE     Lathosterolosis
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   38060690
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP002959.2 and BC012333.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001024956.2.
            
            Summary: This gene encodes an enzyme of cholesterol biosynthesis.
            The encoded protein catalyzes the conversion of lathosterol into
            7-dehydrocholesterol. Mutations in this gene have been associated
            with lathosterolosis. Alternatively spliced transcript variants
            encoding the same protein have been described. [provided by RefSeq,
            Jul 2008].
            
            Transcript Variant: This variant (2) uses an alternate 5' exon
            compared to variant 1. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074967.427941.1,
                                           SRR18074969.1032861.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                AP002959.2         35022-35037
            17-48               AP002959.2         35038-35069
            49-2258             BC012333.1         1-2210
            2259-7035           AP002959.2         50804-55580
FEATURES             Location/Qualifiers
     source          1..7035
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q23.3-q24.1"
     gene            1..7035
                     /gene="SC5D"
                     /gene_synonym="ERG3; S5DES; SC5DL"
                     /note="sterol-C5-desaturase"
                     /db_xref="GeneID:6309"
                     /db_xref="HGNC:HGNC:10547"
                     /db_xref="MIM:602286"
     exon            1..227
                     /gene="SC5D"
                     /gene_synonym="ERG3; S5DES; SC5DL"
                     /inference="alignment:Splign:2.1.0"
     exon            228..447
                     /gene="SC5D"
                     /gene_synonym="ERG3; S5DES; SC5DL"
                     /inference="alignment:Splign:2.1.0"
     CDS             238..1137
                     /gene="SC5D"
                     /gene_synonym="ERG3; S5DES; SC5DL"
                     /EC_number="1.14.19.20"
                     /note="lathosterol dehydrogenase; fungal ERG3,
                     delta-5-desaturase-like;
                     3beta-hydroxysteroid-delta5-desaturase; lathosterol
                     5-desaturase; C-5 sterol desaturase; delta(7)-sterol
                     5-desaturase; sterol-C5-desaturase (ERG3
                     delta-5-desaturase homolog, S. cerevisiae)-like;
                     delta(7)-sterol C5(6)-desaturase; delta(7)-sterol
                     5(6)-desaturase"
                     /codon_start=1
                     /product="lathosterol oxidase"
                     /protein_id="NP_001020127.1"
                     /db_xref="CCDS:CCDS8435.1"
                     /db_xref="GeneID:6309"
                     /db_xref="HGNC:HGNC:10547"
                     /db_xref="MIM:602286"
                     /translation="MDLVLRVADYYFFTPYVYPATWPEDDIFRQAISLLIVTNVGAYI
                     LYFFCATLSYYFVFDHALMKHPQFLKNQVRREIKFTVQALPWISILTVALFLLEIRGY
                     SKLHDDLGEFPYGLFELVVSIISFLFFTDMFIYWIHRGLHHRLVYKRLHKPHHIWKIP
                     TPFASHAFHPIDGFLQSLPYHIYPFIFPLHKVVYLSLYILVNIWTISIHDGDFRVPQI
                     LQPFINGSAHHTDHHMFFDYNYGQYFTLWDRIGGSFKNPSSFEGKGPLSYVKEMTEGK
                     RSSHSGNGCKNEKLFNGEFTKTE"
     exon            448..580
                     /gene="SC5D"
