LOCUS       NM_001167856           11128 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens strawberry notch homolog 1 (SBNO1), transcript variant
            1, mRNA.
ACCESSION   NM_001167856 XM_005253572
VERSION     NM_001167856.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 11128)
  AUTHORS   Coppieters,N., Scalisi,J., Digregorio,M., Leparc,L., Velazquez
            Saez,L., Lombard,A., Rogister,B. and Neirinckx,V.
  TITLE     Study of Strawberry Notch homolog 1 and 2 expression in human
            glioblastoma
  JOURNAL   J Neurooncol 161 (3), 515-523 (2023)
   PUBMED   36695974
  REMARK    GeneRIF: Study of Strawberry Notch homolog 1 and 2 expression in
            human glioblastoma.
REFERENCE   2  (bases 1 to 11128)
  AUTHORS   Bulayeva,K., Lesch,K.P., Bulayev,O., Walsh,C., Glatt,S.,
            Gurgenova,F., Omarova,J., Berdichevets,I. and Thompson,P.M.
  TITLE     Genomic structural variants are linked with intellectual disability
  JOURNAL   J Neural Transm (Vienna) 122 (9), 1289-1301 (2015)
   PUBMED   25626716
REFERENCE   3  (bases 1 to 11128)
  AUTHORS   Tamagawa,Y., Ishimura,N., Uno,G., Yuki,T., Kazumori,H.,
            Ishihara,S., Amano,Y. and Kinoshita,Y.
  TITLE     Notch signaling pathway and Cdx2 expression in the development of
            Barrett's esophagus
  JOURNAL   Lab Invest 92 (6), 896-909 (2012)
   PUBMED   22449796
  REMARK    GeneRIF: Enhanced expression of Cdx2 by stimulation with bile acids
            may induce intestinal differentiation of esophageal columnar cells
            by interaction with the Notch signaling pathway.
REFERENCE   4  (bases 1 to 11128)
  AUTHORS   Taal,H.R., Pourcain,B.S., Thiering,E., Das,S., Mook-Kanamori,D.O.,
            Warrington,N.M., Kaakinen,M., Kreiner-Moller,E., Bradfield,J.P.,
            Freathy,R.M., Geller,F., Guxens,M., Cousminer,D.L., Kerkhof,M.,
            Timpson,N.J., Ikram,M.A., Beilin,L.J., Bonnelykke,K., Buxton,J.L.,
            Charoen,P., Chawes,B.L.K., Eriksson,J., Evans,D.M., Hofman,A.,
            Kemp,J.P., Kim,C.E., Klopp,N., Lahti,J., Lye,S.J., McMahon,G.,
            Mentch,F.D., Muller,M., O'Reilly,P.F., Prokopenko,I.,
            Rivadeneira,F., Steegers,E.A.P., Sunyer,J., Tiesler,C.,
            Yaghootkar,H., Breteler,M.M.B., Debette,S., Fornage,M.,
            Gudnason,V., Launer,L.J., van der Lugt,A., Mosley,T.H.,
            Seshadri,S., Smith,A.V., Vernooij,M.W., Blakemore,A.I.,
            Chiavacci,R.M., Feenstra,B., Fernandez-Benet,J., Grant,S.F.A.,
            Hartikainen,A.L., van der Heijden,A.J., Iniguez,C., Lathrop,M.,
            McArdle,W.L., Molgaard,A., Newnham,J.P., Palmer,L.J., Palotie,A.,
            Pouta,A., Ring,S.M., Sovio,U., Standl,M., Uitterlinden,A.G.,
            Wichmann,H.E., Vissing,N.H., DeCarli,C., van Duijn,C.M.,
            McCarthy,M.I., Koppelman,G.H., Estivill,X., Hattersley,A.T.,
            Melbye,M., Bisgaard,H., Pennell,C.E., Widen,E., Hakonarson,H.,
            Smith,G.D., Heinrich,J., Jarvelin,M.R. and Jaddoe,V.W.V.
  CONSRTM   Cohorts for Heart and Aging Research in Genetic Epidemiology
            (CHARGE) Consortium; Early Genetics & Lifecourse Epidemiology
            (EAGLE) consortium; Early Growth Genetics (EGG) Consortium
  TITLE     Common variants at 12q15 and 12q24 are associated with infant head
            circumference
  JOURNAL   Nat Genet 44 (5), 532-538 (2012)
   PUBMED   22504419
  REMARK    Erratum:[Nat Genet. 2013 June;45(6):713. Sorensen, Thorkild I A
            [removed]]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 11128)
  AUTHORS   Suzuki,C., Takahashi,K., Hayama,S., Ishikawa,N., Kato,T., Ito,T.,
            Tsuchiya,E., Nakamura,Y. and Daigo,Y.
