LOCUS       NM_030962               7450 bp    mRNA    linear   PRI 13-FEB-2025
DEFINITION  Homo sapiens SET binding factor 2 (SBF2), transcript variant 2,
            mRNA.
ACCESSION   NM_030962
VERSION     NM_030962.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7450)
  AUTHORS   Cunningham,G.M., Shen,F., Wu,X., Cantor,E.L., Gardner,L.,
            Philips,S., Jiang,G., Bales,C.L., Tan,Z., Liu,Y., Wan,J.,
            Fehrenbacher,J.C. and Schneider,B.P.
  TITLE     The impact of SBF2 on taxane-induced peripheral neuropathy
  JOURNAL   PLoS Genet 18 (1), e1009968 (2022)
   PUBMED   34986146
  REMARK    GeneRIF: The impact of SBF2 on taxane-induced peripheral
            neuropathy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7450)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 7450)
  AUTHORS   Schneider,B.P., Lai,D., Shen,F., Jiang,G., Radovich,M., Li,L.,
            Gardner,L., Miller,K.D., O'Neill,A., Sparano,J.A., Xue,G.,
            Foroud,T. and Sledge,G.W. Jr.
  TITLE     Charcot-Marie-Tooth gene, SBF2, associated with taxane-induced
            peripheral neuropathy in African Americans
  JOURNAL   Oncotarget 7 (50), 82244-82253 (2016)
   PUBMED   27732968
  REMARK    GeneRIF: Rare variants in SBF2 predict an increased risk of
            taxane-induced peripheral neuropathy in African American breast
            cancer patients receiving paclitaxel.
REFERENCE   4  (bases 1 to 7450)
  AUTHORS   Jean,S., Cox,S., Nassari,S. and Kiger,A.A.
  TITLE     Starvation-induced MTMR13 and RAB21 activity regulates VAMP8 to
            promote autophagosome-lysosome fusion
  JOURNAL   EMBO Rep 16 (3), 297-311 (2015)
   PUBMED   25648148
  REMARK    GeneRIF: Starvation-induced MTMR13 and RAB21 activity regulates
            VAMP8 to promote autophagosome-lysosome fusion.
REFERENCE   5  (bases 1 to 7450)
  AUTHORS   Azzedine,H., Bolino,A., Taieb,T., Birouk,N., Di Duca,M.,
            Bouhouche,A., Benamou,S., Mrabet,A., Hammadouche,T., Chkili,T.,
            Gouider,R., Ravazzolo,R., Brice,A., Laporte,J. and LeGuern,E.
  TITLE     Mutations in MTMR13, a new pseudophosphatase homologue of MTMR2 and
            Sbf1, in two families with an autosomal recessive demyelinating
            form of Charcot-Marie-Tooth disease associated with early-onset
            glaucoma
  JOURNAL   Am J Hum Genet 72 (5), 1141-1153 (2003)
   PUBMED   12687498
  REMARK    GeneRIF: Mutations in MTMR13 were associated with a syndrome of
            demyelinating Charcot-Marie-Tooth disease and early onset glaucoma;
            MTMR13 may be important for the development of both the peripheral
            nerves and the trabeculum meshwork
REFERENCE   6  (bases 1 to 7450)
  AUTHORS   Senderek,J., Bergmann,C., Weber,S., Ketelsen,U.P., Schorle,H.,
            Rudnik-Schoneborn,S., Buttner,R., Buchheim,E. and Zerres,K.
  TITLE     Mutation of the SBF2 gene, encoding a novel member of the
            myotubularin family, in Charcot-Marie-Tooth neuropathy type
            4B2/11p15
  JOURNAL   Hum Mol Genet 12 (3), 349-356 (2003)
   PUBMED   12554688
  REMARK    Erratum:[Hum Mol Genet. 2004 Feb 1;13(3):363]
REFERENCE   7  (bases 1 to 7450)
  AUTHORS   Othmane,K.B., Johnson,E., Menold,M., Graham,F.L., Hamida,M.B.,
            Hasegawa,O., Rogala,A.D., Ohnishi,A., Pericak-Vance,M., Hentati,F.
            and Vance,J.M.
