LOCUS       NM_014963               4906 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens strawberry notch homolog 2 (SBNO2), transcript variant
            1, mRNA.
ACCESSION   NM_014963 XM_375553
VERSION     NM_014963.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4906)
  AUTHORS   Brandstoetter,T., Schmoellerl,J., Grausenburger,R., Kollmann,S.,
            Doma,E., Huuhtanen,J., Klampfl,T., Eder,T., Grebien,F.,
            Hoermann,G., Zuber,J., Mustjoki,S., Maurer,B. and Sexl,V.
  TITLE     SBNO2 is a critical mediator of STAT3-driven hematological
            malignancies
  JOURNAL   Blood 141 (15), 1831-1845 (2023)
   PUBMED   36630607
  REMARK    GeneRIF: SBNO2 is a critical mediator of STAT3-driven hematological
            malignancies.
REFERENCE   2  (bases 1 to 4906)
  AUTHORS   Coppieters,N., Scalisi,J., Digregorio,M., Leparc,L., Velazquez
            Saez,L., Lombard,A., Rogister,B. and Neirinckx,V.
  TITLE     Study of Strawberry Notch homolog 1 and 2 expression in human
            glioblastoma
  JOURNAL   J Neurooncol 161 (3), 515-523 (2023)
   PUBMED   36695974
  REMARK    GeneRIF: Study of Strawberry Notch homolog 1 and 2 expression in
            human glioblastoma.
REFERENCE   3  (bases 1 to 4906)
  AUTHORS   Grill,M., Syme,T.E., Nocon,A.L., Lu,A.Z., Hancock,D., Rose-John,S.
            and Campbell,I.L.
  TITLE     Strawberry notch homolog 2 is a novel inflammatory response factor
            predominantly but not exclusively expressed by astrocytes in the
            central nervous system
  JOURNAL   Glia 63 (10), 1738-1752 (2015)
   PUBMED   25903009
REFERENCE   4  (bases 1 to 4906)
  AUTHORS   Jostins,L., Ripke,S., Weersma,R.K., Duerr,R.H., McGovern,D.P.,
            Hui,K.Y., Lee,J.C., Schumm,L.P., Sharma,Y., Anderson,C.A.,
            Essers,J., Mitrovic,M., Ning,K., Cleynen,I., Theatre,E.,
            Spain,S.L., Raychaudhuri,S., Goyette,P., Wei,Z., Abraham,C.,
            Achkar,J.P., Ahmad,T., Amininejad,L., Ananthakrishnan,A.N.,
            Andersen,V., Andrews,J.M., Baidoo,L., Balschun,T., Bampton,P.A.,
            Bitton,A., Boucher,G., Brand,S., Buning,C., Cohain,A., Cichon,S.,
            D'Amato,M., De Jong,D., Devaney,K.L., Dubinsky,M., Edwards,C.,
            Ellinghaus,D., Ferguson,L.R., Franchimont,D., Fransen,K.,
            Gearry,R., Georges,M., Gieger,C., Glas,J., Haritunians,T., Hart,A.,
            Hawkey,C., Hedl,M., Hu,X., Karlsen,T.H., Kupcinskas,L.,
            Kugathasan,S., Latiano,A., Laukens,D., Lawrance,I.C., Lees,C.W.,
            Louis,E., Mahy,G., Mansfield,J., Morgan,A.R., Mowat,C., Newman,W.,
            Palmieri,O., Ponsioen,C.Y., Potocnik,U., Prescott,N.J.,
            Regueiro,M., Rotter,J.I., Russell,R.K., Sanderson,J.D., Sans,M.,
            Satsangi,J., Schreiber,S., Simms,L.A., Sventoraityte,J.,
            Targan,S.R., Taylor,K.D., Tremelling,M., Verspaget,H.W., De Vos,M.,
            Wijmenga,C., Wilson,D.C., Winkelmann,J., Xavier,R.J., Zeissig,S.,
            Zhang,B., Zhang,C.K., Zhao,H., Silverberg,M.S., Annese,V.,
            Hakonarson,H., Brant,S.R., Radford-Smith,G., Mathew,C.G.,
            Rioux,J.D., Schadt,E.E., Daly,M.J., Franke,A., Parkes,M.,
            Vermeire,S., Barrett,J.C. and Cho,J.H.