                     /gene_synonym="ERG3; S5DES; SC5DL"
                     /inference="alignment:Splign:2.1.0"
     exon            581..681
                     /gene="SC5D"
                     /gene_synonym="ERG3; S5DES; SC5DL"
                     /inference="alignment:Splign:2.1.0"
     exon            682..7035
                     /gene="SC5D"
                     /gene_synonym="ERG3; S5DES; SC5DL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1632..1637
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SC5D"
                     /gene_synonym="ERG3; S5DES; SC5DL"
                     /note="hexamer: AATAAA"
     polyA_site      1661
                     /gene="SC5D"
                     /gene_synonym="ERG3; S5DES; SC5DL"
                     /note="major polyA site"
     regulatory      2236..2241
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SC5D"
                     /gene_synonym="ERG3; S5DES; SC5DL"
                     /note="hexamer: AATAAA"
     polyA_site      2263
                     /gene="SC5D"
                     /gene_synonym="ERG3; S5DES; SC5DL"
                     /note="major polyA site"
     regulatory      7006..7011
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SC5D"
                     /gene_synonym="ERG3; S5DES; SC5DL"
                     /note="hexamer: AATAAA"
     polyA_site      7035
                     /gene="SC5D"
                     /gene_synonym="ERG3; S5DES; SC5DL"
ORIGIN      
        1 tacacctgag cgggctgggc cggggggcga tggaataaaa gaagatggag agacttcagc
       61 gcctgggact cgggtgggcg aggcggaagg tgtcctcgca gcacggcttt tctccgcgcc
      121 gcggttggtt agcgagtgcc ctctgggtgc taggcgttgg gcggatggta ggatcgcggt
      181 agcatacgga tccgagtcct gcgccgagtg agaggagagg ctggcagggg ctaagtgatg
      241 gatcttgtac tccgtgttgc agattactat ttttttacac catacgtgta tccagccaca
      301 tggccagaag atgacatctt ccgacaagct attagtcttc tgattgtaac aaatgttggt
      361 gcttacatcc tttatttctt ctgtgcaaca ctgagctatt attttgtctt cgatcatgca
      421 ttaatgaaac atccacaatt tttaaagaat caagtccgtc gagagattaa gtttactgtc
      481 caggcattgc catggataag tattcttact gttgcactgt tcttgctgga gataagaggt
      541 tacagcaaat tacatgatga cctaggagag tttccatatg gattgtttga acttgtcgtt
      601 agtataatat ctttcctctt tttcactgac atgttcatct actggattca cagaggcctt
      661 catcatagac tggtatataa gcgcctacat aaacctcacc atatttggaa gattcctact
      721 ccatttgcaa gtcatgcttt tcaccctatt gatggctttc ttcagagtct accttaccat
      781 atataccctt ttatctttcc attacacaag gtggtttatt taagtctgta catcttggtt
      841 aatatctgga caatttccat tcatgacggt gattttcgtg tcccccaaat cttacagcca
      901 tttattaatg gctcagctca tcatacagac caccatatgt tctttgacta taattatgga
      961 caatatttca ctttgtggga taggattggc ggctcattca aaaatccttc atcctttgag
     1021 gggaagggac cgctcagtta tgtgaaggag atgacagagg gaaagcgcag cagccattca
     1081 ggaaatggct gtaagaatga aaaattattc aatggagagt ttacaaagac tgaatagatt
     1141 attgcccagt tattcttaag taaggacaaa gaaggaaata tcatcgtatt tctttttttt
     1201 aataaggaaa aaataatatc catacagtca agatacatag taaatggtat catttggaaa
     1261 tcagcatcgt gggcactgct gaggaatgat cctagtggta ggtcagaaga agatgctgtg
     1321 aacaccagga ctttaatctt atgcttaaaa tgccagatgt tgttcggggg acaacttgta
     1381 tctttctagc agcagatctg tagtttgtat agcctcaaca acaattttaa ataagatgga
     1441 gaataaatta ttgaggggac taggctatat gcatttgcct tcatccaccc atgtttatta
     1501 agaatcattg tgcttaataa taccaagact aagcaccata accaagaaat actaatgtaa
