LOCUS       NM_005146               3557 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens spliceosome associated factor 1, recruiter of U4/U6.U5
            tri-snRNP (SART1), mRNA.
ACCESSION   NM_005146
VERSION     NM_005146.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3557)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 3557)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3557)
  AUTHORS   Pan,T., Zhou,Q., Miao,K., Zhang,L., Wu,G., Yu,J., Xu,Y., Xiong,W.,
            Li,Y. and Wang,Y.
  TITLE     Suppressing Sart1 to modulate macrophage polarization by
            siRNA-loaded liposomes: a promising therapeutic strategy for
            pulmonary fibrosis
  JOURNAL   Theranostics 11 (3), 1192-1206 (2021)
   PUBMED   33391530
  REMARK    GeneRIF: Suppressing Sart1 to modulate macrophage polarization by
            siRNA-loaded liposomes: a promising therapeutic strategy for
            pulmonary fibrosis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3557)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3557)
  AUTHORS   Charenton,C., Wilkinson,M.E. and Nagai,K.
  TITLE     Mechanism of 5' splice site transfer for human spliceosome
            activation
  JOURNAL   Science 364 (6438), 362-367 (2019)
   PUBMED   30975767
REFERENCE   6  (bases 1 to 3557)
  AUTHORS   Ishida,H., Komiya,S., Inoue,Y., Yutani,S., Inoue,A. and Itoh,K.
  TITLE     Expression of the SART1 tumor-rejection antigen in human
            osteosarcomas
  JOURNAL   Int J Oncol 17 (1), 29-32 (2000)
   PUBMED   10853014
REFERENCE   7  (bases 1 to 3557)
  AUTHORS   Matsunaga,K., Nakao,M., Masuoka,K., Inoue,Y., Gouhara,R.,
            Imaizumi,T., Nishizaka,S. and Itoh,K.
  TITLE     Cytokines required for induction of histocompatibility leukocyte
            antigen-class I-restricted and tumor-specific cytotoxic T
            lymphocytes by a SART1-derived peptide
  JOURNAL   Jpn J Cancer Res 90 (9), 1007-1015 (1999)
   PUBMED   10551332
REFERENCE   8  (bases 1 to 3557)
  AUTHORS   Kikuchi,M., Nakao,M., Inoue,Y., Matsunaga,K., Shichijo,S.,
            Yamana,H. and Itoh,K.
  TITLE     Identification of a SART-1-derived peptide capable of inducing
            HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes
  JOURNAL   Int J Cancer 81 (3), 459-466 (1999)
   PUBMED   10209962
REFERENCE   9  (bases 1 to 3557)
  AUTHORS   Valenta,R., Natter,S., Seiberler,S., Wichlas,S., Maurer,D.,
            Hess,M., Pavelka,M., Grote,M., Ferreira,F., Szepfalusi,Z.,
            Valent,P. and Stingl,G.
  TITLE     Molecular characterization of an autoallergen, Hom s 1, identified
            by serum IgE from atopic dermatitis patients
  JOURNAL   J Invest Dermatol 111 (6), 1178-1183 (1998)
   PUBMED   9856836
REFERENCE   10 (bases 1 to 3557)
  AUTHORS   Shichijo,S., Nakao,M., Imai,Y., Takasu,H., Kawamoto,M., Niiya,F.,
            Yang,D., Toh,Y., Yamana,H. and Itoh,K.
  TITLE     A gene encoding antigenic peptides of human squamous cell carcinoma
            recognized by cytotoxic T lymphocytes
  JOURNAL   J Exp Med 187 (3), 277-288 (1998)
   PUBMED   9449708
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AU136920.1, AB006198.1 and
            AP006287.2.
            
            On Nov 22, 2018 this sequence version replaced NM_005146.4.