  CONSRTM   International IBD Genetics Consortium (IIBDGC)
  TITLE     Host-microbe interactions have shaped the genetic architecture of
            inflammatory bowel disease
  JOURNAL   Nature 491 (7422), 119-124 (2012)
   PUBMED   23128233
REFERENCE   5  (bases 1 to 4906)
  AUTHORS   Franke,A., McGovern,D.P., Barrett,J.C., Wang,K.,
            Radford-Smith,G.L., Ahmad,T., Lees,C.W., Balschun,T., Lee,J.,
            Roberts,R., Anderson,C.A., Bis,J.C., Bumpstead,S., Ellinghaus,D.,
            Festen,E.M., Georges,M., Green,T., Haritunians,T., Jostins,L.,
            Latiano,A., Mathew,C.G., Montgomery,G.W., Prescott,N.J.,
            Raychaudhuri,S., Rotter,J.I., Schumm,P., Sharma,Y., Simms,L.A.,
            Taylor,K.D., Whiteman,D., Wijmenga,C., Baldassano,R.N., Barclay,M.,
            Bayless,T.M., Brand,S., Buning,C., Cohen,A., Colombel,J.F.,
            Cottone,M., Stronati,L., Denson,T., De Vos,M., D'Inca,R.,
            Dubinsky,M., Edwards,C., Florin,T., Franchimont,D., Gearry,R.,
            Glas,J., Van Gossum,A., Guthery,S.L., Halfvarson,J.,
            Verspaget,H.W., Hugot,J.P., Karban,A., Laukens,D., Lawrance,I.,
            Lemann,M., Levine,A., Libioulle,C., Louis,E., Mowat,C., Newman,W.,
            Panes,J., Phillips,A., Proctor,D.D., Regueiro,M., Russell,R.,
            Rutgeerts,P., Sanderson,J., Sans,M., Seibold,F., Steinhart,A.H.,
            Stokkers,P.C., Torkvist,L., Kullak-Ublick,G., Wilson,D.,
            Walters,T., Targan,S.R., Brant,S.R., Rioux,J.D., D'Amato,M.,
            Weersma,R.K., Kugathasan,S., Griffiths,A.M., Mansfield,J.C.,
            Vermeire,S., Duerr,R.H., Silverberg,M.S., Satsangi,J.,
            Schreiber,S., Cho,J.H., Annese,V., Hakonarson,H., Daly,M.J. and
            Parkes,M.
  TITLE     Genome-wide meta-analysis increases to 71 the number of confirmed
            Crohn's disease susceptibility loci
  JOURNAL   Nat Genet 42 (12), 1118-1125 (2010)
   PUBMED   21102463
REFERENCE   6  (bases 1 to 4906)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   7  (bases 1 to 4906)
  AUTHORS   Torkvist,L., Halfvarson,J., Ong,R.T., Lordal,M., Sjoqvist,U.,
            Bresso,F., Bjork,J., Befrits,R., Lofberg,R., Blom,J., Carlson,M.,
            Padyukov,L., D'Amato,M., Seielstad,M. and Pettersson,S.
  TITLE     Analysis of 39 Crohn's disease risk loci in Swedish inflammatory
            bowel disease patients
  JOURNAL   Inflamm Bowel Dis 16 (6), 907-909 (2010)
   PUBMED   19760754
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 4906)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 4906)
  AUTHORS   Anderson,C.A., Massey,D.C., Barrett,J.C., Prescott,N.J.,
            Tremelling,M., Fisher,S.A., Gwilliam,R., Jacob,J., Nimmo,E.R.,
            Drummond,H., Lees,C.W., Onnie,C.M., Hanson,C., Blaszczyk,K.,
            Ravindrarajah,R., Hunt,S., Varma,D., Hammond,N., Lewis,G.,
            Attlesey,H., Watkins,N., Ouwehand,W., Strachan,D., McArdle,W.,
            Lewis,C.M., Lobo,A., Sanderson,J., Jewell,D.P., Deloukas,P.,
            Mansfield,J.C., Mathew,C.G., Satsangi,J. and Parkes,M.
