LOCUS       NM_033082                898 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens SAP domain containing ribonucleoprotein (SARNP),
            transcript variant 1, mRNA.
ACCESSION   NM_033082
VERSION     NM_033082.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 898)
  AUTHORS   Xie,Y., Gao,S., Zhang,K., Bhat,P., Clarke,B.P., Batten,K., Mei,M.,
            Gazzara,M., Shay,J.W., Lynch,K.W., Angelos,A.E., Hill,P.S.,
            Ivey,A.L., Fontoura,B.M.A. and Ren,Y.
  TITLE     Structural basis for high-order complex of SARNP and DDX39B to
            facilitate mRNP assembly
  JOURNAL   Cell Rep 42 (8), 112988 (2023)
   PUBMED   37578863
  REMARK    GeneRIF: Structural basis for high-order complex of SARNP and
            DDX39B to facilitate mRNP assembly.
REFERENCE   2  (bases 1 to 898)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 898)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 898)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 898)
  AUTHORS   Ellis,J.D., Lleres,D., Denegri,M., Lamond,A.I. and Caceres,J.F.
  TITLE     Spatial mapping of splicing factor complexes involved in exon and
            intron definition
  JOURNAL   J Cell Biol 181 (6), 921-934 (2008)
   PUBMED   18559666
REFERENCE   6  (bases 1 to 898)
  AUTHORS   Sugiura,T., Sakurai,K. and Nagano,Y.
  TITLE     Intracellular characterization of DDX39, a novel growth-associated
            RNA helicase
  JOURNAL   Exp Cell Res 313 (4), 782-790 (2007)
   PUBMED   17196963
  REMARK    GeneRIF: CIP29 physically and functionally associates with DDX39,
            suggesting their cooperation in the RNA metabolism.
REFERENCE   7  (bases 1 to 898)
  AUTHORS   Leaw,C.L., Ren,E.C. and Choong,M.L.
  TITLE     Hcc-1 is a novel component of the nuclear matrix with growth
            inhibitory function
  JOURNAL   Cell Mol Life Sci 61 (17), 2264-2273 (2004)
   PUBMED   15338056
  REMARK    GeneRIF: Hcc-1 plays a role in growth regulation and nucleic acids
            metabolism.
REFERENCE   8  (bases 1 to 898)
  AUTHORS   Hashii,Y., Kim,J.Y., Sawada,A., Tokimasa,S., Hiroyuki,F., Ohta,H.,
            Makiko,K., Takihara,Y., Ozono,K. and Hara,J.
  TITLE     A novel partner gene CIP29 containing a SAP domain with MLL
            identified in infantile myelomonocytic leukemia
  JOURNAL   Leukemia 18 (9), 1546-1548 (2004)
   PUBMED   15284855
REFERENCE   9  (bases 1 to 898)
  AUTHORS   Fukuda,S., Wu,D.W., Stark,K. and Pelus,L.M.
  TITLE     Cloning and characterization of a proliferation-associated
            cytokine-inducible protein, CIP29
  JOURNAL   Biochem Biophys Res Commun 292 (3), 593-600 (2002)
   PUBMED   11922608
  REMARK    GeneRIF: CIP29 appears to be a new cytokine regulated protein
            involved in normal and cancer cell proliferation.
REFERENCE   10 (bases 1 to 898)
  AUTHORS   Choong,M.L., Tan,L.K., Lo,S.L., Ren,E.C., Ou,K., Ong,S.E.,
            Liang,R.C., Seow,T.K. and Chung,M.C.
  TITLE     An integrated approach in the discovery and characterization of a
            novel nuclear protein over-expressed in liver and pancreatic tumors
  JOURNAL   FEBS Lett 496 (2-3), 109-116 (2001)
   PUBMED   11356193
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI520421.1, BC007099.1 and
            AF161434.1.
            
            On Nov 23, 2018 this sequence version replaced NM_033082.3.
            
            Summary: This gene encodes a protein that is upregulated in
            response to various cytokines. The encoded protein may play a role
            in cell cycle progression. A translocation between this gene and
            the myeloid/lymphoid leukemia gene, resulting in expression of a
            chimeric protein, has been associated with acute myelomonocytic
            leukemia. Pseudogenes exist on chromosomes 7 and 8. Alternatively
            spliced transcript variants have been described. [provided by
            RefSeq, Feb 2009].
            
