LOCUS       NM_014706               4154 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens spliceosome associated factor 3, U4/U6 recycling
            protein (SART3), transcript variant 1, mRNA.
ACCESSION   NM_014706
VERSION     NM_014706.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4154)
  AUTHORS   Wang,Y., Zhou,J., He,W., Fu,R., Shi,L., Dang,N.K., Liu,B., Xu,H.,
            Cheng,X. and Bedford,M.T.
  TITLE     SART3 reads methylarginine-marked glycine- and arginine-rich motifs
  JOURNAL   Cell Rep 43 (7), 114459 (2024)
   PUBMED   38985674
  REMARK    GeneRIF: SART3 reads methylarginine-marked glycine- and
            arginine-rich motifs.
REFERENCE   2  (bases 1 to 4154)
  AUTHORS   Kim,J., Taketomi,T., Yamada,A., Uematsu,Y., Ueda,K., Chiba,T. and
            Tsuruta,F.
  TITLE     USP4 regulates TUT1 ubiquitination status in concert with SART3
  JOURNAL   Biochem Biophys Res Commun 701, 149557 (2024)
   PUBMED   38310689
  REMARK    GeneRIF: USP4 regulates TUT1 ubiquitination status in concert with
            SART3.
REFERENCE   3  (bases 1 to 4154)
  AUTHORS   Ayers,K.L., Eggers,S., Rollo,B.N., Smith,K.R., Davidson,N.M.,
            Siddall,N.A., Zhao,L., Bowles,J., Weiss,K., Zanni,G., Burglen,L.,
            Ben-Shachar,S., Rosensaft,J., Raas-Rothschild,A., Jorgensen,A.,
            Schittenhelm,R.B., Huang,C., Robevska,G., van den Bergen,J.,
            Casagranda,F., Cyza,J., Pachernegg,S., Wright,D.K., Bahlo,M.,
            Oshlack,A., O'Brien,T.J., Kwan,P., Koopman,P., Hime,G.R.,
            Girard,N., Hoffmann,C., Shilon,Y., Zung,A., Bertini,E., Milh,M.,
            Ben Rhouma,B., Belguith,N., Bashamboo,A., McElreavey,K., Banne,E.,
            Weintrob,N., BenZeev,B. and Sinclair,A.H.
  TITLE     Variants in SART3 cause a spliceosomopathy characterised by failure
            of testis development and neuronal defects
  JOURNAL   Nat Commun 14 (1), 3403 (2023)
   PUBMED   37296101
  REMARK    GeneRIF: Variants in SART3 cause a spliceosomopathy characterised
            by failure of testis development and neuronal defects.
            Erratum:[Nat Commun. 2023 Jun 15;14(1):3566. doi:
            10.1038/s41467-023-39372-x.. PMID: 37322043]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4154)
  AUTHORS   Li,J., Zhang,Y., Li,J., Xu,Y. and Zhang,G.
  TITLE     A novel SART3::RARG fusion gene in acute myeloid leukemia with
            acute promyelocytic leukemia phenotype and differentiation escape
            to retinoic acid
  JOURNAL   Haematologica 108 (2), 627-632 (2023)
   PUBMED   36300779
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4154)
  AUTHORS   Kanahara,N., Nakata,Y. and Iyo,M.
  TITLE     Genetic association study detected misalignment in previous whole
            exome sequence: association study of ZNF806 and SART3 in tardive
            dystonia
  JOURNAL   Psychiatr Genet 31 (1), 29-31 (2021)
   PUBMED   32941384
  REMARK    GeneRIF: Genetic association study detected misalignment in
            previous whole exome sequence: association study of ZNF806 and
            SART3 in tardive dystonia.
REFERENCE   6  (bases 1 to 4154)
  AUTHORS   Harada,K., Yamada,A., Yang,D., Itoh,K. and Shichijo,S.
