LOCUS       NM_001386342            7321 bp    mRNA    linear   PRI 13-FEB-2025
DEFINITION  Homo sapiens SET binding factor 2 (SBF2), transcript variant 3,
            mRNA.
ACCESSION   NM_001386342 XM_017018374
VERSION     NM_001386342.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7321)
  AUTHORS   Cunningham,G.M., Shen,F., Wu,X., Cantor,E.L., Gardner,L.,
            Philips,S., Jiang,G., Bales,C.L., Tan,Z., Liu,Y., Wan,J.,
            Fehrenbacher,J.C. and Schneider,B.P.
  TITLE     The impact of SBF2 on taxane-induced peripheral neuropathy
  JOURNAL   PLoS Genet 18 (1), e1009968 (2022)
   PUBMED   34986146
  REMARK    GeneRIF: The impact of SBF2 on taxane-induced peripheral
            neuropathy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7321)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 7321)
  AUTHORS   Schneider,B.P., Lai,D., Shen,F., Jiang,G., Radovich,M., Li,L.,
            Gardner,L., Miller,K.D., O'Neill,A., Sparano,J.A., Xue,G.,
            Foroud,T. and Sledge,G.W. Jr.
  TITLE     Charcot-Marie-Tooth gene, SBF2, associated with taxane-induced
            peripheral neuropathy in African Americans
  JOURNAL   Oncotarget 7 (50), 82244-82253 (2016)
   PUBMED   27732968
  REMARK    GeneRIF: Rare variants in SBF2 predict an increased risk of
            taxane-induced peripheral neuropathy in African American breast
            cancer patients receiving paclitaxel.
REFERENCE   4  (bases 1 to 7321)
  AUTHORS   Jean,S., Cox,S., Nassari,S. and Kiger,A.A.
  TITLE     Starvation-induced MTMR13 and RAB21 activity regulates VAMP8 to
            promote autophagosome-lysosome fusion
  JOURNAL   EMBO Rep 16 (3), 297-311 (2015)
   PUBMED   25648148
  REMARK    GeneRIF: Starvation-induced MTMR13 and RAB21 activity regulates
            VAMP8 to promote autophagosome-lysosome fusion.
REFERENCE   5  (bases 1 to 7321)
  AUTHORS   Azzedine,H., Bolino,A., Taieb,T., Birouk,N., Di Duca,M.,
            Bouhouche,A., Benamou,S., Mrabet,A., Hammadouche,T., Chkili,T.,
            Gouider,R., Ravazzolo,R., Brice,A., Laporte,J. and LeGuern,E.
  TITLE     Mutations in MTMR13, a new pseudophosphatase homologue of MTMR2 and
            Sbf1, in two families with an autosomal recessive demyelinating
            form of Charcot-Marie-Tooth disease associated with early-onset
            glaucoma
  JOURNAL   Am J Hum Genet 72 (5), 1141-1153 (2003)
   PUBMED   12687498
  REMARK    GeneRIF: Mutations in MTMR13 were associated with a syndrome of
            demyelinating Charcot-Marie-Tooth disease and early onset glaucoma;
            MTMR13 may be important for the development of both the peripheral
            nerves and the trabeculum meshwork
REFERENCE   6  (bases 1 to 7321)
  AUTHORS   Senderek,J., Bergmann,C., Weber,S., Ketelsen,U.P., Schorle,H.,
            Rudnik-Schoneborn,S., Buttner,R., Buchheim,E. and Zerres,K.
  TITLE     Mutation of the SBF2 gene, encoding a novel member of the
            myotubularin family, in Charcot-Marie-Tooth neuropathy type
            4B2/11p15
  JOURNAL   Hum Mol Genet 12 (3), 349-356 (2003)
   PUBMED   12554688
  REMARK    Erratum:[Hum Mol Genet. 2004 Feb 1;13(3):363]
REFERENCE   7  (bases 1 to 7321)
  AUTHORS   Othmane,K.B., Johnson,E., Menold,M., Graham,F.L., Hamida,M.B.,
            Hasegawa,O., Rogala,A.D., Ohnishi,A., Pericak-Vance,M., Hentati,F.
            and Vance,J.M.
