LOCUS       NM_002971               7822 bp    mRNA    linear   PRI 03-SEP-2024
DEFINITION  Homo sapiens SATB homeobox 1 (SATB1), transcript variant 1, mRNA.
ACCESSION   NM_002971
VERSION     NM_002971.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7822)
  AUTHORS   Sun,L., Wang,F., Wang,X., Zhang,F., Ma,S. and Lv,J.
  TITLE     SATB1 mediated tumor colonization and beta-catenin nuclear
            localization are associated with colorectal cancer progression
  JOURNAL   Cancer Biol Ther 25 (1), 2320307 (2024)
   PUBMED   38385627
  REMARK    GeneRIF: SATB1 mediated tumor colonization and beta-catenin nuclear
            localization are associated with colorectal cancer progression.
REFERENCE   2  (bases 1 to 7822)
  AUTHORS   Vicelic Cutura,L., Vujcic,M., Galusic,D., Blaslov,V., Petric,M.,
            Miljak,A., Lozic,M., Benzon,B., Vukojevic,K., Bubic,T., Kunac,N.,
            Zjacic Puljiz,D., Delic Jukic,I.K., Krizanac,M. and Lozic,B.
  TITLE     SATB1 and p16 Expression and Prognostic Value in Croatian Hodgkin
            Lymphoma Patients: A Unicentric Study
  JOURNAL   Cells 13 (16), 1323 (2024)
   PUBMED   39195213
  REMARK    GeneRIF: SATB1 and p16 Expression and Prognostic Value in Croatian
            Hodgkin Lymphoma Patients: A Unicentric Study.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7822)
  AUTHORS   Zhu,H., Ruan,X., Zhao,K., Kuang,W., Liu,S., Yan,W., Fu,X.,
            Cheng,Z., Li,R. and Peng,H.
  TITLE     The miR-641-STIM1 and SATB1 axes play important roles in the
            regulation of the Th17/Treg balance in ITP
  JOURNAL   Sci Rep 14 (1), 11243 (2024)
   PUBMED   38755179
  REMARK    GeneRIF: The miR-641-STIM1 and SATB1 axes play important roles in
            the regulation of the Th17/Treg balance in ITP.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7822)
  AUTHORS   Yu,K.Q., Li,C.F., Ye,L., Song,Y., Wang,Y.H., Lin,Y.R., Liao,S.T.,
            Mei,Z.C. and Lv,L.
  TITLE     Long Non-Coding RNA ANRIL Regulates Inflammatory Factor Expression
            in Ulcerative Colitis Via the miR-191-5p/SATB1 Axis
  JOURNAL   Inflammation 47 (2), 513-529 (2024)
   PUBMED   37985573
  REMARK    GeneRIF: Long Non-Coding RNA ANRIL Regulates Inflammatory Factor
            Expression in Ulcerative Colitis Via the miR-191-5p/SATB1 Axis.
REFERENCE   5  (bases 1 to 7822)
  AUTHORS   Cui,D., Li,Z., Wei,C., Zhang,Q. and Xiao,C.
  TITLE     Long non-coding RNA LINC00491 accelerates head and neck squamous
            cell carcinoma progression through regulating miR-508-3p/SATB1 axis
            and activating Wnt signaling pathway
  JOURNAL   Cytokine 175, 156444 (2024)
   PUBMED   38150791
  REMARK    GeneRIF: Long non-coding RNA LINC00491 accelerates head and neck
            squamous cell carcinoma progression through regulating
            miR-508-3p/SATB1 axis and activating Wnt signaling pathway.
REFERENCE   6  (bases 1 to 7822)
  AUTHORS   Reddy,P.H., Stockburger,E., Gillevet,P. and Tagle,D.A.
  TITLE     Mapping and characterization of novel (CAG)n repeat cDNAs from
            adult human brain derived by the oligo capture method
  JOURNAL   Genomics 46 (2), 174-182 (1997)
   PUBMED   9417904
REFERENCE   7  (bases 1 to 7822)
  AUTHORS   Xu,L., Deng,H.X., Xia,J.H., Yang,Y., Fan,C.H., Hung,W.Y. and
            Siddque,T.