  TITLE     Binding of a SART3 tumor-rejection antigen to a pre-mRNA splicing
            factor RNPS1: a possible regulation of splicing by a complex
            formation
  JOURNAL   Int J Cancer 93 (5), 623-628 (2001)
   PUBMED   11477570
REFERENCE   7  (bases 1 to 4154)
  AUTHORS   Tanaka,S., Tsuda,N., Kawano,K., Sakamoto,M., Nishida,T.,
            Hashimoto,T., Shichijo,S., Kamura,T. and Itoh,K.
  TITLE     Expression of tumor-rejection antigens in gynecologic cancers
  JOURNAL   Jpn J Cancer Res 91 (11), 1177-1184 (2000)
   PUBMED   11092984
REFERENCE   8  (bases 1 to 4154)
  AUTHORS   Xia,J.H., Yang,Y.F., Deng,H., Tang,B.S., Tang,D.S., He,Y.G.,
            Xia,K., Chen,S.X., Li,Y.X., Pan,Q., Long,Z.G., Dai,H.P., Liao,X.D.,
            Xiao,J.F., Liu,Z.R., Lu,C.Y., Yu,K.P. and Deng,H.X.
  TITLE     Identification of a locus for disseminated superficial actinic
            porokeratosis at chromosome 12q23.2-24.1
  JOURNAL   J Invest Dermatol 114 (6), 1071-1074 (2000)
   PUBMED   10844547
REFERENCE   9  (bases 1 to 4154)
  AUTHORS   Harada,K., Yamada,A., Mine,T., Kawagoe,N., Takasu,H. and Itoh,K.
  TITLE     Mouse homologue of the human SART3 gene encoding tumor-rejection
            antigen
  JOURNAL   Jpn J Cancer Res 91 (2), 239-247 (2000)
   PUBMED   10761712
REFERENCE   10 (bases 1 to 4154)
  AUTHORS   Yang,D., Nakao,M., Shichijo,S., Sasatomi,T., Takasu,H.,
            Matsumoto,H., Mori,K., Hayashi,A., Yamana,H., Shirouzu,K. and
            Itoh,K.
  TITLE     Identification of a gene coding for a protein possessing shared
            tumor epitopes capable of inducing HLA-A24-restricted cytotoxic T
            lymphocytes in cancer patients
  JOURNAL   Cancer Res 59 (16), 4056-4063 (1999)
   PUBMED   10463607
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA391623.1, BC032601.1,
            CN349201.1, BQ231651.1, D63879.1 and AI656011.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Sep 27, 2018 this sequence version replaced NM_014706.3.
            
            Summary: The protein encoded by this gene is an RNA-binding nuclear
            protein that is a tumor-rejection antigen. This antigen possesses
            tumor epitopes capable of inducing HLA-A24-restricted and
            tumor-specific cytotoxic T lymphocytes in cancer patients and may
            be useful for specific immunotherapy. This gene product is found to
            be an important cellular factor for HIV-1 gene expression and viral
            replication. It also associates transiently with U6 and U4/U6
            snRNPs during the recycling phase of the spliceosome cycle. This
            encoded protein is thought to be involved in the regulation of mRNA
            splicing. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.224931.1,
                                           SRR1803617.63153.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000546815.6/ ENSP00000449386.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-151               DA391623.1         221-371
            152-1857            BC032601.1         151-1856
            1858-2289           CN349201.1         77-508
            2290-2733           BQ231651.1         301-744
            2734-3679           D63879.1           2715-3660
            3680-4154           AI656011.1         8-482               c
FEATURES             Location/Qualifiers
     source          1..4154
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q23.3"
