LOCUS       NM_001024401            4986 bp    mRNA    linear   PRI 10-FEB-2024
DEFINITION  Homo sapiens SH3 domain binding kinase 1 (SBK1), mRNA.
ACCESSION   NM_001024401 XM_370948
VERSION     NM_001024401.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4986)
  AUTHORS   Chen,X., Sun,Z., Zhou,S., Jiang,W., Li,J., Song,G. and Zhu,X.
  TITLE     SH3 domain-binding kinase 1 promotes proliferation and inhibits
            apoptosis of cervical cancer via activating the Wnt/beta-catenin
            and Raf/ERK1/2 signaling pathways
  JOURNAL   Mol Carcinog 62 (8), 1147-1162 (2023)
   PUBMED   37132991
  REMARK    GeneRIF: SH3 domain-binding kinase 1 promotes proliferation and
            inhibits apoptosis of cervical cancer via activating the
            Wnt/beta-catenin and Raf/ERK1/2 signaling pathways.
REFERENCE   2  (bases 1 to 4986)
  AUTHORS   Wang,P., Guo,J., Wang,F., Shi,T. and Ma,D.
  TITLE     Human SBK1 is dysregulated in multiple cancers and promotes
            survival of ovary cancer SK-OV-3 cells
  JOURNAL   Mol Biol Rep 38 (5), 3551-3559 (2011)
   PUBMED   21104019
  REMARK    GeneRIF: Results suggest that the wide-spread expression pattern of
            human SBK1 may predict a broad cellular function, and its
            dysregulation in certain cancers suggests an involvement of the
            protein in the pathogenesis of human cancers.
REFERENCE   3  (bases 1 to 4986)
  AUTHORS   Nara,K., Akasako,Y., Matsuda,Y., Fukazawa,Y., Iwashita,S.,
            Kataoka,M. and Nagai,Y.
  TITLE     Cloning and characterization of a novel serine/threonine protein
            kinase gene expressed predominantly in developing brain
  JOURNAL   Eur J Biochem 268 (9), 2642-2651 (2001)
   PUBMED   11322885
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY874862.2.
            
            On Nov 23, 2018 this sequence version replaced NM_001024401.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY874862.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148874, SAMEA2154665
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000341901.5/ ENSP00000343248.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4986              AY874862.2         7-4992
FEATURES             Location/Qualifiers
     source          1..4986
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p12.1"
     gene            1..4986
                     /gene="SBK1"
                     /gene_synonym="SBK"
                     /note="SH3 domain binding kinase 1"
                     /db_xref="GeneID:388228"
                     /db_xref="HGNC:HGNC:17699"
                     /db_xref="MIM:620212"
     exon            1..776
                     /gene="SBK1"
                     /gene_synonym="SBK"
                     /inference="alignment:Splign:2.1.0"
     exon            777..1009
                     /gene="SBK1"
                     /gene_synonym="SBK"
                     /inference="alignment:Splign:2.1.0"
     CDS             784..2058
                     /gene="SBK1"
                     /gene_synonym="SBK"
                     /EC_number="2.7.11.1"
                     /note="SH3-binding domain kinase 1"
                     /codon_start=1
                     /product="serine/threonine-protein kinase SBK1"
                     /protein_id="NP_001019572.1"
                     /db_xref="CCDS:CCDS32416.1"
                     /db_xref="GeneID:388228"
                     /db_xref="HGNC:HGNC:17699"
                     /db_xref="MIM:620212"
                     /translation="MSVGCPEPEPPRSLTCCGPGTAPGPGAGVPLLTEDMQALTLRTL
                     AASDVTKHYELVRELGKGTYGKVDLVVYKGTGTKMALKFVNKSKTKLKNFLREVSITN
