LOCUS       NM_153225               3698 bp    mRNA    linear   PRI 06-NOV-2024
DEFINITION  Homo sapiens somatomedin B and thrombospondin type 1 domain
            containing (SBSPON), mRNA.
ACCESSION   NM_153225 XM_001129570
VERSION     NM_153225.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3698)
  AUTHORS   Barallobre-Barreiro,J., Gupta,S.K., Zoccarato,A.,
            Kitazume-Taneike,R., Fava,M., Yin,X., Werner,T., Hirt,M.N.,
            Zampetaki,A., Viviano,A., Chong,M., Bern,M., Kourliouros,A.,
            Domenech,N., Willeit,P., Shah,A.M., Jahangiri,M., Schaefer,L.,
            Fischer,J.W., Iozzo,R.V., Viner,R., Thum,T., Heineke,J.,
            Kichler,A., Otsu,K. and Mayr,M.
  TITLE     Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin
            Activity in Human Atrial Fibrillation
  JOURNAL   Circulation 134 (11), 817-832 (2016)
   PUBMED   27559042
REFERENCE   2  (bases 1 to 3698)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   3  (bases 1 to 3698)
  AUTHORS   Naba,A., Clauser,K.R., Whittaker,C.A., Carr,S.A., Tanabe,K.K. and
            Hynes,R.O.
  TITLE     Extracellular matrix signatures of human primary metastatic colon
            cancers and their metastases to liver
  JOURNAL   BMC Cancer 14, 518 (2014)
   PUBMED   25037231
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3698)
  AUTHORS   Mishra,A., Yazar,S., Hewitt,A.W., Mountain,J.A., Ang,W.,
            Pennell,C.E., Martin,N.G., Montgomery,G.W., Hammond,C.J.,
            Young,T.L., Macgregor,S. and Mackey,D.A.
  TITLE     Genetic variants near PDGFRA are associated with corneal curvature
            in Australians
  JOURNAL   Invest Ophthalmol Vis Sci 53 (11), 7131-7136 (2012)
   PUBMED   22969067
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3698)
  AUTHORS   Kenny,E.E., Pe'er,I., Karban,A., Ozelius,L., Mitchell,A.A.,
            Ng,S.M., Erazo,M., Ostrer,H., Abraham,C., Abreu,M.T., Atzmon,G.,
            Barzilai,N., Brant,S.R., Bressman,S., Burns,E.R., Chowers,Y.,
            Clark,L.N., Darvasi,A., Doheny,D., Duerr,R.H., Eliakim,R.,
            Giladi,N., Gregersen,P.K., Hakonarson,H., Jones,M.R., Marder,K.,
            McGovern,D.P., Mulle,J., Orr-Urtreger,A., Proctor,D.D., Pulver,A.,
            Rotter,J.I., Silverberg,M.S., Ullman,T., Warren,S.T., Waterman,M.,
            Zhang,W., Bergman,A., Mayer,L., Katz,S., Desnick,R.J., Cho,J.H. and
            Peter,I.
  TITLE     A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests
            novel susceptibility loci
  JOURNAL   PLoS Genet 8 (3), e1002559 (2012)
   PUBMED   22412388
REFERENCE   6  (bases 1 to 3698)
  AUTHORS   Didangelos,A., Yin,X., Mandal,K., Baumert,M., Jahangiri,M. and
            Mayr,M.
  TITLE     Proteomics characterization of extracellular space components in
            the human aorta
  JOURNAL   Mol Cell Proteomics 9 (9), 2048-2062 (2010)
   PUBMED   20551380
REFERENCE   7  (bases 1 to 3698)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Fariss,R.N., Behal,A.,
            Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of human RPE/choroid for the
            NEIBank Project: over 6000 non-redundant transcripts, novel genes
            and splice variants
  JOURNAL   Mol Vis 8, 205-220 (2002)
   PUBMED   12107410
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC042877.1, AC022893.6 and AI698180.1.