  TITLE     Identification of a new locus for autosomal recessive
            Charcot-Marie-Tooth disease with focally folded myelin on
            chromosome 11p15
  JOURNAL   Genomics 62 (3), 344-349 (1999)
   PUBMED   10644431
REFERENCE   8  (bases 1 to 7450)
  AUTHORS   Gambardella,A., Bolino,A., Muglia,M., Valentino,P., Bono,F.,
            Oliveri,R.L., Sabatelli,M., Brancolini,V., Van Broeckhoven,C.,
            Romeo,G., Devoto,M. and Quattrone,A.
  TITLE     Genetic heterogeneity in autosomal recessive hereditary motor and
            sensory neuropathy with focally folded myelin sheaths (CMT4B)
  JOURNAL   Neurology 50 (3), 799-801 (1998)
   PUBMED   9521281
REFERENCE   9  (bases 1 to 7450)
  AUTHORS   Bird,T.D.
  TITLE     Charcot-Marie-Tooth Neuropathy Type 4 - RETIRED CHAPTER, FOR
            HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301641
REFERENCE   10 (bases 1 to 7450)
  AUTHORS   Bird,T.D.
  TITLE     Charcot-Marie-Tooth Hereditary Neuropathy Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301532
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC080023.6, AC100763.2,
            AC011092.4 and AC026250.16.
            
            On Aug 21, 2020 this sequence version replaced NM_030962.3.
            
            Summary: This gene encodes a pseudophosphatase and member of the
            myotubularin-related protein family. This gene maps within the
            CMT4B2 candidate region of chromosome 11p15 and mutations in this
            gene have been associated with Charcot-Marie-Tooth Disease, type
            4B2. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY234241.1, BC101466.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000256190.13/ ENSP00000256190.8
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-205               AC080023.6         117856-118060
            206-291             AC100763.2         160074-160159       c
            292-429             AC011092.4         15212-15349
            430-552             AC011092.4         27023-27145
            553-663             AC011092.4         28318-28428
            664-769             AC011092.4         29636-29741
            770-902             AC011092.4         55504-55636
            903-1011            AC011092.4         57171-57279
            1012-1125           AC011092.4         59814-59927
            1126-1203           AC011092.4         64195-64272
            1204-1317           AC011092.4         65090-65203
            1318-1446           AC011092.4         65650-65778
            1447-1545           AC011092.4         68598-68696
            1546-1750           AC011092.4         89648-89852
            1751-1860           AC011092.4         94311-94420
            1861-2010           AC011092.4         96087-96236
            2011-2079           AC011092.4         162182-162250
            2080-2250           AC026250.16        16807-16977
            2251-2513           AC026250.16        18483-18745
            2514-2686           AC026250.16        21491-21663
            2687-2760           AC026250.16        22454-22527
            2761-2956           AC026250.16        24985-25180
            2957-3084           AC026250.16        28120-28247
            3085-3260           AC026250.16        29463-29638
            3261-3406           AC026250.16        32433-32578
            3407-3605           AC026250.16        35507-35705
