LOCUS       NM_001424318            7880 bp    mRNA    linear   PRI 14-FEB-2025
DEFINITION  Homo sapiens SET binding factor 2 (SBF2), transcript variant 4,
            mRNA.
ACCESSION   NM_001424318
VERSION     NM_001424318.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7880)
  AUTHORS   Cunningham,G.M., Shen,F., Wu,X., Cantor,E.L., Gardner,L.,
            Philips,S., Jiang,G., Bales,C.L., Tan,Z., Liu,Y., Wan,J.,
            Fehrenbacher,J.C. and Schneider,B.P.
  TITLE     The impact of SBF2 on taxane-induced peripheral neuropathy
  JOURNAL   PLoS Genet 18 (1), e1009968 (2022)
   PUBMED   34986146
  REMARK    GeneRIF: The impact of SBF2 on taxane-induced peripheral
            neuropathy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7880)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 7880)
  AUTHORS   Schneider,B.P., Lai,D., Shen,F., Jiang,G., Radovich,M., Li,L.,
            Gardner,L., Miller,K.D., O'Neill,A., Sparano,J.A., Xue,G.,
            Foroud,T. and Sledge,G.W. Jr.
  TITLE     Charcot-Marie-Tooth gene, SBF2, associated with taxane-induced
            peripheral neuropathy in African Americans
  JOURNAL   Oncotarget 7 (50), 82244-82253 (2016)
   PUBMED   27732968
  REMARK    GeneRIF: Rare variants in SBF2 predict an increased risk of
            taxane-induced peripheral neuropathy in African American breast
            cancer patients receiving paclitaxel.
REFERENCE   4  (bases 1 to 7880)
  AUTHORS   Jean,S., Cox,S., Nassari,S. and Kiger,A.A.
  TITLE     Starvation-induced MTMR13 and RAB21 activity regulates VAMP8 to
            promote autophagosome-lysosome fusion
  JOURNAL   EMBO Rep 16 (3), 297-311 (2015)
   PUBMED   25648148
  REMARK    GeneRIF: Starvation-induced MTMR13 and RAB21 activity regulates
            VAMP8 to promote autophagosome-lysosome fusion.
REFERENCE   5  (bases 1 to 7880)
  AUTHORS   Azzedine,H., Bolino,A., Taieb,T., Birouk,N., Di Duca,M.,
            Bouhouche,A., Benamou,S., Mrabet,A., Hammadouche,T., Chkili,T.,
            Gouider,R., Ravazzolo,R., Brice,A., Laporte,J. and LeGuern,E.
  TITLE     Mutations in MTMR13, a new pseudophosphatase homologue of MTMR2 and
            Sbf1, in two families with an autosomal recessive demyelinating
            form of Charcot-Marie-Tooth disease associated with early-onset
            glaucoma
  JOURNAL   Am J Hum Genet 72 (5), 1141-1153 (2003)
   PUBMED   12687498
  REMARK    GeneRIF: Mutations in MTMR13 were associated with a syndrome of
            demyelinating Charcot-Marie-Tooth disease and early onset glaucoma;
            MTMR13 may be important for the development of both the peripheral
            nerves and the trabeculum meshwork
REFERENCE   6  (bases 1 to 7880)
  AUTHORS   Senderek,J., Bergmann,C., Weber,S., Ketelsen,U.P., Schorle,H.,
            Rudnik-Schoneborn,S., Buttner,R., Buchheim,E. and Zerres,K.
  TITLE     Mutation of the SBF2 gene, encoding a novel member of the
            myotubularin family, in Charcot-Marie-Tooth neuropathy type
            4B2/11p15
  JOURNAL   Hum Mol Genet 12 (3), 349-356 (2003)
   PUBMED   12554688
  REMARK    Erratum:[Hum Mol Genet. 2004 Feb 1;13(3):363]
REFERENCE   7  (bases 1 to 7880)
  AUTHORS   Othmane,K.B., Johnson,E., Menold,M., Graham,F.L., Hamida,M.B.,
            Hasegawa,O., Rogala,A.D., Ohnishi,A., Pericak-Vance,M., Hentati,F.
            and Vance,J.M.