            
            Summary: This gene encodes two proteins, the SART1(800) protein
            expressed in the nucleus of the majority of proliferating cells,
            and the SART1(259) protein expressed in the cytosol of epithelial
            cancers. The SART1(259) protein is translated by the mechanism of
            -1 frameshifting during posttranscriptional regulation; its
            full-length sequence is not published yet. The two encoded proteins
            are thought to be involved in the regulation of proliferation. Both
            proteins have tumor-rejection antigens. The SART1(259) protein
            possesses tumor epitopes capable of inducing HLA-A2402-restricted
            cytotoxic T lymphocytes in cancer patients. This SART1(259) antigen
            may be useful in specific immunotherapy for cancer patients and may
            serve as a paradigmatic tool for the diagnosis and treatment of
            patients with atopy. The SART1(259) protein is found to be
            essential for the recruitment of the tri-snRNP to the
            pre-spliceosome in the spliceosome assembly pathway. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.130432.1,
                                           SRR1660807.226377.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000312397.10/ ENSP00000310448.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-360               AU136920.1         46-405
            361-2514            AB006198.1         352-2505
            2515-3556           AP006287.2         94346-95387
            3557-3557           AP006287.2         95388-95388
FEATURES             Location/Qualifiers
     source          1..3557
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.1"
     gene            1..3557
                     /gene="SART1"
                     /gene_synonym="Ara1; HAF; HOMS1; SART1259; SNRNP110;
                     Snu66"
                     /note="spliceosome associated factor 1, recruiter of
                     U4/U6.U5 tri-snRNP"
                     /db_xref="GeneID:9092"
                     /db_xref="HGNC:HGNC:10538"
                     /db_xref="MIM:605941"
     exon            1..360
                     /gene="SART1"
                     /gene_synonym="Ara1; HAF; HOMS1; SART1259; SNRNP110;
                     Snu66"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..2450
                     /gene="SART1"
                     /gene_synonym="Ara1; HAF; HOMS1; SART1259; SNRNP110;
                     Snu66"
                     /note="squamous cell carcinoma antigen recognised by T
                     cells; small nuclear ribonucleoprotein 110kDa (U4/U6.U5);
                     U4/U6.U5 tri-snRNP-associated 110 kDa protein; IgE
                     autoantigen; SART1(259) protein; SART1(800) protein;
                     squamous cell carcinoma antigen recognized by T-cells 1;
                     hypoxia associated factor; SART-1; hSnu66; hSART-1; SNU66
                     homolog; SART1, U4/U6.U5 tri-snRNP-associated protein 1"
                     /codon_start=1
                     /product="U4/U6.U5 tri-snRNP-associated protein 1"
                     /protein_id="NP_005137.1"
                     /db_xref="CCDS:CCDS31611.1"
                     /db_xref="GeneID:9092"
                     /db_xref="HGNC:HGNC:10538"
                     /db_xref="MIM:605941"
                     /translation="MGSSKKHRGEKEAAGTTAAAGTGGATEQPPRHREHKKHKHRSGG
                     SGGSGGERRKRSRERGGERGSGRRGAEAEARSSTHGRERSQAEPSERRVKREKRDDGY
                     EAAASSKTSSGDASSLSIEETNKLRAKLGLKPLEVNAIKKEAGTKEEPVTADVINPMA
                     LRQREELREKLAAAKEKRLLNQKLGKIKTLGEDDPWLDDTAAWIERSRQLQKEKDLAE