  TITLE     Assignment of SATB1 to human chromosome band 3p23 by in situ
            hybridization
  JOURNAL   Cytogenet Cell Genet 77 (3-4), 205-206 (1997)
   PUBMED   9284917
REFERENCE   8  (bases 1 to 7822)
  AUTHORS   Robertson,N.G., Khetarpal,U., Gutierrez-Espeleta,G.A., Bieber,F.R.
            and Morton,C.C.
  TITLE     Isolation of novel and known genes from a human fetal cochlear cDNA
            library using subtractive hybridization and differential screening
  JOURNAL   Genomics 23 (1), 42-50 (1994)
   PUBMED   7829101
REFERENCE   9  (bases 1 to 7822)
  AUTHORS   Nakagomi,K., Kohwi,Y., Dickinson,L.A. and Kohwi-Shigematsu,T.
  TITLE     A novel DNA-binding motif in the nuclear matrix attachment
            DNA-binding protein SATB1
  JOURNAL   Mol Cell Biol 14 (3), 1852-1860 (1994)
   PUBMED   8114718
REFERENCE   10 (bases 1 to 7822)
  AUTHORS   Dickinson,L.A., Joh,T., Kohwi,Y. and Kohwi-Shigematsu,T.
  TITLE     A tissue-specific MAR/SAR DNA-binding protein with unusual binding
            site recognition
  JOURNAL   Cell 70 (4), 631-645 (1992)
   PUBMED   1505028
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC144521.9, AK127242.1,
            AB209761.1, BC001744.1, AA001621.1, DA938384.1 and AC139618.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_002971.5.
            
            Summary: This gene encodes a matrix protein which binds nuclear
            matrix and scaffold-associating DNAs through a unique nuclear
            architecture. The protein recruits chromatin-remodeling factors in
            order to regulate chromatin structure and gene expression.
            [provided by RefSeq, Apr 2016].
            
            Transcript Variant: This variant (1) differs in the 5' UTR and
            lacks an alternate exon in the 3' coding region, compared to
            variant 3. Isoform 1 has a shorter C-terminus, compared to isoform
            2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK127242.1, M97287.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000338745.11/ ENSP00000341024.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AC144521.9         113315-113316       c
            3-772               AK127242.1         7-776
            773-1388            AB209761.1         44-659
            1389-1597           AC144521.9         111720-111928       c
            1598-3122           AK127242.1         1601-3125
            3123-4463           BC001744.1         1558-2898
            4464-5256           AK127242.1         4467-5259
            5257-5425           AA001621.1         324-492
            5426-5558           DA938384.1         473-605
            5559-7822           AC139618.3         125309-127572       c
FEATURES             Location/Qualifiers
     source          1..7822
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p24.3"
     gene            1..7822
                     /gene="SATB1"
                     /gene_synonym="DEFDA; DHDBV; KTZSL"