  TITLE     Identification of a new locus for autosomal recessive
            Charcot-Marie-Tooth disease with focally folded myelin on
            chromosome 11p15
  JOURNAL   Genomics 62 (3), 344-349 (1999)
   PUBMED   10644431
REFERENCE   8  (bases 1 to 7880)
  AUTHORS   Gambardella,A., Bolino,A., Muglia,M., Valentino,P., Bono,F.,
            Oliveri,R.L., Sabatelli,M., Brancolini,V., Van Broeckhoven,C.,
            Romeo,G., Devoto,M. and Quattrone,A.
  TITLE     Genetic heterogeneity in autosomal recessive hereditary motor and
            sensory neuropathy with focally folded myelin sheaths (CMT4B)
  JOURNAL   Neurology 50 (3), 799-801 (1998)
   PUBMED   9521281
REFERENCE   9  (bases 1 to 7880)
  AUTHORS   Bird,T.D.
  TITLE     Charcot-Marie-Tooth Neuropathy Type 4 - RETIRED CHAPTER, FOR
            HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301641
REFERENCE   10 (bases 1 to 7880)
  AUTHORS   Bird,T.D.
  TITLE     Charcot-Marie-Tooth Hereditary Neuropathy Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301532
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC080023.6, AC100763.2,
            AC011092.4 and AC026250.16.
            
            Summary: This gene encodes a pseudophosphatase and member of the
            myotubularin-related protein family. This gene maps within the
            CMT4B2 candidate region of chromosome 11p15 and mutations in this
            gene have been associated with Charcot-Marie-Tooth Disease, type
            4B2. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA1965299, SAMEA1966682
                              [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-542               AC080023.6         108238-108779
            543-635             AC080023.6         111577-111669
            636-721             AC100763.2         160074-160159       c
            722-859             AC011092.4         15212-15349
            860-982             AC011092.4         27023-27145
            983-1093            AC011092.4         28318-28428
            1094-1199           AC011092.4         29636-29741
            1200-1332           AC011092.4         55504-55636
            1333-1441           AC011092.4         57171-57279
            1442-1555           AC011092.4         59814-59927
            1556-1633           AC011092.4         64195-64272
            1634-1747           AC011092.4         65090-65203
            1748-1876           AC011092.4         65650-65778
            1877-1975           AC011092.4         68598-68696
            1976-2180           AC011092.4         89648-89852
            2181-2290           AC011092.4         94311-94420
            2291-2440           AC011092.4         96087-96236
            2441-2509           AC011092.4         162182-162250
            2510-2680           AC026250.16        16807-16977
            2681-2943           AC026250.16        18483-18745
            2944-3116           AC026250.16        21491-21663
            3117-3190           AC026250.16        22454-22527
            3191-3386           AC026250.16        24985-25180
            3387-3514           AC026250.16        28120-28247
            3515-3690           AC026250.16        29463-29638
            3691-3836           AC026250.16        32433-32578
            3837-4035           AC026250.16        35507-35705
            4036-4232           AC026250.16        42783-42979
            4233-4373           AC026250.16        45707-45847
            4374-4558           AC026250.16        58179-58363