                     KRAKLLEEMDQEFGVSTLVEEEFGQRRQDLYSARDLQGLTVEHAIDSFREGETMILTL
                     KDKGVLQEEEDVLVNVNLVDKERAEKNVELRKKKPDYLPYAEDESVDDLAQQKPRSIL
                     SKYDEELEGERPHSFRLEQGGTADGLRERELEEIRAKLRLQAQSLSTVGPRLASEYLT
                     PEEMVTFKKTKRRVKKIRKKEKEVVVRADDLLPLGDQTQDGDFGSRLRGRGRRRVSEV
                     EEEKEPVPQPLPSDDTRVENMDISDEEEGGAPPPGSPQVLEEDEAELELQKQLEKGRR
                     LRQLQQLQQLRDSGEKVVEIVKKLESRQRGWEEDEDPERKGAIVFNATSEFCRTLGEI
                     PTYGLAGNREEQEELMDFERDEERSANGGSESDGEENIGWSTVNLDEEKQQQDFSASS
                     TTILDEEPIVNRGLAAALLLCQNKGLLETTVQKVARVKAPNKSLPSAVYCIEDKMAID
                     DKYSRREEYRGFTQDFKEKDGYKPDVKIEYVDETGRKLTPKEAFRQLSHRFHGKGSGK
                     MKTERRMKKLDEEALLKKMSSSDTPLGTVALLQEKQKAQKTPYIVLSGSGKSMNANTI
                     TK"
     exon            361..418
                     /gene="SART1"
                     /gene_synonym="Ara1; HAF; HOMS1; SART1259; SNRNP110;
                     Snu66"
                     /inference="alignment:Splign:2.1.0"
     exon            419..474
                     /gene="SART1"
                     /gene_synonym="Ara1; HAF; HOMS1; SART1259; SNRNP110;
                     Snu66"
                     /inference="alignment:Splign:2.1.0"
     exon            475..601
                     /gene="SART1"
                     /gene_synonym="Ara1; HAF; HOMS1; SART1259; SNRNP110;
                     Snu66"
                     /inference="alignment:Splign:2.1.0"
     exon            602..707
                     /gene="SART1"
                     /gene_synonym="Ara1; HAF; HOMS1; SART1259; SNRNP110;
                     Snu66"
                     /inference="alignment:Splign:2.1.0"
     exon            708..785
                     /gene="SART1"
                     /gene_synonym="Ara1; HAF; HOMS1; SART1259; SNRNP110;
                     Snu66"
                     /inference="alignment:Splign:2.1.0"
     exon            786..885
                     /gene="SART1"
                     /gene_synonym="Ara1; HAF; HOMS1; SART1259; SNRNP110;
                     Snu66"
                     /inference="alignment:Splign:2.1.0"
     exon            886..1028
                     /gene="SART1"
                     /gene_synonym="Ara1; HAF; HOMS1; SART1259; SNRNP110;
                     Snu66"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1235
                     /gene="SART1"
                     /gene_synonym="Ara1; HAF; HOMS1; SART1259; SNRNP110;
                     Snu66"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1360
                     /gene="SART1"
                     /gene_synonym="Ara1; HAF; HOMS1; SART1259; SNRNP110;
                     Snu66"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1476
                     /gene="SART1"
                     /gene_synonym="Ara1; HAF; HOMS1; SART1259; SNRNP110;
                     Snu66"
                     /inference="alignment:Splign:2.1.0"
     exon            1477..1619
                     /gene="SART1"
                     /gene_synonym="Ara1; HAF; HOMS1; SART1259; SNRNP110;
                     Snu66"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1793
                     /gene="SART1"
                     /gene_synonym="Ara1; HAF; HOMS1; SART1259; SNRNP110;
                     Snu66"
                     /inference="alignment:Splign:2.1.0"
     exon            1794..1904
                     /gene="SART1"
                     /gene_synonym="Ara1; HAF; HOMS1; SART1259; SNRNP110;
                     Snu66"
                     /inference="alignment:Splign:2.1.0"
     exon            1905..1992
                     /gene="SART1"
