LOCUS       NM_133491                912 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens spermidine/spermine N1-acetyltransferase family member
            2 (SAT2), transcript variant 3, mRNA.
ACCESSION   NM_133491
VERSION     NM_133491.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 912)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 912)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 912)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 912)
  AUTHORS   Prescott,J., Thompson,D.J., Kraft,P., Chanock,S.J., Audley,T.,
            Brown,J., Leyland,J., Folkerd,E., Doody,D., Hankinson,S.E.,
            Hunter,D.J., Jacobs,K.B., Dowsett,M., Cox,D.G., Easton,D.F. and De
            Vivo,I.
  TITLE     Genome-wide association study of circulating estradiol,
            testosterone, and sex hormone-binding globulin in postmenopausal
            women
  JOURNAL   PLoS One 7 (6), e37815 (2012)
   PUBMED   22675492
REFERENCE   5  (bases 1 to 912)
  AUTHORS   Guey,L.T., Garcia-Closas,M., Murta-Nascimento,C., Lloreta,J.,
            Palencia,L., Kogevinas,M., Rothman,N., Vellalta,G., Calle,M.L.,
            Marenne,G., Tardon,A., Carrato,A., Garcia-Closas,R., Serra,C.,
            Silverman,D.T., Chanock,S., Real,F.X. and Malats,N.
  CONSRTM   EPICURO/Spanish Bladder Cancer Study investigators
  TITLE     Genetic susceptibility to distinct bladder cancer subphenotypes
  JOURNAL   Eur Urol 57 (2), 283-292 (2010)
   PUBMED   19692168
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 912)
  AUTHORS   Gornati,R., Chini,V., Rimoldi,S., Meregalli,M., Schiaffino,E. and
            Bernardini,G.
  TITLE     Evaluation of SAT-1, SAT-2 and GalNAcT-1 mRNA in colon cancer by
            real-time PCR
  JOURNAL   Mol Cell Biochem 298 (1-2), 59-68 (2007)
   PUBMED   17119850
  REMARK    GeneRIF: The expression of three messengers coding for SAT-1, SAT-2
            and GalNAcT-1 in human samples of intestinal cancer and some cell
            lines (breast cancer and melanomas), was evaluated.
REFERENCE   7  (bases 1 to 912)
  AUTHORS   Han,B.W., Bingman,C.A., Wesenberg,G.E. and Phillips,G.N. Jr.
  TITLE     Crystal structure of Homo sapiens thialysine
            Nepsilon-acetyltransferase (HsSSAT2) in complex with acetyl
            coenzyme A
  JOURNAL   Proteins 64 (1), 288-293 (2006)
   PUBMED   16596569
  REMARK    GeneRIF: Crystallization of this protein and its recombinant form
            and its complexation with coenzyme A.
REFERENCE   8  (bases 1 to 912)
  AUTHORS   Barrios-Rodiles,M., Brown,K.R., Ozdamar,B., Bose,R., Liu,Z.,
            Donovan,R.S., Shinjo,F., Liu,Y., Dembowy,J., Taylor,I.W., Luga,V.,
            Przulj,N., Robinson,M., Suzuki,H., Hayashizaki,Y., Jurisica,I. and
            Wrana,J.L.
  TITLE     High-throughput mapping of a dynamic signaling network in mammalian
            cells
  JOURNAL   Science 307 (5715), 1621-1625 (2005)
   PUBMED   15761153
REFERENCE   9  (bases 1 to 912)
  AUTHORS   Coleman,C.S., Stanley,B.A., Jones,A.D. and Pegg,A.E.
  TITLE     Spermidine/spermine-N1-acetyltransferase-2 (SSAT2) acetylates
            thialysine and is not involved in polyamine metabolism
  JOURNAL   Biochem J 384 (Pt 1), 139-148 (2004)
   PUBMED   15283699
REFERENCE   10 (bases 1 to 912)
  AUTHORS   Chen,Y., Vujcic,S., Liang,P., Diegelman,P., Kramer,D.L. and
            Porter,C.W.
  TITLE     Genomic identification and biochemical characterization of a second
            spermidine/spermine N1-acetyltransferase
  JOURNAL   Biochem J 373 (Pt 3), 661-667 (2003)
   PUBMED   12803540
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC011751.2 and BC065922.1.
            
            On Jun 2, 2019 this sequence version replaced NM_133491.4.