     gene            1..4154
                     /gene="SART3"
                     /gene_synonym="DSAP1; P100; p110; p110(nrb); RP11-13G14;
                     TIP110"
                     /note="spliceosome associated factor 3, U4/U6 recycling
                     protein"
                     /db_xref="GeneID:9733"
                     /db_xref="HGNC:HGNC:16860"
                     /db_xref="MIM:611684"
     exon            1..331
                     /gene="SART3"
                     /gene_synonym="DSAP1; P100; p110; p110(nrb); RP11-13G14;
                     TIP110"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..2911
                     /gene="SART3"
                     /gene_synonym="DSAP1; P100; p110; p110(nrb); RP11-13G14;
                     TIP110"
                     /note="isoform 1 is encoded by transcript variant 1;
                     tat-interacting protein of 110 kDa; SART-3; hSART-3;
                     squamous cell carcinoma antigen recognized by T cells 3;
                     p110 nuclear RNA-binding protein; HIV-1 Tat-interacting
                     protein of 110kDa; PRP24 homolog"
                     /codon_start=1
                     /product="squamous cell carcinoma antigen recognized by
                     T-cells 3 isoform 1"
                     /protein_id="NP_055521.1"
                     /db_xref="CCDS:CCDS9117.1"
                     /db_xref="GeneID:9733"
                     /db_xref="HGNC:HGNC:16860"
                     /db_xref="MIM:611684"
                     /translation="MATAAETSASEPEAESKAGPKADGEEDEVKAARTRRKVLSRAVA
                     AATYKTMGPAWDQQEEGVSESDGDEYAMASSAESSPGEYEWEYDEEEEKNQLEIERLE
                     EQLSINVYDYNCHVDLIRLLRLEGELTKVRMARQKMSEIFPLTEELWLEWLHDEISMA
                     QDGLDREHVYDLFEKAVKDYICPNIWLEYGQYSVGGIGQKGGLEKVRSVFERALSSVG
                     LHMTKGLALWEAYREFESAIVEAARLEKVHSLFRRQLAIPLYDMEATFAEYEEWSEDP
                     IPESVIQNYNKALQQLEKYKPYEEALLQAEAPRLAEYQAYIDFEMKIGDPARIQLIFE
                     RALVENCLVPDLWIRYSQYLDRQLKVKDLVLSVHNRAIRNCPWTVALWSRYLLAMERH
                     GVDHQVISVTFEKALNAGFIQATDYVEIWQAYLDYLRRRVDFKQDSSKELEELRAAFT
                     RALEYLKQEVEERFNESGDPSCVIMQNWARIEARLCNNMQKARELWDSIMTRGNAKYA
                     NMWLEYYNLERAHGDTQHCRKALHRAVQCTSDYPEHVCEVLLTMERTEGSLEDWDIAV
                     QKTETRLARVNEQRMKAAEKEAALVQQEEEKAEQRKRARAEKKALKKKKKIRGPEKRG
                     ADEDDEKEWGDDEEEQPSKRRRVENSIPAAGETQNVEVAAGPAGKCAAVDVEPPSKQK
                     EKAASLKRDMPKVLHDSSKDSITVFVSNLPYSMQEPDTKLRPLFEACGEVVQIRPIFS
                     NRGDFRGYCYVEFKEEKSALQALEMDRKSVEGRPMFVSPCVDKSKNPDFKVFRYSTSL
                     EKHKLFISGLPFSCTKEELEEICKAHGTVKDLRLVTNRAGKPKGLAYVEYENESQASQ
                     AVMKMDGMTIKENIIKVAISNPPQRKVPEKPETRKAPGGPMLLPQTYGARGKGRTQLS
                     LLPRALQRPSAAAPQAENGPAAAPAVAAPAATEAPKMSNADFAKLFLRK"
     exon            332..458
                     /gene="SART3"
                     /gene_synonym="DSAP1; P100; p110; p110(nrb); RP11-13G14;
                     TIP110"
                     /inference="alignment:Splign:2.1.0"
     exon            459..563
                     /gene="SART3"
                     /gene_synonym="DSAP1; P100; p110; p110(nrb); RP11-13G14;
                     TIP110"
                     /inference="alignment:Splign:2.1.0"
     exon            564..748
                     /gene="SART3"
