LOCUS       NM_145017               1532 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens stabilizer of axonemal microtubules 4 (SAXO4),
            transcript variant 1, mRNA.
ACCESSION   NM_145017
VERSION     NM_145017.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1532)
  AUTHORS   Oviedo,M.J., Ramirez,E., Cifuentes,M., Farkas,C., Mella,A.,
            Bertinat,R., Gajardo,R., Ferrada,L., Jara,N., De Lima,I.,
            Martinez,F., Nualart,F. and Salazar,K.
  TITLE     Is IIIG9 a New Protein with Exclusive Ciliary Function? Analysis of
            Its Potential Role in Cancer and Other Pathologies
  JOURNAL   Cells 11 (20), 3327 (2022)
   PUBMED   36291193
  REMARK    GeneRIF: Is IIIG9 a New Protein with Exclusive Ciliary Function?
            Analysis of Its Potential Role in Cancer and Other Pathologies.
            Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1532)
  AUTHORS   Lim,S.H., Snider,J., Birimberg-Schwartz,L., Ip,W., Serralha,J.C.,
            Botelho,H.M., Lopes-Pacheco,M., Pinto,M.C., Moutaoufik,M.T.,
            Zilocchi,M., Laselva,O., Esmaeili,M., Kotlyar,M., Lyakisheva,A.,
            Tang,P., Lopez Vazquez,L., Akula,I., Aboualizadeh,F., Wong,V.,
            Grozavu,I., Opacak-Bernardi,T., Yao,Z., Mendoza,M., Babu,M.,
            Jurisica,I., Gonska,T., Bear,C.E., Amaral,M.D. and Stagljar,I.
  TITLE     CFTR interactome mapping using the mammalian membrane two-hybrid
            high-throughput screening system
  JOURNAL   Mol Syst Biol 18 (2), e10629 (2022)
   PUBMED   35156780
REFERENCE   3  (bases 1 to 1532)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1532)
  AUTHORS   Cifuentes,M., Baeza,V., Arrabal,P.M., Visser,R., Grondona,J.M.,
            Saldivia,N., Martinez,F., Nualart,F. and Salazar,K.
  TITLE     Expression of a Novel Ciliary Protein, IIIG9, During the
            Differentiation and Maturation of Ependymal Cells
  JOURNAL   Mol Neurobiol 55 (2), 1652-1664 (2018)
   PUBMED   28194645
REFERENCE   5  (bases 1 to 1532)
  AUTHORS   Sigg,M.A., Menchen,T., Lee,C., Johnson,J., Jungnickel,M.K.,
            Choksi,S.P., Garcia,G. 3rd, Busengdal,H., Dougherty,G.W.,
            Pennekamp,P., Werner,C., Rentzsch,F., Florman,H.M., Krogan,N.,
            Wallingford,J.B., Omran,H. and Reiter,J.F.
  TITLE     Evolutionary Proteomics Uncovers Ancient Associations of Cilia with
            Signaling Pathways
  JOURNAL   Dev Cell 43 (6), 744-762 (2017)
   PUBMED   29257953
REFERENCE   6  (bases 1 to 1532)
  AUTHORS   Fardilha,M., Esteves,S.L., Korrodi-Gregorio,L., Vintem,A.P.,
            Domingues,S.C., Rebelo,S., Morrice,N., Cohen,P.T., da Cruz e
            Silva,O.A. and da Cruz e Silva,E.F.
  TITLE     Identification of the human testis protein phosphatase 1
            interactome
  JOURNAL   Biochem Pharmacol 82 (10), 1403-1415 (2011)
   PUBMED   21382349
REFERENCE   7  (bases 1 to 1532)
  AUTHORS   Hendrickx,A., Beullens,M., Ceulemans,H., Den Abt,T., Van Eynde,A.,
            Nicolaescu,E., Lesage,B. and Bollen,M.
