LOCUS       NM_001348699            3304 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens stabilizer of axonemal microtubules 2 (SAXO2),
            transcript variant 1, mRNA.
ACCESSION   NM_001348699
VERSION     NM_001348699.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3304)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3304)
  AUTHORS   Dacheux,D., Roger,B., Bosc,C., Landrein,N., Roche,E., Chansel,L.,
            Trian,T., Andrieux,A., Papaxanthos-Roche,A., Marthan,R.,
            Robinson,D.R. and Bonhivers,M.
  TITLE     Human FAM154A (SAXO1) is a microtubule-stabilizing protein specific
            to cilia and related structures
  JOURNAL   J Cell Sci 128 (7), 1294-1307 (2015)
   PUBMED   25673876
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC026624.8 and DB233386.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001348699.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DB233386.1, DRR138524.349075.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2144333
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000682753.1/ ENSP00000508095.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AC026624.8         24810-24813         c
            5-576               DB233386.1         1-572
            577-3304            AC026624.8         2704-5431           c
FEATURES             Location/Qualifiers
     source          1..3304
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q25.2"
     gene            1..3304
                     /gene="SAXO2"
                     /gene_synonym="FAM154B"
                     /note="stabilizer of axonemal microtubules 2"
                     /db_xref="GeneID:283726"
                     /db_xref="HGNC:HGNC:33727"
     exon            1..115
                     /gene="SAXO2"
                     /gene_synonym="FAM154B"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..1439
                     /gene="SAXO2"
                     /gene_synonym="FAM154B"
                     /note="isoform a is encoded by transcript variant 1;
                     protein FAM154B; family with sequence similarity 154,
                     member B"
                     /codon_start=1
                     /product="stabilizer of axonemal microtubules 2 isoform a"
                     /protein_id="NP_001335628.1"
                     /db_xref="CCDS:CCDS92049.1"
                     /db_xref="GeneID:283726"
                     /db_xref="HGNC:HGNC:33727"
                     /translation="MGAKSMRSWCLCQICSCGRHHCPRGTTRIYENSGVFCPTTEYLE
                     KYPMYDNVLPPQSLKAKQEIRACHGKMEGITTFKSDYCPYEIVKQPRHVPEEYKPKQG
                     KIDLGTTYKRDLNSYKVQPVAIVRPLERQVKKGKLDTVPTYKDDYRAWDLHKSELYKP
                     EQTYHPPTVKFGNSTTFQDDFVPQEIKPRQSFKPSSVVKRSTAPFNGITSHRLDYIPH
                     QLELKFERPKEVYKPTDQRFEDLTTHRCDFQGLIGETAKLCRPVHTRVTQNALFEGST
                     EFRESFQPWEIPPPEVKKVPEYVPPTGSMLLNSTSHLDYVPYQANHVVPIRPVSQKRS
                     NNFPFQGKSIMKEDFPAWESCRQGLIKKQQQIPNPSGKFDGLSTFRSHYVPHELIPTE
                     SCKPLNIAFKSSVPFDDVTMYSVEYTPKRQEICPASYPSPPGYIFDNTNSQGHKFFRK
                     IIPAVKAF"
     exon            116..295
                     /gene="SAXO2"
                     /gene_synonym="FAM154B"
                     /inference="alignment:Splign:2.1.0"
     exon            296..495
                     /gene="SAXO2"
                     /gene_synonym="FAM154B"
                     /inference="alignment:Splign:2.1.0"
     exon            496..3304
                     /gene="SAXO2"
                     /gene_synonym="FAM154B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3279..3284
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SAXO2"
                     /gene_synonym="FAM154B"
                     /note="hexamer: AATAAA"
     polyA_site      3304
                     /gene="SAXO2"
                     /gene_synonym="FAM154B"
                     /note="major polyA site"
ORIGIN      
        1 gactacggcg ggcgctgtgg gagtggagaa gctgcaagtg ctgaggcgcg gtggaggaaa
       61 gcatgggagc caagagtatg aggagctggt gtctgtgtca gatttgtagc tgcgggcgac