                     /gene_synonym="DSAP1; P100; p110; p110(nrb); RP11-13G14;
                     TIP110"
                     /inference="alignment:Splign:2.1.0"
     exon            749..800
                     /gene="SART3"
                     /gene_synonym="DSAP1; P100; p110; p110(nrb); RP11-13G14;
                     TIP110"
                     /inference="alignment:Splign:2.1.0"
     exon            801..925
                     /gene="SART3"
                     /gene_synonym="DSAP1; P100; p110; p110(nrb); RP11-13G14;
                     TIP110"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1081
                     /gene="SART3"
                     /gene_synonym="DSAP1; P100; p110; p110(nrb); RP11-13G14;
                     TIP110"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1220
                     /gene="SART3"
                     /gene_synonym="DSAP1; P100; p110; p110(nrb); RP11-13G14;
                     TIP110"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1328
                     /gene="SART3"
                     /gene_synonym="DSAP1; P100; p110; p110(nrb); RP11-13G14;
                     TIP110"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1406
                     /gene="SART3"
                     /gene_synonym="DSAP1; P100; p110; p110(nrb); RP11-13G14;
                     TIP110"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1465
                     /gene="SART3"
                     /gene_synonym="DSAP1; P100; p110; p110(nrb); RP11-13G14;
                     TIP110"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..1575
                     /gene="SART3"
                     /gene_synonym="DSAP1; P100; p110; p110(nrb); RP11-13G14;
                     TIP110"
                     /inference="alignment:Splign:2.1.0"
     exon            1576..1688
                     /gene="SART3"
                     /gene_synonym="DSAP1; P100; p110; p110(nrb); RP11-13G14;
                     TIP110"
                     /inference="alignment:Splign:2.1.0"
     exon            1689..1765
                     /gene="SART3"
                     /gene_synonym="DSAP1; P100; p110; p110(nrb); RP11-13G14;
                     TIP110"
                     /inference="alignment:Splign:2.1.0"
     exon            1766..1934
                     /gene="SART3"
                     /gene_synonym="DSAP1; P100; p110; p110(nrb); RP11-13G14;
                     TIP110"
                     /inference="alignment:Splign:2.1.0"
     exon            1935..2389
                     /gene="SART3"
                     /gene_synonym="DSAP1; P100; p110; p110(nrb); RP11-13G14;
                     TIP110"
                     /inference="alignment:Splign:2.1.0"
     exon            2390..2542
                     /gene="SART3"
                     /gene_synonym="DSAP1; P100; p110; p110(nrb); RP11-13G14;
                     TIP110"
                     /inference="alignment:Splign:2.1.0"
     exon            2543..2733
                     /gene="SART3"
                     /gene_synonym="DSAP1; P100; p110; p110(nrb); RP11-13G14;
                     TIP110"
                     /inference="alignment:Splign:2.1.0"
     exon            2734..4154
                     /gene="SART3"
                     /gene_synonym="DSAP1; P100; p110; p110(nrb); RP11-13G14;
                     TIP110"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3660..3665
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SART3"