  TITLE     Docking motif-guided mapping of the interactome of protein
            phosphatase-1
  JOURNAL   Chem Biol 16 (4), 365-371 (2009)
   PUBMED   19389623
REFERENCE   8  (bases 1 to 1532)
  AUTHORS   Danielson,P.E., Sautkulis,L.N., Foye,P.E., Hedlund,P.B. and
            Carson,M.J.
  TITLE     A novel mRNA expressed along brain ventricles
  JOURNAL   Brain Res Gene Expr Patterns 1 (2), 83-88 (2002)
   PUBMED   15018803
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI561157.1 and BC053995.1.
            
            On Nov 23, 2018 this sequence version replaced NM_145017.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK057333.1, JF442033.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2144333
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            MANE Ensembl match                 :: ENST00000338608.7/
                                                  ENSP00000344140.2
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-227               BI561157.1         6-232
            228-1532            BC053995.1         132-1436
FEATURES             Location/Qualifiers
     source          1..1532
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.2"
     gene            1..1532
                     /gene="SAXO4"
                     /gene_synonym="C11orf66; IIIG9; PPP1R32"
                     /note="stabilizer of axonemal microtubules 4"
                     /db_xref="GeneID:220004"
                     /db_xref="HGNC:HGNC:28869"
                     /db_xref="MIM:619047"
     exon            1..97
                     /gene="SAXO4"
                     /gene_synonym="C11orf66; IIIG9; PPP1R32"
                     /inference="alignment:Splign:2.1.0"
     exon            98..234
                     /gene="SAXO4"
                     /gene_synonym="C11orf66; IIIG9; PPP1R32"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..1403
                     /gene="SAXO4"
                     /gene_synonym="C11orf66; IIIG9; PPP1R32"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein phosphatase 1 regulatory subunit 32"
                     /codon_start=1
                     /product="stabilizer of axonemal microtubules 4 isoform 1"
                     /protein_id="NP_659454.2"
                     /db_xref="CCDS:CCDS8008.1"
                     /db_xref="GeneID:220004"
                     /db_xref="HGNC:HGNC:28869"
                     /db_xref="MIM:619047"
                     /translation="MMGKLPLGVVSPYVKMSSGGYTDPLKFYATSYCTAYGREDFKPR
                     VGSHVGTGYKSNFQPVVSCQASLEALDNPARGEQAQDHFQSVASQSYRPLEVPDGKHP
                     LPWSMRQTSSGYGREKPSAGPPTKEVRKVHFDTQEHGPQAITGLEPREVPLLHQQQGQ
                     DPLERENFRHGPRFMTSEYNSKYLRDPLDQPDFLQKKSIGAKEGSGFTKQSHQSPIVF
                     QPPSQALPGDPALLPGQSVTKSDFLPKTHLHGDEFLPVLARGSKRETAFSRGNERILN
                     PRVPPPCPEPSSVSHQQFQPLHRMQQTNVALLGRETVGKKEPTGFSLNNPMYVRSPCD
                     PDRDQRYLTTYNQGYFENIPKGLDQEGWTRGGIQPQMPGGYALSQPVSCMEATPNPME
                     SLRHLHPHVGRTLTSADPFYQNTPHSSRCVAHS"
     exon            235..352
                     /gene="SAXO4"
                     /gene_synonym="C11orf66; IIIG9; PPP1R32"
                     /inference="alignment:Splign:2.1.0"
     exon            353..506
                     /gene="SAXO4"
                     /gene_synonym="C11orf66; IIIG9; PPP1R32"
                     /inference="alignment:Splign:2.1.0"
     exon            507..635
                     /gene="SAXO4"
                     /gene_synonym="C11orf66; IIIG9; PPP1R32"
                     /inference="alignment:Splign:2.1.0"
     exon            636..699
                     /gene="SAXO4"
                     /gene_synonym="C11orf66; IIIG9; PPP1R32"