                     /gene_synonym="Ara1; HAF; HOMS1; SART1259; SNRNP110;
                     Snu66"
                     /inference="alignment:Splign:2.1.0"
     exon            1993..2083
                     /gene="SART1"
                     /gene_synonym="Ara1; HAF; HOMS1; SART1259; SNRNP110;
                     Snu66"
                     /inference="alignment:Splign:2.1.0"
     exon            2084..2219
                     /gene="SART1"
                     /gene_synonym="Ara1; HAF; HOMS1; SART1259; SNRNP110;
                     Snu66"
                     /inference="alignment:Splign:2.1.0"
     exon            2220..2309
                     /gene="SART1"
                     /gene_synonym="Ara1; HAF; HOMS1; SART1259; SNRNP110;
                     Snu66"
                     /inference="alignment:Splign:2.1.0"
     exon            2310..2431
                     /gene="SART1"
                     /gene_synonym="Ara1; HAF; HOMS1; SART1259; SNRNP110;
                     Snu66"
                     /inference="alignment:Splign:2.1.0"
     exon            2432..3557
                     /gene="SART1"
                     /gene_synonym="Ara1; HAF; HOMS1; SART1259; SNRNP110;
                     Snu66"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2492..2497
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SART1"
                     /gene_synonym="Ara1; HAF; HOMS1; SART1259; SNRNP110;
                     Snu66"
                     /note="hexamer: AATAAA"
     polyA_site      2516
                     /gene="SART1"
                     /gene_synonym="Ara1; HAF; HOMS1; SART1259; SNRNP110;
                     Snu66"
                     /note="major polyA site"
     regulatory      3213..3218
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SART1"
                     /gene_synonym="Ara1; HAF; HOMS1; SART1259; SNRNP110;
                     Snu66"
                     /note="hexamer: AATAAA"
     regulatory      3222..3227
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SART1"
                     /gene_synonym="Ara1; HAF; HOMS1; SART1259; SNRNP110;
                     Snu66"
                     /note="hexamer: AAGAAA"
     polyA_site      3235
                     /gene="SART1"
                     /gene_synonym="Ara1; HAF; HOMS1; SART1259; SNRNP110;
                     Snu66"
     polyA_site      3248
                     /gene="SART1"
                     /gene_synonym="Ara1; HAF; HOMS1; SART1259; SNRNP110;
                     Snu66"
     regulatory      3537..3542
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SART1"
                     /gene_synonym="Ara1; HAF; HOMS1; SART1259; SNRNP110;
                     Snu66"
                     /note="hexamer: AATAAA"
     polyA_site      3557
                     /gene="SART1"
                     /gene_synonym="Ara1; HAF; HOMS1; SART1259; SNRNP110;
                     Snu66"
ORIGIN      
        1 cgttgtctgg gctcggcggc agccgggctc ggagtggacg tgccactatg gggtcgtcca
       61 agaagcatcg cggagagaag gaggcggccg ggacgacggc ggcggccggc accgggggtg
      121 ccaccgagca gccgccgcgg caccgggaac acaaaaaaca caagcaccgg agtggcggca
      181 gtggcggtag cggtggcgaa cgacggaagc ggagccggga acgtgggggc gagcgcggga
      241 gcgggcggcg cggggccgaa gctgaggccc ggagcagcac gcacgggcgg gagcgcagcc
      301 aggcagagcc ctccgagcgg cgcgtgaagc gggagaagcg cgatgacggc tacgaggccg
      361 ctgccagctc caaaactagc tcaggcgatg cctcctcact cagcatcgag gagactaaca
      421 aactccgggc aaagttgggg ctgaaaccct tggaggttaa tgccatcaag aaggaggcgg
      481 gcaccaagga ggagcccgtg acagctgatg tcatcaaccc tatggccttg cgacagcgag
      541 aggagctgcg ggagaagctg gcggctgcca aggagaagcg cctgctgaac caaaagctgg
      601 ggaagataaa gaccctagga gaggatgacc cctggctgga cgacactgca gcctggatcg