            
            On Nov 22, 2018 this sequence version replaced NM_153225.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK292970.1, SRR1660807.229619.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA2142853,
                                           SAMEA2147920 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000297354.7/ ENSP00000297354.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1222              BC042877.1         101-1322
            1223-3642           AC022893.6         13546-15965
            3643-3698           AI698180.1         7-62                c
FEATURES             Location/Qualifiers
     source          1..3698
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q21.11"
     gene            1..3698
                     /gene="SBSPON"
                     /gene_synonym="C8orf84; RPESP"
                     /note="somatomedin B and thrombospondin type 1 domain
                     containing"
                     /db_xref="GeneID:157869"
                     /db_xref="HGNC:HGNC:30362"
                     /db_xref="MIM:621005"
     exon            1..319
                     /gene="SBSPON"
                     /gene_synonym="C8orf84; RPESP"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..900
                     /gene="SBSPON"
                     /gene_synonym="C8orf84; RPESP"
                     /note="RPE-spondin; somatomedin-B and thrombospondin
                     type-1 domain-containing protein"
                     /codon_start=1
                     /product="somatomedin-B and thrombospondin type-1
                     domain-containing protein precursor"
                     /protein_id="NP_694957.3"
                     /db_xref="CCDS:CCDS43747.2"
                     /db_xref="GeneID:157869"
                     /db_xref="HGNC:HGNC:30362"
                     /db_xref="MIM:621005"
                     /translation="MRTLWMALCALSRLWPGAQAGCAEAGRCCPGRDPACFARGWRLD
                     RVYGTCFCDQACRFTGDCCFDYDRACPARPCFVGEWSPWSGCADQCKPTTRVRRRSVQ
                     QEPQNGGAPCPPLEERAGCLEYSTPQGQDCGHTYVPAFITTSAFNKERTRQATSPHWS
                     THTEDAGYCMEFKTESLTPHCALENWPLTRWMQYLREGYTVCVDCQPPAMNSVSLRCS
                     GDGLDSDGNQTLHWQAIGNPRCQGTWKKVRRVDQCSCPAVHSFIFI"
     exon            320..514
                     /gene="SBSPON"
                     /gene_synonym="C8orf84; RPESP"
                     /inference="alignment:Splign:2.1.0"
     exon            515..605
                     /gene="SBSPON"
                     /gene_synonym="C8orf84; RPESP"
                     /inference="alignment:Splign:2.1.0"
     exon            606..782
                     /gene="SBSPON"
                     /gene_synonym="C8orf84; RPESP"
                     /inference="alignment:Splign:2.1.0"
     exon            783..3698
                     /gene="SBSPON"
                     /gene_synonym="C8orf84; RPESP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1203..1208
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SBSPON"
                     /gene_synonym="C8orf84; RPESP"
                     /note="hexamer: AGTAAA"
     polyA_site      1228
                     /gene="SBSPON"
                     /gene_synonym="C8orf84; RPESP"
                     /note="major polyA site"
     regulatory      1692..1697
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SBSPON"
                     /gene_synonym="C8orf84; RPESP"
                     /note="hexamer: AATAAT"
     polyA_site      1710
                     /gene="SBSPON"
                     /gene_synonym="C8orf84; RPESP"
                     /note="major polyA site"
     regulatory      3000..3005
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SBSPON"
                     /gene_synonym="C8orf84; RPESP"
                     /note="hexamer: AATAAA"
     polyA_site      3026
                     /gene="SBSPON"
                     /gene_synonym="C8orf84; RPESP"
     regulatory      3402..3407
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SBSPON"
                     /gene_synonym="C8orf84; RPESP"
                     /note="hexamer: AATACA"
     polyA_site      3419
                     /gene="SBSPON"
                     /gene_synonym="C8orf84; RPESP"
     regulatory      3674..3679
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SBSPON"
                     /gene_synonym="C8orf84; RPESP"
                     /note="hexamer: AATAAA"
     polyA_site      3698
                     /gene="SBSPON"
                     /gene_synonym="C8orf84; RPESP"
ORIGIN      
        1 gtgcctcgcc ggccgctcgg gcagctcccg ggccgcggcc agccgaggat cagagcgctt