  TITLE     Identification of Myc-associated protein with JmjC domain as a
            novel therapeutic target oncogene for lung cancer
  JOURNAL   Mol Cancer Ther 6 (2), 542-551 (2007)
   PUBMED   17308053
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC137767.16 and AC068768.31.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001167856.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.72761.1,
                                           SRR1660809.214416.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000602398.3/ ENSP00000473665.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-147               AC137767.16        42447-42593
            148-279             AC137767.16        56853-56984
            280-384             AC137767.16        59161-59265
            385-697             AC137767.16        61724-62036
            698-798             AC137767.16        66206-66306
            799-895             AC137767.16        70803-70899
            896-1056            AC137767.16        73081-73241
            1057-1190           AC137767.16        75919-76052
            1191-1281           AC137767.16        76785-76875
            1282-1443           AC137767.16        78399-78560
            1444-1579           AC137767.16        79267-79402
            1580-1685           AC137767.16        79482-79587
            1686-1839           AC137767.16        79715-79868
            1840-2022           AC137767.16        80960-81142
            2023-2120           AC137767.16        81695-81792
            2121-2272           AC137767.16        83463-83614
            2273-2470           AC068768.31        1535-1732
            2471-2638           AC068768.31        2401-2568
            2639-2814           AC068768.31        2660-2835
            2815-2946           AC068768.31        3236-3367
            2947-3082           AC068768.31        5911-6046
            3083-3195           AC068768.31        7607-7719
            3196-3267           AC068768.31        7823-7894
            3268-3367           AC068768.31        9548-9647
            3368-3442           AC068768.31        12138-12212
            3443-3589           AC068768.31        13411-13557
            3590-3684           AC068768.31        13684-13778
            3685-3777           AC068768.31        13865-13957
            3778-3915           AC068768.31        18548-18685
            3916-3992           AC068768.31        20367-20443
            3993-4186           AC068768.31        25096-25289
            4187-11128          AC068768.31        27217-34158
FEATURES             Location/Qualifiers
     source          1..11128
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.31"
     gene            1..11128
                     /gene="SBNO1"
                     /gene_synonym="MOP3; Sno"
                     /note="strawberry notch homolog 1"
                     /db_xref="GeneID:55206"
                     /db_xref="HGNC:HGNC:22973"
                     /db_xref="MIM:614274"
     exon            1..147
                     /gene="SBNO1"
                     /gene_synonym="MOP3; Sno"
                     /inference="alignment:Splign:2.1.0"
     CDS             148..4329
                     /gene="SBNO1"
                     /gene_synonym="MOP3; Sno"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein strawberry notch homolog 1; monocyte protein 3"
                     /codon_start=1
                     /product="protein strawberry notch homolog 1 isoform 1"
                     /protein_id="NP_001161328.1"
                     /db_xref="CCDS:CCDS53844.1"
                     /db_xref="GeneID:55206"