                     SLSSSPFIIKVFDVVFETEDCYVFAQEYAPAGDLFDIIPPQVGLPEDTVKRCVQQLGL
                     ALDFMHGRQLVHRDIKPENVLLFDRECRRVKLADFGMTRRVGCRVKRVSGTIPYTAPE
                     VCQAGRADGLAVDTGVDVWAFGVLIFCVLTGNFPWEAASGADAFFEEFVRWQRGRLPG
                     LPSQWRRFTEPALRMFQRLLALEPERRGPAKEVFRFLKHELTSELRRRPSHRARKPPG
                     DRPPAAGPLRLEAPGPLKRTVLTESGSGSRPAPPAVGSVPLPVPVPVPVPVPVPVPEP
                     GLAPQGPPGRTDGRADKSKGQVVLATAIEICV"
     exon            1010..1212
                     /gene="SBK1"
                     /gene_synonym="SBK"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..4986
                     /gene="SBK1"
                     /gene_synonym="SBK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4966..4971
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SBK1"
                     /gene_synonym="SBK"
                     /note="hexamer: AACAAA"
     polyA_site      4986
                     /gene="SBK1"
                     /gene_synonym="SBK"
                     /note="major polyA site"
ORIGIN      
        1 gatgccgcga tggagcgcag cccgggcggg cgccggggcc ggggcccgag cgccaggcgg
       61 agcgcgagct ggagccgcag ccggagcccg ggccaggccg ggggccggga gcgcagggcc
      121 gggctgctcg tagcggcggc gaccgagccc cccagcggct gaggggcttc cagcgcccgc
      181 cggtggccgg gacccactaa agcccccgca gccgaggagt gcggggagcc cccttccaca
      241 tccaggatcc ggcgagcctc ggggaagagg gggggccctc ccggatccga caccgagcga
      301 ctcccctgcg gggaaagcgg agacttcctc ggtatttaga agacagcaag ccccctacgg
      361 caccgcaagg actccccctc ctcagtctgg gcccccgccc caagacctag aacgcagtgc
      421 ccccaggccg ggattgcgag aaccccctcc caagatccgg tcattacaac tccacacctc
      481 aagacaagaa gacccagctc agaacgcccc tagatcaggg gatcccaatt ccccccaact
      541 ccggtacata gaaatcccaa atctaggcag ccggggacag caagagacac tctcaccagc
      601 aagaagcctc ggggatcccc cccctaaagc tccaggactt gggcgactga gcccctggcg
      661 gcaccgcttg caccccggtc catggtcgtg gcgccctgag cccccggggc cgggcagacg
      721 aagaccgcga cggcgcccag gccccctgcc gcggcgtccc cgcggcccca gcccagggag
      781 aagatgagcg tgggctgccc agagcctgag ccgccccgct ccctgacctg ctgtgggccg
      841 gggactgccc ctgggcctgg tgccggtgtg ccccttctca ctgaagacat gcaggccctg
      901 actctccgca cactggccgc cagcgacgtc accaagcact acgaactagt ccgggagctg
      961 ggcaaaggca cctatgggaa ggttgacctg gtggtctaca agggcacagg cacaaaaatg
     1021 gcactgaagt ttgtgaacaa gagcaaaacc aagctgaaga acttcctacg ggaggtgagc
     1081 atcaccaaca gcctctcctc cagccccttc atcatcaagg tctttgacgt ggtctttgag
     1141 acagaggact gctacgtctt tgcccaggag tacgcacctg ctggggacct gtttgacatc
     1201 atccctcccc aggtggggct ccctgaggac acggtgaagc gctgtgtgca gcagctgggc
     1261 ctggcgctgg acttcatgca cgggcggcag ctggtgcacc gcgacatcaa gcccgagaac
     1321 gtgctgctgt tcgaccgcga gtgccgccgc gtaaagctgg ccgacttcgg catgacgcgc
     1381 cgcgtgggct gccgcgtcaa gcgcgtgagc ggcaccatcc cttacacggc gcctgaggtg
     1441 tgccaggcgg gccgcgccga cgggctggcg gtggacacgg gcgtggacgt gtgggccttc
     1501 ggcgtgctca tcttctgcgt gctcaccggc aacttcccgt gggaggcggc gtcgggcgcc
     1561 gacgccttct tcgaggagtt cgtgcgctgg cagcggggcc gcctgccggg gctgccttcg
     1621 cagtggcgcc gcttcaccga gcccgcgctg cgcatgttcc agcgcttact ggccctggag
     1681 cccgagcgcc gcggcccagc caaggaggtg ttccgcttcc tcaagcacga gctcacgtcc
     1741 gagctgcgcc gccggccctc gcaccgcgcg cgcaagcccc ccggggaccg cccgcccgcc
     1801 gccgggccac tgcgcctcga ggcgcctggg ccgctcaagc ggacggtgct gaccgagagc
     1861 ggcagcggct cccggcccgc gccccccgcc gtcgggtcgg tgcccttgcc cgtgccggtg
     1921 ccggtgccag tgcccgtgcc ggtgcctgtg cccgagcccg gcctagctcc ccaggggccc
     1981 cccggccgga ccgacggccg cgcggacaag agcaaagggc aggtggtgct ggccacggcc
     2041 atcgagatct gcgtctgagt cgcctccgcc gccctcggac ccgggagcag cccgggcccg