                     /note="SATB homeobox 1"
                     /db_xref="GeneID:6304"
                     /db_xref="HGNC:HGNC:10541"
                     /db_xref="MIM:602075"
     exon            1..1713
                     /gene="SATB1"
                     /gene_synonym="DEFDA; DHDBV; KTZSL"
                     /inference="alignment:Splign:2.1.0"
     exon            1714..1948
                     /gene="SATB1"
                     /gene_synonym="DEFDA; DHDBV; KTZSL"
                     /inference="alignment:Splign:2.1.0"
     CDS             1738..4029
                     /gene="SATB1"
                     /gene_synonym="DEFDA; DHDBV; KTZSL"
                     /note="isoform 1 is encoded by transcript variant 1;
                     special AT-rich sequence binding protein 1 (binds to
                     nuclear matrix/scaffold-associating DNA); DNA-binding
                     protein SATB1"
                     /codon_start=1
                     /product="DNA-binding protein SATB1 isoform 1"
                     /protein_id="NP_002962.1"
                     /db_xref="CCDS:CCDS2631.1"
                     /db_xref="GeneID:6304"
                     /db_xref="HGNC:HGNC:10541"
                     /db_xref="MIM:602075"
                     /translation="MDHLNEATQGKEHSEMSNNVSDPKGPPAKIARLEQNGSPLGRGR
                     LGSTGAKMQGVPLKHSGHLMKTNLRKGTMLPVFCVVEHYENAIEYDCKEEHAEFVLVR
                     KDMLFNQLIEMALLSLGYSHSSAAQAKGLIQVGKWNPVPLSYVTDAPDATVADMLQDV
                     YHVVTLKIQLHSCPKLEDLPPEQWSHTTVRNALKDLLKDMNQSSLAKECPLSQSMISS
                     IVNSTYYANVSAAKCQEFGRWYKHFKKTKDMMVEMDSLSELSQQGANHVNFGQQPVPG
                     NTAEQPPSPAQLSHGSQPSVRTPLPNLHPGLVSTPISPQLVNQQLVMAQLLNQQYAVN
                     RLLAQQSLNQQYLNHPPPVSRSMNKPLEQQVSTNTEVSSEIYQWVRDELKRAGISQAV
                     FARVAFNRTQGLLSEILRKEEDPKTASQSLLVNLRAMQNFLQLPEAERDRIYQDERER
                     SLNAASAMGPAPLISTPPSRPPQVKTATIATERNGKPENNTMNINASIYDEIQQEMKR
                     AKVSQALFAKVAATKSQGWLCELLRWKEDPSPENRTLWENLSMIRRFLSLPQPERDAI
                     YEQESNAVHHHGDRPPHIIHVPAEQIQQQQQQQQQQQQQQQAPPPPQPQQQPQTGPRL
                     PPRQPTVASPAESDEENRQKTRPRTKISVEALGILQSFIQDVGLYPDEEAIQTLSAQL
                     DLPKYTIIKFFQNQRYYLKHHGKLKDNSGLEVDVAEYKEEELLKDLEESVQDKNTNTL
                     FSVKLEEELSVEGNTDINTDLKD"
     exon            1949..2125
                     /gene="SATB1"
                     /gene_synonym="DEFDA; DHDBV; KTZSL"
                     /inference="alignment:Splign:2.1.0"
     exon            2126..2252
                     /gene="SATB1"
                     /gene_synonym="DEFDA; DHDBV; KTZSL"
                     /inference="alignment:Splign:2.1.0"
     exon            2253..2376
                     /gene="SATB1"
                     /gene_synonym="DEFDA; DHDBV; KTZSL"
                     /inference="alignment:Splign:2.1.0"
     exon            2377..2488
                     /gene="SATB1"