            3606-3802           AC026250.16        42783-42979
            3803-3943           AC026250.16        45707-45847
            3944-4128           AC026250.16        58179-58363
            4129-4305           AC026250.16        62495-62671
            4306-4407           AC026250.16        66201-66302
            4408-4593           AC026250.16        67018-67203
            4594-4720           AC026250.16        79246-79372
            4721-4848           AC026250.16        84520-84647
            4849-5082           AC026250.16        85861-86094
            5083-5187           AC026250.16        87465-87569
            5188-5381           AC026250.16        89885-90078
            5382-5469           AC026250.16        90765-90852
            5470-5601           AC026250.16        93565-93696
            5602-7450           AC026250.16        94687-96535
FEATURES             Location/Qualifiers
     source          1..7450
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..7450
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /note="SET binding factor 2"
                     /db_xref="GeneID:81846"
                     /db_xref="HGNC:HGNC:2135"
                     /db_xref="MIM:607697"
     exon            1..205
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     CDS             151..5700
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /note="isoform 2 is encoded by transcript variant 2;
                     myotubularin-related protein 13; DENN/MADD domain
                     containing 7B; inactive phosphatidylinositol 3-phosphatase
                     13"
                     /codon_start=1
                     /product="myotubularin-related protein 13 isoform 2"
                     /protein_id="NP_112224.1"
                     /db_xref="CCDS:CCDS31427.1"
                     /db_xref="GeneID:81846"
                     /db_xref="HGNC:HGNC:2135"
                     /db_xref="MIM:607697"
                     /translation="MARLADYFIVVGYDHEKPGSGEGLGKIIQRFPQKDWDDTPFPQG
                     IELFCQPGGWQLSRERKQPTFFVVVLTDIDSDRHYCSCLTFYEAEINLQGTKKEEIEG
                     EAKVSGLIQPAEVFAPKSLVLVSRLYYPEIFRACLGLIYTVYVDSLNVSLESLIANLC
                     ACLVPAAGGSQKLFSLGAGDRQLIQTPLHDSLPITGTSVALLFQQLGIQNVLSLFCAV
                     LTENKVLFHSASFQRLSDACRALESLMFPLKYSYPYIPILPAQLLEVLSSPTPFIIGV
                     HSVFKTDVHELLDVIIADLDGGTIKIPECIHLSSLPEPLLHQTQSALSLILHPDLEVA
                     DHAFPPPRTALSHSKMLDKEVRAVFLRLFAQLFQGYRSCLQLIRIHAEPVIHFHKTAF
                     LGQRGLVENDFLTKVLSGMAFAGFVSERGPPYRSCDLFDELVAFEVERIKVEENNPVK
                     MIKHVRELAEQLFKNENPNPHMAFQKVPRPTEGSHLRVHILPFPEINEARVQELIQEN
                     VAKNQNAPPATRIEKKCVVPAGPPVVSIMDKVTTVFNSAQRLEVVRNCISFIFENKIL
                     ETEKTLPAALRALKGKAARQCLTDELGLHVQQNRAILDHQQFDYIIRMMNCTLQDCSS
                     LEEYNIAAALLPLTSAFYRKLAPGVSQFAYTCVQDHPIWTNQQFWETTFYNAVQEQVR
                     SLYLSAKEDNHAPHLKQKDKLPDDHYQEKTAMDLAAEQLRLWPTLSKSTQQELVQHEE
                     STVFSQAIHFANLMVNLLVPLDTSKNKLLRTSAPGDWESGSNSIVTNSIAGSVAESYD
                     TESGFEDSENTDIANSVVRFITRFIDKVCTESGVTQDHIKSLHCMIPGIVAMHIETLE
                     AVHRESRRLPPIQKPKILRPALLPGEEIVCEGLRVLLDPDGREEATGGLLGGPQLLPA
                     EGALFLTTYRILFRGTPHDQLVGEQTVVRSFPIASITKEKKITMQNQLQQNMQEGLQI
                     TSASFQLIKVAFDEEVSPEVVEIFKKQLMKFRYPQSIFSTFAFAAGQTTPQIILPKQK
                     EKNTSFRTFSKTIVKGAKRAGKMTIGRQYLLKKKTGTIVEERVNRPGWNEDDDVSVSD
