LOCUS       NM_021818               3094 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens salvador family WW domain containing protein 1 (SAV1),
            mRNA.
ACCESSION   NM_021818
VERSION     NM_021818.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3094)
  AUTHORS   Liu,T., Guo,W., Luo,K., Li,L., Dong,J., Liu,M., Shi,X., Wang,Z.,
            Zhang,J., Yin,J., Qiu,N., Lu,M., Chen,D., Jia,X., Liu,H., Gu,Y.,
            Xiong,Y., Zheng,G., Xu,G., He,Z. and Zhang,Z.
  TITLE     Smoke-induced SAV1 Gene Promoter Hypermethylation Disrupts YAP
            Negative Feedback and Promotes Malignant Progression of Non-small
            Cell Lung Cancer
  JOURNAL   Int J Biol Sci 18 (11), 4497-4512 (2022)
   PUBMED   35864957
  REMARK    GeneRIF: Smoke-induced SAV1 Gene Promoter Hypermethylation Disrupts
            YAP Negative Feedback and Promotes Malignant Progression of
            Non-small Cell Lung Cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3094)
  AUTHORS   Qi,S., Zhu,Y., Liu,X., Li,P., Wang,Y., Zeng,Y., Yu,A., Wang,Y.,
            Sha,Z., Zhong,Z., Zhu,R., Yuan,H., Ye,D., Huang,S., Ling,C., Xu,Y.,
            Zhou,D., Zhang,L. and Yu,F.X.
  TITLE     WWC proteins mediate LATS1/2 activation by Hippo kinases and imply
            a tumor suppression strategy
  JOURNAL   Mol Cell 82 (10), 1850-1864 (2022)
   PUBMED   35429439
REFERENCE   3  (bases 1 to 3094)
  AUTHORS   Yu,T., Yao,L., Yin,H., Teng,Y., Hong,M. and Wu,Q.
  TITLE     ALKBH5 Promotes Multiple Myeloma Tumorigenicity through inducing
            m6A-demethylation of SAV1 mRNA and Myeloma Stem Cell Phenotype
  JOURNAL   Int J Biol Sci 18 (6), 2235-2248 (2022)
   PUBMED   35414790
  REMARK    GeneRIF: ALKBH5 Promotes Multiple Myeloma Tumorigenicity through
            inducing m(6)A-demethylation of SAV1 mRNA and Myeloma Stem Cell
            Phenotype.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3094)
  AUTHORS   Paul,A., Annunziato,S., Lu,B., Sun,T., Evrova,O., Planas-Paz,L.,
            Orsini,V., Terracciano,L.M., Charlat,O., Loureiro,Z.Y., Ji,L.,
            Zamponi,R., Sigoillot,F., Lei,H., Lindeman,A., Russ,C.,
            Reece-Hoyes,J.S., Nicholson,T.B., Tchorz,J.S. and Cong,F.
  TITLE     Cell adhesion molecule KIRREL1 is a feedback regulator of Hippo
            signaling recruiting SAV1 to cell-cell contact sites
  JOURNAL   Nat Commun 13 (1), 930 (2022)
   PUBMED   35177623
  REMARK    GeneRIF: Cell adhesion molecule KIRREL1 is a feedback regulator of
            Hippo signaling recruiting SAV1 to cell-cell contact sites.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3094)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 3094)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   7  (bases 1 to 3094)
  AUTHORS   Chan,E.H., Nousiainen,M., Chalamalasetty,R.B., Schafer,A.,
            Nigg,E.A. and Sillje,H.H.
  TITLE     The Ste20-like kinase Mst2 activates the human large tumor
            suppressor kinase Lats1
  JOURNAL   Oncogene 24 (12), 2076-2086 (2005)
   PUBMED   15688006
REFERENCE   8  (bases 1 to 3094)
  AUTHORS   Yoo,N.J., Soung,Y.H., Lee,J.W., Park,W.S., Kim,S.Y., Nam,S.W.,
            Han,J.H., Kim,S.H., Lee,J.Y. and Lee,S.H.
  TITLE     Mutational analysis of salvador gene in human carcinomas
  JOURNAL   APMIS 111 (6), 595-598 (2003)
   PUBMED   12969014
  REMARK    GeneRIF: Salvador gene is not frequently mutated in human carcinoma
            tissues.
REFERENCE   9  (bases 1 to 3094)
  AUTHORS   Tapon,N., Harvey,K.F., Bell,D.W., Wahrer,D.C., Schiripo,T.A.,
            Haber,D. and Hariharan,I.K.
  TITLE     salvador Promotes both cell cycle exit and apoptosis in Drosophila
            and is mutated in human cancer cell lines
  JOURNAL   Cell 110 (4), 467-478 (2002)
   PUBMED   12202036
REFERENCE   10 (bases 1 to 3094)
  AUTHORS   Valverde,P.
  TITLE     Cloning, expression, and mapping of hWW45, a novel human WW
            domain-containing gene
  JOURNAL   Biochem Biophys Res Commun 276 (3), 990-998 (2000)
   PUBMED   11027580
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA479812.1, AK023071.1,
            BC006385.2 and DB543756.1.