                     /gene_synonym="DEFDA; DHDBV; KTZSL"
                     /inference="alignment:Splign:2.1.0"
     exon            2489..2943
                     /gene="SATB1"
                     /gene_synonym="DEFDA; DHDBV; KTZSL"
                     /inference="alignment:Splign:2.1.0"
     exon            2944..3156
                     /gene="SATB1"
                     /gene_synonym="DEFDA; DHDBV; KTZSL"
                     /inference="alignment:Splign:2.1.0"
     exon            3157..3312
                     /gene="SATB1"
                     /gene_synonym="DEFDA; DHDBV; KTZSL"
                     /inference="alignment:Splign:2.1.0"
     exon            3313..3516
                     /gene="SATB1"
                     /gene_synonym="DEFDA; DHDBV; KTZSL"
                     /inference="alignment:Splign:2.1.0"
     exon            3517..7822
                     /gene="SATB1"
                     /gene_synonym="DEFDA; DHDBV; KTZSL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5237..5242
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SATB1"
                     /gene_synonym="DEFDA; DHDBV; KTZSL"
                     /note="hexamer: ATTAAA"
     polyA_site      5257
                     /gene="SATB1"
                     /gene_synonym="DEFDA; DHDBV; KTZSL"
                     /note="major polyA site"
     regulatory      7374..7379
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SATB1"
                     /gene_synonym="DEFDA; DHDBV; KTZSL"
                     /note="hexamer: AATAAA"
     polyA_site      7393
                     /gene="SATB1"
                     /gene_synonym="DEFDA; DHDBV; KTZSL"
     regulatory      7792..7797
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SATB1"
                     /gene_synonym="DEFDA; DHDBV; KTZSL"
                     /note="hexamer: AATAAA"
     polyA_site      7822
                     /gene="SATB1"
                     /gene_synonym="DEFDA; DHDBV; KTZSL"
ORIGIN      
        1 actttctcgc tcgctcccgt tccccggacg cggcggatga gccggccccg ctggggaagg
       61 ctccgggcgg cggcgggcgg ccgggaggag gctgcgtgct cggggctggg gctgcgagcg
      121 gggtgatttt gtattaaaat gaggaggagg aagaagaggc acccacagcg gcagcggcgg
      181 cggcggcggc agcagcagca ggagcagcgg cggagagggc tgcagcccgg gcggacgcgc
      241 ggagccgagc ggggcacggc ggcggcagcg acagcggccg ggatgagtca actaataatt
      301 taatgggggc agagacggca gcgaggggta gagctagcga gggagagagc gagagaagca
      361 gccccgtccg gggactcgcg ctcacactca cgcacacaca caaacacaca cacacctctc
      421 cctgtgccac ccagcaacac ccggcctcgt cacaacaaca acagccgcgg ccgccctcta
      481 tcctgcccgg gggcccagcc gaaagccagg gcgactctag aggacgctgc ccgcccccct
      541 ctttcatttc gggaaactcc tgatcagttt tgtcggggtt tctgggtttc ttttccccca
      601 aagtcctagt gccattgtgg tgctcgttgt ttacctcgga ctctggacga gtgagagctt
      661 ggcgactttt tggggggagg gggcggggag tttgtcgctg cctaggcggt ggaggtggct
      721 gggggtgcct tctgatcttc ctcctcctcc ccctcccccc gaacctcttc tctcctcact