  TITLE     Identification of a new locus for autosomal recessive
            Charcot-Marie-Tooth disease with focally folded myelin on
            chromosome 11p15
  JOURNAL   Genomics 62 (3), 344-349 (1999)
   PUBMED   10644431
REFERENCE   8  (bases 1 to 7321)
  AUTHORS   Gambardella,A., Bolino,A., Muglia,M., Valentino,P., Bono,F.,
            Oliveri,R.L., Sabatelli,M., Brancolini,V., Van Broeckhoven,C.,
            Romeo,G., Devoto,M. and Quattrone,A.
  TITLE     Genetic heterogeneity in autosomal recessive hereditary motor and
            sensory neuropathy with focally folded myelin sheaths (CMT4B)
  JOURNAL   Neurology 50 (3), 799-801 (1998)
   PUBMED   9521281
REFERENCE   9  (bases 1 to 7321)
  AUTHORS   Bird,T.D.
  TITLE     Charcot-Marie-Tooth Neuropathy Type 4 - RETIRED CHAPTER, FOR
            HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301641
REFERENCE   10 (bases 1 to 7321)
  AUTHORS   Bird,T.D.
  TITLE     Charcot-Marie-Tooth Hereditary Neuropathy Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301532
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC080023.6, AC100763.2,
            AC011092.4 and AC026250.16.
            
            On Aug 21, 2020 this sequence version replaced XM_017018374.2.
            
            Summary: This gene encodes a pseudophosphatase and member of the
            myotubularin-related protein family. This gene maps within the
            CMT4B2 candidate region of chromosome 11p15 and mutations in this
            gene have been associated with Charcot-Marie-Tooth Disease, type
            4B2. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853567.4840.1,
                                           SRR14038197.2560559.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-205               AC080023.6         117856-118060
            206-291             AC100763.2         160074-160159       c
            292-429             AC011092.4         15212-15349
            430-552             AC011092.4         27023-27145
            553-663             AC011092.4         28318-28428
            664-769             AC011092.4         29636-29741
            770-902             AC011092.4         55504-55636
            903-1011            AC011092.4         57171-57279
            1012-1125           AC011092.4         59814-59927
            1126-1203           AC011092.4         64195-64272
            1204-1317           AC011092.4         65090-65203
            1318-1416           AC011092.4         68598-68696
            1417-1621           AC011092.4         89648-89852
            1622-1731           AC011092.4         94311-94420
            1732-1881           AC011092.4         96087-96236
            1882-1950           AC011092.4         162182-162250
            1951-2121           AC026250.16        16807-16977
            2122-2384           AC026250.16        18483-18745
            2385-2557           AC026250.16        21491-21663
            2558-2631           AC026250.16        22454-22527
            2632-2827           AC026250.16        24985-25180
            2828-2955           AC026250.16        28120-28247
            2956-3131           AC026250.16        29463-29638
            3132-3277           AC026250.16        32433-32578
            3278-3476           AC026250.16        35507-35705
            3477-3673           AC026250.16        42783-42979