      121 atcattgtcc acgtggaacc acaaggattt atgaaaattc tggggtgttt tgccctacaa
      181 ctgaatattt ggaaaaatat cctatgtatg acaatgttct tccacctcag agtcttaaag
      241 ccaagcaaga aattcgagca tgccatggta aaatggaagg aataactaca tttaagtcgg
      301 attattgtcc ttatgaaata gttaaacagc ctcgccatgt gccagaagaa tataaaccaa
      361 aacaagggaa gattgatctt ggtactacct acaaacggga tttgaattcg tataaagtgc
      421 agcctgtggc aatagtccgg cctttggaga gacaagttaa aaaaggaaaa ttggacactg
      481 tcccaaccta taaagacgat tatagagctt gggaccttca taaaagtgaa ctttataagc
      541 cagaacaaac ttaccacccg cctactgtga aatttggaaa ttcaactaca tttcaggatg
      601 attttgttcc tcaggagata aagcctaggc aaagctttaa accctcctct gtggtcaaac
      661 gttctacagc cccttttaat ggtattacaa gtcatcgcct tgattatata cctcatcagc
      721 ttgaactcaa gtttgaaagg ccaaaagaag tttacaaacc aactgaccaa cgctttgagg
      781 atctcacaac tcaccggtgt gactttcagg gtctcattgg tgaaactgca aaactctgca
      841 gacctgtaca caccagagtg acccagaatg ctctgtttga aggaagcact gaattccgtg
      901 aaagttttca accatgggaa atcccaccac ctgaggtcaa gaaagtacca gagtatgtgc
      961 ctcctacagg tagcatgctg ttaaacagca caagccatct tgactatgtt ccatatcagg
     1021 ccaaccatgt tgttcccatc aggccagttt ctcaaaaaag aagtaacaat tttcctttcc
     1081 aaggaaaaag catcatgaaa gaagattttc cagcatggga aagttgtcgt caaggactta
     1141 ttaagaagca gcagcagatt cccaacccat ctggaaaatt tgatggtttg agcactttca
     1201 gatctcacta tgtgccacat gaattgatcc caacagagag ttgcaaacct ttaaatattg
     1261 cttttaagag ttctgttcca tttgatgatg taaccatgta ctctgtagag tacacaccga
     1321 aaagacagga aatttgccca gccagctatc cctctcctcc aggttatatt ttcgacaata
     1381 caaattccca aggtcataaa ttcttccgca agattattcc tgcagtgaag gccttctaat
     1441 aaccaaaatg tgcttaaaag gaaggtacta gcaagttgtt gtttttccaa gagaaaactc
     1501 aatttttata gttaaaaaat ttatgatata ataaatcatt ttttatattt ttaaacaaga
     1561 aaattggaaa atatattata agaaatcaga atcttaaaac cattttttat tgatatttta
     1621 atcaagattg ttctttaatg tgcatttcag aaggttgaat aatatgcatt cccatgagaa
     1681 ctattttagt attcaacata ctgcttagta gcttgtcccc agtctattat catttgtaat
     1741 tctgtttata attatggcaa ttgtatggtt attcacatac catttgtcat ttatcaagca
     1801 catcaggatt atctagaaca acattgaaaa tgatacatgg attcctcttc caaggcaaca
     1861 ggattcatta tactcagact tcacggcatc tacatagcat ccactgaatc aagttttggt
     1921 tggtggtata cagactgctg cactgctcct caccatgttc aagttagcaa gaggcactgt
     1981 ggtgtggcaa ggaaaggctc tgtgtgctgg gaatcgaagg acttgagttc aagttctgac
     2041 taataattat tattattttt agagacaggg tctcactgtc acccgtgctg gagtccagtg
     2101 gcataatcac agcttactgc agcctcagcc tcctgagctc aagtgatcct cctgcctcag
     2161 cctcccaaat agctgggact acaagggtgt gccaccacac ctggctattt tttttaaaca
     2221 tactttgtag agacaggttc ttgctgtatt agtcaggctg ttcaatctat tggccaggct
     2281 gctattgaat cccaccttgg cttcccaaag cactgggatt acaggcatga gccactatac
     2341 ccaacctgag tttaagttct aataatatag atttctattt gtactacctt aggcagtgac
     2401 tcatatctct gagcctcagt gtctttattt gtaaaatgat gtctgttctc aaaaagagtt
     2461 tgttttgagc atcagactgt atggtacatt ttaatcctta aagtacaaat gtggaggatt
     2521 tttttttaaa attgctcaat ctctttttgt acttgttttc tccttttcaa attaggataa
     2581 ttacttactc aatgctcatt ttctggcctg tagcaaggat tgtaaaataa cctaatttgc
     2641 tttgagctta tgagtagtat atacttctga gaggagtctt gtcctttaaa acttcatgag
     2701 cacctgagaa attcttaaca gagaatggaa agcttggaat ggggtaaata cagtggtttg
     2761 aataacagta tttgcagaaa ggaaaaagta ttatttgcta gggtagtttt aggaagactg
     2821 acagctctga agaaatcttt agggtaaatg taggtaattt tgcacctaat tgccaggcca
     2881 agtcactgtt tagaggaaga accagcccca gcagggggca taatcacctg gttcacctct
     2941 tccggtgtga agataagtga taaggtaaag aatgatgcca gtaagtatag tagaaacact
     3001 ctattgcatt tataaatgct aaaaatttcc gaatgaatta aactcttatt gggtggtttc
     3061 tttttttaaa aaaattaaat aattgcatta tgggagaata tgatttattt tagcataaag
     3121 tgaattttag tcttttatgg cttcagaatt atttcaaaat atactttatt gaaaatcaat
     3181 atttggttat tttaattgtt caaaagtaat ttgttcttta catttattag taaaagtatg
     3241 gtgtgtgaaa ctatatttcc atgcaacata ataaaatcaa taaaaggaat ggattttcaa
     3301 gaaa
//