                     /db_xref="HGNC:HGNC:22973"
                     /db_xref="MIM:614274"
                     /translation="MVEPGQDLLLAALSESGISPNDLFDIDGGDAGLATPMPTPSVQQ
                     SVPLSALELGLETEAAVPVKQEPETVPTPALLNVRQQPPSTTTFVLNQINHLPPLGST
                     IVMTKTPPVTTNRQTITLTKFIQTTASTRPSVSAPTVRNAMTSAPSKDQVQLKDLLKN
                     NSLNELMKLKPPANIAQPVATAATDVSNGTVKKESSNKEGARMWINDMKMRSFSPTMK
                     VPVVKEDDEPEEEDEEEMGHAETYAEYMPIKLKIGLRHPDAVVETSSLSSVTPPDVWY
                     KTSISEETIDNGWLSALQLEAITYAAQQHETFLPNGDRAGFLIGDGAGVGKGRTIAGI
                     IYENYLLSRKRALWFSVSNDLKYDAERDLRDIGAKNILVHSLNKFKYGKISSKHNGSV
                     KKGVIFATYSSLIGESQSGGKYKTRLKQLLHWCGDDFDGVIVFDECHKAKNLCPVGSS
                     KPTKTGLAVLELQNKLPKARVVYASATGASEPRNMAYMNRLGIWGEGTPFREFSDFIQ
                     AVERRGVGAMEIVAMDMKLRGMYIARQLSFTGVTFKIEEVLLSQSYVKMYNKAVKLWV
                     IARERFQQAADLIDAEQRMKKSMWGQFWSAHQRFFKYLCIASKVKRVVQLAREEIKNG
                     KCVVIGLQSTGEARTLEALEEGGGELNDFVSTAKGVLQSLIEKHFPAPDRKKLYSLLG
                     IDLTAPSNNSSPRDSPCKENKIKKRKGEEITREAKKARKVGGLTGSSSDDSGSESDAS
                     DNEESDYESSKNMSSGDDDDFNPFLDESNEDDENDPWLIRKDHKKNKEKKKKKSIDPD
                     SIQSALLASGLGSKRPSFSSTPVISPAPNSTPANSNTNSNSSLITSQDAVERAQQMKK
                     DLLDKLEKLAEDLPPNTLDELIDELGGPENVAEMTGRKGRVVSNDDGSISYESRSELD
                     VPVEILNITEKQRFMDGDKNIAIISEAASSGISLQADRRAKNQRRRVHMTLELPWSAD
                     RAIQQFGRTHRSNQVTAPEYVFLISELAGEQRFASIVAKRLESLGALTHGDRRATESR
                     DLSRFNFDNKYGRNALEIVMKSIVNLDSPMVSPPPDYPGEFFKDVRQGLIGVGLINVE
                     DRSGILTLDKDYNNIGKFLNRILGMEVHQQNALFQYFADTLTAVVQNAKKNGRYDMGI
                     LDLGSGDEKVRKSDVKKFLTPGYSTSGHVELYTISVERGMSWEEATKIWAELTGPDDG
                     FYLSLQIRNNKKTAILVKEVNPKKKLFLVYRPNTGKQLKLEIYADLKKKYKKVVSDDA
                     LMHWLDQYNSSADTCTHAYWRGNCKKASLGLVCEIGLRCRTYYVLCGSVLSVWTKVEG
                     VLASVSGTNVKMQIVRLRTEDGQRIVGLIIPANCVSPLVNLLSTSDQSQQLAVQQKQL
                     WQQHHPQSITNLSNA"
     exon            148..279
                     /gene="SBNO1"
                     /gene_synonym="MOP3; Sno"
                     /inference="alignment:Splign:2.1.0"
     exon            280..384
                     /gene="SBNO1"
                     /gene_synonym="MOP3; Sno"
                     /inference="alignment:Splign:2.1.0"
     exon            385..697
                     /gene="SBNO1"
                     /gene_synonym="MOP3; Sno"
                     /inference="alignment:Splign:2.1.0"
     exon            698..798
                     /gene="SBNO1"
                     /gene_synonym="MOP3; Sno"
                     /inference="alignment:Splign:2.1.0"
     exon            799..895
                     /gene="SBNO1"
                     /gene_synonym="MOP3; Sno"
                     /inference="alignment:Splign:2.1.0"
     exon            896..1056
                     /gene="SBNO1"
                     /gene_synonym="MOP3; Sno"
                     /inference="alignment:Splign:2.1.0"
     exon            1057..1190
                     /gene="SBNO1"
                     /gene_synonym="MOP3; Sno"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1281
                     /gene="SBNO1"
                     /gene_synonym="MOP3; Sno"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1443
                     /gene="SBNO1"
                     /gene_synonym="MOP3; Sno"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1579
                     /gene="SBNO1"
                     /gene_synonym="MOP3; Sno"
                     /inference="alignment:Splign:2.1.0"