     1561 agattgtttc ttgtttcagg aatggttaat tcttcaacgt tggtatgata atgataactt
     1621 gttttgactt gaataaagta ctacatcagt gtggaaaaaa attctgatac attagcagct
     1681 atgtaaatga cctaattgat agcaggtgta ataagactat cgtcttccta cacataggag
     1741 gctcattctc tggacacact atcacctatt acattttact gattaacaaa taaattggaa
     1801 tttaaaaata tcgatatcac catgatttaa tccagatctg ggattatgta gctaaacatt
     1861 gtgatgatta ttatttaaaa ccattattta ataagagtaa aaatatgtga atctggatat
     1921 atttaaaaaa agaaatttga tgcccagata atatattagg cactactgat tttttagtta
     1981 aattgatgca ctacactttt gatgtttgaa gttacaaacc tgtaattttt ttgtaaagga
     2041 aataattgcc aaatacctag gcccattgct gacgattagt tctaaaatct tattcctcct
     2101 cttctcccct cacttttccc tacttcctct gcaaaaagat ttaacaaata cattcataag
     2161 gaaatgtgtg ttgtaacaaa tatattgcaa aaacatagtt tgtaaaggca ttctataagc
     2221 tatttatgta aaatcaataa aagttgatca taattaaact gtatcagttg agtattatag
     2281 cagcacaaag tattctttgt acagattttg tgccaatttg aagccacaga aatgatgtgg
     2341 attgttaatt gtgttttaga acatccccgg acactcagtg tcacaggggg aaagaagtgg
     2401 gtaccacatt ctgtttatat ttcacatttt aactagattt gagtgttttt agcaagaaat
     2461 cagtcttaaa atctaatgtc tgggatccag aagaaaatgt ctttaatctg tgagttattg
     2521 tcacaatgtc atcttattta aatgtaccaa ttagcatttt gtaataggca aatgtcattt
     2581 agtgcttttc accaatccca ctcacccccg gtgctccgcc ttgcctaaga aaaagaaatt
     2641 aaggagaagt aaactttatt tcctaatata atgtcagctg atatttattg agcttttcct
     2701 ctttgcccag agactaggac ccaaagaagt taagtaacta ttcccaggtt tatttctctc
     2761 tcatatgatg tcccatgtgg atgtttgtgg tcagtggaca gctttccacc tagtctttct
     2821 gcgacccagg ctccttcctc ttggggctct gcctttctct cagtccatag agccctcttt
     2881 gttgaaagag cacataggaa aagaaggaaa agtctgtgtg gaaaatgttt ctgggtcagg
     2941 cctggaagtg gtgcatatct cttccgccca tgttcctttg gacagaactc cgtcacatgg
     3001 cccacctaga gagattttgg gaaatgtgtc cagctgtgtg cctgggagga agggggcacc
     3061 attttcttga gcagctagac agtttgccgt atttgtggtg ttctcctctt gttgatgttg
     3121 aaatggtgaa tgagccataa agtatttcag gttatccaca cactaatcat ctcagtgtct
     3181 ttaattctta actccaatat gaatgtttaa agcttcctct agattcttat tcctatataa
     3241 ctaatagaga agaaaggaca gcttcctatg gggaagacag aggcttcctc atagatgtta
     3301 ggaataatca aacttgcccc tgccctttca cccgtctcaa attctggtct tttaaagcag
     3361 cgttatgtta agtagtccta acattgtaat atacagtact gccacattct cctactttct
     3421 attagaggaa gtcagagaat atttatggaa gtgaggaccc aaattacctt ctacagatga
     3481 cttttatagt tacaggacag aaagtgaaaa tcaaggttac gttttctact tttgtggtag
     3541 aaattgagaa gtgggtggat atggttcgag aagacctttc agaaacacag agactgagtc
     3601 tttgtcttcc atgctgtctc tgcagtactg agtgaatttc cttataccct tgtatcatgt
     3661 tttcctccca tcttctagaa gctggggaca gatttggaag agaattacac aagttcagtt
     3721 ttttgataca tggattttac agtgcatgca ggttatttat gtagagagga ggtctgggag
     3781 aaagatggaa actagggaga tgactgagaa caaagatatt tgggattaac acagatagaa
     3841 gaaaagtttg aaaccatgag attgtcacag catgaaaaaa gatattcaaa gacactaacc
     3901 aacttgaggg gtgcagtggt ctgaatgtgt cctccaaaat tcaaatgtgg aaatgtattt
     3961 gccagtgaga tagtatgtag aggtggggcc ttgaggaagt gattaagtca tgagggctct
     4021 gggattaatg acttaaaaag aggtgtgagg cagctgttca gcccttctgt ctcctgtccc
     4081 tttttttttt tttttttttg agatggagtc ttgctctgtt gccccaggct ggagtgcagt
     4141 ggcgtgatct tggttcactg caagctccac ctcccgggtt cacgccattc tcctgcctca
     4201 gcctcccgag tagctgggac tacaggtgcc cgccaccacc acgcccggct aattttttat
     4261 atttttagta gagatggggt ttcaccgtgt tagccaggat ggtcttgatc tcctgacctc