            3674-3814           AC026250.16        45707-45847
            3815-3999           AC026250.16        58179-58363
            4000-4176           AC026250.16        62495-62671
            4177-4278           AC026250.16        66201-66302
            4279-4464           AC026250.16        67018-67203
            4465-4591           AC026250.16        79246-79372
            4592-4719           AC026250.16        84520-84647
            4720-4953           AC026250.16        85861-86094
            4954-5058           AC026250.16        87465-87569
            5059-5252           AC026250.16        89885-90078
            5253-5340           AC026250.16        90765-90852
            5341-5472           AC026250.16        93565-93696
            5473-7321           AC026250.16        94687-96535
FEATURES             Location/Qualifiers
     source          1..7321
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..7321
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /note="SET binding factor 2"
                     /db_xref="GeneID:81846"
                     /db_xref="HGNC:HGNC:2135"
                     /db_xref="MIM:607697"
     exon            1..205
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     CDS             151..5571
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /note="isoform 3 is encoded by transcript variant 3;
                     myotubularin-related protein 13; DENN/MADD domain
                     containing 7B; inactive phosphatidylinositol 3-phosphatase
                     13"
                     /codon_start=1
                     /product="myotubularin-related protein 13 isoform 3"
                     /protein_id="NP_001373271.1"
                     /db_xref="CCDS:CCDS91439.1"
                     /db_xref="GeneID:81846"
                     /db_xref="HGNC:HGNC:2135"
                     /db_xref="MIM:607697"
                     /translation="MARLADYFIVVGYDHEKPGSGEGLGKIIQRFPQKDWDDTPFPQG
                     IELFCQPGGWQLSRERKQPTFFVVVLTDIDSDRHYCSCLTFYEAEINLQGTKKEEIEG
                     EAKVSGLIQPAEVFAPKSLVLVSRLYYPEIFRACLGLIYTVYVDSLNVSLESLIANLC
                     ACLVPAAGGSQKLFSLGAGDRQLIQTPLHDSLPITGTSVALLFQQLGIQNVLSLFCAV
                     LTENKVLFHSASFQRLSDACRALESLMFPLKYSYPYIPILPAQLLEVLSSPTPFIIGV
                     HSVFKTDVHELLDVIIADLDGGTIKIPECIHLSSLPEPLLHQTQSALSLILHPDLEVA
                     DHAFPPPRTALSHSKMLDKEVRAVFLRLFAQLFQGYRSCLQLIRIHAEPVIHFHKLVA
                     FEVERIKVEENNPVKMIKHVRELAEQLFKNENPNPHMAFQKVPRPTEGSHLRVHILPF
                     PEINEARVQELIQENVAKNQNAPPATRIEKKCVVPAGPPVVSIMDKVTTVFNSAQRLE
                     VVRNCISFIFENKILETEKTLPAALRALKGKAARQCLTDELGLHVQQNRAILDHQQFD
                     YIIRMMNCTLQDCSSLEEYNIAAALLPLTSAFYRKLAPGVSQFAYTCVQDHPIWTNQQ
                     FWETTFYNAVQEQVRSLYLSAKEDNHAPHLKQKDKLPDDHYQEKTAMDLAAEQLRLWP
                     TLSKSTQQELVQHEESTVFSQAIHFANLMVNLLVPLDTSKNKLLRTSAPGDWESGSNS
                     IVTNSIAGSVAESYDTESGFEDSENTDIANSVVRFITRFIDKVCTESGVTQDHIKSLH
                     CMIPGIVAMHIETLEAVHRESRRLPPIQKPKILRPALLPGEEIVCEGLRVLLDPDGRE
                     EATGGLLGGPQLLPAEGALFLTTYRILFRGTPHDQLVGEQTVVRSFPIASITKEKKIT
                     MQNQLQQNMQEGLQITSASFQLIKVAFDEEVSPEVVEIFKKQLMKFRYPQSIFSTFAF
                     AAGQTTPQIILPKQKEKNTSFRTFSKTIVKGAKRAGKMTIGRQYLLKKKTGTIVEERV
