LOCUS       NM_015278               7460 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens SAM and SH3 domain containing 1 (SASH1), transcript
            variant 1, mRNA.
ACCESSION   NM_015278
VERSION     NM_015278.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7460)
  AUTHORS   Li,S., Su,Y., Tian,J., Wang,K., Wang,X., Ding,L. and Li,C.
  TITLE     The downregulation of SASH1 expression promotes breast cancer
            occurrence and invasion accompanied by the activation of
            PI3K-Akt-mTOR signaling pathway
  JOURNAL   Sci Rep 14 (1), 21914 (2024)
   PUBMED   39300116
  REMARK    GeneRIF: The downregulation of SASH1 expression promotes breast
            cancer occurrence and invasion accompanied by the activation of
            PI3K-Akt-mTOR signaling pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7460)
  AUTHORS   Zhou,Z., Wang,P., Wang,Q., Dong,Z., Chen,X., Zhuo,R., Wu,R.,
            Liu,Y., Yang,L. and Liu,M.
  TITLE     SASH1 contributes to glial cell migration in the early development
            of the central nervous system
  JOURNAL   Dev Biol 504, 49-57 (2023)
   PUBMED   37741309
  REMARK    GeneRIF: SASH1 contributes to glial cell migration in the early
            development of the central nervous system.
REFERENCE   3  (bases 1 to 7460)
  AUTHORS   Kou,F., Wu,L., Zheng,Y., Yi,Y., Ji,Z., Huang,Z., Guo,S. and Yang,L.
  TITLE     HMGB1/SET/HAT1 complex-mediated SASH1 repression drives glycolysis
            and metastasis in lung adenocarcinoma
  JOURNAL   Oncogene 42 (46), 3407-3421 (2023)
   PUBMED   37794134
  REMARK    GeneRIF: HMGB1/SET/HAT1 complex-mediated SASH1 repression drives
            glycolysis and metastasis in lung adenocarcinoma.
REFERENCE   4  (bases 1 to 7460)
  AUTHORS   Ding,Y., Chen,Q., Shan,H., Liu,J., Lv,C., Wang,Y., Yuan,L.,
            Chen,Y., Wang,Z., Yin,Y., Xiao,K., Li,J. and Liu,W.
  TITLE     SASH1: A Novel Eph Receptor Partner and Insights into SAM-SAM
            Interactions
  JOURNAL   J Mol Biol 435 (19), 168243 (2023)
   PUBMED   37619706
  REMARK    GeneRIF: SASH1: A Novel Eph Receptor Partner and Insights into
            SAM-SAM Interactions.
REFERENCE   5  (bases 1 to 7460)
  AUTHORS   Park,E.G., Lee,D.H., Kim,W.R., Lee,Y.J., Bae,W.H., Kim,J.M.,
            Shin,H.J., Ha,H., Yi,J.M., Cho,S.G., Choi,Y.H., Leem,S.H.,
            Cha,H.J., Kim,S.W. and Kim,H.S.
  TITLE     Human Endogenous Retrovirus-H-Derived miR-4454 Inhibits the
            Expression of DNAJB4 and SASH1 in Non-Muscle-Invasive Bladder
            Cancer
  JOURNAL   Genes (Basel) 14 (7), 1410 (2023)
   PUBMED   37510314
  REMARK    GeneRIF: Human Endogenous Retrovirus-H-Derived miR-4454 Inhibits
            the Expression of DNAJB4 and SASH1 in Non-Muscle-Invasive Bladder
            Cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7460)
  AUTHORS   Rimkus,C., Martini,M., Friederichs,J., Rosenberg,R., Doll,D.,
            Siewert,J.R., Holzmann,B. and Janssen,K.P.
  TITLE     Prognostic significance of downregulated expression of the
            candidate tumour suppressor gene SASH1 in colon cancer
  JOURNAL   Br J Cancer 95 (10), 1419-1423 (2006)
   PUBMED   17088907
  REMARK    GeneRIF: Downregulated expression of the candidate tumour
            suppressor gene SASH1 is associated with colon cancer
REFERENCE   7  (bases 1 to 7460)
  AUTHORS   Benzinger,A., Muster,N., Koch,H.B., Yates,J.R. 3rd and Hermeking,H.