            4559-4735           AC026250.16        62495-62671
            4736-4837           AC026250.16        66201-66302
            4838-5023           AC026250.16        67018-67203
            5024-5150           AC026250.16        79246-79372
            5151-5278           AC026250.16        84520-84647
            5279-5512           AC026250.16        85861-86094
            5513-5617           AC026250.16        87465-87569
            5618-5811           AC026250.16        89885-90078
            5812-5899           AC026250.16        90765-90852
            5900-6031           AC026250.16        93565-93696
            6032-7880           AC026250.16        94687-96535
FEATURES             Location/Qualifiers
     source          1..7880
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..7880
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /note="SET binding factor 2"
                     /db_xref="GeneID:81846"
                     /db_xref="HGNC:HGNC:2135"
                     /db_xref="MIM:607697"
     exon            1..542
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            543..635
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     CDS             545..6130
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /note="isoform 4 is encoded by transcript variant 4;
                     myotubularin-related protein 13; DENN/MADD domain
                     containing 7B; inactive phosphatidylinositol 3-phosphatase
                     13"
                     /codon_start=1
                     /product="myotubularin-related protein 13 isoform 4"
                     /protein_id="NP_001411247.1"
                     /db_xref="GeneID:81846"
                     /db_xref="HGNC:HGNC:2135"
                     /db_xref="MIM:607697"
                     /translation="MWFHHVAHAGLELLISRDPLALAYQSARITGSGEGLGKIIQRFP
                     QKDWDDTPFPQGIELFCQPGGWQLSRERKQPTFFVVVLTDIDSDRHYCSCLTFYEAEI
                     NLQGTKKEEIEGEAKVSGLIQPAEVFAPKSLVLVSRLYYPEIFRACLGLIYTVYVDSL
                     NVSLESLIANLCACLVPAAGGSQKLFSLGAGDRQLIQTPLHDSLPITGTSVALLFQQL
                     GIQNVLSLFCAVLTENKVLFHSASFQRLSDACRALESLMFPLKYSYPYIPILPAQLLE
                     VLSSPTPFIIGVHSVFKTDVHELLDVIIADLDGGTIKIPECIHLSSLPEPLLHQTQSA
                     LSLILHPDLEVADHAFPPPRTALSHSKMLDKEVRAVFLRLFAQLFQGYRSCLQLIRIH
                     AEPVIHFHKTAFLGQRGLVENDFLTKVLSGMAFAGFVSERGPPYRSCDLFDELVAFEV
                     ERIKVEENNPVKMIKHVRELAEQLFKNENPNPHMAFQKVPRPTEGSHLRVHILPFPEI
                     NEARVQELIQENVAKNQNAPPATRIEKKCVVPAGPPVVSIMDKVTTVFNSAQRLEVVR
                     NCISFIFENKILETEKTLPAALRALKGKAARQCLTDELGLHVQQNRAILDHQQFDYII
                     RMMNCTLQDCSSLEEYNIAAALLPLTSAFYRKLAPGVSQFAYTCVQDHPIWTNQQFWE
                     TTFYNAVQEQVRSLYLSAKEDNHAPHLKQKDKLPDDHYQEKTAMDLAAEQLRLWPTLS
                     KSTQQELVQHEESTVFSQAIHFANLMVNLLVPLDTSKNKLLRTSAPGDWESGSNSIVT
                     NSIAGSVAESYDTESGFEDSENTDIANSVVRFITRFIDKVCTESGVTQDHIKSLHCMI
                     PGIVAMHIETLEAVHRESRRLPPIQKPKILRPALLPGEEIVCEGLRVLLDPDGREEAT
                     GGLLGGPQLLPAEGALFLTTYRILFRGTPHDQLVGEQTVVRSFPIASITKEKKITMQN
                     QLQQNMQEGLQITSASFQLIKVAFDEEVSPEVVEIFKKQLMKFRYPQSIFSTFAFAAG
                     QTTPQIILPKQKEKNTSFRTFSKTIVKGAKRAGKMTIGRQYLLKKKTGTIVEERVNRP
                     GWNEDDDVSVSDESELPTSTTLKASEKSTMEQLVEKACFRDYQRLGLGTISGSSSRSR
                     PEYFRITASNRMYSLCRSYPGLLVVPQAVQDSSLPRVARCYRHNRLPVVCWKNSRSGT