  CONSRTM   Wellcome Trust Case Control Consortium
  TITLE     Investigation of Crohn's disease risk loci in ulcerative colitis
            further defines their molecular relationship
  JOURNAL   Gastroenterology 136 (2), 523-9 (2009)
   PUBMED   19068216
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   10 (bases 1 to 4906)
  AUTHORS   El Kasmi,K.C., Smith,A.M., Williams,L., Neale,G., Panopoulos,A.D.,
            Watowich,S.S., Hacker,H., Foxwell,B.M. and Murray,P.J.
  TITLE     Cutting edge: A transcriptional repressor and corepressor induced
            by the STAT3-regulated anti-inflammatory signaling pathway
  JOURNAL   J Immunol 179 (11), 7215-7219 (2007)
   PUBMED   18025162
  REMARK    GeneRIF: The SBNO2 is component of the pathways that contribute to
            the downstream anti-inflammatory effects of IL-10.
            Erratum:[J Immunol. 2008 Mar 1;180(5):3612. Panopolous, Athanasia
            [corrected to Panopoulos, Athanasia D]]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC400108.1, AB023180.1, BQ950129.1, BG332816.1, AK125139.1 and
            AI433817.1.
            
            On Nov 23, 2018 this sequence version replaced NM_014963.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB023180.1, AK292407.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361757.8/ ENSP00000354733.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 DC400108.1         16-23
            9-1308              AB023180.1         1-1300
            1309-1924           BQ950129.1         83-698
            1925-2443           BG332816.1         125-643
            2444-4902           AK125139.1         2074-4532
            4903-4906           AI433817.1         28-31               c
FEATURES             Location/Qualifiers
     source          1..4906
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..4906
                     /gene="SBNO2"
                     /gene_synonym="KIAA0963; SNO; STNO"
                     /note="strawberry notch homolog 2"
                     /db_xref="GeneID:22904"
                     /db_xref="HGNC:HGNC:29158"
                     /db_xref="MIM:615729"
     exon            1..97
                     /gene="SBNO2"
                     /gene_synonym="KIAA0963; SNO; STNO"
                     /inference="alignment:Splign:2.1.0"
     exon            98..316
                     /gene="SBNO2"
                     /gene_synonym="KIAA0963; SNO; STNO"
                     /inference="alignment:Splign:2.1.0"
     CDS             224..4324
                     /gene="SBNO2"
                     /gene_synonym="KIAA0963; SNO; STNO"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein strawberry notch homolog 2"
                     /codon_start=1
                     /product="protein strawberry notch homolog 2 isoform 1"
                     /protein_id="NP_055778.2"
                     /db_xref="CCDS:CCDS45894.1"
                     /db_xref="GeneID:22904"
                     /db_xref="HGNC:HGNC:29158"
                     /db_xref="MIM:615729"
                     /translation="MLAVGPAMDRDYPQHEPPPAGSLLYSPPPLQSAMLHCPYWNTFS
                     LPPYPAFSSDSRPFMSSASFLGSQPCPDTSYAPVATASSLPPKTCDFAQDSSYFEDFS
                     NISIFSSSVDSLSDIVDTPDFLPADSLNQVSTIWDDNPAPSTHDKLFQLSRPFAGFED
                     FLPSHSTPLLVSYQEQSVQSQPEEEDEAEEEEAEELGHTETYADYVPSKSKIGKQHPD