                     ESELPTSTTLKASEKSTMEQLVEKACFRDYQRLGLGTISGSSSRSRPEYFRITASNRM
                     YSLCRSYPGLLVVPQAVQDSSLPRVARCYRHNRLPVVCWKNSRSGTLLLRSGGFHGKG
                     VVGLFKSQNSPQAAPTSSLESSSSIEQEKYLQALLNAVSVHQKLRGNSTLTVRPAFAL
                     SPGVWASLRSSTRLISSPTSFIDVGARLAGKDHSASFSNSSYLQNQLLKRQAALYIFG
                     EKSQLRNFKVEFALNCEFVPVEFHEIRQVKASFKKLMRACIPSTIPTDSEVTFLKALG
                     DSEWFPQLHRIMQLAVVVSEVLENGSSVLVCLEEGWDITAQVTSLVQLLSDPFYRTLE
                     GFQMLVEKEWLSFGHKFSQRSSLTLNCQGSGFAPVFLQFLDCVHQVHNQYPTEFEFNL
                     YYLKFLAFHYVSNRFKTFLLDSDYERLEHGTLFDDKGEKHAKKGVCIWECIDRMHKRS
                     PIFFNYLYSPLEIEALKPNVNVSSLKKWDYYIEETLSTGPSYDWMMLTPKHFPSEDSD
                     LAGEAGPRSQRRTVWPCYDDVSCTQPDALTSLFSEIEKLEHKLNQAPEKWQQLWERVT
                     VDLKEEPRTDRSQRHLSRSPGIVSTNLPSYQKRSLLHLPDSSMGEEQNSSISPSNGVE
                     RRAATLYSQYTSKNDENRSFEGTLYKRGALLKGWKPRWFVLDVTKHQLRYYDSGEDTS
                     CKGHIDLAEVEMVIPAGPSMGAPKHTSDKAFFDLKTSKRVYNFCAQDGQSAQQWMDKI
                     QSCISDA"
     exon            206..291
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            292..429
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            430..552
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            553..663
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            664..769
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            770..902
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1011
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1125
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1203
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1317
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1446
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1545
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1750
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..1860
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            1861..2010
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            2011..2079
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            2080..2250
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            2251..2513
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            2514..2686
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            2687..2760
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            2761..2956
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            2957..3084
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            3085..3260
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            3261..3406
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            3407..3605
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            3606..3802
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            3803..3943
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            3944..4128
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            4129..4305
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            4306..4407
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            4408..4593
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            4594..4720
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            4721..4848