     exon            1580..1685
                     /gene="SBNO1"
                     /gene_synonym="MOP3; Sno"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..1839
                     /gene="SBNO1"
                     /gene_synonym="MOP3; Sno"
                     /inference="alignment:Splign:2.1.0"
     exon            1840..2022
                     /gene="SBNO1"
                     /gene_synonym="MOP3; Sno"
                     /inference="alignment:Splign:2.1.0"
     exon            2023..2120
                     /gene="SBNO1"
                     /gene_synonym="MOP3; Sno"
                     /inference="alignment:Splign:2.1.0"
     exon            2121..2272
                     /gene="SBNO1"
                     /gene_synonym="MOP3; Sno"
                     /inference="alignment:Splign:2.1.0"
     exon            2273..2470
                     /gene="SBNO1"
                     /gene_synonym="MOP3; Sno"
                     /inference="alignment:Splign:2.1.0"
     exon            2471..2638
                     /gene="SBNO1"
                     /gene_synonym="MOP3; Sno"
                     /inference="alignment:Splign:2.1.0"
     exon            2639..2814
                     /gene="SBNO1"
                     /gene_synonym="MOP3; Sno"
                     /inference="alignment:Splign:2.1.0"
     exon            2815..2946
                     /gene="SBNO1"
                     /gene_synonym="MOP3; Sno"
                     /inference="alignment:Splign:2.1.0"
     exon            2947..3082
                     /gene="SBNO1"
                     /gene_synonym="MOP3; Sno"
                     /inference="alignment:Splign:2.1.0"
     exon            3083..3195
                     /gene="SBNO1"
                     /gene_synonym="MOP3; Sno"
                     /inference="alignment:Splign:2.1.0"
     exon            3196..3267
                     /gene="SBNO1"
                     /gene_synonym="MOP3; Sno"
                     /inference="alignment:Splign:2.1.0"
     exon            3268..3367
                     /gene="SBNO1"
                     /gene_synonym="MOP3; Sno"
                     /inference="alignment:Splign:2.1.0"
     exon            3368..3442
                     /gene="SBNO1"
                     /gene_synonym="MOP3; Sno"
                     /inference="alignment:Splign:2.1.0"
     exon            3443..3589
                     /gene="SBNO1"
                     /gene_synonym="MOP3; Sno"
                     /inference="alignment:Splign:2.1.0"
     exon            3590..3684
                     /gene="SBNO1"
                     /gene_synonym="MOP3; Sno"
                     /inference="alignment:Splign:2.1.0"
     exon            3685..3777
                     /gene="SBNO1"
                     /gene_synonym="MOP3; Sno"
                     /inference="alignment:Splign:2.1.0"
     exon            3778..3915
                     /gene="SBNO1"
                     /gene_synonym="MOP3; Sno"
                     /inference="alignment:Splign:2.1.0"
     exon            3916..3992
                     /gene="SBNO1"
                     /gene_synonym="MOP3; Sno"
                     /inference="alignment:Splign:2.1.0"
     exon            3993..4186
                     /gene="SBNO1"
                     /gene_synonym="MOP3; Sno"
                     /inference="alignment:Splign:2.1.0"
     exon            4187..11128
                     /gene="SBNO1"
                     /gene_synonym="MOP3; Sno"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5687..5692
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SBNO1"
                     /gene_synonym="MOP3; Sno"