                     NRPGWNEDDDVSVSDESELPTSTTLKASEKSTMEQLVEKACFRDYQRLGLGTISGSSS
                     RSRPEYFRITASNRMYSLCRSYPGLLVVPQAVQDSSLPRVARCYRHNRLPVVCWKNSR
                     SGTLLLRSGGFHGKGVVGLFKSQNSPQAAPTSSLESSSSIEQEKYLQALLNAVSVHQK
                     LRGNSTLTVRPAFALSPGVWASLRSSTRLISSPTSFIDVGARLAGKDHSASFSNSSYL
                     QNQLLKRQAALYIFGEKSQLRNFKVEFALNCEFVPVEFHEIRQVKASFKKLMRACIPS
                     TIPTDSEVTFLKALGDSEWFPQLHRIMQLAVVVSEVLENGSSVLVCLEEGWDITAQVT
                     SLVQLLSDPFYRTLEGFQMLVEKEWLSFGHKFSQRSSLTLNCQGSGFAPVFLQFLDCV
                     HQVHNQYPTEFEFNLYYLKFLAFHYVSNRFKTFLLDSDYERLEHGTLFDDKGEKHAKK
                     GVCIWECIDRMHKRSPIFFNYLYSPLEIEALKPNVNVSSLKKWDYYIEETLSTGPSYD
                     WMMLTPKHFPSEDSDLAGEAGPRSQRRTVWPCYDDVSCTQPDALTSLFSEIEKLEHKL
                     NQAPEKWQQLWERVTVDLKEEPRTDRSQRHLSRSPGIVSTNLPSYQKRSLLHLPDSSM
                     GEEQNSSISPSNGVERRAATLYSQYTSKNDENRSFEGTLYKRGALLKGWKPRWFVLDV
                     TKHQLRYYDSGEDTSCKGHIDLAEVEMVIPAGPSMGAPKHTSDKAFFDLKTSKRVYNF
                     CAQDGQSAQQWMDKIQSCISDA"
     exon            206..291
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            292..429
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            430..552
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            553..663
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            664..769
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            770..902
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1011
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1125
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1203
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1317
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1416
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1621
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            1622..1731
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            1732..1881
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            1882..1950
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            1951..2121
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            2122..2384
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            2385..2557
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            2558..2631
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            2632..2827
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            2828..2955
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            2956..3131
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            3132..3277
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            3278..3476
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            3477..3673
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            3674..3814
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            3815..3999
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            4000..4176
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            4177..4278
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            4279..4464
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            4465..4591
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            4592..4719
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            4720..4953