                     RVVETSTLSSVPPPDITYTLALPSDSGALSALQLEAITYACQQHEVLLPSGQRAGFLI
                     GDGAGVGKGRTVAGVILENHLRGRKKALWFSVSNDLKYDAERDLRDIEATGIAVHALS
                     KIKYGDTTTSEGVLFATYSALIGESQAGGQHRTRLRQILDWCGEAFEGVIVFDECHKA
                     KNAGSTKMGKAVLDLQNKLPLARVVYASATGASEPRNMIYMSRLGIWGEGTPFRNFEE
                     FLHAIEKRGVGAMEIVAMDMKVSGMYIARQLSFSGVTFRIEEIPLAPAFECVYNRAAL
                     LWAEALNVFQQAADWIGLESRKSLWGQFWSAHQRFFKYLCIAAKVRRLVELAREELAR
                     DKCVVIGLQSTGEARTREVLGENDGHLNCFVSAAEGVFLSLIQKHFPSTKRKRDRGAG
                     SKRKRRPRGRGAKAPRLACETAGVIRISDDSSTESDPGLDSDFNSSPESLVDDDVVIV
                     DAVGLPSDDRGPLCLLQRDPHGPGVLERVERLKQDLLDKVRRLGRELPVNTLDELIDQ
                     LGGPQRVAEMTGRKGRVVSRPDGTVAFESRAEQGLSIDHVNLREKQRFMSGEKLVAII
                     SEASSSGVSLQADRRVQNQRRRVHMTLELPWSADRAIQQFGRTHRSNQVSAPEYVFLI
                     SELAGERRFASIVAKRLESLGALTHGDRRATESRDLSKYNFENKYGTRALHCVLTTIL
                     SQTENKVPVPQGYPGGVPTFFRDMKQGLLSVGIGGRESRNGCLDVEKDCSITKFLNRI
                     LGLEVHKQNALFQYFSDTFDHLIEMDKREGKYDMGILDLAPGIEEIYEESQQVFLAPG
                     HPQDGQVVFYKISVDRGLKWEDAFAKSLALTGPYDGFYLSYKVRGNKPSCLLAEQNRG
                     QFFTVYKPNIGRQSQLEALDSLRRKFHRVTAEEAKEPWESGYALSLTHCSHSAWNRHC
                     RLAQEGKDCLQGLRLRHHYMLCGALLRVWGRIAAVMADVSSSSYLQIVRLKTKDRKKQ
                     VGIKIPEGCVRRVLQELRLMDADVKRRQAPALGCPAPPAPRPLALPCGPGEVLDLTYS
                     PPAEAFPPPPHFSFPAPLSLDAGPGVVPLGTPDAQADPAALAHQGCDINFKEVLEDML
                     RSLHAGPPSEGALGEGAGAGGAAGGGPERQSVIQFSPPFPGAQAPL"
     exon            317..390
                     /gene="SBNO2"
                     /gene_synonym="KIAA0963; SNO; STNO"
                     /inference="alignment:Splign:2.1.0"
     exon            391..502
                     /gene="SBNO2"
                     /gene_synonym="KIAA0963; SNO; STNO"
                     /inference="alignment:Splign:2.1.0"
     exon            503..664
                     /gene="SBNO2"
                     /gene_synonym="KIAA0963; SNO; STNO"
                     /inference="alignment:Splign:2.1.0"
     exon            665..745
                     /gene="SBNO2"
                     /gene_synonym="KIAA0963; SNO; STNO"
                     /inference="alignment:Splign:2.1.0"
     exon            746..851
                     /gene="SBNO2"
                     /gene_synonym="KIAA0963; SNO; STNO"
                     /inference="alignment:Splign:2.1.0"
     exon            852..1003
                     /gene="SBNO2"
                     /gene_synonym="KIAA0963; SNO; STNO"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1137
                     /gene="SBNO2"
                     /gene_synonym="KIAA0963; SNO; STNO"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1228
                     /gene="SBNO2"
                     /gene_synonym="KIAA0963; SNO; STNO"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1372
                     /gene="SBNO2"
                     /gene_synonym="KIAA0963; SNO; STNO"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1490
                     /gene="SBNO2"
                     /gene_synonym="KIAA0963; SNO; STNO"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..1596
                     /gene="SBNO2"
                     /gene_synonym="KIAA0963; SNO; STNO"
