LOCUS       NM_018322               2018 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens SAYSVFN motif domain containing 1 (SAYSD1), transcript
            variant 1, mRNA.
ACCESSION   NM_018322
VERSION     NM_018322.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2018)
  AUTHORS   Wang,L., Xu,Y., Yun,S., Yuan,Q., Satpute-Krishnan,P. and Ye,Y.
  TITLE     SAYSD1 senses UFMylated ribosome to safeguard co-translational
            protein translocation at the endoplasmic reticulum
  JOURNAL   Cell Rep 42 (1), 112028 (2023)
   PUBMED   36848233
REFERENCE   2  (bases 1 to 2018)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   3  (bases 1 to 2018)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA977455.1, BC022007.2, AL035690.10 and AF086405.1.
            
            On Nov 23, 2018 this sequence version replaced NM_018322.2.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.236195.1,
                                           SRR3476690.1010934.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000229903.5/ ENSP00000229903.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-78                DA977455.1         1-78
            79-1175             BC022007.2         3-1099
            1176-1443           AL035690.10        40595-40862
            1444-2018           AF086405.1         1-575
FEATURES             Location/Qualifiers
     source          1..2018
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.2"
     gene            1..2018
                     /gene="SAYSD1"
                     /gene_synonym="C6orf64"
                     /note="SAYSVFN motif domain containing 1"
                     /db_xref="GeneID:55776"
                     /db_xref="HGNC:HGNC:21025"
     exon            1..304
                     /gene="SAYSD1"
                     /gene_synonym="C6orf64"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..649
                     /gene="SAYSD1"
                     /gene_synonym="C6orf64"
                     /note="isoform 1 is encoded by transcript variant 1;
                     SAYSvFN domain-containing protein 1"
                     /codon_start=1
                     /product="SAYSvFN domain-containing protein 1 isoform 1"
                     /protein_id="NP_060792.1"
                     /db_xref="CCDS:CCDS4840.1"
                     /db_xref="GeneID:55776"
                     /db_xref="HGNC:HGNC:21025"
                     /translation="MEQRLAEFRAARKRAGLAAQPPAASQGAQTPGEKAEAAATLKAA
                     PGWLKRFLVWKPRPASARAQPGLVQEAAQPQGSTSETPWNTAIPLPSCWDQSFLTNIT
                     FLKVLLWLVLLGLFVELEFGLAYFVLSLFYWMYVGTRGPEEKKEGEKSAYSVFNPGCE
                     AIQGTLTAEQLERELQLRPLAGR"
     exon            305..2018
                     /gene="SAYSD1"
                     /gene_synonym="C6orf64"
                     /inference="alignment:Splign:2.1.0"
     regulatory      869..874
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SAYSD1"
                     /gene_synonym="C6orf64"
                     /note="hexamer: TATAAA"
     polyA_site      888
                     /gene="SAYSD1"
                     /gene_synonym="C6orf64"
                     /note="major polyA site"
     regulatory      1167..1172
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SAYSD1"
                     /gene_synonym="C6orf64"
                     /note="hexamer: AATAAA"
     polyA_site      1186
                     /gene="SAYSD1"
                     /gene_synonym="C6orf64"
     regulatory      1986..1991
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SAYSD1"
                     /gene_synonym="C6orf64"
                     /note="hexamer: ATTAAA"
     polyA_site      2018
                     /gene="SAYSD1"
                     /gene_synonym="C6orf64"
ORIGIN      
        1 aggcgcacgg cggccggcgc gggccgagcg gaggcaactg ctgtgcggcc tgcgggcgcg
       61 cgctccctta tcggccaacg gacgcgaggc gcgcgccatg gaacagcggt tagctgagtt
      121 tcgggcggcg cggaaacggg cgggtctggc ggcccaaccc cctgctgcca gtcagggcgc
      181 acaaacccca ggagagaagg cggaagcagc agcgactcta aaggcagccc caggctggct
      241 aaagcggttc ctggtatgga aacctaggcc cgcgagtgcc cgggcccagc ccggcctagt
      301 tcaggaagcg gctcagcccc agggcagcac atcagagaca ccatggaaca cagccattcc
      361 tctgccgtcg tgctgggacc agtctttcct gaccaatatc accttcttga aggttcttct
      421 ctggttggtc ctgctgggac tgtttgtgga actggaattt ggcctggcat attttgtcct
      481 gtccttgttc tattggatgt acgtcgggac acgaggccct gaagagaaga aagagggaga
      541 gaagagcgcc tactctgtgt tcaatccagg ctgtgaagcc atccagggca ccctgactgc
      601 agagcagttg gagcgcgagt tacagttgag acccctggca gggagatagg acccagctgt
      661 gctgtcatgc agctaacctc tgatgtggtc ttcctcacca ttggctatgg atttgatttc
      721 aggtgtatag gactaagggc agcttgcggg ttagctctgt gactgcatag tttttctacc
      781 ttctttccct gatcttttgc tgccatttga tctttgatag ttttggtgaa actctctaaa
      841 atacattcac tgtgggtccg acgcaattta taaaaattat gtactcaaga agggagacct
      901 gtttgtttca tttctcatct gtttgggaga tgattttaga gcactagaaa ggcactgggg
      961 agattctcag cttaaaacat ccagcagttt gaagtatgat taggtacatc agggctgcat
     1021 tgtcaatgtt ctctttaagt cttttaacat ttatagcaat tttttttttc ccggagagtt
     1081 taggttgcaa gttttgggtt tcttgtttgt ttttgttttg cttcctgctt taattcttta
     1141 attttcagtc attactggta ttgaaaaata aaatatcttt aaaacatctc ctcttcagaa
     1201 ataggtccct cttcattgcc catcaccatc ttccactctc ctattatttt gccactactc
     1261 agtaaaggaa ggtaggaaga gacaaacgcc taagtgcagg tgtggggagg gatttcacaa
     1321 gtggttatta acggccagtt cagcaagaag tgttgagtgt gtacaaaggg gagggctgga
     1381 agtgttaact ccagacccgt tggctgcttg agttgtttct tatattctaa agcagcagtc
     1441 cctaaccttt ttggcaccag ggaccagttt tgtggaacac agtttttcca tggacggggt
     1501 ggtggtggag gatgaaactt ccacctcaga tcatcaggca ttagagtctc ataaggagca
     1561 cgcaacctag atccctcgca tgcgcagttc acaatacggt tctaagggct ttagagtaag
     1621 cagctttttc acctgtgggc ctctggtgag aaattctgta aattgtgata atcaggctgg
     1681 attttaatgc tgcttttcca gtacaatgtt agagtttggg ttcattaaaa ttaggcaaac
     1741 tcccattggg ttagggcttc tctcattcca ttttgtggct aaccttactg tgtttcagcc
     1801 cttgctgaaa attcttctga tatgtgttgc ccttcctcac agccctttgg ccattgggag
     1861 tttggctgtc cctcagagcc atccggtcaa gcagatggtc tgttctatct cacagaaaag
     1921 tcttttcttc catgagttct gtctgaactg aacatgtaaa aagtatggga aacagatgaa
     1981 tccctattaa acatgaagtt ttgattgtat ttaagata
//