     2101 ccccgagccg gtgcccggtg cggcggtagg gaatggagcc acctcgccgc ggggcagggg
     2161 gcgcagcggt agactaggca ggacgcggcc cggcacctgg tccgtccccg gcgggctggt
     2221 gagggggcca ccaaagaccc ctagcgcggc ctggtgagcg ggggcttggc ccagaggagc
     2281 caagccgcac agacccgaga attcggaggc caccacacaa cacacacaca cacacacaca
     2341 cacacacaca cacacacaca cacacacaca cacacgccag gagcaaggga gctttcgggc
     2401 cacactccca gacgcctccc tgagccctgg aacccggact cgttgctcct ggccttccat
     2461 accccctggc agatcatcct gcggtcccac cccagatccc ctcctcctcg ccatcccatt
     2521 ctgccccctc cccaccctgg gtacagaaag ggactgaagt gttgggcaga gagggggctt
     2581 aaggcccctg ggcacaggct gggatcaggg cagtgagcga agggcagctg tgtcctgccc
     2641 tcccttctgg aggctggagg ggagaggcca agcccttgga aaatgtagca aatgtctgga
     2701 tgtcgcataa gtgcgtgtat gtgcgggaca ggccccgaga agctagtgac tcctgcacac
     2761 ccccattgca caaatgaaat cacagcccag gagggagggt agcttggcac tggctgagaa
     2821 atagagctct ctccccgccc ctccccctaa ccacaaggga ttgtcctgac aacttgtggg
     2881 gatagaaggg ctcacagggc aggggtctca gctgccccca tccttagggc aggggagtta
     2941 gtgtggagcc gagagcaggt cccagctccc cctgccagcc gcactgtccc aggcccaggg
     3001 acctctgccg ggtcctccca gcccttgcca cacagcctag acgtagtagc ctgggcttcc
     3061 agcaggtggc gagctggttc gtgctggaaa tttctcctgg gtttcttggg gtcaaacatg
     3121 ccaacctcca agaccccatc ctcacgtctc ccacttttct ggcgctggag tgtgcagggc
     3181 gtaggacctg catgtgtggg tgtgagaatg ggggcggtgg acaccagggg gcgagtgtgt
     3241 gactaggtgt gtgtgcacat gtgtagggtg cagacgcatg ggtgccatcc tttgcgttca
     3301 gtgactgtgc gtccagaccc ctcaccagcg gcccccccac cacaccctgg tcctcccagg
     3361 cagctgtccc agggcgccca ggcctgcctt gcaccacagc cctcaggaaa tccggcaagg
     3421 aggcccctgc aggttggttc aggcccccag gtagcaaaac agagacaaca gcagccccgc
     3481 ctgaccccct gcccctctct gtggaggccc gggacccccg caataagcac cacatgggtg
     3541 aggctgtccc tgtcagggtc ccctgccagg gtccctcctg gggttctggg ccatttgagg
     3601 ggctctttga tgggccaggc cggccagagt gaactccgag cactttctgg ctggtgcccc
     3661 aacctctcca ctccccactc attcccacct tgaaaaaggg ctataggtcc cctgccctgc
     3721 ccgggtccag tttacaaaca gtgtggggtg gccccagggc ctggccccac tctccctgct
     3781 gtgcccactc ctctccagac tccacctccc cagtgggtat gggccctcca catgccaggt
     3841 aagtagcaaa cccccactcc ctccaaggac caggtctcag agaaggccct ggtcactgcc
     3901 cccggcccac ctggagccca tcggggctgc ctctcccagc cgcgacttct ccttttgcct
     3961 taggcctcgc gacatcctga tctctcctgc aataactagg aatcgagatt ccacagtaga
     4021 cgtcccttgc cgtgctcgct ctctctctcg cgcgcgctct ctctctccct ctctctctct
     4081 ctctctctct ctctctctct ctctctctct ctctctcctc tctttctctc tctccctctc
     4141 tctgttaaga tcctgttcgg gagtttcccc agccgttgta gtatctagta tgttagagtt
     4201 gggaggggac catagttatg tagcccagcc ccctcattcc cagaggcacc cagagggcca
     4261 gcctccagcc tgaccccaga gcagaaccgg aacaccaggt tggggccctg gtgctgccac
     4321 ctcctctgct ggtcgggctg ggaccctttg ccccttagga gaggtgttgg tcacagatgt
     4381 ttacctcagt ttatgtcact gtcgaagaaa caaaaaataa tagcaaaaaa taacactgta
     4441 gacatgaaga cttagaagac aaaaaaaaaa aaatcacaca aaaaatctcc cttgttgcga
     4501 ttcttctgtg aaggtacagt gtgtatgtgt gtatgtgtgt atgtgtgtgc gtgtctctgt
     4561 cccagaccct gtgtccccca cactgccccc tgtccttcgg tgcttcccag agacccctct
     4621 gagctggcct gtggggcacg ggaagccccc tggatgggag gcggggccac aggtcggcta
     4681 gagggtctcc accaggccca ctgaacagaa ccccacggct gccagaatgt tccctgagcc
     4741 cacactgtgg ccagtgggac agtcctggtg gctgacatca gcgtccatgc ttggctcagg
     4801 gcctggggcg gggtcctggg tagagtccta gccccagagc cccagcccct catgtcttgc
     4861 cgcccttcct ccatgtgttt gtaaatactc tggcatcctt tggccctgag aaggttttta
     4921 aatgtgttat ttacttctct aaacatgacg attgctataa aaataaacaa aagtttagaa
     4981 aaatga
//