                     LLLRSGGFHGKGVVGLFKSQNSPQAAPTSSLESSSSIEQEKYLQALLNAVSVHQKLRG
                     NSTLTVRPAFALSPGVWASLRSSTRLISSPTSFIDVGARLAGKDHSASFSNSSYLQNQ
                     LLKRQAALYIFGEKSQLRNFKVEFALNCEFVPVEFHEIRQVKASFKKLMRACIPSTIP
                     TDSEVTFLKALGDSEWFPQLHRIMQLAVVVSEVLENGSSVLVCLEEGWDITAQVTSLV
                     QLLSDPFYRTLEGFQMLVEKEWLSFGHKFSQRSSLTLNCQGSGFAPVFLQFLDCVHQV
                     HNQYPTEFEFNLYYLKFLAFHYVSNRFKTFLLDSDYERLEHGTLFDDKGEKHAKKGVC
                     IWECIDRMHKRSPIFFNYLYSPLEIEALKPNVNVSSLKKWDYYIEETLSTGPSYDWMM
                     LTPKHFPSEDSDLAGEAGPRSQRRTVWPCYDDVSCTQPDALTSLFSEIEKLEHKLNQA
                     PEKWQQLWERVTVDLKEEPRTDRSQRHLSRSPGIVSTNLPSYQKRSLLHLPDSSMGEE
                     QNSSISPSNGVERRAATLYSQYTSKNDENRSFEGTLYKRGALLKGWKPRWFVLDVTKH
                     QLRYYDSGEDTSCKGHIDLAEVEMVIPAGPSMGAPKHTSDKAFFDLKTSKRVYNFCAQ
                     DGQSAQQWMDKIQSCISDA"
     exon            636..721
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            722..859
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            860..982
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1093
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1199
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1332
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1441
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1555
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..1633
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            1634..1747
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            1748..1876
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            1877..1975
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            1976..2180
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            2181..2290
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            2291..2440
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            2441..2509
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            2510..2680
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            2681..2943
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            2944..3116
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            3117..3190
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            3191..3386
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            3387..3514
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            3515..3690
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            3691..3836
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            3837..4035
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            4036..4232
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            4233..4373
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            4374..4558
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            4559..4735
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            4736..4837
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            4838..5023
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            5024..5150
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            5151..5278
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            5279..5512
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            5513..5617
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            5618..5811
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            5812..5899