       61 gccccggggg tctgtcgcgt cgcaggcgcc gccggagccc tggccatgag gaccctgtgg
      121 atggcgctgt gcgcgctgtc gcggctgtgg cccggggccc aggccggctg cgccgaggcc
      181 gggcgctgct gtcccggccg ggaccccgcc tgcttcgccc gcggctggag gctggacagg
      241 gtctacggga cgtgtttctg cgaccaagcc tgtcgcttca ccggggactg ctgcttcgac
      301 tacgacaggg cgtgcccagc tcgcccgtgc ttcgtggggg aatggagccc ctggagtggt
      361 tgtgcagacc agtgcaagcc tacaacccgt gtgcggaggc gctcggtgca gcaggagcct
      421 cagaacggcg gggcgccctg cccacccctg gaagagagag ctggctgcct ggagtactcc
      481 accccgcagg gccaggactg cgggcacacc tatgttcctg cctttataac tacctctgca
      541 ttcaacaagg agagaacacg acaagctacg tctccacact ggtctacaca cacagaggat
      601 gctggatact gtatggagtt taagacagag tccttgactc ctcactgtgc tctggaaaac
      661 tggcccttga ctagatggat gcagtatctc cgagagggat acacggtgtg tgtggattgt
      721 cagcctccag ctatgaactc tgtgagcctt cgttgttctg gagatggcct ggactccgat
      781 ggaaatcaga ctctccattg gcaagcaatt ggtaatcctc ggtgtcaagg aacttggaaa
      841 aaagttcggc gagtagacca gtgttcttgt ccagctgttc acagttttat ttttatatag
      901 atggtgatat aaatatttcc aaatgcattt gtaaacattc taaatattct caagtcatgt
      961 tcaatgtttc ctaaaccttc aattttggcc aaagtcccca aacacatcat tgccacactc
     1021 tgaagtagag aaagaaaatt taggggccag ttctcaagga acacaggtcc tttattttta
     1081 ttttaactaa gttgaagacc cactcaaaaa gctcttgtgg ttttatgttc ttgacctttc
     1141 aactggagtc ctctcattca gcaggtggcc cgtgagacac agaatacatg tctgtttgct
     1201 aaagtaaaat tactgtaact cagtccgatt attggtgacg gaagtgtcat ttaaggggat
     1261 ctatgttttg aaccttgcag tctattttat aatcttttaa aagtttctca ctttaaaaca
     1321 tgtatacagg tatgcacact ctacacatat atttccatat atttaatatt ccataaattc
     1381 tgaaataatt tcaagcaaat tatcacaaat aatttttcca cagggcaaat tatttaaaat
     1441 tttagtaagc attctgtaat gaaaaaccaa gttatactaa aaacattttt tgaagaagaa
     1501 attttttttt tgcttaagaa gtgaaaggat caaatgctca ttgtaggtca atgggagttc
     1561 ttttaaatgt tataattttc atgaaaagaa atgttgacac cagtgaatga aacaattgct
     1621 ttcattctga aaattctacc accatttgca tctaagatta tttccaaggc ttaaagcctg
     1681 aagctgaata aaataatctt tcagagtcca gcttcaagtt tagttgatgt aagctcacta
     1741 tttttttcct accgcatgca ttttctaatg tttggggtgg atggtgtgtc ggttatggaa
     1801 ggcatagacg tcattacagg tgctacgatc tcacacacac acaaggaaat gttagtctcc
     1861 ttattttatg attggaaaat caatgaccta gaggcaaaat ggcatgttta aggacctggg
     1921 atgacaagtc attctgcagt cagccacaga gccaaatttg gactcctcaa ccagaactcc
     1981 atgaaaagcc tgactttgcc aaacactgtg ctggaaaagc taagcccctt tcatttgtga
     2041 agtaaatttt aaattcaaga tatttagttt agagaattga gtcttgagat gtaaactaca
     2101 tgagatttct ttggtttcaa ttgaataata ttcactaaca aatgatttac taaaatacgt
     2161 atttcttggt ccttatcatg taatgacaga ttcacaacag caataaggat ggagatttcc
     2221 ccaataatta ataacaccga gagtagcaat attttttact gtattttcat ttaattgtca
     2281 aagttgtttt tgtggaaaat taaattcttc agaaattaat aataaaatat gtgagtctca
     2341 tcaaggctag caactttaag tcagtattaa cattttcata ctgtttctaa catttattaa
     2401 gctagatttt tgaagctatg tctgggtaat ttccaatgtt acttaaaagt ttttttttct
     2461 ttgagacaga gtctcactct gttgcccagg ctggagtgca gtggccccat ctcggctcac
     2521 tgcaagctcc gcctcccggg ttcacgccat tcttctgcct cagcctccca agtagctggg
     2581 actacaggcg ccgtcatcac gcctggctaa ttttttgttt ttttttttta gtagagacag
     2641 ggtttcactg tgttagccag ggtggtctcg atctcctgac ctcgtgatcc acccacctcg
     2701 gcctcccaag gtgctgggat tatgggcgtg agccactgcg cctggcctgt tacttaaaat
     2761 ttttatacta gtaaataaac tttttgttca catttataaa agctctatat ttgtttgact
     2821 agaaaataac ccaaattttc tggaccagtc agagaatgat aaaatttcac caaaaataaa
     2881 acaaaaaaat ccttcagaac tgataggtat aggtacaaca actactaata gcaataaagc
     2941 aatggtgctt ttatagttcc gatatgtgtt ataacattta acataattga ggtgtataaa
     3001 ataaattttt caccttatgc atttaatttt tggtggatga ccagtaattg ctttcttatt
     3061 gaagttaaat ttttgttatt tctattcttg agaaaatttt atgggctaga ggagttaact
     3121 gttaaataac agttttgaaa agcttgttat taattttagc aaagcccaag ggaaatagtt
     3181 cagaactgaa acatgtagtc caagtgatga atgaaaaacc aaaagttttt attttcaaat
     3241 ttaaaaatca aagtatataa gacctcttgg cactcttttt taataagtac cttagtctta
     3301 gggccctatc cccaggcact ctaaaaagat ttacgaactc taaaatccct taatagactg
     3361 attttcaaaa gtgctcatgg aaaataattc gaacaaaaat aaatacagcc accaggaaag
     3421 aagggaaaag aagcaaggga taatggccat ttttgaagag aaaagtgaaa aacaagtgaa
     3481 ggaaaaaaag aatagaaaaa ggaataaggt aactataatc acagtattct ttttggagtt
     3541 ttgctttggt ttttattcga gaatgttaca attaagcata aaccgcaaca gcaataattt
     3601 aaagtgtttg gttatcatct ggcataaaaa tttcagttag ctatcttttc tagatgtgca
     3661 caaaattgat gttaataaaa ctggttcctg ccctctaa
//