      781 tgctgggacc ccagacgctc acagccccgc gtcaatgggc agggagaggg tccttgcggc
      841 tgttgtcagc gagggcagaa tcaaaagtgg cattttagtg cctttccggg gcttttctcg
      901 cgaccccctg ccccccaccc tcgctgtccc ccgctagatg ccctcgttgg gggtgcgagg
      961 ctgtggggaa aagtttaagg tttgttaata ttagtcgcga ttgttggcga ggggggtggg
     1021 ggtgattgga agggaggcga ggtggccttc ccaatgcgcg ttattcgggg ttattgaaga
     1081 ataatattgc aagtgacagc cagaagtaga ctttctgtcc tcacaccgaa gaacccgagt
     1141 gagcaggagg gagggagaga cgcgaagaga ccttttttcc tttttggaga ccttgtccgc
     1201 agtgattttt ttttttttaa gagaatcctc agtcaccacg tcgtttcccc agcaccatca
     1261 cagtgtacag ctcataacgg gttttgcttt gtttttacga tttcccccca acgaatcact
     1321 tgtcagatca attttatctt cttcctcctc cctgcttccc actctcccct cctccccatc
     1381 gcaaaccctg ttctctgagg ttagacattt tacaaacccc tatatgttgg ttttcgaatt
     1441 gtgatttttt ttttaaaccc ctttctcatg gctactcttc tagacgttta tttctgccct
     1501 tcccccgctt aggggggcgg gggtagggga aaggaaaata atacaatttc aggggaagtc
     1561 gccttcaggt ctgctgcttt tttatttttt tttttttaat taaaaaaaaa aaggacatag
     1621 aaaacatcag tcttgaactt ctcttcaaga acccgggctg caaaggaaat ctcctttgtt
     1681 tttgttattt atgtgctgtc aagttttgaa gtggtgatct ttagacagtg actgagtatg
     1741 gatcatttga acgaggcaac tcaggggaaa gaacattcag aaatgtctaa caatgtgagt
     1801 gatccgaagg gtccaccagc caagattgcc cgcctggagc agaacgggag cccgctagga
     1861 agaggaaggc ttgggagtac aggtgcaaaa atgcagggag tgcctttaaa acactcgggc
     1921 catctgatga aaaccaacct taggaaagga accatgctgc cagttttctg tgtggtggaa
     1981 cattatgaaa acgccattga atatgattgc aaggaggagc atgcagaatt tgtgctggtg
     2041 agaaaggata tgcttttcaa ccagctgatc gaaatggcat tgctgtctct aggttattca
     2101 catagctctg ctgcccaggc caaagggcta atccaggttg gaaagtggaa tccagttcca
     2161 ctgtcttacg tgacagatgc ccctgatgct acagtagcag atatgcttca agatgtgtat
     2221 catgtggtca cattgaaaat tcagttacac agttgcccca aactagaaga cttgcctccc
     2281 gaacaatggt cgcacaccac agtgaggaat gctctgaagg acttactgaa agatatgaat
     2341 cagagttcat tggccaagga gtgccccctt tcacagagta tgatttcttc cattgtgaac
     2401 agtacttact atgcaaatgt ctcagcagca aaatgtcaag aatttggaag gtggtacaaa
     2461 catttcaaga agacaaaaga tatgatggtt gaaatggata gtctttctga gctatcccag
     2521 caaggcgcca atcatgtcaa ttttggccag caaccagttc cagggaacac agccgagcag
     2581 cctccatccc ctgcgcagct ctcccatggc agccagccct ctgtccggac acctcttcca
     2641 aacctgcacc ctgggctcgt atcaacacct atcagtcctc aattggtcaa ccagcagctg
     2701 gtgatggctc agctgctgaa ccagcagtat gcagtgaata gacttttagc ccagcagtcc
     2761 ttaaaccaac aatacttgaa ccaccctccc cctgtcagta gatctatgaa taagcctttg
     2821 gagcaacagg tttcgaccaa cacagaggtg tcttccgaaa tctaccagtg ggtacgcgat
     2881 gaactgaaac gagcaggaat ctcccaggcg gtatttgcac gtgtggcttt taacagaact
     2941 cagggcttgc tttcagaaat cctccgaaag gaagaggacc ccaagactgc atcccagtct
     3001 ttgctggtaa accttcgggc tatgcagaat ttcttgcagt taccggaagc tgaaagagac
     3061 cgaatatacc aggacgaaag ggaaaggagc ttgaatgctg cctcggccat gggtcctgcc