  TITLE     Targeted proteomic analysis of 14-3-3 sigma, a p53 effector
            commonly silenced in cancer
  JOURNAL   Mol Cell Proteomics 4 (6), 785-795 (2005)
   PUBMED   15778465
REFERENCE   8  (bases 1 to 7460)
  AUTHORS   Cheng,J., Kapranov,P., Drenkow,J., Dike,S., Brubaker,S., Patel,S.,
            Long,J., Stern,D., Tammana,H., Helt,G., Sementchenko,V.,
            Piccolboni,A., Bekiranov,S., Bailey,D.K., Ganesh,M., Ghosh,S.,
            Bell,I., Gerhard,D.S. and Gingeras,T.R.
  TITLE     Transcriptional maps of 10 human chromosomes at 5-nucleotide
            resolution
  JOURNAL   Science 308 (5725), 1149-1154 (2005)
   PUBMED   15790807
REFERENCE   9  (bases 1 to 7460)
  AUTHORS   Xing,Q.H., Wang,M.T., Chen,X.D., Feng,G.Y., Ji,H.Y., Yang,J.D.,
            Gao,J.J., Qin,W., Qian,X.Q., Wu,S.N. and He,L.
  TITLE     A gene locus responsible for dyschromatosis symmetrica hereditaria
            (DSH) maps to chromosome 6q24.2-q25.2
  JOURNAL   Am J Hum Genet 73 (2), 377-382 (2003)
   PUBMED   12815562
REFERENCE   10 (bases 1 to 7460)
  AUTHORS   Zeller,C., Hinzmann,B., Seitz,S., Prokoph,H., Burkhard-Goettges,E.,
            Fischer,J., Jandrig,B., Schwarz,L.E., Rosenthal,A. and Scherneck,S.
  TITLE     SASH1: a candidate tumor suppressor gene on chromosome 6q24.3 is
            downregulated in breast cancer
  JOURNAL   Oncogene 22 (19), 2972-2983 (2003)
   PUBMED   12771949
  REMARK    GeneRIF: tumor suppressor gene possibly involved in tumorigenesis
            of breast and other solid cancers
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK025495.1, AJ507735.1 and
            AK024403.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_015278.4.
            
            Summary: This gene encodes a scaffold protein involved in the TLR4
            signaling pathway that may stimulate cytokine production and
            endothelial cell migration in response to invading pathogens. The
            encoded protein has also been described as a potential tumor
            suppressor that may negatively regulate proliferation, apoptosis,
            and invasion of cancer cells, and reduced expression of this gene
            has been observed in multiple human cancers. Mutations in this gene
            may be associated with abnormal skin pigmentation in human
            patients. [provided by RefSeq, Oct 2016].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BN000088.1, AJ507735.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367467.8/ ENSP00000356437.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-224               AK025495.1         246-469
            225-2880            AJ507735.1         1-2656
            2881-2890           AK024403.1         2111-2120
            2891-4189           AJ507735.1         2667-3965
            4190-4199           AK024403.1         3420-3429
            4200-7460           AJ507735.1         3976-7236
FEATURES             Location/Qualifiers
     source          1..7460
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q24.3-q25.1"
     gene            1..7460
                     /gene="SASH1"
                     /gene_synonym="CAPOK; dJ323M4.1; DUH; DUH1; SH3D6A"
                     /note="SAM and SH3 domain containing 1"
