LOCUS       NM_001370096            2251 bp    mRNA    linear   PRI 14-FEB-2024
DEFINITION  Homo sapiens SH3 domain binding kinase family member 2 (SBK2),
            mRNA.
ACCESSION   NM_001370096
VERSION     NM_001370096.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2251)
  AUTHORS   Manning,G., Whyte,D.B., Martinez,R., Hunter,T. and Sudarsanam,S.
  TITLE     The protein kinase complement of the human genome
  JOURNAL   Science 298 (5600), 1912-1934 (2002)
   PUBMED   12471243
  REMARK    GeneRIF: Better known as SgK069. Contains predicted active kinase
            domain, classified into the NKF1 metazoan-specific family of
            kinases. 'Bsk146' is an obsolete term for it's paralog, SBK1.
            Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC008735.9.
            
            On Aug 28, 2019 this sequence version replaced NM_001370096.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038191.2187435.1,
                                           SRR18074967.2824576.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2159607, SAMN03465406
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000413299.6/ ENSP00000389015.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                AC008735.9         139213-139292
            81-335              AC008735.9         140050-140304
            336-538             AC008735.9         145001-145203
            539-2251            AC008735.9         146023-147735
FEATURES             Location/Qualifiers
     source          1..2251
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.42"
     gene            1..2251
                     /gene="SBK2"
                     /gene_synonym="SGK069"
                     /note="SH3 domain binding kinase family member 2"
                     /db_xref="GeneID:646643"
                     /db_xref="HGNC:HGNC:34416"
                     /db_xref="MIM:620414"
     exon            1..80
                     /gene="SBK2"
                     /gene_synonym="SGK069"
                     /inference="alignment:Splign:2.1.0"
     exon            81..335
                     /gene="SBK2"
                     /gene_synonym="SGK069"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..1129
                     /gene="SBK2"
                     /gene_synonym="SGK069"
                     /EC_number="2.7.11.1"
                     /note="Sugen kinase 69; SH3-binding domain kinase family,
                     member 2"
                     /codon_start=1
                     /product="serine/threonine-protein kinase SBK2"
                     /protein_id="NP_001357025.1"
                     /db_xref="CCDS:CCDS42631.1"
                     /db_xref="GeneID:646643"
                     /db_xref="HGNC:HGNC:34416"
                     /db_xref="MIM:620414"
                     /translation="MPGKQSEEGPAEAGASEDSEEEGLGGLTLEELQQGQEAARALED
                     MMTLSAQTLVRAEVDELYEEVRPLGQGCYGRVLLVTHRQKGTPLALKQLPKPRTSLRG
                     FLYEFCVGLSLGAHSAIVTAYGIGIESAHSYSFLTEPVLHGDLMAFIQPKVGLPQPAV
                     HRCAAQLASALEYIHARGLVYRDLKPENVLVCDPACRRFKLTDFGHTRPRGTLLRLAG
                     PPIPYTAPELCAPPPLPEGLPIQPALDAWALGVLLFCLLTGYFPWDRPLAEADPFYED
                     FLIWQASGQPRDRPQPWFGLAAAADALLRGLLDPHPRRRSAVIAIREHLGRPWRQREG
                     EAEAVGAVEEEAGQ"
     exon            336..538
                     /gene="SBK2"
                     /gene_synonym="SGK069"