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            5900..6031
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            6032..7880
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7740..7745
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /note="hexamer: ATTAAA"
     polyA_site      7763
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /note="major polyA site"
     regulatory      7860..7865
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /note="hexamer: AATAAA"
     polyA_site      7880
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
ORIGIN      
        1 acttctctcc tgggggccaa actgggaagg aaaggctaag ccacggggct tcctgcttcg
       61 tgcttgtggg tttctggggt cctactaacc actcctctaa tcgaatgtcc tgaagcccag
      121 cgactcgacg gagaggccaa aggtgcgaga ccactagcca aacaggcttc tagtcctcac
      181 ctcccggcaa ttcgctgtgt gaaggtgggc gagtcatgtc ccatctctcg agtccccatc
      241 ttagagccgg tccccagcag acctttaagc ttccttccta ctctgccata tggctctgag
      301 ctccggtgca aaggcggctg ggcagtgggt cgcgcggacc ttgcccagag tggtctgtct
      361 gggccgcgca ctgctggctt agctgccttt tcactctcgg gactcaacag tggacattgc
      421 acctggggaa gaaatggccg cgcggaagtt atttaaggac tcttcctgga aggagtcacc
      481 tgagcggacc tgaattccat ctgaggacgg aggacagatt ccgggccctg accctggccc
      541 tgagatgtgg tttcatcatg ttgcccacgc tggtcttgaa ctcctgatct caagagatcc
      601 actcgccttg gcctaccaaa gtgctaggat tacaggatca ggagaaggtc tggggaaaat
      661 aatccagaga tttccacaga aggactggga tgatacacct tttccacagg gaattgagtt
      721 gttttgtcag cctggcgggt ggcagctgtc cagagagagg aagcagccaa cgttctttgt
      781 ggttgtcctg acagacattg actcagatcg acattactgc tcatgcctaa ccttctatga
      841 ggcagagatc aatcttcagg gaacaaagaa ggaagagatt gaaggtgaag caaaagtgtc
      901 tggtttaatt cagcctgcag aagtgtttgc tcccaaaagc ctggtgttgg tatccagatt
      961 atattatcca gaaattttta gggcttgcct gggtttgatc tataccgtgt atgtggacag
     1021 cctgaatgtc tccttggaaa gtctaattgc aaacctttgt gcctgccttg tcccagcggc
     1081 tggagggtct cagaagctgt tttctttggg tgcaggagat agacagttga tccagactcc
     1141 tttacatgat agtcttccta tcacgggcac tagtgtggct ctcctgttcc agcaattggg
     1201 aattcaaaat gtcctcagcc tcttttgtgc agtcctcaca gaaaataagg ttctcttcca
     1261 ttctgcaagt ttccagagac ttagtgatgc ttgtagagcc ctggaatctt taatgtttcc
     1321 tcttaaatat agttatcctt atatccctat tctcccggct cagctactgg aagttctaag
     1381 ttccccaacg cctttcatta ttggagtaca ttctgtcttt aaaactgatg tccatgaact
     1441 tttagatgta atcatagcag atttggatgg aggcactatt aaaattcccg aatgtattca
     1501 cctctcttcc ctcccagaac cacttctaca tcagactcaa tcagctcttt ctttgatttt
     1561 acacccagat ttggaagtag cagatcatgc ttttcctcct ccacgaacag ctttatccca
     1621 ctcaaaaatg ctggataaag aggtgcgagc cgttttcctt agattatttg cacaactctt
     1681 ccaaggatat agatcctgcc tgcaacttat aagaattcat gcagagccag taatacattt
     1741 ccacaagaca gcattcttgg ggcagcgtgg tttggtcgag aatgatttcc tcactaaagt
     1801 actcagtgga atggcatttg caggttttgt ttcagaaaga ggtcctcctt atagatcttg
     1861 tgatctcttt gatgagttgg tagcctttga agtagagaga attaaagttg aagaaaataa
     1921 cccagtgaag atgataaagc atgtcaggga acttgctgag caactattca aaaatgagaa
     1981 tccaaatcct catatggcat tccagaaagt tccacggcca acagaaggat cccatttgcg
     2041 agttcatatt cttcctttcc cagagattaa tgaagcccgg gttcaggaat taatacagga
     2101 aaatgttgct aagaaccaga atgcacctcc tgccacacga atagaaaaga aatgtgttgt
     2161 gccagcaggt ccacctgttg tttcgataat ggacaaggtg acgacagttt tcaacagtgc
     2221 acaaagacta gaagttgtca gaaactgtat ctcattcata tttgaaaata aaattttgga