                     /db_xref="GeneID:23328"
                     /db_xref="HGNC:HGNC:19182"
                     /db_xref="MIM:607955"
     exon            1..386
                     /gene="SASH1"
                     /gene_synonym="CAPOK; dJ323M4.1; DUH; DUH1; SH3D6A"
                     /inference="alignment:Splign:2.1.0"
     CDS             231..3974
                     /gene="SASH1"
                     /gene_synonym="CAPOK; dJ323M4.1; DUH; DUH1; SH3D6A"
                     /note="isoform 1 is encoded by transcript variant 1; SAM
                     and SH3 domain-containing protein 1; proline-glutamate
                     repeat-containing protein"
                     /codon_start=1
                     /product="SAM and SH3 domain-containing protein 1 isoform
                     1"
                     /protein_id="NP_056093.3"
                     /db_xref="CCDS:CCDS5212.1"
                     /db_xref="GeneID:23328"
                     /db_xref="HGNC:HGNC:19182"
                     /db_xref="MIM:607955"
                     /translation="MEDAGAAGPGPEPEPEPEPEPEPAPEPEPEPKPGAGTSEAFSRL
                     WTDVMGILDGSLGNIDDLAQQYADYYNTCFSDVCERMEELRKRRVSQDLEVEKPDASP
                     TSLQLRSQIEESLGFCSAVSTPEVERKNPLHKSNSEDSSVGKGDWKKKNKYFWQNFRK
                     NQKGIMRQTSKGEDVGYVASEITMSDEERIQLMMMVKEKMITIEEALARLKEYEAQHR
                     QSAALDPADWPDGSYPTFDGSSNCNSREQSDDETEESVKFKRLHKLVNSTRRVRKKLI
                     RVEEMKKPSTEGGEEHVFENSPVLDERSALYSGVHKKPLFFDGSPEKPPEDDSDSLTT
                     SPSSSSLDTWGAGRKLVKTFSKGESRGLIKPPKKMGTFFSYPEEEKAQKVSRSLTEGE
                     MKKGLGSLSHGRTCSFGGFDLTNRSLHVGSNNSDPMGKEGDFVYKEVIKSPTASRISL
                     GKKVKSVKETMRKRMSKKYSSSVSEQDSGLDGMPGSPPPSQPDPEHLDKPKLKAGGSV
                     ESLRSSLSGQSSMSGQTVSTTDSSTSNRESVKSEDGDDEEPPYRGPFCGRARVHTDFT
                     PSPYDTDSLKLKKGDIIDIISKPPMGTWMGLLNNKVGTFKFIYVDVLSEDEEKPKRPT
                     RRRRKGRPPQPKSVEDLLDRINLKEHMPTFLFNGYEDLDTFKLLEEEDLDELNIRDPE
                     HRAVLLTAVELLQEYDSNSDQSGSQEKLLVDSQGLSGCSPRDSGCYESSENLENGKTR
                     KASLLSAKSSTEPSLKSFSRNQLGNYPTLPLMKSGDALKQGQEEGRLGGGLAPDTSKS
                     CDPPGVTGLNKNRRSLPVSICRSCETLEGPQTVDTWPRSHSLDDLQVEPGAEQDVPTE
                     VTEPPPQIVPEVPQKTTASSTKAQPLEQDSAVDNALLLTQSKRFSEPQKLTTKKLEGS
                     IAASGRGLSPPQCLPRNYDAQPPGAKHGLARTPLEGHRKGHEFEGTHHPLGTKEGVDA
                     EQRMQPKIPSQPPPVPAKKSRERLANGLHPVPMGPSGALPSPDAPCLPVKRGSPASPT
                     SPSDCPPALAPRPLSGQAPGSPPSTRPPPWLSELPENTSLQEHGVKLGPALTRKVSCA
                     RGVDLETLTENKLHAEGIDLTEEPYSDKHGRCGIPEALVQRYAEDLDQPERDVAANMD
                     QIRVKQLRKQHRMAIPSGGLTEICRKPVSPGCISSVSDWLISIGLPMYAGTLSTAGFS
                     TLSQVPSLSHTCLQEAGITEERHIRKLLSAARLFKLPPGPEAM"
     exon            387..515
                     /gene="SASH1"
                     /gene_synonym="CAPOK; dJ323M4.1; DUH; DUH1; SH3D6A"
                     /inference="alignment:Splign:2.1.0"
     exon            516..566
                     /gene="SASH1"
                     /gene_synonym="CAPOK; dJ323M4.1; DUH; DUH1; SH3D6A"
                     /inference="alignment:Splign:2.1.0"
     exon            567..616
                     /gene="SASH1"