            
            Transcript Variant: This variant (3) uses an alternate 5' terminal
            exon, resulting in a novel 5' UTR and the use of an alternate start
            codon, compared to variant 1. The encoded isoform (3) has a
            distinct N-terminus, and is shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7410570.629893.1,
                                           SRR7410570.629886.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000269298.10/ ENSP00000269298.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-908               BC011751.2         26-933
            909-912             BC065922.1         1560-1563
FEATURES             Location/Qualifiers
     source          1..912
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..912
                     /gene="SAT2"
                     /gene_synonym="SSAT-2; SSAT2"
                     /note="spermidine/spermine N1-acetyltransferase family
                     member 2"
                     /db_xref="GeneID:112483"
                     /db_xref="HGNC:HGNC:23160"
                     /db_xref="MIM:611463"
     exon            1..252
                     /gene="SAT2"
                     /gene_synonym="SSAT-2; SSAT2"
                     /inference="alignment:Splign:2.1.0"
     CDS             187..699
                     /gene="SAT2"
                     /gene_synonym="SSAT-2; SSAT2"
                     /EC_number="2.3.1.57"
                     /note="isoform 3 is encoded by transcript variant 3;
                     diamine N-acetyltransferase 2; polyamine
                     N-acetyltransferase 2; diamine acetyltransferase 2;
                     thialysine N-epsilon-acetyltransferase;
                     spermidine/spermine N(1)-acetyltransferase 2"
                     /codon_start=1
                     /product="thialysine N-epsilon-acetyltransferase isoform
                     3"
                     /protein_id="NP_597998.1"
                     /db_xref="CCDS:CCDS11116.1"
                     /db_xref="GeneID:112483"
                     /db_xref="HGNC:HGNC:23160"
                     /db_xref="MIM:611463"
                     /translation="MASVRIREAKEGDCGDILRLIRELAEFEKLSDQVKISEEALRAD
                     GFGDNPFYHCLVAEILPAPGKLLGPCVVGYGIYYFIYSTWKGRTIYLEDIYVMPEYRG
                     QGIGSKIIKKVAEVALDKGCSQFRLAVLDWNQRAMDLYKALGAQDLTEAEGWHFFCFQ
                     GEATRKLAGK"
     exon            253..304
                     /gene="SAT2"
                     /gene_synonym="SSAT-2; SSAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            305..388
                     /gene="SAT2"
                     /gene_synonym="SSAT-2; SSAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            389..490
                     /gene="SAT2"
                     /gene_synonym="SSAT-2; SSAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            491..531
                     /gene="SAT2"
                     /gene_synonym="SSAT-2; SSAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            532..912
                     /gene="SAT2"
                     /gene_synonym="SSAT-2; SSAT2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      888..893
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SAT2"
                     /gene_synonym="SSAT-2; SSAT2"
                     /note="hexamer: AATAAA"
     polyA_site      912
                     /gene="SAT2"
                     /gene_synonym="SSAT-2; SSAT2"
                     /note="major polyA site"
ORIGIN      
        1 ctctcctccc gtacggcgcc ggaatcccag ctccacttac caggccgcgg ctaccccgcc
       61 gtcccccccg actcccgcca ccccgctctc tcaggctctt caggatccaa gtccgtaggc
      121 cctttaaggg gtctagttgc cgtttgcgag gccctgggac tttggtccca gacagcgggg
      181 atccggatgg cttccgtgcg gatccgagag gccaaggagg gagactgtgg agatatcctg
      241 aggctgattc gggagctagc cgaattcgaa aaactctcgg atcaggtgaa gatcagtgaa
      301 gaagccctga gagcagatgg ctttggagac aatcctttct atcactgttt ggtagcagag
      361 attcttccag cgcccgggaa gctactgggg ccctgcgtgg tgggctatgg gatatactat
      421 ttcatctaca gtacatggaa gggacgcacc atttatctgg aggatatcta tgtgatgccg
      481 gaatatcggg gtcaagggat tggttccaaa ataatcaaaa aggtggctga ggtggccttg
      541 gataagggct gctcccaatt ccgcctggcc gtcctggact ggaaccagag ggccatggac
      601 ttgtacaagg ccctaggagc ccaagatctg acggaagctg agggctggca cttcttctgc
      661 tttcaaggag aggcaacgag aaagttggca ggaaagtgac gccatcccta ggaggatctc
      721 tgtcttgagt ttctccttcc ccatcagctg aagcactctt cagagactac gtccacagac
      781 actgatgctg aggcctccct ggaggaagga gggttagggg tgcctatcct caagtattgg
      841 aagagcagaa ttgagggaga gacctttctt ccttgttgag ggtgaaaaat aaataagaat
      901 tacatgtcct ga
//
