LOCUS       NM_001166034            1946 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens suprabasin (SBSN), transcript variant 1, mRNA.
ACCESSION   NM_001166034
VERSION     NM_001166034.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1946)
  AUTHORS   Chen,H., Chen,X., Zhang,Z., Bao,W., Gao,Z., Li,D., Xie,X., Zhou,P.,
            Yang,C., Zhou,Z., Pan,J., Kuang,X., Tang,R., Feng,Z., Zhou,L.,
            Zhu,D., Yang,J., Wang,L., Huang,H., Tang,D., Liu,J. and Jiang,L.
  TITLE     Extracellular vesicles-transferred SBSN drives glioma
            aggressiveness by activating NF-kappaB via ANXA1-dependent
            ubiquitination of NEMO
  JOURNAL   Oncogene 41 (49), 5253-5265 (2022)
   PUBMED   36316443
  REMARK    GeneRIF: Extracellular vesicles-transferred SBSN drives glioma
            aggressiveness by activating NF-kappaB via ANXA1-dependent
            ubiquitination of NEMO.
REFERENCE   2  (bases 1 to 1946)
  AUTHORS   Tan,H., Wang,L. and Liu,Z.
  TITLE     Suprabasin: Role in human cancers and other diseases
  JOURNAL   Mol Biol Rep 49 (2), 1453-1461 (2022)
   PUBMED   34775572
  REMARK    GeneRIF: Suprabasin: Role in human cancers and other diseases.
            Review article
REFERENCE   3  (bases 1 to 1946)
  AUTHORS   Pribyl,M., Hodny,Z. and Kubikova,I.
  TITLE     Suprabasin-A Review
  JOURNAL   Genes (Basel) 12 (1), 108 (2021)
   PUBMED   33477529
  REMARK    GeneRIF: Suprabasin-A Review.
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1946)
  AUTHORS   Pribyl,M., Hubackova,S., Moudra,A., Vancurova,M., Polackova,H.,
            Stopka,T., Jonasova,A., Bokorova,R., Fuchs,O., Stritesky,J.,
            Salovska,B., Bartek,J. and Hodny,Z.
  TITLE     Aberrantly elevated suprabasin in the bone marrow as a candidate
            biomarker of advanced disease state in myelodysplastic syndromes
  JOURNAL   Mol Oncol 14 (10), 2403-2419 (2020)
   PUBMED   32696549
  REMARK    GeneRIF: Aberrantly elevated suprabasin in the bone marrow as a
            candidate biomarker of advanced disease state in myelodysplastic
            syndromes.
REFERENCE   5  (bases 1 to 1946)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1946)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   7  (bases 1 to 1946)
  AUTHORS   Toulza,E., Mattiuzzo,N.R., Galliano,M.F., Jonca,N., Dossat,C.,
            Jacob,D., de Daruvar,A., Wincker,P., Serre,G. and Guerrin,M.
  TITLE     Large-scale identification of human genes implicated in epidermal
            barrier function
  JOURNAL   Genome Biol 8 (6), R107 (2007)
   PUBMED   17562024
REFERENCE   8  (bases 1 to 1946)
  AUTHORS   Matsui,T., Hayashi-Kisumi,F., Kinoshita,Y., Katahira,S., Morita,K.,
            Miyachi,Y., Ono,Y., Imai,T., Tanigawa,Y., Komiya,T. and Tsukita,S.
  TITLE     Identification of novel keratinocyte-secreted peptides
            dermokine-alpha/-beta and a new stratified epithelium-secreted
            protein gene complex on human chromosome 19q13.1
  JOURNAL   Genomics 84 (2), 384-397 (2004)
   PUBMED   15234001
REFERENCE   9  (bases 1 to 1946)
  AUTHORS   Moffatt,P., Salois,P., St-Amant,N., Gaumond,M.H. and Lanctot,C.