     4321 atgatctgcc tgcctcggcc tcccaaagtg ctgggattat aggtgtgagc caccatgccc
     4381 agccccttct gtcccttcta acgtgaggac ccagcaacaa ggtaccatct tgaaagcagc
     4441 aactggggac tcagcagaca ccaaaccaac tggtgcttaa ccgtgacttc ccagcctcca
     4501 gagctgtaag aaaataaatt tctattattt atagattacc cagttgaaga tactttgtta
     4561 aggcagtaca aatggactaa gacaaggggg aagaaatttg cattcctgat cttcccaact
     4621 tcttcaaatt cacaacactt gaatgacagt cttatttcag cacttactgc tatcacctat
     4681 tacttttatg tgtgtcttac ctatttgaga tgccagattc cttggaagta gagaccgtgt
     4741 ctgaatcatc attgtattaa accactcatc cttaacaaat gcccaagcca tggttaaagt
     4801 tcaataaata ctttgttgaa tttattaata aaatggcaga aatgtcattc tcttccatat
     4861 atgtttaata aatccctgat aggtgctaag cactgcacta ggtaaaaatt ctcttctgat
     4921 gctgtctttt tggccaacca tttttttatc atttattcat tagctgacat ttgctaagtg
     4981 ctttggaggg gtcaaaaggg gaagtaatga gaaatcaaag atggtcccta catcaaggat
     5041 aaactatctt tttttagtca ctcaaagtca taaccctttg gaaacaaaac ccaccagtac
     5101 cccagatttt gaccacagat gaatcagtac tacaaggact ggttagaggg ttgaatgaat
     5161 ctgtatactc agcacttaac acagcactct gggtaaaaga aaaaagatcc tcaaagatat
     5221 tagttggtta catcaagaaa ggacaaactt aggttaatct ataacttcat ctcagaggaa
     5281 caggaacttt ggagataaac agggctctgc cacttgcaag ttgcaccatc cctggtttct
     5341 ccatctgtaa attgattaaa acactgccta tctaataaga ttaaataagt tagaagcatt
     5401 cagttaaatg tcaactgaaa ctattgttca tgtaaattgt gcttgatgct ttttctttct
     5461 agattcaatg attattgtca ttttacctcc ataggccctc aatagaaatc agttgcagag
     5521 ggcagaagcc tagatatttt caccttaaaa ttggagggtg aaagacattg aggtgaagta
     5581 gagatagagg gtacacagaa aaatcgtata agtaaaacta acatcgttaa cattatttac
     5641 tgtaagttat ctttgtaaga gtggtaaaat acattgtgtt gttaaataat ttcatttaaa
     5701 aaatgcatca ctttgtgtgt ttttatattg ctaaaaccat aaggccagtc tacaaggttt
     5761 gtagataaaa tagaaacata ccttccttga aaagcagaat aaatttttta aaggcaggaa
     5821 ggaagtgttt gaaccatgtg tcaacaagct ttactgtcaa agcaggcttt tggtatggga
     5881 agaaaaatac ttataaatac ttgttttaat atttgcttta ttaaaataca tttaaaatac
     5941 agcattttta aatctctaag ctcaacttga agatataaga acagtaaatt tgataaaaat
     6001 gagaaattac attcccattt ctttaacaat ttgtaaattc caattatcct gaacatttaa
     6061 taccatttac atattttatt aatcacattt tcttaaacat ttgataagag atttaatatt
     6121 ttgatccaac taccaaaaaa gcagacttgt gtacttgaca gatttttcta aacacttcac
     6181 aactcacgat tcaaacaaag acaaaatagc atatcaaaag ttaatcactc agttggaaag
     6241 cactcatacc ataggctttt attcatttct tgaataattt tgttatatct tcctctttta
     6301 ggctgcaatg agctataatt gcactactgc actccacgct gggtgacaga gcaagaccct
     6361 atctctaaaa ataaaaaagt atatatatat aaaaatatct tcctctatta taatttaact
     6421 cattaagcca tttatttaga tgtaaacttg cccccctgac atgtggtatg aaacaaatag
     6481 aaacctagaa atttagtgca tattcaaata ttaagacaga cactggtgtg gtgacttttg
     6541 tctgtcgctt cattgggacg ttttttcttt ctgatcaact taatgaaatt ataatttact
     6601 ataattaagt gtagccattt ttactgtaga gttcaatgat ctttgatgaa cgtgtacacc
     6661 catgtaacca ccacccccaa tcaaagtaaa gaacattttc ttaccagaat aaatttcctc
     6721 tccgtttgca gtcattctcc ccagccctag gtcaccactg atccaccttc tgttactgga
     6781 aggttagttt tcttccctga tttagaattt catataaatt aaatcagata gtatatactc
     6841 ttgtgtttag tttctttagc ttaacatgtt tagagatatt tgctgttgcc tgtgtctgta
     6901 gctttttgtt ttcattgctg aatagtattt cattgtaata taccacagtt ggtttatgta
     6961 tttgctgatg aatatttgtg ttatttccag cgtgggatta ttatgaataa agttgctaca
     7021 aacatttgta tacaa
//