                     /note="hexamer: AATAAA"
     polyA_site      5710
                     /gene="SBNO1"
                     /gene_synonym="MOP3; Sno"
                     /note="major polyA site"
     regulatory      11109..11114
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SBNO1"
                     /gene_synonym="MOP3; Sno"
                     /note="hexamer: AATAAA"
     polyA_site      11128
                     /gene="SBNO1"
                     /gene_synonym="MOP3; Sno"
                     /note="major polyA site"
ORIGIN      
        1 aggggcgtca agatggcggc ggggaggtag gcagagcagg acgccgctgc tgccgccgcc
       61 accgccgcct ccgctccagt cgcctctggt ccttcaaact cacacctccc gggaggagct
      121 gtgctggcgc cgggtcccgc ggggaaaatg gtggagccag ggcaagattt actgcttgct
      181 gctttgagtg agagtggaat tagtccgaat gacctctttg atattgatgg tggagatgca
      241 gggcttgcaa ctccaatgcc taccccgtca gttcagcagt cagtgccact tagtgcatta
      301 gaactaggtt tggagaccga agcagcagtt cctgttaaac aagaaccaga gactgtacct
      361 actccagcac tattaaatgt gaggcagcag cctccatcta ctacaacatt tgtgctgaat
      421 caaataaatc atcttccacc cttgggatct acaattgtaa tgactaaaac accacctgta
      481 acaaccaaca ggcaaaccat cactttaact aagtttatcc agactactgc aagcacacgc
      541 ccgtcagtct cagcaccaac agtacgaaat gccatgacct ctgcaccttc aaaagaccaa
      601 gttcagctta aagatctact gaaaaataat agtcttaatg aactgatgaa actaaagcca
      661 cctgctaata ttgctcagcc agtagcaaca gcagctactg atgtaagcaa tggtacagta
      721 aagaaagagt cttctaataa agaaggagct agaatgtgga taaacgacat gaagatgagg
      781 agtttttccc caaccatgaa ggttcctgtt gtaaaagaag atgatgaacc agaggaagaa
      841 gatgaagaag aaatgggtca tgcagaaacc tatgcagaat acatgccaat aaaattaaaa
      901 attggcctac gtcatccaga tgctgtagtg gaaaccagct ctttatccag tgttactcct
      961 cctgatgttt ggtacaaaac atccatttct gaggaaacca ttgataatgg ctggttatca
     1021 gcattgcagc ttgaggcaat tacatatgca gcccagcaac atgaaacttt cctacctaat
     1081 ggagatcgtg ctggcttctt aataggtgat ggtgccggtg taggaaaagg aaggacgata
     1141 gcaggaatca tctatgaaaa ttatttgttg agtagaaaac gagcattgtg gtttagtgtt
     1201 tcaaatgact taaagtatga tgctgaaaga gatttaaggg atattggagc aaaaaacatt
     1261 ttggttcatt cgttaaataa gtttaaatac ggaaaaattt cttccaaaca taatgggagt
     1321 gtgaaaaagg gtgttatttt tgctacttac tcttcactta ttggtgaaag ccagtctggc
     1381 ggcaagtata aaactaggtt aaaacaactt ctgcattggt gcggtgatga cttcgatgga
     1441 gtgatagtgt ttgatgagtg tcataaagcc aaaaacttat gtcctgttgg ttcttcaaag
     1501 ccaaccaaga caggcttagc agttttagag cttcagaaca aattgccaaa agccagagtt
     1561 gtttatgcta gtgcaactgg tgcttctgaa ccacgcaaca tggcctatat gaaccgtctt
     1621 ggcatatggg gtgagggtac tccatttaga gaattcagtg attttattca agcagtagaa
     1681 cggagaggag ttggtgccat ggaaatagtt gctatggata tgaagcttag aggaatgtac
     1741 attgctcgac aactgagctt tactggagtg accttcaaaa ttgaggaagt tcttctttct
     1801 cagagctacg ttaaaatgta taacaaagct gtcaagctgt gggtcatcgc cagagagcgg
     1861 tttcagcaag ctgcagatct gattgatgct gagcaacgaa tgaagaagtc catgtggggt
     1921 cagttctggt ctgctcacca gaggttcttc aaatacttat gcatagcatc caaagttaaa
     1981 agggttgtgc aactagctcg agaggaaatc aagaatggaa aatgtgttgt aattggtctg
     2041 cagtctacag gagaagctag aacattagaa gctttggaag agggcggggg agaattgaat
     2101 gattttgttt caactgccaa aggtgtgttg cagtcactca ttgaaaaaca ttttcctgct
     2161 ccagacagga aaaaacttta tagtttacta ggaatcgatt tgacagctcc aagtaacaac
     2221 agttcgccaa gagatagtcc ttgtaaagaa aataaaataa agaagcggaa aggtgaagaa
     2281 ataactcgag aagccaaaaa agcacgaaaa gtaggtggcc ttactggtag cagttctgac
     2341 gacagtggaa gtgaatctga tgcctctgat aatgaagaaa gtgactatga gagctctaaa
     2401 aacatgagtt ctggagatga tgacgatttc aacccatttt tagatgagtc taatgaggat