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            4954..5058
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            5059..5252
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            5253..5340
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            5341..5472
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     exon            5473..7321
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7181..7186
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /note="hexamer: ATTAAA"
     polyA_site      7204
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /note="major polyA site"
     regulatory      7301..7306
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /note="hexamer: AATAAA"
     polyA_site      7321
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
ORIGIN      
        1 agagcgcgcc tcggttgtca aacatggctg aagcgctgcc gctgccgcta ctgccgctgc
       61 agggaaaatg ctgagccctc ccgggccggg tgggcggcgg cggcgagggc ggcgacgggg
      121 acccgcttcc cgagcgcggc ggcggcggcc atggcccggc tggctgacta cttcatcgtg
      181 gtaggctatg accacgagaa gccaggatca ggagaaggtc tggggaaaat aatccagaga
      241 tttccacaga aggactggga tgatacacct tttccacagg gaattgagtt gttttgtcag
      301 cctggcgggt ggcagctgtc cagagagagg aagcagccaa cgttctttgt ggttgtcctg
      361 acagacattg actcagatcg acattactgc tcatgcctaa ccttctatga ggcagagatc
      421 aatcttcagg gaacaaagaa ggaagagatt gaaggtgaag caaaagtgtc tggtttaatt
      481 cagcctgcag aagtgtttgc tcccaaaagc ctggtgttgg tatccagatt atattatcca
      541 gaaattttta gggcttgcct gggtttgatc tataccgtgt atgtggacag cctgaatgtc
      601 tccttggaaa gtctaattgc aaacctttgt gcctgccttg tcccagcggc tggagggtct
      661 cagaagctgt tttctttggg tgcaggagat agacagttga tccagactcc tttacatgat
      721 agtcttccta tcacgggcac tagtgtggct ctcctgttcc agcaattggg aattcaaaat
      781 gtcctcagcc tcttttgtgc agtcctcaca gaaaataagg ttctcttcca ttctgcaagt
      841 ttccagagac ttagtgatgc ttgtagagcc ctggaatctt taatgtttcc tcttaaatat
      901 agttatcctt atatccctat tctcccggct cagctactgg aagttctaag ttccccaacg
      961 cctttcatta ttggagtaca ttctgtcttt aaaactgatg tccatgaact tttagatgta
     1021 atcatagcag atttggatgg aggcactatt aaaattcccg aatgtattca cctctcttcc
     1081 ctcccagaac cacttctaca tcagactcaa tcagctcttt ctttgatttt acacccagat
     1141 ttggaagtag cagatcatgc ttttcctcct ccacgaacag ctttatccca ctcaaaaatg
     1201 ctggataaag aggtgcgagc cgttttcctt agattatttg cacaactctt ccaaggatat
     1261 agatcctgcc tgcaacttat aagaattcat gcagagccag taatacattt ccacaagttg
     1321 gtagcctttg aagtagagag aattaaagtt gaagaaaata acccagtgaa gatgataaag
     1381 catgtcaggg aacttgctga gcaactattc aaaaatgaga atccaaatcc tcatatggca
     1441 ttccagaaag ttccacggcc aacagaagga tcccatttgc gagttcatat tcttcctttc
     1501 ccagagatta atgaagcccg ggttcaggaa ttaatacagg aaaatgttgc taagaaccag
     1561 aatgcacctc ctgccacacg aatagaaaag aaatgtgttg tgccagcagg tccacctgtt
     1621 gtttcgataa tggacaaggt gacgacagtt ttcaacagtg cacaaagact agaagttgtc
     1681 agaaactgta tctcattcat atttgaaaat aaaattttgg aaactgaaaa gacccttcct
     1741 gctgcactca gagcccttaa aggaaaggca gcaagacagt gtctcactga tgaattgggt
     1801 ttgcatgtcc agcaaaaccg ggcaatatta gaccatcaac agtttgacta cataataagg
     1861 atgatgaatt gtactctaca ggattgttca agtttagaag aatacaacat tgccgcagca
     1921 ttactccctt tgaccagtgc tttctatagg aaacttgccc ctggagtcag ccagtttgct