                     /gene_synonym="DSAP1; P100; p110; p110(nrb); RP11-13G14;
                     TIP110"
                     /note="hexamer: ATTAAA"
     polyA_site      3683
                     /gene="SART3"
                     /gene_synonym="DSAP1; P100; p110; p110(nrb); RP11-13G14;
                     TIP110"
                     /note="major polyA site"
     regulatory      3770..3775
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SART3"
                     /gene_synonym="DSAP1; P100; p110; p110(nrb); RP11-13G14;
                     TIP110"
                     /note="hexamer: AATAGA"
     polyA_site      3791
                     /gene="SART3"
                     /gene_synonym="DSAP1; P100; p110; p110(nrb); RP11-13G14;
                     TIP110"
     regulatory      4108..4113
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SART3"
                     /gene_synonym="DSAP1; P100; p110; p110(nrb); RP11-13G14;
                     TIP110"
                     /note="hexamer: ATTAAA"
     regulatory      4132..4137
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SART3"
                     /gene_synonym="DSAP1; P100; p110; p110(nrb); RP11-13G14;
                     TIP110"
                     /note="hexamer: AATAAA"
     polyA_site      4137
                     /gene="SART3"
                     /gene_synonym="DSAP1; P100; p110; p110(nrb); RP11-13G14;
                     TIP110"
     polyA_site      4154
                     /gene="SART3"
                     /gene_synonym="DSAP1; P100; p110; p110(nrb); RP11-13G14;
                     TIP110"
ORIGIN      
        1 gagtcattag aagcgcaaga tggcgactgc ggccgaaacc tcggcttcag aacccgaggc
       61 tgagtccaag gctgggccca aggctgacgg agaggaggat gaggttaagg cggctaggac
      121 aaggaggaag gtgttatcgc gggctgtggc cgctgcgaca tacaagacca tggggccagc
      181 gtgggatcag caggaggaag gcgtgagcga gagcgatggg gatgagtacg ccatggcttc
      241 ctccgcggag agctcccccg gggagtacga gtgggaatat gacgaagagg aggagaaaaa
      301 ccagctggag attgagagac tggaggagca gttgtctatc aacgtctatg actacaactg
      361 ccatgtggac ttgatcagac tgctcaggct ggaaggggag cttaccaagg tgaggatggc
      421 ccgccagaag atgagtgaaa tctttccctt gactgaagag ctctggctgg agtggctgca
      481 tgacgagatc agcatggccc aggatggcct ggacagagag cacgtgtatg acctctttga
      541 gaaagccgtg aaggattaca tttgtcctaa catttggcta gagtatggcc agtactcagt
      601 tggtgggatt ggtcagaaag gtggccttga gaaagttcgc tccgtgtttg aaagggctct
      661 ctcgtctgtt ggtttacata tgaccaaagg actcgccctc tgggaggctt accgagagtt
      721 tgaaagtgcg attgtggaag ctgctcggct tgagaaagtc cacagtcttt tccggcgaca
      781 gttggcgatc ccactctatg atatggaggc cacatttgca gagtatgaag aatggtcaga
      841 agacccaata ccagagtcag taattcagaa ctataacaaa gcactacagc agctggagaa
      901 atataaaccc tatgaagaag cactgttgca ggcagaggca ccaaggctgg cagaatatca
      961 agcatatatc gattttgaga tgaaaattgg cgatcctgct cgcattcagt tgatctttga
     1021 gcgcgccctg gtcgagaact gccttgtccc agacttatgg atccgttaca gtcagtacct
     1081 agatcgacaa ctgaaagtaa aggatttggt tttatctgta cataaccgcg ctattagaaa
     1141 ctgcccctgg acagttgcct tatggagtcg gtacctcttg gccatggaga gacatggagt
     1201 tgatcatcaa gtaatttctg taaccttcga gaaagctttg aatgccggct tcatccaggc
     1261 cactgattat gtggagattt ggcaggcata ccttgattac ctgaggagaa gggttgattt
     1321 caaacaagac tccagtaaag agctggagga gttgagggcc gcctttactc gtgccttgga
     1381 gtatctgaag caggaggtgg aagagcgttt caatgagagt ggtgatccaa gctgcgtgat