     2461 gatgaaaatg atccctggtt aattagaaaa gaccacaaga aaaacaaaga gaaaaaaaag
     2521 aagaaaagta tagatccaga ttctattcaa agtgccttat tagcatcagg tcttggatca
     2581 aaacgaccta gtttttcatc tacaccagtt atctcacctg ctcctaacag tacaccagct
     2641 aacagtaaca ccaacagtaa cagtagcctt ataacaagtc aggatgctgt ggaaagggct
     2701 cagcagatga agaaagacct gcttgataag ctagaaaaat tagctgaaga cctcccccct
     2761 aataccctgg atgaacttat cgatgaactt ggtggccctg agaacgttgc tgagatgact
     2821 ggccgcaagg gacgggttgt gagcaatgat gatggaagca tatcttatga gtcaagatct
     2881 gaacttgatg tgcctgtgga aatactaaac atcacagaaa aacaacgatt tatggatgga
     2941 gataagaata ttgctatcat ctcagaagct gccagctcgg gtatttcatt acaagcagat
     3001 aggagagcta aaaatcaaag gcgaagagtt catatgactt tagaattacc ttggagcgct
     3061 gatagagcaa ttcaacagtt cggacgtact catagatcaa accaagttac tgctcctgag
     3121 tatgtctttc tgatatctga actggcagga gaacaaagat ttgcatctat tgttgctaaa
     3181 agacttgaga gtttgggggc acttacacat ggtgatagaa gggcaacaga atctagagat
     3241 ctgagcaggt tcaactttga taataagtat ggaagaaatg ctttagaaat tgtcatgaaa
     3301 tccattgtaa acttggattc tcctatggta tcaccacctc cagactatcc tggagaattt
     3361 tttaaagatg ttcgacaagg actgataggc gttggcctga taaatgtaga agatcgctcg
     3421 ggaattctta ctctcgataa agattataac aacataggaa aattcttaaa tagaatttta
     3481 ggcatggagg tgcatcagca gaatgcgtta tttcagtatt ttgcggacac acttactgca
     3541 gttgttcaaa atgccaaaaa aaatggaaga tatgatatgg gaatcttaga tcttggttct
     3601 ggagatgaaa aagtgcggaa aagtgatgtt aaaaagtttc tgactccagg atattcaacc
     3661 tctggccacg tagaattata cacaattagt gtagagaggg gaatgtcatg ggaggaagct
     3721 accaagattt gggctgagct gacaggacca gacgatggct tttacttgtc attgcaaata
     3781 aggaacaaca agaaaactgc catcttagtt aaagaagtga atcctaaaaa gaaacttttc
     3841 ttagtttatc gaccaaatac tgggaagcag ctcaaattag aaatttatgc tgatctaaaa
     3901 aagaaatata agaaggtcgt ctcagatgat gccctgatgc actggttaga tcagtataat
     3961 tcatctgcag atacttgtac tcatgcttat tggcgcggca attgcaaaaa agcaagcttg
     4021 gggctagttt gtgaaatagg tcttcgttgc cgtacatatt atgtattatg tggttcagtg
     4081 ctgagtgtct ggacaaaagt tgagggtgtt ctagcatctg tcagtggcac aaacgtgaag
     4141 atgcagatcg tgcggctaag aacggaagat gggcaacgga ttgtaggttt gatcattccg
     4201 gcaaattgtg tgtctcctct tgtaaatctc ctatcaactt cagaccagtc tcaacagctt
     4261 gcggtccaac agaaacagct atggcaacag catcaccctc agagcatcac caacttgagc
     4321 aacgcatgaa gaacagacag gtttcaacat ggatggatct gaaatgctgt tgaagcatat
     4381 catttgcata aaaatcaggg acagtttcca aagaattata tatttttttc agttgtgctc
     4441 tctagttagt ttttttggga gtaaggacaa acctggaata gatagcaaaa ctgaaaatca
     4501 gcagtgctga tggtggtaca tatgtctttc ctttagcttc tcccctgata attcccatct
     4561 gcttttactt cgggtgagca gagggggatg tgtgtgtgcg tgtgtgtcag tctgtttgtg
     4621 agtgtgttaa aggctacaga ccacagttgg tttaaaatgc ttggaacttc ccaaactggc
     4681 tttactttat gtttatacag tgctcagggt taacgcagta catccatgcc attgctgtgg
     4741 gaggtatccc cggatgcatg tgttttgagt ctataaatat agaaaatata tattggtttc
     4801 tttttccaac ttaataggtt tattaaagca tgaaatgaaa ggttgcatat catgcattca
     4861 ggttattttc taatttttgt tctgacagtg catgtctttg gaagcatgct gaaacaagat
     4921 taacacagga gtcgagtaac agagagaaac atttgttaga tgtacagcat tggttattgc
     4981 atttttatag tgtttatacc tgggtattgc ttcaaaccct gcagacccct ccttcccctt
     5041 ctccctgccc tgggtttctg gtcaaggtaa tgaatacata catttttctg tgataaaact
     5101 cttaaaagtt aattttaatg tattaatagt attcctaatg tgtgctgcag aaatggctat
     5161 gagcctctta aatttacatt tgcaacttaa aggtagtttt agaaggaagt acaaattggc
     5221 tttcatcttg caaacaatcg ttttttactt cattatctta atttgctttg tcactcataa
     5281 aaaggaaacc atacctgagt tgtagacaat gaggaaacac ttgaggcttc tgctgtgtgt