     2281 aactgaaaag acccttcctg ctgcactcag agcccttaaa ggaaaggcag caagacagtg
     2341 tctcactgat gaattgggtt tgcatgtcca gcaaaaccgg gcaatattag accatcaaca
     2401 gtttgactac ataataagga tgatgaattg tactctacag gattgttcaa gtttagaaga
     2461 atacaacatt gccgcagcat tactcccttt gaccagtgct ttctatagga aacttgcccc
     2521 tggagtcagc cagtttgctt acacgtgtgt acaagaccac cccatttgga caaatcagca
     2581 attttgggag acaacctttt acaatgcagt gcaggaacag gttcgctccc tttatctctc
     2641 agccaaggaa gacaatcatg ccccgcatct gaagcaaaag gataagcttc ctgatgacca
     2701 ttatcaggag aagacagcaa tggacctggc agctgagcaa ctacgccttt ggcctaccct
     2761 gagcaagtca actcagcaag agctagtgca acatgaggaa agcactgtct ttagtcaggc
     2821 cattcacttt gcaaacctca tggtgaacct gctagttcca ctcgacacaa gtaaaaacaa
     2881 gctcctaaga acatcagcgc caggtgactg ggagagcgga agcaacagca ttgtcacaaa
     2941 cagtattgca ggaagtgtag ctgagagcta tgatacagag agtgggtttg aagattcaga
     3001 gaatactgac attgccaatt ctgttgtgcg gttcattacc cgatttattg acaaagtttg
     3061 tacagagagt ggagttactc aggatcacat caagagcctt cattgcatga taccaggaat
     3121 tgtagctatg cacattgaga ccctagaagc agtacatcga gaaagcagaa gacttccgcc
     3181 tattcagaag cccaagattc ttagacctgc tctgctgcca ggagaagaaa ttgtctgtga
     3241 gggtcttcga gtcttgctgg atcctgatgg aagagaagaa gctactggag gtcttcttgg
     3301 aggccctcag ctcctgccag cagaaggagc cttgttcctc accacataca gaattctctt
     3361 cagaggaaca ccccatgatc agttagtggg tgagcagaca gttgtgcgga gctttcccat
     3421 tgcctccatc accaaggaga agaagattac aatgcagaac cagctacagc agaacatgca
     3481 agaaggactg cagatcacat cagcatcttt tcagttgatt aaggtagcat ttgatgaaga
     3541 agtcagtcca gaagtagtag agatctttaa gaaacagctg atgaagttcc gttatcctca
     3601 gtccattttc agtacctttg cttttgctgc tggacaaact accccacaaa taattttacc
     3661 aaaacagaag gaaaagaaca cttcttttcg taccttctca aaaacaattg tgaaaggtgc
     3721 caaaagggca gggaaaatga caattgggcg gcaatattta ctgaagaaga agacagggac
     3781 aattgtggaa gaaagagtaa atcgtcctgg atggaatgaa gatgatgatg tatctgtttc
     3841 agatgagagt gagctcccca caagtaccac cctgaaggcc tccgagaagt ctacaatgga
     3901 acagttggtg gaaaaagctt gtttcagaga ctatcagcgt ttaggtttag gaaccataag
     3961 tggcagctct tcccgttcaa gacccgagta ttttagaatt actgcctcca acaggatgta
     4021 ttcactctgc cggagctatc ctggcctttt agtcgtacct caagctgtac aggacagtag
     4081 tttaccaaga gtagctcgct gctatcgaca caatcgcctg cctgttgtat gttggaagaa
     4141 ctcaagaagt ggtactctgc tcctccgatc tggaggattc catgggaagg gagtcgttgg
     4201 tcttttcaaa tctcagaact cccctcaggc cgctcctacc tcctctttag aatcttccag
     4261 tagcatagaa caagagaaat acttgcaagc cttactgaat gctgtttctg tccatcagaa
     4321 actcagaggc aacagcactc ttactgtcag gccagccttt gctctatctc caggtgtgtg
     4381 ggcaagtctt cgctctagca ctcgcttgat cagctctcca acatccttca ttgatgttgg
     4441 cgcccggctg gcaggcaagg atcactcggc ctccttcagt aacagcagct acctacaaaa
     4501 ccagctcttg aaacggcaag cagcccttta catatttggt gaaaagtcgc aactaaggaa
     4561 cttcaaggta gaatttgctt taaattgtga gtttgttcct gttgaatttc atgaaatccg
     4621 gcaagtgaaa gccagtttta agaagctgat gagggcttgt atcccaagca ccatccctac
     4681 tgactcagaa gtgaccttcc tgaaagcgct gggagattct gagtggttcc cacagcttca
     4741 caggataatg cagctggctg tggttgtatc agaagtactt gagaatggtt cctcagtttt
     4801 ggtctgtttg gaggaaggct gggacatcac tgcacaagtg acatccctgg ttcagttact
     4861 cagtgatccc ttttatagga cacttgaagg cttccagatg ttggttgaaa aagagtggct
     4921 ctcttttggt cacaaattca gtcagaggag cagcttgacc ctcaactgtc aggggagtgg
     4981 ttttgctcca gtcttcttac agttcttaga ctgtgtacac caggttcaca accagtatcc
     5041 aactgagttt gaattcaatc tctattactt aaagttcttg gctttccact atgtgtctaa