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            4849..5082
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            5083..5187
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            5188..5381
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            5382..5469
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            5470..5601
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            5602..7450
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7310..7315
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /note="hexamer: ATTAAA"
     polyA_site      7333
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /note="major polyA site"
     regulatory      7430..7435
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /note="hexamer: AATAAA"
     polyA_site      7450
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
ORIGIN      
        1 agagcgcgcc tcggttgtca aacatggctg aagcgctgcc gctgccgcta ctgccgctgc
       61 agggaaaatg ctgagccctc ccgggccggg tgggcggcgg cggcgagggc ggcgacgggg
      121 acccgcttcc cgagcgcggc ggcggcggcc atggcccggc tggctgacta cttcatcgtg
      181 gtaggctatg accacgagaa gccaggatca ggagaaggtc tggggaaaat aatccagaga
      241 tttccacaga aggactggga tgatacacct tttccacagg gaattgagtt gttttgtcag
      301 cctggcgggt ggcagctgtc cagagagagg aagcagccaa cgttctttgt ggttgtcctg
      361 acagacattg actcagatcg acattactgc tcatgcctaa ccttctatga ggcagagatc
      421 aatcttcagg gaacaaagaa ggaagagatt gaaggtgaag caaaagtgtc tggtttaatt
      481 cagcctgcag aagtgtttgc tcccaaaagc ctggtgttgg tatccagatt atattatcca
      541 gaaattttta gggcttgcct gggtttgatc tataccgtgt atgtggacag cctgaatgtc
      601 tccttggaaa gtctaattgc aaacctttgt gcctgccttg tcccagcggc tggagggtct
      661 cagaagctgt tttctttggg tgcaggagat agacagttga tccagactcc tttacatgat
      721 agtcttccta tcacgggcac tagtgtggct ctcctgttcc agcaattggg aattcaaaat
      781 gtcctcagcc tcttttgtgc agtcctcaca gaaaataagg ttctcttcca ttctgcaagt
      841 ttccagagac ttagtgatgc ttgtagagcc ctggaatctt taatgtttcc tcttaaatat
      901 agttatcctt atatccctat tctcccggct cagctactgg aagttctaag ttccccaacg
      961 cctttcatta ttggagtaca ttctgtcttt aaaactgatg tccatgaact tttagatgta
     1021 atcatagcag atttggatgg aggcactatt aaaattcccg aatgtattca cctctcttcc
     1081 ctcccagaac cacttctaca tcagactcaa tcagctcttt ctttgatttt acacccagat
     1141 ttggaagtag cagatcatgc ttttcctcct ccacgaacag ctttatccca ctcaaaaatg
     1201 ctggataaag aggtgcgagc cgttttcctt agattatttg cacaactctt ccaaggatat
     1261 agatcctgcc tgcaacttat aagaattcat gcagagccag taatacattt ccacaagaca
     1321 gcattcttgg ggcagcgtgg tttggtcgag aatgatttcc tcactaaagt actcagtgga
     1381 atggcatttg caggttttgt ttcagaaaga ggtcctcctt atagatcttg tgatctcttt
     1441 gatgagttgg tagcctttga agtagagaga attaaagttg aagaaaataa cccagtgaag
     1501 atgataaagc atgtcaggga acttgctgag caactattca aaaatgagaa tccaaatcct
     1561 catatggcat tccagaaagt tccacggcca acagaaggat cccatttgcg agttcatatt
     1621 cttcctttcc cagagattaa tgaagcccgg gttcaggaat taatacagga aaatgttgct
     1681 aagaaccaga atgcacctcc tgccacacga atagaaaaga aatgtgttgt gccagcaggt
     1741 ccacctgttg tttcgataat ggacaaggtg acgacagttt tcaacagtgc acaaagacta
     1801 gaagttgtca gaaactgtat ctcattcata tttgaaaata aaattttgga aactgaaaag
     1861 acccttcctg ctgcactcag agcccttaaa ggaaaggcag caagacagtg tctcactgat
     1921 gaattgggtt tgcatgtcca gcaaaaccgg gcaatattag accatcaaca gtttgactac
     1981 ataataagga tgatgaattg tactctacag gattgttcaa gtttagaaga atacaacatt