     5341 tcttttgtta ttgttgttat tgttgttact cagtaacttg aatattgttt aatgtgttgt
     5401 aagacgtaga gtttatctca agctgttaaa aatggtaatg tacaaatgtg aatagacact
     5461 tatctatata atatgggtaa gttttgtttc gcctataata gatgtttata aaaacaagtg
     5521 aggggacagt tggtcttttt atcttttctt tctttttctt tcttttcttt ttttcttttt
     5581 tttttttttt tttttttttt ttgcttccac aggttgcact attgaaaaat cgagattgta
     5641 taaacctggt aaaaagctgc aagatgccaa aatcttgtag atgtcaaata aaaagttatt
     5701 atactaacaa gaagtggact cttgtttagg ccctcactgg tgaccttcag aagtagtctg
     5761 tgacggggac tcagcagaat ttgtgtgttg tctcagcatt ccaggtagcc ttatagtttg
     5821 gcttaaaact tatccctaaa atgtaagatg gcattgaggg aaagggtata atgatagtac
     5881 ttctgaatgt tttttaagtt gaattgtttg taaacttctt gcagaattgg gtgagatgtg
     5941 tgttaaaact gacaaacctg gctgaaagct tagggcgttc atcctcttgt gtctccttta
     6001 gcctgagttt ggttatgtca agcttaccgt aagttttctt aggatttatt tattcttggt
     6061 gcctaaaaga ataaattgaa agtactttct gttctttggc acattttgcc cagcggatgc
     6121 aacttctatc ctcagtccag ttcatatatc tcaggcagtg atccattttg tatcagccag
     6181 tttcccttgt tagggccgct agacccggct ggcagccaag agcagcactc tccccacctt
     6241 cagcagaact tctcagctca tgtgtgtgtt tttaaaagca gtaggcagct tccatcagca
     6301 atggaagtgt cccccactcc agtggtggag gtgcagtcgc tggacctgag gaagtgggga
     6361 agcattacaa accctcctgc agtaagaatg gcagagttgg gaaggatctt ctctcgcagg
     6421 ctgttggccc aactcctctt ttctgtgtat gagggcatct tagtttttta tggcgttttc
     6481 aaagcagcat atgaggattc ttagcatgca gctaagtgac aacccccatg gcctatgatg
     6541 taatgtttgc tctggactag ccatcttgat aaataggagt gtatgtatct taggttcttt
     6601 gtagaacagc tatttttttt tctcattaaa aaggcctctg aaagccctct caaaatggac
     6661 ctcacaaagg caaccagtgt gaatggatgg gagctggggt gctgcatgcc caggctggtc
     6721 atggtgtgtg cagcacccag agagttgcac ccaccccttc ttcaggtgga catccgacct
     6781 ttacactgtg gtcttgcaaa aatcagcgag ttagtttggc cgccctgtga agcttcagca
     6841 ttcaaggtcc tcttctgtta aaacccaact cgtagccggg cgtggtggct cactcctata
     6901 atcccagcac ttcgggaggc caaggcaggt gcatcacttg aggccaggag ttcgagacca
     6961 gcctggtcca catggcaaaa ccccatctgt accaaaaaat acaaaaaatt tgccgctgac
     7021 ttctgtaaaa taggtccatt cattgcagga tctaaatgcc acacctgaat tcagaggcct
     7081 tgtttaatta accccatgtc cactttgcct ctgcaatgcc tttttctttt tagcaatatg
     7141 gctctgagca caaagatttg gttggaaatc atgttcgtgt tttcagagtt tacagcgtca
     7201 attgtactga aaaccacttc cagagtctaa agcagctcag atgttatctc tgggggaatt
     7261 agtgttcccc tcatttagca acctccatac cacaaggtct ctgtctgtag ttactgggat
     7321 tatccagata cactatcaat gatacaaatt cataggagta ttaatgcatt tctttaaaca
     7381 caacttgatt aagaagcaaa tatgttaagc agttttcttt ttctgctgct aaattacagt
     7441 tagacacttc agtatcttct ctttacatgt gtatataaat tagtaagaac ctgcatccaa
     7501 agcaatgtag tgtgtgtatg tatctatata tatttattct aactcagcac ttcagaagcc
     7561 tttttgagtt acaacaatat tttagtttgc ctcatctgta gaggtaaaat ttctatatta
     7621 ccaagctcca gaggaatatg atattttaca ggcacaattt tctggctgta gtccctgggg
     7681 cattcatttg ctggcctcca tgggatgctg ttagaacaat tgttagccgg caagagaaga
     7741 aaggctacca ggacagcatt tataattgta gaatgggagc cttcttccct ctcccctcca
     7801 ctttcatttt agcatgagat aaaaaaatag attggaaatg attgttgcat ctcacttcat
     7861 ggaagtaggg gcagaagttc cctctggatc cttttcttga caagcagtca agaggaaggt
     7921 ccccatacac atgtacctgt gtgatacttg gtagtttcta agaatggtgc tacataagcg
     7981 ttgctgttag gctgggatcc tattaatgaa cgtttgatta gttcaggcct cccaatggca
     8041 aaggcagaca ccgtggagat ggacatttac tgactcccct tctgtgtggc ttcggtctcc
     8101 ctggctaaca ccacacctgt gcgtactgcg ctcggcccac tttgctgcag aaacgtagca
     8161 agcgtttcat gtcagggcta cagctgagag caaaaactgc aaaaaaaaaa aaaaatgtct