                     /gene_synonym="CAPOK; dJ323M4.1; DUH; DUH1; SH3D6A"
                     /inference="alignment:Splign:2.1.0"
     exon            617..657
                     /gene="SASH1"
                     /gene_synonym="CAPOK; dJ323M4.1; DUH; DUH1; SH3D6A"
                     /inference="alignment:Splign:2.1.0"
     exon            658..744
                     /gene="SASH1"
                     /gene_synonym="CAPOK; dJ323M4.1; DUH; DUH1; SH3D6A"
                     /inference="alignment:Splign:2.1.0"
     exon            745..857
                     /gene="SASH1"
                     /gene_synonym="CAPOK; dJ323M4.1; DUH; DUH1; SH3D6A"
                     /inference="alignment:Splign:2.1.0"
     exon            858..959
                     /gene="SASH1"
                     /gene_synonym="CAPOK; dJ323M4.1; DUH; DUH1; SH3D6A"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1092
                     /gene="SASH1"
                     /gene_synonym="CAPOK; dJ323M4.1; DUH; DUH1; SH3D6A"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1439
                     /gene="SASH1"
                     /gene_synonym="CAPOK; dJ323M4.1; DUH; DUH1; SH3D6A"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..1514
                     /gene="SASH1"
                     /gene_synonym="CAPOK; dJ323M4.1; DUH; DUH1; SH3D6A"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..1658
                     /gene="SASH1"
                     /gene_synonym="CAPOK; dJ323M4.1; DUH; DUH1; SH3D6A"
                     /inference="alignment:Splign:2.1.0"
     exon            1659..1794
                     /gene="SASH1"
                     /gene_synonym="CAPOK; dJ323M4.1; DUH; DUH1; SH3D6A"
                     /inference="alignment:Splign:2.1.0"
     exon            1795..1964
                     /gene="SASH1"
                     /gene_synonym="CAPOK; dJ323M4.1; DUH; DUH1; SH3D6A"
                     /inference="alignment:Splign:2.1.0"
     exon            1965..2174
                     /gene="SASH1"
                     /gene_synonym="CAPOK; dJ323M4.1; DUH; DUH1; SH3D6A"
                     /inference="alignment:Splign:2.1.0"
     exon            2175..2325
                     /gene="SASH1"
                     /gene_synonym="CAPOK; dJ323M4.1; DUH; DUH1; SH3D6A"
                     /inference="alignment:Splign:2.1.0"
     exon            2326..2439
                     /gene="SASH1"
                     /gene_synonym="CAPOK; dJ323M4.1; DUH; DUH1; SH3D6A"
                     /inference="alignment:Splign:2.1.0"
     exon            2440..3578
                     /gene="SASH1"
                     /gene_synonym="CAPOK; dJ323M4.1; DUH; DUH1; SH3D6A"
                     /inference="alignment:Splign:2.1.0"
     exon            3579..3710
                     /gene="SASH1"
                     /gene_synonym="CAPOK; dJ323M4.1; DUH; DUH1; SH3D6A"
                     /inference="alignment:Splign:2.1.0"
     exon            3711..7460
                     /gene="SASH1"
                     /gene_synonym="CAPOK; dJ323M4.1; DUH; DUH1; SH3D6A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7441..7446
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SASH1"