                     /inference="alignment:Splign:2.1.0"
     exon            700..812
                     /gene="SAXO4"
                     /gene_synonym="C11orf66; IIIG9; PPP1R32"
                     /inference="alignment:Splign:2.1.0"
     exon            813..872
                     /gene="SAXO4"
                     /gene_synonym="C11orf66; IIIG9; PPP1R32"
                     /inference="alignment:Splign:2.1.0"
     exon            873..959
                     /gene="SAXO4"
                     /gene_synonym="C11orf66; IIIG9; PPP1R32"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1073
                     /gene="SAXO4"
                     /gene_synonym="C11orf66; IIIG9; PPP1R32"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1168
                     /gene="SAXO4"
                     /gene_synonym="C11orf66; IIIG9; PPP1R32"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1333
                     /gene="SAXO4"
                     /gene_synonym="C11orf66; IIIG9; PPP1R32"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..1417
                     /gene="SAXO4"
                     /gene_synonym="C11orf66; IIIG9; PPP1R32"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..1532
                     /gene="SAXO4"
                     /gene_synonym="C11orf66; IIIG9; PPP1R32"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1512..1517
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SAXO4"
                     /gene_synonym="C11orf66; IIIG9; PPP1R32"
                     /note="hexamer: AATAAA"
     polyA_site      1532
                     /gene="SAXO4"
                     /gene_synonym="C11orf66; IIIG9; PPP1R32"
                     /note="major polyA site"
ORIGIN      
        1 gtttctcctg cttggcctcc tccaggaggg ctggcttctc tgcagagctc tgcttcctgc
       61 agcctctccc cgacctcaga gcctctgcag aggaaaggcc ccctggggcc ctgccccaca
      121 gcatcatgat ggggaaactc cccctggggg tcgtctcccc ttatgtgaag atgagttcgg
      181 ggggctacac ggaccccctg aaattctacg ccaccagcta ctgcaccgcc tacggtcggg
      241 aggatttcaa gccccgtgtg ggcagtcacg taggcaccgg ctacaaatca aatttccagc
      301 ccgtggtctc atgccaagcc agtctggagg ccttagacaa cccggccagg ggggaacaag
      361 cccaggacca tttccagtct gtggccagcc agagctaccg ccccctggag gtgcctgacg
      421 gcaagcatcc cctgccctgg agcatgcgcc agaccagctc aggctatggg cgggagaagc
      481 ccagtgcggg tccccccacc aaggaggtcc ggaaggtcca tttcgacacc caggagcacg
      541 ggcctcaggc catcacgggg ctggagccca gggaagtgcc tctgctccac cagcagcagg
      601 gccaggaccc gctggagcgg gagaacttcc gacatggccc acgcttcatg acgtcggagt
      661 acaattccaa gtatctcagg gaccctctag accagccaga tttcttgcag aagaaatcga
      721 tcggcgcaaa ggaggggagt ggcttcacca aacagtccca ccagagcccc attgtcttcc
      781 aaccgccctc acaggccctc cctggggacc ctgccctcct cccaggccag agtgtcacca
      841 agtcagactt cctccccaag actcacctac atggagatga gttcctacct gtgttggcca
      901 gaggctccaa gcgggaaaca gccttcagcc gagggaatga aaggattctg aaccccagag
      961 tgccccctcc ctgcccagaa cccagcagcg tgagtcacca gcagtttcag ccacttcatc
     1021 ggatgcaaca gacaaacgtt gccctgcttg gccgggagac tgtggggaaa aaggagccca
     1081 cagggttcag ccttaacaac cccatgtatg tccggagccc ctgtgatcct gacagggatc
     1141 agcgatacct gaccacctac aaccaagggt actttgagaa catccccaag ggtctagacc
     1201 aggaaggctg gactcgaggt ggcatccagc cccagatgcc aggaggctac gccctcagcc
     1261 agccggtcag ctgcatggag gccaccccca accccatgga gagcctgcgg cacctgcatc
     1321 cccacgtggg aagaaccctg acctcagctg accccttcta ccagaacaca cctcacagca
     1381 gccgctgcgt ggcacacagc tgagccctga gcccttggtt tgtcaatcct aggggacagg
     1441 agccaggcta ctgtctgtac ccccactcca tcccccaggg gaacacccct gcccagctac
     1501 tttcctaatg aaataaagag cattgaagca ga
//