     1981 tacacgtgtg tacaagacca ccccatttgg acaaatcagc aattttggga gacaaccttt
     2041 tacaatgcag tgcaggaaca ggttcgctcc ctttatctct cagccaagga agacaatcat
     2101 gccccgcatc tgaagcaaaa ggataagctt cctgatgacc attatcagga gaagacagca
     2161 atggacctgg cagctgagca actacgcctt tggcctaccc tgagcaagtc aactcagcaa
     2221 gagctagtgc aacatgagga aagcactgtc tttagtcagg ccattcactt tgcaaacctc
     2281 atggtgaacc tgctagttcc actcgacaca agtaaaaaca agctcctaag aacatcagcg
     2341 ccaggtgact gggagagcgg aagcaacagc attgtcacaa acagtattgc aggaagtgta
     2401 gctgagagct atgatacaga gagtgggttt gaagattcag agaatactga cattgccaat
     2461 tctgttgtgc ggttcattac ccgatttatt gacaaagttt gtacagagag tggagttact
     2521 caggatcaca tcaagagcct tcattgcatg ataccaggaa ttgtagctat gcacattgag
     2581 accctagaag cagtacatcg agaaagcaga agacttccgc ctattcagaa gcccaagatt
     2641 cttagacctg ctctgctgcc aggagaagaa attgtctgtg agggtcttcg agtcttgctg
     2701 gatcctgatg gaagagaaga agctactgga ggtcttcttg gaggccctca gctcctgcca
     2761 gcagaaggag ccttgttcct caccacatac agaattctct tcagaggaac accccatgat
     2821 cagttagtgg gtgagcagac agttgtgcgg agctttccca ttgcctccat caccaaggag
     2881 aagaagatta caatgcagaa ccagctacag cagaacatgc aagaaggact gcagatcaca
     2941 tcagcatctt ttcagttgat taaggtagca tttgatgaag aagtcagtcc agaagtagta
     3001 gagatcttta agaaacagct gatgaagttc cgttatcctc agtccatttt cagtaccttt
     3061 gcttttgctg ctggacaaac taccccacaa ataattttac caaaacagaa ggaaaagaac
     3121 acttcttttc gtaccttctc aaaaacaatt gtgaaaggtg ccaaaagggc agggaaaatg
     3181 acaattgggc ggcaatattt actgaagaag aagacaggga caattgtgga agaaagagta
     3241 aatcgtcctg gatggaatga agatgatgat gtatctgttt cagatgagag tgagctcccc
     3301 acaagtacca ccctgaaggc ctccgagaag tctacaatgg aacagttggt ggaaaaagct
     3361 tgtttcagag actatcagcg tttaggttta ggaaccataa gtggcagctc ttcccgttca
     3421 agacccgagt attttagaat tactgcctcc aacaggatgt attcactctg ccggagctat
     3481 cctggccttt tagtcgtacc tcaagctgta caggacagta gtttaccaag agtagctcgc
     3541 tgctatcgac acaatcgcct gcctgttgta tgttggaaga actcaagaag tggtactctg
     3601 ctcctccgat ctggaggatt ccatgggaag ggagtcgttg gtcttttcaa atctcagaac
     3661 tcccctcagg ccgctcctac ctcctcttta gaatcttcca gtagcataga acaagagaaa
     3721 tacttgcaag ccttactgaa tgctgtttct gtccatcaga aactcagagg caacagcact
     3781 cttactgtca ggccagcctt tgctctatct ccaggtgtgt gggcaagtct tcgctctagc
     3841 actcgcttga tcagctctcc aacatccttc attgatgttg gcgcccggct ggcaggcaag
     3901 gatcactcgg cctccttcag taacagcagc tacctacaaa accagctctt gaaacggcaa
     3961 gcagcccttt acatatttgg tgaaaagtcg caactaagga acttcaaggt agaatttgct
     4021 ttaaattgtg agtttgttcc tgttgaattt catgaaatcc ggcaagtgaa agccagtttt
     4081 aagaagctga tgagggcttg tatcccaagc accatcccta ctgactcaga agtgaccttc
     4141 ctgaaagcgc tgggagattc tgagtggttc ccacagcttc acaggataat gcagctggct
     4201 gtggttgtat cagaagtact tgagaatggt tcctcagttt tggtctgttt ggaggaaggc
     4261 tgggacatca ctgcacaagt gacatccctg gttcagttac tcagtgatcc cttttatagg
     4321 acacttgaag gcttccagat gttggttgaa aaagagtggc tctcttttgg tcacaaattc
     4381 agtcagagga gcagcttgac cctcaactgt caggggagtg gttttgctcc agtcttctta
     4441 cagttcttag actgtgtaca ccaggttcac aaccagtatc caactgagtt tgaattcaat
     4501 ctctattact taaagttctt ggctttccac tatgtgtcta atcgctttaa aacatttctc
     4561 ctggattcag actatgaaag attagagcac ggaactttat ttgatgataa aggagaaaag
     4621 catgccaaaa aaggagtctg tatttgggaa tgtattgaca gaatgcacaa gaggagtccc