     2041 gccgcagcat tactcccttt gaccagtgct ttctatagga aacttgcccc tggagtcagc
     2101 cagtttgctt acacgtgtgt acaagaccac cccatttgga caaatcagca attttgggag
     2161 acaacctttt acaatgcagt gcaggaacag gttcgctccc tttatctctc agccaaggaa
     2221 gacaatcatg ccccgcatct gaagcaaaag gataagcttc ctgatgacca ttatcaggag
     2281 aagacagcaa tggacctggc agctgagcaa ctacgccttt ggcctaccct gagcaagtca
     2341 actcagcaag agctagtgca acatgaggaa agcactgtct ttagtcaggc cattcacttt
     2401 gcaaacctca tggtgaacct gctagttcca ctcgacacaa gtaaaaacaa gctcctaaga
     2461 acatcagcgc caggtgactg ggagagcgga agcaacagca ttgtcacaaa cagtattgca
     2521 ggaagtgtag ctgagagcta tgatacagag agtgggtttg aagattcaga gaatactgac
     2581 attgccaatt ctgttgtgcg gttcattacc cgatttattg acaaagtttg tacagagagt
     2641 ggagttactc aggatcacat caagagcctt cattgcatga taccaggaat tgtagctatg
     2701 cacattgaga ccctagaagc agtacatcga gaaagcagaa gacttccgcc tattcagaag
     2761 cccaagattc ttagacctgc tctgctgcca ggagaagaaa ttgtctgtga gggtcttcga
     2821 gtcttgctgg atcctgatgg aagagaagaa gctactggag gtcttcttgg aggccctcag
     2881 ctcctgccag cagaaggagc cttgttcctc accacataca gaattctctt cagaggaaca
     2941 ccccatgatc agttagtggg tgagcagaca gttgtgcgga gctttcccat tgcctccatc
     3001 accaaggaga agaagattac aatgcagaac cagctacagc agaacatgca agaaggactg
     3061 cagatcacat cagcatcttt tcagttgatt aaggtagcat ttgatgaaga agtcagtcca
     3121 gaagtagtag agatctttaa gaaacagctg atgaagttcc gttatcctca gtccattttc
     3181 agtacctttg cttttgctgc tggacaaact accccacaaa taattttacc aaaacagaag
     3241 gaaaagaaca cttcttttcg taccttctca aaaacaattg tgaaaggtgc caaaagggca
     3301 gggaaaatga caattgggcg gcaatattta ctgaagaaga agacagggac aattgtggaa
     3361 gaaagagtaa atcgtcctgg atggaatgaa gatgatgatg tatctgtttc agatgagagt
     3421 gagctcccca caagtaccac cctgaaggcc tccgagaagt ctacaatgga acagttggtg
     3481 gaaaaagctt gtttcagaga ctatcagcgt ttaggtttag gaaccataag tggcagctct
     3541 tcccgttcaa gacccgagta ttttagaatt actgcctcca acaggatgta ttcactctgc
     3601 cggagctatc ctggcctttt agtcgtacct caagctgtac aggacagtag tttaccaaga
     3661 gtagctcgct gctatcgaca caatcgcctg cctgttgtat gttggaagaa ctcaagaagt
     3721 ggtactctgc tcctccgatc tggaggattc catgggaagg gagtcgttgg tcttttcaaa
     3781 tctcagaact cccctcaggc cgctcctacc tcctctttag aatcttccag tagcatagaa
     3841 caagagaaat acttgcaagc cttactgaat gctgtttctg tccatcagaa actcagaggc
     3901 aacagcactc ttactgtcag gccagccttt gctctatctc caggtgtgtg ggcaagtctt
     3961 cgctctagca ctcgcttgat cagctctcca acatccttca ttgatgttgg cgcccggctg
     4021 gcaggcaagg atcactcggc ctccttcagt aacagcagct acctacaaaa ccagctcttg
     4081 aaacggcaag cagcccttta catatttggt gaaaagtcgc aactaaggaa cttcaaggta
     4141 gaatttgctt taaattgtga gtttgttcct gttgaatttc atgaaatccg gcaagtgaaa
     4201 gccagtttta agaagctgat gagggcttgt atcccaagca ccatccctac tgactcagaa
     4261 gtgaccttcc tgaaagcgct gggagattct gagtggttcc cacagcttca caggataatg
     4321 cagctggctg tggttgtatc agaagtactt gagaatggtt cctcagtttt ggtctgtttg
     4381 gaggaaggct gggacatcac tgcacaagtg acatccctgg ttcagttact cagtgatccc
     4441 ttttatagga cacttgaagg cttccagatg ttggttgaaa aagagtggct ctcttttggt
     4501 cacaaattca gtcagaggag cagcttgacc ctcaactgtc aggggagtgg ttttgctcca
     4561 gtcttcttac agttcttaga ctgtgtacac caggttcaca accagtatcc aactgagttt
     4621 gaattcaatc tctattactt aaagttcttg gctttccact atgtgtctaa tcgctttaaa
     4681 acatttctcc tggattcaga ctatgaaaga ttagagcacg gaactttatt tgatgataaa