                     /gene_synonym="CAPOK; dJ323M4.1; DUH; DUH1; SH3D6A"
                     /note="hexamer: AATAAA"
     polyA_site      7460
                     /gene="SASH1"
                     /gene_synonym="CAPOK; dJ323M4.1; DUH; DUH1; SH3D6A"
                     /note="major polyA site"
ORIGIN      
        1 gggaaagttt ctggagttgt cagtcgcgca gcccgtggcc acctagaccc gaggtgcggg
       61 cgcctgcgaa gggcccccgc ggggtggccg gggccgccgg ggcatgcagc gcgggggcgc
      121 ggctcggtga cgccgcgggc ggggacccgg catccgggca ggctgcgcgc gggtgcgggg
      181 cgagggcgcc gcggggactg ggacgcacgg cccgcgcgcg ggacacggcc atggaggacg
      241 cgggagcagc tggcccgggg ccggagcctg agcccgagcc cgagccggag cccgagcccg
      301 cgccggagcc ggaaccggag cccaagccgg gtgctggcac atccgaggcg ttctcccgac
      361 tctggaccga cgtgatgggt atcctggacg gttcactggg aaacatcgat gacctggcgc
      421 agcagtatgc agattattac aacacctgtt tctccgacgt gtgcgagagg atggaggagc
      481 tgcggaaacg gcgggtttcc caggacctgg aagtggagaa acccgatgct agccccacgt
      541 cacttcagct gcggtcccag atcgaagagt cgcttggctt ctgtagcgcc gtgtcaaccc
      601 cagaagtgga aagaaagaac cctcttcata aatcaaactc agaagacagc tctgtaggaa
      661 aaggagactg gaagaagaaa aataagtatt tctggcagaa cttccgaaag aaccagaaag
      721 gaataatgag acagacttca aaaggagaag acgttggtta tgttgccagt gaaataacga
      781 tgagcgatga ggagcggatt cagctaatga tgatggtcaa agaaaagatg atcacaattg
      841 aggaagcact tgctaggctc aaggaatacg aggcccagca ccggcagtcg gctgccctgg
      901 accctgctga ctggccagat ggttcttacc caacgtttga tggctcatca aactgcaatt
      961 caagagaaca atcggatgat gagactgagg agtcggtgaa gtttaagagg ttacacaagc
     1021 tggtaaactc cactcgcaga gtcagaaaga aactaattag ggtggaagaa atgaaaaaac
     1081 ccagcactga aggtggggag gagcacgtgt ttgagaattc gccggtcctg gatgaacggt
     1141 ccgccctcta ctctggcgtg cacaagaagc cccttttctt tgatggctct cctgagaaac
     1201 ctcccgaaga tgactcagac tctctcacca cgtctccatc ctccagcagc ctggacacct
     1261 ggggggctgg ccggaagttg gtcaaaacct tcagcaaagg agagagccgg ggcctgatta
     1321 agccccccaa gaagatgggg acattcttct cctacccaga agaagaaaag gcccagaaag
     1381 tgtcccgctc cctcaccgag ggggagatga agaagggtct cgggtcccta agccacggga
     1441 gaacctgcag ttttggagga tttgacttga cgaatcgctc tctgcacgtt ggcagtaata
     1501 attctgaccc aatgggtaaa gaaggagact ttgtgtacaa agaagtcatc aaatcaccta
     1561 ctgcctctcg catctctctt gggaaaaagg tgaaatcagt gaaagagacg atgagaaaga
     1621 gaatgtctaa aaaatacagc agctctgtct ctgagcagga ctcgggcctt gatggaatgc
     1681 ctggctcccc tccgccttca cagcccgacc ccgaacactt ggacaagccc aagctcaagg
     1741 ccgggggttc tgtagaaagt cttcgcagtt ctctcagtgg gcagagctcc atgagcggtc
     1801 aaacagtgag caccactgat tcctcaacca gcaaccggga aagcgtcaag tcggaagatg
     1861 gggatgacga agagccgcct taccgaggcc cgttctgcgg gcgtgccagg gtgcacaccg
     1921 acttcacccc cagtccctat gacacagact cactcaagct caagaaagga gatatcatcg
     1981 atataatcag caagccaccc atggggacct ggatgggcct gctgaacaac aaagtcggca
     2041 cgttcaagtt catctacgtg gacgtgctca gtgaagacga ggagaaaccc aaacgcccca
     2101 ccaggaggcg tcggaaagga cgaccacccc agcccaagtc tgtggaggat ctcctggatc
     2161 ggattaacct aaaagagcac atgcccactt tcctgttcaa tggatatgaa gatttggaca
     2221 cctttaagct gctggaggag gaagacttgg atgagttaaa tatcagggac ccggaacaca
     2281 gagctgttct cttgacagca gtggagctgt tacaagagta tgacagtaac agcgaccagt