     5101 tcgctttaaa acatttctcc tggattcaga ctatgaaaga ttagagcacg gaactttatt
     5161 tgatgataaa ggagaaaagc atgccaaaaa aggagtctgt atttgggaat gtattgacag
     5221 aatgcacaag aggagtccca ttttctttaa ttatttatat tcaccattgg aaatagaggc
     5281 tctaaagccc aatgtaaacg tctctagcct caagaagtgg gattactaca tagaagagac
     5341 cctgtccaca ggcccttcct atgactggat gatgctaacc cccaagcact tcccctccga
     5401 agactctgac ctggctggag aagctgggcc acggagccag aggagaacag tgtggccatg
     5461 ctatgatgat gtcagctgta ctcagcctga tgctctcacc agccttttca gtgaaattga
     5521 aaaattggag cacaaattga accaagcccc tgagaagtgg cagcagctgt gggaaagggt
     5581 aaccgtggac cttaaagaag aaccaagaac agatcgctcc caaagacacc tgtcgagatc
     5641 cccaggaatt gtgtctacca acctaccttc ctatcagaag aggtctctgc tacatctccc
     5701 agacagcagc atgggggagg aacagaattc cagcatctcc ccatccaatg gagtggagcg
     5761 aagagcagcc acgctctata gccagtatac atccaagaat gatgaaaaca ggtcctttga
     5821 gggaacactt tataaaagag gggctttgct gaaaggttgg aagccccgtt ggtttgtttt
     5881 ggatgtaaca aaacatcagc tgcgctacta tgactcaggt gaggacacaa gctgtaaagg
     5941 ccacattgat ctggctgaag tagaaatggt catccctgct ggccccagca tgggagcccc
     6001 aaagcacaca agtgacaagg ctttctttga tctcaagacc agcaaacgtg tgtataactt
     6061 ctgcgcccag gatggacaga gtgcccagca atggatggac aagatccaga gttgtatctc
     6121 tgatgcctga tgcccatggt caacccacgc agaagaaaca gaagaactca tgctgccaga
     6181 tagatagaaa aagaagcatg gatccttgag gagctgacaa caagttatcc cagggcctga
     6241 ggttctcctg cccagtcccc tcttgcaggg gttgctatat ctacttaacc tgaataggtg
     6301 tttcacacag gtctggtcaa cagccccatg cactccctgt atcttgcact aaatttttct
     6361 aacagggtct tagtggttaa tgatcagaag atgtctcctg agccaactgt gaacctcacc
     6421 caggcaaaat ggctaccacc tacttgggtc cttcttcatg aaagctatag atcctttttt
     6481 gttctctgag gtcataattt cctcggagac ctgtttaaca agcaaaaatc aaaaccctcc
     6541 aagattgtct catattctac ctggactagg tttcctatga gagacatcta cttgtaatgc
     6601 ctgacctttg agatgctcag ttctctggtg ctgccaaaag atgcttccat ggtccgtgct
     6661 ctgccagtgg ggttcacaac aagagacgtc attgttcagt agcaggcaaa gagggagcac
     6721 acagcattat tctgatggaa aaagattatc cagggaatgg tacaacaatg accagcccaa
     6781 tgcaggaaaa cactacttcc aaaacactga attctctaga ccagaggtgc tctgaggatc
     6841 cagggccttg tgttcttatg tatcttctgc ttcctgacag cttctttttc aaaataacat
     6901 gcaaaaaaag ctgaatgcac taactcacaa aacaaacact tgcactgaat tcccaatgaa
     6961 gtgaagatgt tggaaagaca gaggccagct atttaggacc atacgcacct gtgacaaggg
     7021 ctgtgttgac cacagtcaca ctgtggcatg actggatacc caaactacac ttctacacat
     7081 gaaaagtaag aactgtcttt agattttctt tactttgata acttgtgatt gtttagctta
     7141 agacccaaga aatgctgttt gctcatggta aacagaaaca gcatcttcgc tacaaccact
     7201 gacaccagct ggcgtcatag gtagctagat cattgcattt gttttgaaat gttaatatgt
     7261 taaatactaa actaatattt caaaaatgtg tatatatgat ttctatatcc ttgtttttca
     7321 gatagcctgc ttataattta atataaatta actgatgcat tcataagatt tcaataatga
     7381 aatggttccc ttttaaaaaa taaaaatact ttgtagatta aaaataaatc agaatttcaa
     7441 atttaaaatt gtccacacac taggaaatag aactgtgtta atatataaga aatctgggga
     7501 taattaagaa tgaaggactt ttctatcatt tccattttat aaattgccac ctgtgaaaat
     7561 ggtttttgca cattatttgt atttttcttt gtatatgaaa taattttttg tactttgtaa
     7621 aatatggagc ccattgtacc ttcagctatt tgagactata cacagtgctt cttttgtaac
     7681 tggattactt taactttcgt gaaggcatta cattgcctca cattcactaa ccaccttgaa
     7741 ttaaatttat ttcttaagaa aaagcatccc tcatttactg tgaactaaag ttcattctgt
     7801 agtgcacagc attcaggagg gtaacactca ggattcatac atgggactaa aggttcaaga
     7861 ataaaacaaa gcatgaccca
//