     4741 ggagaaaagc atgccaaaaa aggagtctgt atttgggaat gtattgacag aatgcacaag
     4801 aggagtccca ttttctttaa ttatttatat tcaccattgg aaatagaggc tctaaagccc
     4861 aatgtaaacg tctctagcct caagaagtgg gattactaca tagaagagac cctgtccaca
     4921 ggcccttcct atgactggat gatgctaacc cccaagcact tcccctccga agactctgac
     4981 ctggctggag aagctgggcc acggagccag aggagaacag tgtggccatg ctatgatgat
     5041 gtcagctgta ctcagcctga tgctctcacc agccttttca gtgaaattga aaaattggag
     5101 cacaaattga accaagcccc tgagaagtgg cagcagctgt gggaaagggt aaccgtggac
     5161 cttaaagaag aaccaagaac agatcgctcc caaagacacc tgtcgagatc cccaggaatt
     5221 gtgtctacca acctaccttc ctatcagaag aggtctctgc tacatctccc agacagcagc
     5281 atgggggagg aacagaattc cagcatctcc ccatccaatg gagtggagcg aagagcagcc
     5341 acgctctata gccagtatac atccaagaat gatgaaaaca ggtcctttga gggaacactt
     5401 tataaaagag gggctttgct gaaaggttgg aagccccgtt ggtttgtttt ggatgtaaca
     5461 aaacatcagc tgcgctacta tgactcaggt gaggacacaa gctgtaaagg ccacattgat
     5521 ctggctgaag tagaaatggt catccctgct ggccccagca tgggagcccc aaagcacaca
     5581 agtgacaagg ctttctttga tctcaagacc agcaaacgtg tgtataactt ctgcgcccag
     5641 gatggacaga gtgcccagca atggatggac aagatccaga gttgtatctc tgatgcctga
     5701 tgcccatggt caacccacgc agaagaaaca gaagaactca tgctgccaga tagatagaaa
     5761 aagaagcatg gatccttgag gagctgacaa caagttatcc cagggcctga ggttctcctg
     5821 cccagtcccc tcttgcaggg gttgctatat ctacttaacc tgaataggtg tttcacacag
     5881 gtctggtcaa cagccccatg cactccctgt atcttgcact aaatttttct aacagggtct
     5941 tagtggttaa tgatcagaag atgtctcctg agccaactgt gaacctcacc caggcaaaat
     6001 ggctaccacc tacttgggtc cttcttcatg aaagctatag atcctttttt gttctctgag
     6061 gtcataattt cctcggagac ctgtttaaca agcaaaaatc aaaaccctcc aagattgtct
     6121 catattctac ctggactagg tttcctatga gagacatcta cttgtaatgc ctgacctttg
     6181 agatgctcag ttctctggtg ctgccaaaag atgcttccat ggtccgtgct ctgccagtgg
     6241 ggttcacaac aagagacgtc attgttcagt agcaggcaaa gagggagcac acagcattat
     6301 tctgatggaa aaagattatc cagggaatgg tacaacaatg accagcccaa tgcaggaaaa
     6361 cactacttcc aaaacactga attctctaga ccagaggtgc tctgaggatc cagggccttg
     6421 tgttcttatg tatcttctgc ttcctgacag cttctttttc aaaataacat gcaaaaaaag
     6481 ctgaatgcac taactcacaa aacaaacact tgcactgaat tcccaatgaa gtgaagatgt
     6541 tggaaagaca gaggccagct atttaggacc atacgcacct gtgacaaggg ctgtgttgac
     6601 cacagtcaca ctgtggcatg actggatacc caaactacac ttctacacat gaaaagtaag
     6661 aactgtcttt agattttctt tactttgata acttgtgatt gtttagctta agacccaaga
     6721 aatgctgttt gctcatggta aacagaaaca gcatcttcgc tacaaccact gacaccagct
     6781 ggcgtcatag gtagctagat cattgcattt gttttgaaat gttaatatgt taaatactaa
     6841 actaatattt caaaaatgtg tatatatgat ttctatatcc ttgtttttca gatagcctgc
     6901 ttataattta atataaatta actgatgcat tcataagatt tcaataatga aatggttccc
     6961 ttttaaaaaa taaaaatact ttgtagatta aaaataaatc agaatttcaa atttaaaatt
     7021 gtccacacac taggaaatag aactgtgtta atatataaga aatctgggga taattaagaa
     7081 tgaaggactt ttctatcatt tccattttat aaattgccac ctgtgaaaat ggtttttgca
     7141 cattatttgt atttttcttt gtatatgaaa taattttttg tactttgtaa aatatggagc
     7201 ccattgtacc ttcagctatt tgagactata cacagtgctt cttttgtaac tggattactt
     7261 taactttcgt gaaggcatta cattgcctca cattcactaa ccaccttgaa ttaaatttat
     7321 ttcttaagaa aaagcatccc tcatttactg tgaactaaag ttcattctgt agtgcacagc
     7381 attcaggagg gtaacactca ggattcatac atgggactaa aggttcaaga ataaaacaaa
     7441 gcatgaccca
//