     1441 tatgcagaac tgggctagga ttgaggctcg actgtgcaat aacatgcaga aagctcggga
     1501 actctgggat agcatcatga ccagaggaaa tgccaagtac gccaacatgt ggctagagta
     1561 ttacaacctg gaaagagctc atggtgacac ccagcactgc cggaaggctc tgcaccgggc
     1621 cgtccagtgc accagtgact acccagagca cgtctgcgaa gtgttactca ccatggagag
     1681 gacagaaggt tctttagaag attgggatat agctgttcag aaaactgaaa cccgattagc
     1741 tcgtgtcaat gagcagagaa tgaaggctgc agagaaggaa gcagcccttg tgcagcaaga
     1801 agaagaaaag gctgaacaac ggaaaagagc tcgggctgag aagaaagcgt taaaaaagaa
     1861 gaaaaagatc agaggcccag agaagcgcgg agcagatgag gatgatgaga aagagtgggg
     1921 cgatgatgaa gaagagcagc cttccaaacg cagaagggtc gagaacagca tccctgcagc
     1981 tggagaaaca caaaatgtag aagtagcagc agggcccgct gggaaatgtg ctgccgtaga
     2041 tgtggagccc ccttcgaagc agaaggagaa ggcagcctcc ctgaagaggg acatgcccaa
     2101 ggtgctgcac gacagcagca aggacagcat caccgtcttt gtcagcaacc tgccctacag
     2161 catgcaggag ccggacacga agctcaggcc actcttcgag gcctgtgggg aggtggtcca
     2221 gatccgaccc atcttcagca accgtgggga tttccgaggt tactgctacg tggagtttaa
     2281 agaagagaaa tcagcccttc aggcactgga gatggaccgg aaaagtgtag aagggaggcc
     2341 aatgtttgtt tccccctgtg tggataagag caaaaacccc gattttaagg tgttcaggta
     2401 cagcacttcc ctagagaaac acaagctgtt catctcaggc ctgcctttct cctgtactaa
     2461 agaggaacta gaagaaatct gtaaggctca tggcaccgtg aaggacctca ggctggtcac
     2521 caaccgggct ggcaaaccaa agggcctggc ctacgtggag tatgaaaatg aatcccaggc
     2581 gtcgcaggct gtgatgaaga tggacggcat gactatcaaa gagaacatca tcaaagtggc
     2641 aatcagcaac cctcctcaga ggaaagttcc agagaagccg gagaccagga aggcaccagg
     2701 tggccccatg cttttgccgc agacatacgg agcgaggggg aagggaagga cgcagctgtc
     2761 tctactgcct cgtgccctgc agcgcccaag tgctgcagct cctcaggctg agaacggccc
     2821 tgccgcggct cctgcagttg ccgccccagc agccaccgag gcacccaaga tgtccaatgc
     2881 cgattttgcc aagctgtttc tgagaaagtg aacgggacgc tgggagacag gaaatgcctt
     2941 acttcactct ggcccggcgg acctcccacc acccagcagt gcactgggga tggacaggcc
     3001 tggtgtgctg cgtgctcgca accacagatg gctcctcggc tttagacaga aaggggaagg
     3061 ggttctaagt caagagcctt tcagtgctcc ctcatattga gggcagtggc agaaaagtga
     3121 ccactctgca ggctgggccc aggatgtggt gtcctgagat agttttgtat cttaaagact
     3181 gaggcacaga agcgaaacga gaacacactg tttttgagac acagttgtcc aaatgtttct
     3241 ggccagctcc ggcccctttt tgtatgacac ttctcttcca ccctgcacag cacatgtgcc
     3301 cgtcattctt ttaattttaa aagatgaaat ggcagatgct agtaattcac agaatggcct
     3361 cttgtggggg tgggtctgag ggaagtcagc tataaaacat ttgctggagt tttgttcaat
     3421 ggggctgtgc atttttatat tatgtgtttg taaatgacat gtcagccatt gtttcatgtt
     3481 tcctaaaagc agaatatttg caacatttgt tttgtatagg aattatttgt gccacctgct
     3541 gtggactgtt ttctttgcct agtgactagt gacctgtgtt gtctaaacat gagtttcagc
     3601 cctttggttt tgtttaatac catgtcaaat gcaaacttca attctcccca tttagcttta
     3661 ttaaactgac gttctcttca aaacttcttg ctgaatggta ctcagatgtg cattcacata
     3721 cagatgtgtt ttgaagtggg tgtaccttgc tttacctaat agatgtgtaa atagaacttt
     3781 tgtaagtcaa atcccattgt cactttgatt taaattattc cagctgtgat gtgtcttcat
     3841 tttatagcag tttgacactg gagcttttga gcttttttac ctcacatctt ttatcaaata
     3901 atatttactg ctttgaaaac agcaacagca ttggccagtt cagtagggga agcttgcttt
     3961 attaagacac tctggagaaa gacgtcaggg aatccttgta tatgtcgtgg gaatcaactc
     4021 ctcatttatc tgttgcgtaa gtttaagttt ttgtgcatca gtcgggtttt ctatattttt
     4081 ttaacttaac attttttaat ataaccgatt aaaaagtaga cagaacagta aaataaactc
     4141 ctgtgtgcct acca
//