                     /inference="alignment:Splign:2.1.0"
     exon            1597..1750
                     /gene="SBNO2"
                     /gene_synonym="KIAA0963; SNO; STNO"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..1927
                     /gene="SBNO2"
                     /gene_synonym="KIAA0963; SNO; STNO"
                     /inference="alignment:Splign:2.1.0"
     exon            1928..2025
                     /gene="SBNO2"
                     /gene_synonym="KIAA0963; SNO; STNO"
                     /inference="alignment:Splign:2.1.0"
     exon            2026..2108
                     /gene="SBNO2"
                     /gene_synonym="KIAA0963; SNO; STNO"
                     /inference="alignment:Splign:2.1.0"
     exon            2109..2300
                     /gene="SBNO2"
                     /gene_synonym="KIAA0963; SNO; STNO"
                     /inference="alignment:Splign:2.1.0"
     exon            2301..2470
                     /gene="SBNO2"
                     /gene_synonym="KIAA0963; SNO; STNO"
                     /inference="alignment:Splign:2.1.0"
     exon            2471..2602
                     /gene="SBNO2"
                     /gene_synonym="KIAA0963; SNO; STNO"
                     /inference="alignment:Splign:2.1.0"
     exon            2603..2738
                     /gene="SBNO2"
                     /gene_synonym="KIAA0963; SNO; STNO"
                     /inference="alignment:Splign:2.1.0"
     exon            2739..2851
                     /gene="SBNO2"
                     /gene_synonym="KIAA0963; SNO; STNO"
                     /inference="alignment:Splign:2.1.0"
     exon            2852..2923
                     /gene="SBNO2"
                     /gene_synonym="KIAA0963; SNO; STNO"
                     /inference="alignment:Splign:2.1.0"
     exon            2924..3032
                     /gene="SBNO2"
                     /gene_synonym="KIAA0963; SNO; STNO"
                     /inference="alignment:Splign:2.1.0"
     exon            3033..3107
                     /gene="SBNO2"
                     /gene_synonym="KIAA0963; SNO; STNO"
                     /inference="alignment:Splign:2.1.0"
     exon            3108..3251
                     /gene="SBNO2"
                     /gene_synonym="KIAA0963; SNO; STNO"
                     /inference="alignment:Splign:2.1.0"
     exon            3252..3346
                     /gene="SBNO2"
                     /gene_synonym="KIAA0963; SNO; STNO"
                     /inference="alignment:Splign:2.1.0"
     exon            3347..3439
                     /gene="SBNO2"
                     /gene_synonym="KIAA0963; SNO; STNO"
                     /inference="alignment:Splign:2.1.0"
     exon            3440..3571
                     /gene="SBNO2"
                     /gene_synonym="KIAA0963; SNO; STNO"
                     /inference="alignment:Splign:2.1.0"
     exon            3572..3648
                     /gene="SBNO2"
                     /gene_synonym="KIAA0963; SNO; STNO"
                     /inference="alignment:Splign:2.1.0"
     exon            3649..3839
                     /gene="SBNO2"
                     /gene_synonym="KIAA0963; SNO; STNO"
                     /inference="alignment:Splign:2.1.0"
     exon            3840..4906