     4681 attttcttta attatttata ttcaccattg gaaatagagg ctctaaagcc caatgtaaac
     4741 gtctctagcc tcaagaagtg ggattactac atagaagaga ccctgtccac aggcccttcc
     4801 tatgactgga tgatgctaac ccccaagcac ttcccctccg aagactctga cctggctgga
     4861 gaagctgggc cacggagcca gaggagaaca gtgtggccat gctatgatga tgtcagctgt
     4921 actcagcctg atgctctcac cagccttttc agtgaaattg aaaaattgga gcacaaattg
     4981 aaccaagccc ctgagaagtg gcagcagctg tgggaaaggg taaccgtgga ccttaaagaa
     5041 gaaccaagaa cagatcgctc ccaaagacac ctgtcgagat ccccaggaat tgtgtctacc
     5101 aacctacctt cctatcagaa gaggtctctg ctacatctcc cagacagcag catgggggag
     5161 gaacagaatt ccagcatctc cccatccaat ggagtggagc gaagagcagc cacgctctat
     5221 agccagtata catccaagaa tgatgaaaac aggtcctttg agggaacact ttataaaaga
     5281 ggggctttgc tgaaaggttg gaagccccgt tggtttgttt tggatgtaac aaaacatcag
     5341 ctgcgctact atgactcagg tgaggacaca agctgtaaag gccacattga tctggctgaa
     5401 gtagaaatgg tcatccctgc tggccccagc atgggagccc caaagcacac aagtgacaag
     5461 gctttctttg atctcaagac cagcaaacgt gtgtataact tctgcgccca ggatggacag
     5521 agtgcccagc aatggatgga caagatccag agttgtatct ctgatgcctg atgcccatgg
     5581 tcaacccacg cagaagaaac agaagaactc atgctgccag atagatagaa aaagaagcat
     5641 ggatccttga ggagctgaca acaagttatc ccagggcctg aggttctcct gcccagtccc
     5701 ctcttgcagg ggttgctata tctacttaac ctgaataggt gtttcacaca ggtctggtca
     5761 acagccccat gcactccctg tatcttgcac taaatttttc taacagggtc ttagtggtta
     5821 atgatcagaa gatgtctcct gagccaactg tgaacctcac ccaggcaaaa tggctaccac
     5881 ctacttgggt ccttcttcat gaaagctata gatccttttt tgttctctga ggtcataatt
     5941 tcctcggaga cctgtttaac aagcaaaaat caaaaccctc caagattgtc tcatattcta
     6001 cctggactag gtttcctatg agagacatct acttgtaatg cctgaccttt gagatgctca
     6061 gttctctggt gctgccaaaa gatgcttcca tggtccgtgc tctgccagtg gggttcacaa
     6121 caagagacgt cattgttcag tagcaggcaa agagggagca cacagcatta ttctgatgga
     6181 aaaagattat ccagggaatg gtacaacaat gaccagccca atgcaggaaa acactacttc
     6241 caaaacactg aattctctag accagaggtg ctctgaggat ccagggcctt gtgttcttat
     6301 gtatcttctg cttcctgaca gcttcttttt caaaataaca tgcaaaaaaa gctgaatgca
     6361 ctaactcaca aaacaaacac ttgcactgaa ttcccaatga agtgaagatg ttggaaagac
     6421 agaggccagc tatttaggac catacgcacc tgtgacaagg gctgtgttga ccacagtcac
     6481 actgtggcat gactggatac ccaaactaca cttctacaca tgaaaagtaa gaactgtctt
     6541 tagattttct ttactttgat aacttgtgat tgtttagctt aagacccaag aaatgctgtt
     6601 tgctcatggt aaacagaaac agcatcttcg ctacaaccac tgacaccagc tggcgtcata
     6661 ggtagctaga tcattgcatt tgttttgaaa tgttaatatg ttaaatacta aactaatatt
     6721 tcaaaaatgt gtatatatga tttctatatc cttgtttttc agatagcctg cttataattt
     6781 aatataaatt aactgatgca ttcataagat ttcaataatg aaatggttcc cttttaaaaa
     6841 ataaaaatac tttgtagatt aaaaataaat cagaatttca aatttaaaat tgtccacaca
     6901 ctaggaaata gaactgtgtt aatatataag aaatctgggg ataattaaga atgaaggact
     6961 tttctatcat ttccatttta taaattgcca cctgtgaaaa tggtttttgc acattatttg
     7021 tatttttctt tgtatatgaa ataatttttt gtactttgta aaatatggag cccattgtac
     7081 cttcagctat ttgagactat acacagtgct tcttttgtaa ctggattact ttaactttcg
     7141 tgaaggcatt acattgcctc acattcacta accaccttga attaaattta tttcttaaga
     7201 aaaagcatcc ctcatttact gtgaactaaa gttcattctg tagtgcacag cattcaggag
     7261 ggtaacactc aggattcata catgggacta aaggttcaag aataaaacaa agcatgaccc
     7321 a
//