      661 agaggagccg gcagctgcag aaggagaagg acctggcaga gaagagggcc aagttactgg
      721 aggagatgga ccaagagttt ggtgtcagca ctctggtgga ggaggagttc gggcagaggc
      781 ggcaggacct gtacagtgcc cgggacctgc agggcctcac cgtggagcat gccattgatt
      841 ccttccgaga aggggagaca atgattctta ccctcaagga caaaggcgtg ctgcaggagg
      901 aggaggacgt gctggtgaac gtgaacctgg tggataagga gcgggcagag aaaaatgtgg
      961 agctgcggaa gaagaagcct gactacctgc cctatgccga ggacgagagc gtggacgacc
     1021 tggcgcagca aaaacctcgc tctatcctgt ccaagtatga cgaagagctt gaaggggagc
     1081 ggccacattc cttccgcttg gagcagggcg gcacggctga tggcctgcgg gagcgggagc
     1141 tggaggagat ccgggccaag ctgcggctgc aggctcagtc cctgagcaca gtggggcccc
     1201 ggctggcctc cgaatacctc acgcctgagg agatggtgac ctttaaaaag accaagcgga
     1261 gggtgaagaa aatccgcaag aaggagaagg aggtagtagt gcgggcagat gacttgctgc
     1321 ctctcgggga ccagactcag gatggggact ttggttccag actgcgggga cggggtcgcc
     1381 gccgagtgtc cgaagtggag gaggagaagg agcctgtgcc tcagcccctg ccgtcggacg
     1441 acacccgagt ggagaacatg gacatcagtg atgaggagga aggtggagct ccaccgccgg
     1501 ggtccccgca ggtgctggag gaggacgagg cggagctgga gctgcagaag cagctggaga
     1561 agggacgccg gctgcgacag ttacagcagc tacagcagct gcgagacagt ggcgagaagg
     1621 tggtggagat tgtgaagaag ctggagtctc gccagcgggg ctgggaggag gatgaggatc
     1681 ccgagcggaa gggggccatc gtgttcaacg ccacgtccga gttctgccgc accttggggg
     1741 agatccccac ctacgggctg gctggcaatc gcgaggagca ggaggagctc atggactttg
     1801 aacgggatga ggagcgctca gccaacggtg gctccgaatc tgacggggag gagaacatcg
     1861 gctggagcac ggtgaacctg gacgaggaga agcagcagca ggatttctct gcttcctcca
     1921 ccaccatcct ggacgaggaa ccgatcgtga atagggggct ggcagctgcc ctgctcctgt
     1981 gtcagaacaa agggctgctg gagaccacag tgcagaaggt ggcccgggtg aaggccccca
     2041 acaagtcgct gccctcagcc gtgtactgca tcgaggataa gatggccatc gatgacaagt
     2101 acagccggag ggaggaatac cgaggcttca cacaggactt caaggagaag gacggctaca
     2161 aacccgacgt taagatcgaa tacgtggatg agacgggccg gaaactcaca cccaaggagg
     2221 ctttccggca gctgtcgcac cgcttccatg gcaagggctc aggcaagatg aagacagagc
     2281 ggcggatgaa gaagctggac gaggaggcgc tcctgaagaa gatgagctcc agcgacacgc
     2341 ccctgggcac cgtggccctg ctccaggaga agcagaaggc tcagaagacc ccctacatcg
     2401 tgctcagcgg cagcggcaag agcatgaacg cgaacaccat caccaagtga cagcgccctc
     2461 ccgccccggc cctgcctcaa ccttcatatt aaataaagct ccctccttat tttttcctcc
     2521 ctggtcgtgg tacagattcc agggttggat ctttggttgg gtgtggcaca gagtctggct
     2581 cctgctaggt gagacctggc catcaaatga cacaaacaac taaacgatgg aagagagagc
     2641 gagcccgggt cctctaaggc tccttccttc tcccctggct gtcggtcaca cctctgcagg
     2701 gccggctctc tgatagaaag tggaaggcgg ttttagaaac tcatcaccct gctctctcct
     2761 ggcctcgggg gctgcacagg tcactgtcct gtaatgtctc ccggtcaggg cagcccagga
     2821 ctgcccagcc tggtgggctg gggattgggc tttgggtagg gcacaggtgc caccttctgt
     2881 cctggctgtc ctgtgccacc ctggtctgtg tctagaggag tgaaactccc agggttgggc
     2941 tgggagtatt tggtgcacgc ggtatgggga gggctgagct cagtgcctcc tgggagactt
     3001 gtcccgtgta cagtgaccca gaaagatgag attccttggc ctgaactctg tgatagagtg
     3061 tgactgagct gctgggggac atgtgagcct caaatccata gaaagacaaa cggccacctt
     3121 gggtgcccag gatactggtg cctggcccca cgtacaccca catacttctc agatggctcc
     3181 cacattttaa gattttaaaa atgaaaccaa aaaataaatt gaagaaaact gtaaacttta
     3241 aagaataatc agctgggcgc agtggctcat gcttgtaatc acagcacttt aggaggctga
     3301 ggcaggagga ctgtttgagc ccaggagttt gagaccaacc tgagtaaggt ggcaaaaccc
     3361 catctctacc aaaaatacaa agattagcca ggcgtggtgg tgagcgcctg tagtcccagc
     3421 tacttgggat gctgaggtgg gaggatcact tgaacctggg agacacaggc tgcagtgggc
     3481 cctgattgag ccaccacact gcagcctagg tgacagtcag accctgtctc aaaaaaaata
     3541 aaaaaaattt aaaataa
//