     2341 caggatccca ggagaagctg ctcgttgaca gccagggcct gagtggatgc tcaccccgag
     2401 actcaggatg ctacgaaagc agtgagaacc tggaaaacgg caagactcgg aaagctagcc
     2461 tcctatctgc caagtcatcc accgagccca gcttgaagtc ttttagcaga aaccagttgg
     2521 gcaattaccc aacattgcct ttaatgaaat caggggatgc actgaagcag ggacaggagg
     2581 agggcaggct gggtggtggc cttgccccag acacgtccaa gagctgtgac ccacctggtg
     2641 tgactggttt gaataaaaac cgaagaagcc tcccagtttc catctgccgg agctgtgaga
     2701 ccctggaggg cccccagact gtggacactt ggccccgatc ccattccctg gatgaccttc
     2761 aagtggagcc tggtgctgag caagacgtgc ctaccgaggt gacagaaccg ccccctcaga
     2821 ttgtacctga agtgccacag aagacgaccg cctcttccac gaaggcccag cccctggagc
     2881 aagactctgc tgtcgacaat gcattgctac tgacccaaag caagagattt tctgaacctc
     2941 agaaattgac aactaagaaa ctggagggct caatcgcagc ctctggtcgc ggcctgtcac
     3001 cccctcagtg tttgcccaga aactatgatg ctcagcctcc tggagctaaa cacggtttag
     3061 caaggacgcc tctggagggc cacagaaaag gacacgagtt tgaaggaaca caccatcccc
     3121 tgggcaccaa agaaggggta gatgctgagc agagaatgca gcccaaaatt ccatcacagc
     3181 ctccacctgt tcctgccaaa aagagcagag aacgccttgc taacggactc caccctgttc
     3241 ccatgggccc cagtggggcc ctccccagtc ccgatgcgcc atgcctgcca gtgaaaaggg
     3301 gcagccccgc cagccccacc agccctagcg actgtccccc agcactggct cccaggcctc
     3361 tctcagggca ggcgcctggc agcccaccaa gcacaaggcc gcccccctgg ctctcagagc
     3421 tccccgagaa cacaagcctc caggagcacg gtgtgaagct gggcccggct ttgaccagga
     3481 aggtctcctg tgcccgggga gtggatctag aaacgctcac tgaaaacaag ctgcacgctg
     3541 aaggcatcga tctcacggag gagccgtatt ctgataagca tggccgctgt gggattcctg
     3601 aagccctggt gcagagatac gcagaggact tggatcagcc cgagcgggac gtcgccgcca
     3661 acatggacca gatccgggtg aagcagcttc ggaagcagca ccgcatggcg attccaagtg
     3721 gtggactcac ggaaatctgc cgaaagcccg tctctcctgg gtgcatttcg tctgtgtcag
     3781 attggctcat ttccatcggt ctgcccatgt acgccggcac cctctccacc gcgggcttca
     3841 gcacactgag ccaagtgcct tctctgtctc acacttgcct tcaggaggcc ggcatcacag
     3901 aggagagaca cataagaaag ctcctatctg cagccagact cttcaaactg ccgccaggcc
     3961 ctgaggccat gtagccaggc ccggaatggg cctctctgga caagagccac cctttcactg
     4021 tgcatatgat gctgatgcaa ttcctccatc atctctggac gtgcagacca gatccagaag
     4081 aaaggcctgg cgtgtggcca aacagcgtga aaccttggca caggactgag gatcctctcc
     4141 tccagaaaag ccccctcgag gaaataaatt agtgcggttc tctttgaccc ccaaagacaa
     4201 gacaagcact tatttttatt ttcagaagac aaaagaacca agatgccaac tggctgcgaa
     4261 tgctctatct ccagtctgtc tctgtgtact ggtagaggct gggaggagta gggggcagcc
     4321 tgttccattt ctgatagtgc ccttgctctt ctgtctgtca tcttgcagga tgcccgaggg
     4381 ccagatgggc ttagctaggc caaagtaaca gactcaagag ttattgtaca ttactgacca
     4441 cgctcatttg ttcaaaagtt agaacatctg gctgcaccag gaaaaaaaaa aaaaaaaagt
     4501 cctgttcttc tttagataaa caagagacat tttcataatt gctttctagc aatcagcttt
     4561 tatttgcctt aatataagct tttaagcagt tatctaacta gtgtccacaa ccctgtaacc
     4621 atacttccac atcttcagct taggcagaca tcgaacctct ctgggatgtt tccagcaaaa
     4681 gtgagctttt ctaatcgtct cattgtaaca tggcttattt tgtagaggta ttcatcagcc
     4741 acacacttca tgttggtttt tggtttttaa gctaactaca aatctagtaa aaagctatct
     4801 gaaattcaca aatatcatgt gtgtgcgtgc gtgcgtgcgc gtgtgtgtct gtattcatag
     4861 tgactgcttt tggttttaac cagtttagta tcgttactgt gtggatcgtc gcgctgcagt