     8221 cattgaatgc cagttgtctg atacaaatgc agtgtctttt aagtgacaga aacacaccta
     8281 aatacctgca actcaagctc gctagcattt tttttttgag tacttgagat aaaatccaaa
     8341 acccaccctc taattttgtg ctgtatttat atatatgtac ataaatgtat atatagagaa
     8401 atgttgagtt cttctggatt ctgaatgtaa ataattcttg taaattggga ctctgcccac
     8461 ctgtttctcc cttttccctc ttcccttcag ctctatttat tcttttcttg actttcccat
     8521 atggggcatc ttatgacttt tttttttttt tttttttaag aaaagtatgg aaaacttttc
     8581 atttagaaaa gtatttgttc ctgtatttta gaattcagtt ttgcatcttt gctgtagaat
     8641 tcctgttttg tgttaatgtt ttttactatg tcttattgtg ttgtgtgcaa tgcattgtac
     8701 tggggggatg cacttgagtg ccatttctga tactgtcatt gtatgactgc tgatgctcgt
     8761 ttatgttgtt ctttggaagc tatagtgagc ctgatgtttt cacattttaa aaaatgcttc
     8821 ctgagacttc tttaagctcc tctaacttct tcagtgcatt tgggatcaaa cttagctctt
     8881 agatcagcaa acctgacttg cttctacttt tgcaattttt caggccttac catatttctt
     8941 atctctgtct tcccacctga taggaaaatc ttgcagattt gaaacagtgg tttctggcct
     9001 gctgctgcag caaattccct atgtttattt aagaagtcgg gcctatgctt ttaacctaca
     9061 aatgatgagt aatttacttg caatgaacac aggtagcctg ctgctgttta taacctgttg
     9121 aggatattta tagcaggcag gaggcaggcc tagtgtgtta ttgacaggtg actttagaga
     9181 atgtacattg gccgggtgcg gtggctcacg cctgtaatcc cagcactttg ggaggccgag
     9241 gcgggcggat catgaggtca ggagattgag accatctcct ggctaacacg gtgaaacccc
     9301 gtctctacta aaaatacaaa aaaaaaaaaa acttagccag gcgtggtggc gggtgcctgt
     9361 agtcccagct actcaggagg ctgaggcagg agaatggcat gaacctggga ggcagagctt
     9421 gcagtgagcc cagatcgcgc cactgcactc cagcctgggc aacagaccga gactccgtct
     9481 cgaaaaaaaa aaaagagaga gaatgtacat taaggaacaa ttgtcctcca aaagagagcc
     9541 aagcaactgc tctggagcct cctaggctga ctctgctgga gggtgagaca agcagattcc
     9601 cattgcagca ctggtccctg gggtaccctg aacggctgtg ctctccaccc ttgtatcggt
     9661 gagtggatct tgtctacatc agccgtaagc ctagaagcag agcgggatcg aggcgttttt
     9721 aataattcga gttgggaaga cccggatggt tcatcaaaat gatggtgttg agcacccggg
     9781 aggcagacat tgggtatttg ttcacaattt tgcacctgta agaaaatgtt cctttataac
     9841 tttcaaggat tgccgtgagc gtctttgggg ccttttcatt catgtacaag tttcattcat
     9901 tactattcaa cttggtagac ttggtgaaaa atgtaaaagc attctgtatt tggatcagtc
     9961 ttgggaacta aatttgtcgt gaattggggc ctgtcacaga ttgcctccag tgtgcatcct
    10021 ccacgcagac cctccttgct cagtctccct ctggcgccca tggggaagcc gtgctgtggt
    10081 tggcagtgcg gccatctggg ctgccgcaac gtggcagggc accgtccagc aagactgccc
    10141 cttagtgcag ggctaagcaa ggaaaagaag aagcccaaaa aggcgggttc tttttgatac
    10201 ttgtaattca ggcgtcctcc agagtgaagg ccactctgca ggcccctggt gagaacctgt
    10261 ctggcttttc cactgcgggc ccctaaccag taccctgccc ttgtggccca tttgtgcctg
    10321 ggcagatgtt tctggccagc agacactgaa ggcctttttg ctgtgacagt atttatggca
    10381 ctgaagagga taaagaagct tgagccctct ttctgactcc cactttatgg ggcagagaga
    10441 gctttttttc tacatagcac attgcagtct caccgctatc agaaaaatat cctgttcatg
    10501 gtttatactg aatttgcaaa ctactgatat gatttttcaa taaccacttg tatcttccat
    10561 catccatgag aggtgggaag aggtacactg tatctctgca ataaaacttt ggccaggttc
    10621 tacctcctct gagcaaagga tacttttcta tgtaggtgta gatggttctc ctttactaat
    10681 ctgacatggt gcatctggag acaacatctg atgggatcca aagacaactt gaaacaaagg
    10741 tggatgtcag ctcttggtgt gttttcattt ggttctcttt tttaaatctc ccttttgtta
    10801 tcgctcctgt tgtagcgtgt ccatcagtgt gtgaagggtg cgccctgttc caatgatact
    10861 gcattgctgc atccagcctt tcgtgggagc acggtaccaa gcgtccggaa ttgattatcc
    10921 caatcatttt tgatatgtaa ctgaaaaatt tggtctcatg caataaaaat gtactggctg
    10981 cattttagca aggtttattt actcttgcaa gtaaaaacga tcaaccgtga agcgtaacaa
    11041 attctgtatt tagttttttt ttctgttgtg gtggtttttg ttttgttttt tgtttttgta
    11101 agattctaaa taaattaaat acgagtca
//