  TITLE     Identification of a conserved cluster of skin-specific genes
            encoding secreted proteins
  JOURNAL   Gene 334, 123-131 (2004)
   PUBMED   15256262
REFERENCE   10 (bases 1 to 1946)
  AUTHORS   Park,G.T., Lim,S.E., Jang,S.I. and Morasso,M.I.
  TITLE     Suprabasin, a novel epidermal differentiation marker and potential
            cornified envelope precursor
  JOURNAL   J Biol Chem 277 (47), 45195-45202 (2002)
   PUBMED   12228223
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY358701.1, BX648076.1, BF838582.1 and CU448844.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001166034.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX648076.1, SRR1803612.445973.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145893, SAMEA2147596
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000452271.7/ ENSP00000430242.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AY358701.1         41-41
            2-922               BX648076.1         4-924
            923-1110            BF838582.1         34-221
            1111-1301           CU448844.1         104-294
            1302-1946           BX648076.1         1304-1948
FEATURES             Location/Qualifiers
     source          1..1946
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.12"
     gene            1..1946
                     /gene="SBSN"
                     /gene_synonym="UNQ698"
                     /note="suprabasin"
                     /db_xref="GeneID:374897"
                     /db_xref="HGNC:HGNC:24950"
                     /db_xref="MIM:609969"
     exon            1..894
                     /gene="SBSN"
                     /gene_synonym="UNQ698"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..1803
                     /gene="SBSN"
                     /gene_synonym="UNQ698"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; HLAR698"
                     /codon_start=1
                     /product="suprabasin isoform 1 precursor"
                     /protein_id="NP_001159506.1"
                     /db_xref="CCDS:CCDS54253.1"
                     /db_xref="GeneID:374897"
                     /db_xref="HGNC:HGNC:24950"
                     /db_xref="MIM:609969"
                     /translation="MHLARLVGSCSLLLLLGALSGWAASDDPIEKVIEGINRGLSNAE
                     REVGKALDGINSGITHAGREVEKVFNGLSNMGSHTGKELDKGVQGLNHGMDKVAHEIN
                     HGIGQAGKEAEKLGHGVNNAAGQVGKEADKLIHHGVHHGANQAGSEAGKFGQGVDNAA
                     GQAGNEAGRFGQGVHHAAGQAGNEAGRFGQGVHHAAGQAGNEAGRFGQGAHHGLSEGW
                     KETEKFGQGIHHAAGQVGKEAEKFGQGAHHAAGQAGNEAGRFGQGVHHGLSEGWKETE
                     KFGQGVHHTAGQVGKEAEKFGQGAHHAAGQAGNEAGRFGQGAHHAAGQAGNEAGRFGQ
                     GVHHGLSEGWKETEKFGQGVHHAASQFGKETEKLGHGVHHGVNEAWKEAEKFGQGVHH
                     AASQVGKEEDRVVQGLHHGVSQAGREAGQFGHDIHHTAGQAGKEGDIAVHGVQPGVHE
                     AGKEAGQFGQGVHHTLEQAGKEADKAVQGFHTGVHQAGKEAEKLGQGVNHAADQAGKE
                     VEKLGQGAHHAAGQAGKELQNAHNGVNQASKEANQLLNGNHQSGSSSHQGGATTTPLA
                     SGASVNTPFINLPALWRSVANIMP"
     exon            895..1668
                     /gene="SBSN"
                     /gene_synonym="UNQ698"
                     /inference="alignment:Splign:2.1.0"