                     /inference="alignment:Splign:2.1.0"
     exon            539..2251
                     /gene="SBK2"
                     /gene_synonym="SGK069"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2228..2233
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SBK2"
                     /gene_synonym="SGK069"
                     /note="hexamer: AATAAA"
     polyA_site      2251
                     /gene="SBK2"
                     /gene_synonym="SGK069"
                     /note="major polyA site"
ORIGIN      
        1 aggcctctgc tggcatgagc cctaagtgcc gggcactgac cacagccggc ggccggaggg
       61 tcaggagggc cttggaggag agatgcccgg caaacagtct gaggaagggc cggcggaggc
      121 aggggcttcg gaggacagcg aggaggaggg tctgggcggc ctgacattag aggagctcca
      181 gcagggccag gaggctgccc gcgcgctgga ggacatgatg acgctgagtg ctcagaccct
      241 ggtccgagcc gaggtggacg agctctacga ggaagtgcgt cccctgggcc agggttgcta
      301 tggccgcgtc cttctggtca cccatcgtca gaaaggcaca cccctggcac tgaagcagct
      361 cccgaaaccc cgcacgtccc tccgtggctt cctgtacgag ttctgtgtgg ggctctcgct
      421 gggcgcgcac tcagccatcg tgacggccta cggcattggc atcgagtcgg cacactccta
      481 cagcttcctg acggagcccg tcctgcacgg ggacctcatg gccttcatcc agcccaaggt
      541 gggcctcccg cagcccgcgg tgcaccgctg cgccgcccag ctggcctccg ccctggagta
      601 catccacgcc cgcggcctgg tgtaccggga cctgaagccg gagaacgtcc tggtgtgcga
      661 cccggcctgc cggcgcttca agctgaccga cttcggccac acgaggcctc gcgggacgct
      721 gctgcgcctg gccgggccgc ccatccccta cacggccccc gagctctgcg cgcccccgcc
      781 gctccccgag ggcctgccca ttcagcccgc cctggacgcc tgggcgctgg gcgtcctgct
      841 cttctgcctc ctcacgggct acttcccctg ggaccggccc ctggccgagg ccgacccctt
      901 ctacgaggac ttcctcatct ggcaggcgtc gggccagccc cgggaccgcc ctcagccctg
      961 gttcggcctg gccgccgcgg ccgacgcgct tctgcggggg ctgctggacc ctcacccccg
     1021 aaggaggagc gctgtgatcg ccatcaggga gcacctgggg cgcccctgga ggcagcggga
     1081 gggcgaggcg gaggcagtgg gagcggtgga agaggaggct gggcagtgag gaggccccgg
     1141 gggatgcaga aagggaagcc gccccacccg aggcccccaa ggccaacggc ttttggtgtc
     1201 tcctcggtgt gttttcatcc atggggcttg ggattcccct cggcgtcctc ctcctctctc
     1261 ctctctgcag gctgcattcc tcccttggtc catgagggcc tcagacctct gcatgtccct
     1321 ccatacctgc cgccaccttc cccagggtct cagacctccg cgtggctctc ggtacctgcc
     1381 gccaccttcc ccagggcctc tgcacttgct gtttgctcag ggcactttag gctcatcccc
     1441 tcacccctcg catttttatt ttttttgaga cagggtctcg ctctgtctcc caggctggag
     1501 tgcagtggtg ctatctctgc tcactgcagt ctcaaaatcc acagctcaag caatcttcct
     1561 gcctcagcct cctgagtagc tgggactaca ggcatgcgcc accacgctag gctaattttt
     1621 aacttttttt agagatggag gggtcttgct atgttgccca ggtgggtgtc aactcctggc
     1681 ctcaaacaat cctcctgcct cagcctcctg agtagctggg actacaggca tgcgccacca
     1741 cgctaggcta atttttaact ttttaaaaag atggttgggg gcgggtcttg ctgtgttgct
     1801 caggctagtc tcaaattcct ggcctggagc gagtctccca cctcggcctc ccgcagtgct
     1861 gggattacag ctgcgcgttg taaatgctta ctgtctgcct cctcatcccc ccactctgct
     1921 gttgctctag gacgtgtatc ctcttctaac tgcatggctt attttttgtg gttattttgt
     1981 gagctcctgg agtcgggggt ctttgccgcc ttccgtctgc tgacagaccc catgtactca
     2041 gcgatggcct gcagcaggga tcaggaaatg tctgttaaat aaattagcct gtctggtgtg
     2101 gcgcagcctc ccctccgtcc ctgtcctccc gccgtcctct ctccttctct ccggccgggt
     2161 ctccctccca cctggcacca ccctctctgt gatgtgtttt gccttctctc gccccagcca
     2221 ctctgcaaat aaactccatc tggcgctcag a
//