            
            On May 17, 2019 this sequence version replaced NM_021818.3.
            
            Summary: WW domain-containing proteins are found in all eukaryotes
            and play an important role in the regulation of a wide variety of
            cellular functions such as protein degradation, transcription, and
            RNA splicing. This gene encodes a protein with two WW domains, a
            SARAH domain, and a coiled-coil region and is ubiquitously
            expressed in adult tissues. This protein binds to MST1 (mammalian
            sterile 20-like kinase 1) and promotes MST1-induced apoptosis. It
            has also been shown to bind to HAX1 (hematopoietic cell-specific
            protein 1 (HS1)-associated protein X-1) and to attenuate the
            anti-apoptotic effects of HAX1. Studies in human and mouse suggest
            this gene acts as a tumor suppressor. [provided by RefSeq, Aug
            2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK021500.1, SRR1660805.200144.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000324679.5/ ENSP00000324729.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-124               DA479812.1         33-156
            125-1750            AK023071.1         1-1626
            1751-2321           BC006385.2         1671-2241
            2322-2750           AK023071.1         2192-2620
            2751-3094           DB543756.1         1-344               c
FEATURES             Location/Qualifiers
     source          1..3094
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q22.1"
     gene            1..3094
                     /gene="SAV1"
                     /gene_synonym="SAV; WW45; WWP4"
                     /note="salvador family WW domain containing protein 1"
                     /db_xref="GeneID:60485"
                     /db_xref="HGNC:HGNC:17795"
                     /db_xref="MIM:607203"
     exon            1..433
                     /gene="SAV1"
                     /gene_synonym="SAV; WW45; WWP4"
                     /inference="alignment:Splign:2.1.0"
     CDS             340..1491
                     /gene="SAV1"
                     /gene_synonym="SAV; WW45; WWP4"
                     /note="1700040G09Rik; salvador homolog 1; WW
                     domain-containing adaptor 45; hWW45; 45 kDa WW domain
                     protein"
                     /codon_start=1
                     /product="protein salvador homolog 1"
                     /protein_id="NP_068590.1"
                     /db_xref="CCDS:CCDS9701.1"
                     /db_xref="GeneID:60485"
                     /db_xref="HGNC:HGNC:17795"
                     /db_xref="MIM:607203"
                     /translation="MLSRKKTKNEVSKPAEVQGKYVKKETSPLLRNLMPSFIRHGPTI
                     PRRTDICLPDSSPNAFSTSGDVVSRNQSFLRTPIQRTPHEIMRRESNRLSAPSYLARS
                     LADVPREYGSSQSFVTEVSFAVENGDSGSRYYYSDNFFDGQRKRPLGDRAHEDYRYYE
                     YNHDLFQRMPQNQGRHASGIGRVAATSLGNLTNHGSEDLPLPPGWSVDWTMRGRKYYI
                     DHNTNTTHWSHPLEREGLPPGWERVESSEFGTYYVDHTNKKAQYRHPCAPSVPRYDQP
                     PPVTYQPQQTERNQSLLVPANPYHTAEIPDWLQVYARAPVKYDHILKWELFQLADLDT
                     YQGMLKLLFMKELEQIVKMYEAYRQALLTELENRKQRQQWYAQQHGKNF"
     exon            434..874
                     /gene="SAV1"
                     /gene_synonym="SAV; WW45; WWP4"
                     /inference="alignment:Splign:2.1.0"
     exon            875..1145
                     /gene="SAV1"
                     /gene_synonym="SAV; WW45; WWP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1289
                     /gene="SAV1"
                     /gene_synonym="SAV; WW45; WWP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..3094
                     /gene="SAV1"
                     /gene_synonym="SAV; WW45; WWP4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3018..3023
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SAV1"
                     /gene_synonym="SAV; WW45; WWP4"
                     /note="hexamer: AATATA"
     polyA_site      3035