     3121 cccctcatca gcacaccacc cagccgtcct ccccaggtga aaacagctac tattgccact
     3181 gaaaggaatg ggaaaccaga gaacaatacc atgaacatta atgcttccat ttatgatgag
     3241 attcagcagg aaatgaagcg tgctaaagtg tctcaagcac tgtttgcaaa ggttgcagca
     3301 accaaaagcc agggatggtt gtgcgagctg ttacgctgga aagaagatcc ttctccagaa
     3361 aacagaaccc tgtgggagaa cctctccatg atccgaaggt tcctcagtct tcctcagcca
     3421 gaacgtgatg ccatttatga acaggagagc aacgcggtgc atcaccatgg cgacaggccg
     3481 ccccacatta tccatgttcc agcagagcag attcagcaac agcagcagca acagcaacag
     3541 cagcagcagc agcagcaggc accgccgcct ccacagccac agcagcagcc acagacaggc
     3601 cctcggctcc ccccacggca acccacggtg gcctctccag cagagtcaga tgaggaaaac
     3661 cgacagaaga cccggccacg aacaaaaatt tcagtggaag ccttgggaat cctccagagt
     3721 ttcatacaag acgtgggcct gtaccctgac gaagaggcca tccagactct gtctgcccag
     3781 ctcgaccttc ccaagtacac catcatcaag ttctttcaga accagcggta ctatctcaag
     3841 caccacggca aactgaagga caattccggt ttagaggtcg atgtggcaga atataaagaa
     3901 gaggagctgc tgaaggattt ggaagagagt gtccaagata aaaatactaa cacccttttt
     3961 tcagtgaaac tagaagaaga gctgtcagtg gaaggaaaca cagacattaa tactgatttg
     4021 aaagactgag ataaaagtat ttgtttcgtt caacagtgcc actggtattt actaacaaaa
     4081 tgaaaagtcc accttgtctt ctctcagaaa acctttgttg ttcattgttt ggccaatgaa
     4141 tcttcaaaaa cttgcacaaa cagaaaagtt ggaaaaggat aatacagact gcactaaatg
     4201 ttttcctctg ttttacaaac tgcttggcag ccccaggtga agcatcaagg attgtttggt
     4261 attaaaattt gtgttcacgg gatgcaccaa agtgtgtacc ccgtaagcat gaaaccagtg
     4321 ttttttgttt tttttttagt tcttattccg gagcctcaaa caagcattat accttctgtg
     4381 attatgattt cctctcctat aattatttct gtagcactcc acactgatct ttggaaactt
     4441 gccccttatt taaaaaaaaa aaagaaaaaa aagagtttgt tactctattg tatgttacaa
     4501 aagaactata gactgtggaa tgcagtttaa agatgacata tgccaacaaa tgccttgtat
     4561 tatatggcac tgccgtaatt caaatttgtt tttattttgg aaataaaagt tcactgtact
     4621 tttttttcat tctcattgtt acatgatttt ttaaaaaaag gaaaagaaaa tgtgaaacac
     4681 aatttagtcc tcattattta tttgtagatc ctgcagcatc atgttgtaat taattttttg
     4741 gaagtttccg ttaaatgtaa tattgcttct cttgttacca tactgattct tttctattta
     4801 taaatgtatt ttgatgggca gtaaaacaaa gtgtcttaaa agttttaaat agagaaaatg
     4861 tgctttacac agttgcctat aaaaagtgct ctatgttatc caagcaattc atactataag
     4921 cttcactctt attgttgtat gcaattttta ctatcatgca aataagctta ggtaaataaa
     4981 actaatagat caccttagaa aattatgcaa ttaatgtgaa aataattgat gtttgcaatg
     5041 tgtcttcctt tggtttacaa tcaattttaa agctacatct gtataaaatt tctgtataaa
     5101 ggtgtatttc ttttttatga gtttatggct atgaaaacag ctattttgtt acagctggct
     5161 gtttttataa gtgtatcaca attttcttta tgcagaaatg ttctgactag gagtggttat
     5221 tgactgtaac tacacaatta aaattgtttg tatcgtatga catggtaggg tttgtctgct
     5281 tatgtgaagt aactaaagga gtcaaaggat ggccctctca tttaggtgca tgttaataac
     5341 ttgttatttc actgatttta aaaagagcaa ttgacaagtt acttgaaaca ctgtaaattt
     5401 aaatcacaaa cacatgctca tttttaaata ggtatgaaat ttcacaatga aaataacctg