     exon            1669..1734
                     /gene="SBSN"
                     /gene_synonym="UNQ698"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..1779
                     /gene="SBSN"
                     /gene_synonym="UNQ698"
                     /inference="alignment:Splign:2.1.0"
     exon            1780..1946
                     /gene="SBSN"
                     /gene_synonym="UNQ698"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1929..1934
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SBSN"
                     /gene_synonym="UNQ698"
                     /note="hexamer: AATAAA"
     polyA_site      1946
                     /gene="SBSN"
                     /gene_synonym="UNQ698"
                     /note="major polyA site"
ORIGIN      
        1 ctctgcatcc ttcccgacct tcccagcaat atgcatcttg cacgtctggt cggctcctgc
       61 tccctccttc tgctactggg ggccctgtct ggatgggcgg ccagcgatga ccccattgag
      121 aaggtcattg aagggatcaa ccgagggctg agcaatgcag agagagaggt gggcaaggcc
      181 ctggatggca tcaacagtgg aatcacgcat gccggaaggg aagtggagaa ggttttcaac
      241 ggacttagca acatggggag ccacaccggc aaggagttgg acaaaggcgt ccaggggctc
      301 aaccacggca tggacaaggt tgcccatgag atcaaccatg gtattggaca agcaggaaag
      361 gaagcagaga agcttggcca tggggtcaac aacgctgctg gacaggttgg gaaggaggca
      421 gacaaactga tccatcatgg ggtccatcac ggggccaacc aggcgggaag tgaggcaggg
      481 aagtttggcc agggagtcga caatgctgca gggcaggctg gaaatgaggc tgggaggttt
      541 ggccagggag tccaccatgc tgcagggcag gccggaaatg aggctgggag gtttggccag
      601 ggagtccacc atgctgcagg gcaggccgga aatgaggctg ggagatttgg ccagggggcc
      661 caccatggtc tcagtgaggg ctggaaggag acagagaagt ttggccaggg gatccaccat
      721 gctgccggtc aggttgggaa ggaggcagag aagtttggcc agggggccca ccatgctgcg
      781 gggcaggccg gaaatgaggc agggagattt ggccaggggg tccaccatgg tctcagtgag
      841 ggctggaagg agacagagaa gtttggccag ggggtccacc atactgctgg tcaggttggg
      901 aaggaggcag agaagtttgg ccagggggcc caccatgctg cggggcaggc cggaaatgag
      961 gcagggagat ttggccaggg ggcccaccat gctgcggggc aggccggaaa tgaggctggg
     1021 aggtttggcc agggggtcca ccatggtctc agtgagggct ggaaggagac agagaagttt
     1081 ggccaggggg tccaccatgc tgccagtcag tttgggaagg aaacagagaa gctcggccat
     1141 ggggtccacc atggggttaa tgaggcctgg aaggaagcag agaagtttgg ccagggtgtc
     1201 caccatgctg cctcgcaggt ggggaaggag gaagacagag tggtccaagg cctccatcat
     1261 ggcgttagtc aggctggaag ggaggcgggg cagtttggcc acgacattca ccacacagca
     1321 gggcaggctg ggaaagaggg agacatagca gttcatggtg tccaacctgg ggtccacgag
     1381 gccgggaagg aggcagggca gtttggccag ggagttcacc atacccttga acaggccggg
     1441 aaggaagcag acaaagcggt ccaagggttc cacactgggg tccaccaggc tgggaaggaa
     1501 gcagagaaac ttggccaagg ggtcaaccat gctgctgacc aggctggaaa ggaagtggag
     1561 aagcttggcc aaggtgccca ccatgctgct ggccaggccg ggaaggagct gcagaatgct
     1621 cataatgggg tcaaccaagc cagcaaggag gccaaccagc tgctgaatgg caaccatcaa
     1681 agcggatctt ccagccatca aggaggggcc acaaccacgc cgttagcctc tggggcctcg
     1741 gtcaacacgc ctttcatcaa ccttcccgcc ctgtggagga gcgtcgccaa catcatgccc
     1801 taaactggca tccggccttg ctgggagaat aatgtcgccg ttgtcacatc agctgacatg
     1861 acctggaggg gttgggggtg ggggacaggt ttctgaaatc cctgaagggg gttgtactgg
     1921 gatttgtgaa taaacttgat acacta
//