                     /gene="SAV1"
                     /gene_synonym="SAV; WW45; WWP4"
                     /note="major polyA site"
ORIGIN      
        1 agtggtagcg gttattcggc ggcccgcggc ggaccatggc cctggccctg gcccggcgtc
       61 gctgggcttt cctcacggcg tccccgagca gcgtcgcaga gcgggccgac ttccgggaag
      121 gaactgacca gcgactgagc ggcggccggc gcgcttagcg ccctgaacat gcggcagtcc
      181 ctgcgggcga ccccgggctc cggacaggcg gcggcggagg cggcggctcg ggagggaagg
      241 aggcggcggc gccggcggag gtggcggcgg agacggccgg cgcccggcgc ggagccctag
      301 ggaggcagtt cagcgcggcc tcgggcctcg tcgagaagga tgctgtcccg aaagaaaacc
      361 aaaaacgaag tgtccaagcc ggccgaggtg caggggaagt acgtgaagaa ggagacgtcg
      421 cctctgcttc ggaatcttat gccttcattc atccggcatg gtccaacaat tccaagacga
      481 actgatatct gtcttccaga ttcaagccct aatgcctttt caacttctgg agatgtagtt
      541 tcaagaaacc agagtttcct tagaactcca attcaaagaa cacctcatga aataatgaga
      601 agagaaagca acagattatc tgcaccttct tatcttgcca gaagtctagc agatgtccct
      661 agagagtatg gttcttctca gtcatttgta acggaagtta gttttgctgt tgaaaatgga
      721 gactctggtt cccgatatta ttattcagac aatttttttg atggtcagag aaagcggcca
      781 cttggagatc gtgcacatga agactacaga tattatgaat acaaccatga tctcttccaa
      841 agaatgccac agaatcaggg gaggcatgct tcaggtattg ggagagttgc tgctacatct
      901 ttaggaaatt tgactaacca tggttctgaa gatttacccc ttcctcctgg ctggtctgtg
      961 gactggacaa tgagagggag aaaatattat atagatcata acacaaatac aactcactgg
     1021 agccatcctc ttgagcgaga aggacttcct cctggatggg aacgagttga gtcatccgaa
     1081 tttggaacct attatgtaga tcacacaaat aagaaggccc aatacaggca tccctgtgct
     1141 cctagtgtac ctcggtatga tcaaccacct cctgtcacat accagccaca gcaaactgaa
     1201 agaaatcagt cccttctggt acctgcaaat ccatatcata ctgcagaaat tcctgactgg
     1261 cttcaggttt acgcacgagc ccctgtgaaa tatgaccaca ttctgaagtg ggaactcttc
     1321 cagctggctg acctggatac ataccaggga atgctaaagt tgctcttcat gaaagaattg
     1381 gagcagattg ttaaaatgta tgaagcatac agacaagccc ttcttacaga gttggaaaac
     1441 cgaaagcaga gacagcagtg gtatgcccaa caacatggaa aaaatttttg agctgatttt
     1501 ttaaaaattt aagttttgta agagctttaa aatattttca cagataaaaa attgcaaaca
     1561 agtactctgg ttaataaatg ctgcttcctt tgtggaaatt ataaaattct aactttacat
     1621 gtattttgtt attagaaatt ttcttttatt gaatgagaaa aattagtcta tcattttaag
     1681 agccaatatg gcaaacactt tcaaatactg tatattagga aactgttttg gtattcttga
     1741 tggaaaaaaa cgcagcggaa atgtcattat gaacagatgt taaataggaa attattactt
     1801 gttaacttct tacagcagta gtaccttctt taaaaaaaaa aaagaatctg cggtattttt
     1861 ttaaaaaaaa agtttaccgc tgtagtgtga aatattgtct ggaaagggat ggtttaaata
     1921 ttaccatgat gtagttgaaa tataaaatag gatttggaac cttattgtga taaatattta
     1981 tatatgatgt atgtttgtct cccctctcca aagtaaggaa cccagctggg cgtggtggct
     2041 cactcctgta atcccagcat tttgggaggc cgaggtgggt ggaccgcttg agtccacgag
     2101 tttaagacca gcctgggcaa catggtgaag ccccatctct acaaaaaata caaaaaaatt
     2161 agccgggtat gatggtgtgt gcctctagtc ccagctactt gggaggctga ggtcagagga
     2221 tggcttgagc ccaagaggca gaggttgcag ggtcaagatc gcaccacttg cactgcagcc
     2281 tgagagagag agagccagac cttgtctcaa aaaataaaaa ataaaaaaat aaaaacaaaa
     2341 taaggaatcc ttttaaagca tgttgagaaa gtattttttg gtatgaatgg gtgacgggcc
     2401 ttttaatctt tcaggaatac atataagcag gaatacttag cctgtattgg gaaggtgcgt
     2461 gaaactcaaa gttgctaaca tcatcttcct tattttcagc cagtgctgtt actgcattta
     2521 gcatggctct gacgaggcag tggagagttc ctgacagcat agcatactgc cttctgacag
     2581 actgggttaa gctaccaaaa atgacaacca gggattcaaa aaaaattttt ggtcattaaa
     2641 tcgaatgtat attattactt tttaattttc taagtattta tcacaggact ttaacaccat
     2701 atatttccct cccagttttt ctcccctttt ggtttaatag ttaaaacatt tttcataatt
     2761 agtgctgtac atttgattgc aaacaaattg gtgatacttc taaactataa ctataaatct
     2821 ctagaattct gtgaatttca acattatttg aagtagttct tcagttatat ttacatgtgt
     2881 tgtaaatatg taaatatact tttagcttag gaagtcttcc agaatacaaa ctactcccag
     2941 ttagatatca gtgagtttga ataactgaag aaatgttgac aatgttaagt gtttgatttt
     3001 atataacaag cttattaaat atatttttgt ggaaactaag cgcgtggttt ttgagtccat
     3061 gttttagaca tagtgctgta tttcattttt ctgt
//