                     /gene="SBNO2"
                     /gene_synonym="KIAA0963; SNO; STNO"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4883..4888
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SBNO2"
                     /gene_synonym="KIAA0963; SNO; STNO"
                     /note="hexamer: AATATA"
     polyA_site      4906
                     /gene="SBNO2"
                     /gene_synonym="KIAA0963; SNO; STNO"
                     /note="major polyA site"
ORIGIN      
        1 aagatggcgc ccgaaacccg gaagtgagcg gcggcagctg cgaggctcgg agaaacaggc
       61 gccgcgggct ccgcgcccgg ccggacccgg gcccgagatc atgatgctgc cgccaccgcc
      121 gccaccacgg agcgagaagc ccagatagac gccccggcgg ccccgggtcc tggagtcccg
      181 ccgcctgctg cccggccgag gaccccaccc cgcctgccgc ccgatgcttg cagtggggcc
      241 cgccatggac agggattacc cgcagcatga acccccgccg gcgggcagcc tcctgtacag
      301 cccgccgccc ctgcagagcg ccatgctgca ctgcccctac tggaacacct tctcgctgcc
      361 gccataccct gccttctcca gcgacagccg cccgttcatg agctccgcct ccttcctcgg
      421 cagccagccc tgcccagaca ccagctatgc ccccgtggcc accgcctcca gcttgccacc
      481 aaagacctgc gactttgctc aggactcctc ctattttgag gacttctcca acatctccat
      541 cttctcctcg tccgtggact ccctgtcgga catcgtggac acgcccgact tcctgccggc
      601 tgacagcctc aaccaggtgt ccaccatctg ggacgataac cctgccccct ccacccacga
      661 taagctgttc cagctcagca ggccgtttgc aggcttcgag gactttctgc cctcccacag
      721 caccccgctt ctcgtcagct accaggagca gagtgtgcag agccagccag aggaggagga
      781 cgaggctgag gaggaggagg cggaggagct ggggcacaca gagacctacg ccgactacgt
      841 gccgtccaag tccaagatcg ggaagcagca cccagaccgc gtggtggaga ccagcacact
      901 gtccagcgtc ccacccccag acatcaccta caccctggcc ctgccctcgg acagcggggc
      961 cctgtctgcc ctgcagctag aggccatcac ctacgcctgc cagcaacacg aggtcctgct
     1021 ccccagcggg cagcgcgcgg gctttctcat cggcgatggg gccggcgtgg gcaaaggccg
     1081 gacggtggcc ggagtcatcc tggagaacca cctgcgcggc cggaagaaag cattgtggtt
     1141 cagcgtctcc aacgacctca agtacgatgc ggagcgcgac ctgcgggaca tcgaagccac
     1201 gggcatcgcg gtgcacgcgc tcagcaagat caagtacggt gacaccacta cctcagaggg
     1261 cgtcctcttc gccacctact ccgccctgat tggggagagc caggccggcg gccagcaccg
     1321 cactcgcctc cggcagatcc tggactggtg tggggaggcc ttcgagggcg tcatcgtgtt
     1381 cgacgagtgt cacaaagcca agaatgccgg ctccaccaag atgggcaagg ctgtgctaga
     1441 cctgcagaac aagctgcccc tggcccgcgt ggtctacgcc agcgccacag gtgcctctga
     1501 gcctcggaac atgatctaca tgagccgctt gggtatctgg ggcgagggca cacccttccg
     1561 gaactttgag gagttcctgc acgccatcga gaagaggggc gttggcgcca tggagatcgt
     1621 ggccatggac atgaaggtca gcggcatgta catcgcacgc cagctcagct tctccggcgt
     1681 caccttccgc atcgaggaga tcccgctggc cccagccttc gagtgcgtct acaaccgcgc
     1741 ggccctgctg tgggccgagg ccctgaacgt gttccagcag gcggccgact ggatcggcct
     1801 ggagtcgcgc aagtccctgt ggggccagtt ctggtcggca caccagcgct tcttcaagta
     1861 tctgtgcatc gcagccaagg tgcgccggct ggtggagctg gcccgagagg agctggcgcg
     1921 agacaagtgc gtggtcatcg ggctgcagtc cacgggcgag gcgcgcacgc gggaggtgct
     1981 gggggagaac gatgggcacc tcaactgctt cgtctcggcc gctgaaggcg tgttcctgtc
     2041 gctaattcag aagcactttc cgtccaccaa gagaaagcgg gacagaggag cgggcagcaa
     2101 gcggaaacgg cgacctcggg gacgcggggc caaagccccc cggctggcgt gcgagacagc
     2161 gggcgtcatc cgcatcagtg acgacagcag cacggagtcg gaccctggcc tggacagcga
     2221 cttcaactcc tcccccgagt ccctggtgga tgacgacgtt gtcatcgttg atgcagtcgg