     5461 tttggttaac attttgctta ataagtagag ataggatggt caaaagactc tccgacaaaa
     5521 acaaatccag tctctagcag ttatgttgtt agaatggatt catctgtgct tatttcacaa
     5581 tacttcattt atagcaatgc ttttccttaa gctaatgtat aaatatttct aaaggccatt
     5641 aatagtaaca aaataagtag gggaaaaaat ggaccttctg tataaaaacc ccttagcttt
     5701 tttttttcac aagttataag tggaataagt taataactga gctcgtaagt gtatctcata
     5761 actataagag ctacatgaag aaaataggaa taacacacct ggtatttaaa cacaatcttc
     5821 aaaattcttg caacattaaa catagtaaaa tgccagaata taaaatgagg tgtgctaatg
     5881 gtcacaggat tgaggccagc attacagttt ggggtgattt ttcttttatt tgctccctca
     5941 ctttgtttcc tagatgctag taggggtatc tgggttgctt gagataccat tttgcaattg
     6001 ccccttctct ttctgcctac catcttctca ggccctgatg agcttattgg taggcaactg
     6061 ggctgcttta gtgttgaact tgtactttag aaactgaagt ggaatcattg aaaactttca
     6121 ataaagcttt aaagttccat ttacttttga agcacagcta agctcctctg aaggcagctg
     6181 gtttgttgca aacttaaaat tgtactgaaa agttgccact ttttatttag taagaaaaca
     6241 aacattctgg ctcactagag ttcagaaaag taataatttg agccaaagga atttgaatta
     6301 agaaaataga aactaggttt catgtattta aaaaatagga aataaaatag aaactcaaat
     6361 gccatgaagt tatcttcctc ttccttatat cccctaagtt tgggttgcaa ataactttcc
     6421 aattcctaat aacctaaatt attttgaaat agtgttttca gtgaaatgat gaatgtttga
     6481 atgtttgttt ggtaatcaac ataacaatgc taacaaaatt cccacttaga ttttttaact
     6541 tttaaaagtc agcgtggttt tgataatttg atattttaaa tgcccacaca tacacacaca
     6601 cacacacaca cacacacaca agcacatgtt aataaactga taggatggag tgagcaaaat
     6661 tgttttcagg gaagatggca cattttagaa aagacttgcc cagatgatct tccatattgc
     6721 tcccccaatg tcatttatcg ctcatgccaa tcctcctctt gttacctgtg gctatggtaa
     6781 aattccttta acaagcttca ttgtgtccaa gtatttcaga gacttttaaa agctgggcat
     6841 gacatagcgt tttgtgctgt taagacctta gcagagtcag gtagtttacg ggtaatattc
     6901 aaccttgtgc atctgaatct gtcatggatt cccttcactc agcactttgc cactaatttg
     6961 tattacactc tgtggccata taatacttgc acattatgca aaaaaaaatg ttgatagtat
     7021 ctccttgcca cacaatatgc agagttgaca acctttgaaa accaaggtaa ctaatatgta
     7081 tgtcctagtt gtgtggcgct tggtaacaaa gtctgtacat attatgtata aaatgtgtat
     7141 tggttagcat ttagtactaa gaaattctga gtttaaaata agtgattttt ttcaaagtag
     7201 cgatatctat atctgtgttt atctaaaaat actggcttga atagaaaaca ttctcagatg
     7261 attcaagatt gagtaaaaat gagaatccca tacattccat tattaaattc tgccctattc
     7321 ccaattgtta gcatctggct gatattaagg tctttgattg tcacaatatt ctcaataaat
     7381 gagacattct gaactgcctg gtgatatttt caaaaagagc aattaaaatg tgtattccct
     7441 ctaatacagc tgatagaact gttgtgttaa agcaagttgg aaatttgcat gatagtgtgg
     7501 aaaccaatgg aggtccaaaa tattaatcat atctaaaata tcagaaaata tcaatactag
     7561 tcttctttat gcatattttt gactttttaa gagggcttat gaattcaatg tttcttctga
     7621 ggcaatcctt ttaatgtaaa tactaaatac ttgcatgtct tttgacaaag gctaaactac
     7681 aatctattaa tatgcacatt tttgataaaa tataaagtac cctaattaaa gaaattgtgg
     7741 tagaaggtgt atgtcctgaa tactatacct gtttaacaat accaaatgtt aaataaaaat
     7801 agtttgaaat taatgtttaa aa
//