     4921 attgacttgg aatcctgacc atgtccatcc caaaattcag tcctcagtta acggatcatg
     4981 tttgcaaaag gtcactgtga ggctgcatat ttcagaaaga tgtccttaat aagggaagtc
     5041 atgtataaga tgttttctaa aagacttttc agtattacaa ctaatactat tattatcctt
     5101 ctttttttat ttagataatt cttttaattt aaacaaaggt tcactatgga accagacaaa
     5161 tctcattagc catgtgttaa gtatttgcta ctttaaattg ttttacaact gatttcagca
     5221 cattctatcc tttttttttt ttgaaatgga gtttcgctct tgtcacccag gctggagtgc
     5281 aatggcacga tcttggctca ctgcaacctc agtctcccag gttcaagtga ttctcctgcc
     5341 ttagcctccc gagtagctgg gattataggc acccaccacc acgcccagct aatttttgta
     5401 ttattagtag agacagggtt tcaccatgtt ggccaggctg gtctcaaact caactcctga
     5461 cctcaggtgg tccacccgcc tcagcctccc aaagtgctgg gattacaggt gtgagccacc
     5521 gcacctggcc tctgtcctct tttagtctag tgtctggttt tctagcaaac agtaaattta
     5581 aacaagtaaa ctattatggt ttccattgct tacaaaatga ttttccttta cattcttatc
     5641 atgaacacta ttttaagcat caaatgcaat catctaaaat ataaaggtca atcatttata
     5701 atagaaacac cttgaccaca agcccttgat tgaacatttt ataatatttc atctacttat
     5761 taaaacaaat aatttccctt gggttggagg ggaagtgatt tcataaatta attagaaagc
     5821 catctttagc atattgctta tgtctggatc catgtttctg aggaaaaaga cattctcagg
     5881 tgatgtattt ttttcatgca ttagtatgca tttttaaaaa ataatgcatg tttctttaat
     5941 aattaatttt catcttctat aagatgccat gtgaagaagt tgtggaaatg tagaataaaa
     6001 agctaaagct gccaaatttc tgttgaactc ttaaaaacag ctcatgtttg tttgtcctct
     6061 cgggttgtgg cctagcctat ttgcaatgta atgaagctgc agggttcttg tatagctaaa
     6121 gcgttcaatg catttcacgt gctgtggtgg atgtgggtgc tgtagacagg cttcttctct
     6181 tcctgctctc aaaatacctc ggcttgacat ttggacagat cctgtcattg tttaagctga
     6241 gcaaaaaacc acacaaaagt tgtgtaagag atgagataac aaaggagcga gagaaatctc
     6301 atgtgaattt ccaagtttta attcgttctc catgaaggat tttcatttca gtgaaagtcg
     6361 cagcagaaga gggaactttc tggagttttt gagaatgcca aaccacattt ttatcacact
     6421 tctttggaaa tcaatgcctt tgcatagaaa atcaaattca gggaccacaa agaattttca
     6481 gtgggaatgt ctagtctgag gggtctgagg ttgtttttac tttattgtgt tgtttaaata
     6541 ttttaaaaat atctttagcg tttggtcttt tttttttctg taaacattta atttggtctg
     6601 agaaaagctg aatgtttggg tgtgacgttt gactgaggtg gattggggct gcctgtggac
     6661 attagtgaac aggtggtagg cttcaggaat atccagtttt aatcagttgc atttggtaca
     6721 gaattttgag taatggtgaa aattgttgtc tttggaaagc acaaaagaaa cctggaaagg
     6781 cagttcggct caggtagcta cacataacat tgtgtatgat tttcacttca aagctgtctg
     6841 gaaggaaatg cagtcagctc cagctagtac tatttatgta cccagataac taagatattg
     6901 tttcatggcc ttgccttagt cagaggccct tttctctgtc ctgaaccccc aggtatgggt
     6961 gaaattggaa attactaatc tattggaaat cagttcctga catagtaaag tttgctttca
     7021 taactgcagc aaaaaaggtc aacttgccaa gtcactgctg ccatgtgtgt actgtattat
     7081 tttcagaaaa aaatataata gtctgagtcc aagttatctt gatttaaaat tgatagagaa
     7141 aagaaactgt cgagcaagtt atataacaac taacaacatt gcactttctg tatatgaaat
     7201 caatatttaa ataacttatt tttctccatt gctgttctta aaaacattgt aagtagctgt
     7261 aatataccag taccaatatg ttcttgcaat tgcttcagcc caagaaagct gtgtattgtt
     7321 ttaaaaattg taaaaattat tgtgatgatt catttagcat aaagagaggt ggacggaagg
     7381 gttttcctat gtatcaaaac ttgtctataa ttatgtcatc tatgtaccta gaaaaaagta
     7441 aataaatttc ttcagttgaa
//