     2281 gctccccagt gacgaccggg gacccctgtg cctcctgcag agagacccgc atggccccgg
     2341 ggtcctggag cgggtggagc ggctgaagca ggatctgctg gacaaagtgc ggcggctggg
     2401 ccgggaactg ccagtcaaca ccctggacga gctcatcgac cagctgggcg gcccccagcg
     2461 ggtggcggag atgaccggca ggaaaggccg cgtggtgtcc aggcccgacg ggacggtggc
     2521 cttcgagtcg cgggcagagc agggtctgtc catcgaccac gtgaacctca gggagaagca
     2581 gcgcttcatg agcggcgaga agctcgtggc catcatctcg gaggcctcca gctcgggtgt
     2641 ctccctccaa gccgaccgcc gtgtccagaa ccagcggcgc cgcgtgcaca tgaccttgga
     2701 gctgccgtgg agcgccgacc gcgccatcca gcagttcggc cgcacccacc ggtccaacca
     2761 ggtctccgcg ccagagtatg tcttcctcat ctcggagctg gccggggagc gccggttcgc
     2821 ctccatcgtg gccaagcgcc tggagagtct gggggccctg acccacggag accgccgcgc
     2881 cacggagtcc cgtgacctca gcaagtacaa ctttgagaac aagtatggca cccgggccct
     2941 gcactgtgtc ctcaccacca tcctgagcca gactgagaac aaagtgcctg tgccccaggg
     3001 ataccctgga ggggtcccca ccttcttccg ggacatgaag cagggcctgc tgtctgtggg
     3061 cattggtggc cgggagtccc ggaatggctg cctggacgtg gagaaggact gttccatcac
     3121 caagttcctg aaccgcatcc tggggctgga ggtgcacaag cagaacgccc tgttccagta
     3181 cttctcagac accttcgacc acctcatcga gatggacaag cgggagggca aatacgacat
     3241 gggcatcctg gaccttgctc ccggtatcga ggagatctac gaggagagcc agcaggtgtt
     3301 cctggctccc gggcacccgc aggacgggca ggtggtcttc tacaagatca gcgtggaccg
     3361 cggcctgaag tgggaggacg cctttgccaa gtcgctggcg ctgacgggcc cctatgacgg
     3421 cttctacctc tcctacaagg tccgcggtaa caagcccagc tgcctgctgg cggagcagaa
     3481 ccgcggccag ttcttcacgg tgtacaagcc caacatcggc cggcagagcc agctggaggc
     3541 cctggacagc ctccgccgca agttccaccg ggtcaccgcg gaggaggcca aggagccctg
     3601 ggagagtggc tacgctttgt cgctgacgca ctgcagccac agcgcctgga accggcactg
     3661 ccggctggcg caggagggta aggactgcct gcaggggctg cggctgcggc accactacat
     3721 gctgtgcggc gcgctgctgc gcgtgtgggg ccgcatcgcc gccgtcatgg ccgacgtcag
     3781 cagcagcagc tacctgcaga tcgtgcggct gaagaccaag gacaggaaga agcaagtggg
     3841 catcaagatc cccgagggct gcgtgcgccg ggtgctgcag gagctgcggc tgatggatgc
     3901 ggacgtgaag cgcaggcagg cgcccgccct gggctgcccc gccccgcccg ccccgcgccc
     3961 gctggcgctg ccttgcggcc ccggagaggt gctggacctc acctacagcc ccccggccga
     4021 ggccttcccg ccgcccccgc acttctcttt cccggcgccg ctgtccctgg acgccggccc
     4081 cggcgtcgtg ccgctgggca cccccgacgc ccaggccgac cctgcggccc tcgcgcacca
     4141 gggctgcgac atcaacttca aggaggtgct ggaggacatg ctgcgctcgc tgcacgcggg
     4201 gccgccctcc gagggcgcgc tgggggaggg cgcgggggcg gggggcgcgg cgggcggtgg
     4261 tcccgagcgg cagagcgtga tccagttcag cccacccttc cccggcgccc aggctcctct
     4321 ctgacacgcc tttaggcgaa acatgcccca agacacaggg accgtttctc ccctaggagc
     4381 agcggtgggg agcagggcca aggtcccctg accactgctc agaggagccc taggccctgg
     4441 ccgcagtgcc ttcagcgccc gacccgggcc cccacctggt cagccctggc ggggcccact
     4501 caggacagct gggggccggg gcgtggcagg gccctctctg tgcctctcct cccaagtagg
     4561 aaggggctcc gggtggctgc tctgggactg ggcacccaca agggctcagt gggcccaaac
     4621 ccttgaaatc cgtgaaaccg ggtggtccca agagctagaa actcaggaaa ccccaggtgc
     4681 tcagggcccc gcgtctcggg ggctccgtgg ggcagacccc tgctaatata tgcaattctc
     4741 cctcccccag cccttccctg acccctaagt tattgcccgc tcacctctcc caggccccag
     4801 gccgcggagc tggcagggtg gcgcctgcgg tttctatgta tttatagcaa gttctgatgt
     4861 acatatgtaa aggacttttt taaatatatg tgccttttgc ctactt
//