            Transcript Variant: This variant (1) represents the shortest
            transcript and encodes the functional protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.16237.1,
                                           SRR1660805.38117.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000336133.8/ ENSP00000337632.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 BI520421.1         33-34
            3-660               BC007099.1         1-658
            661-898             AF161434.1         662-899
FEATURES             Location/Qualifiers
     source          1..898
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.2"
     gene            1..898
                     /gene="SARNP"
                     /gene_synonym="CIP29; HCC1; HSPC316; THO1"
                     /note="SAP domain containing ribonucleoprotein"
                     /db_xref="GeneID:84324"
                     /db_xref="HGNC:HGNC:24432"
                     /db_xref="MIM:610049"
     exon            1..59
                     /gene="SARNP"
                     /gene_synonym="CIP29; HCC1; HSPC316; THO1"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..656
                     /gene="SARNP"
                     /gene_synonym="CIP29; HCC1; HSPC316; THO1"
                     /note="cytokine induced protein 29 kDa; hepatocellular
                     carcinoma 1; proliferation associated cytokine-inducible
                     protein CIP29; nuclear protein Hcc-1; cytokine-induced
                     protein of 29 kDa"
                     /codon_start=1
                     /product="SAP domain-containing ribonucleoprotein"
                     /protein_id="NP_149073.1"
                     /db_xref="CCDS:CCDS8892.1"
                     /db_xref="GeneID:84324"
                     /db_xref="HGNC:HGNC:24432"
                     /db_xref="MIM:610049"
                     /translation="MATETVELHKLKLAELKQECLARGLETKGIKQDLIHRLQAYLEE
                     HAEEEANEEDVLGDETEEEETKPIELPVKEEEPPEKTVDVAAEKKVVKITSEIPQTER
                     MQKRAERFNVPVSLESKKAARAARFGISSVPTKGLSSDNKPMVNLDKLKERAQRFGLN
                     VSSISRKSEDDEKLKKRKERFGIVTSSAGTGTTEDTEAKKRKRAERFGIA"
     exon            60..159
                     /gene="SARNP"
                     /gene_synonym="CIP29; HCC1; HSPC316; THO1"
                     /inference="alignment:Splign:2.1.0"
     exon            160..206
                     /gene="SARNP"
                     /gene_synonym="CIP29; HCC1; HSPC316; THO1"
                     /inference="alignment:Splign:2.1.0"
     exon            207..274
                     /gene="SARNP"
                     /gene_synonym="CIP29; HCC1; HSPC316; THO1"
                     /inference="alignment:Splign:2.1.0"
     exon            275..326
                     /gene="SARNP"
                     /gene_synonym="CIP29; HCC1; HSPC316; THO1"
                     /inference="alignment:Splign:2.1.0"
     exon            327..400
                     /gene="SARNP"
                     /gene_synonym="CIP29; HCC1; HSPC316; THO1"
                     /inference="alignment:Splign:2.1.0"
     exon            401..429
                     /gene="SARNP"
                     /gene_synonym="CIP29; HCC1; HSPC316; THO1"
                     /inference="alignment:Splign:2.1.0"
     exon            430..455
                     /gene="SARNP"
                     /gene_synonym="CIP29; HCC1; HSPC316; THO1"
                     /inference="alignment:Splign:2.1.0"
     exon            456..524
                     /gene="SARNP"
                     /gene_synonym="CIP29; HCC1; HSPC316; THO1"
                     /inference="alignment:Splign:2.1.0"
     exon            525..614
                     /gene="SARNP"
                     /gene_synonym="CIP29; HCC1; HSPC316; THO1"
                     /inference="alignment:Splign:2.1.0"
     exon            615..898
                     /gene="SARNP"
                     /gene_synonym="CIP29; HCC1; HSPC316; THO1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      875..880
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SARNP"
                     /gene_synonym="CIP29; HCC1; HSPC316; THO1"
                     /note="hexamer: AATAAA"
     polyA_site      898
                     /gene="SARNP"
                     /gene_synonym="CIP29; HCC1; HSPC316; THO1"
                     /note="major polyA site"
ORIGIN      
        1 ctagtggagt gaggggtaac aagatggcga ccgagacggt ggagctccat aagctaaagc
       61 ttgccgaact aaagcaagaa tgtcttgctc gtggtttgga gaccaaggga ataaagcaag
      121 atcttatcca cagactccag gcatatcttg aagaacatgc tgaagaggag gcaaatgaag
      181 aagatgtact gggagatgaa acagaggaag aagaaacaaa gcccattgag ctccctgtca
      241 aagaggaaga accccctgaa aaaactgttg atgtggcagc agagaagaaa gtggtgaaaa
      301 ttacatctga aataccacag actgagagaa tgcagaagag ggctgaacga ttcaatgtac
      361 ctgtgagctt ggagagtaag aaagctgctc gggcagctag gtttgggatt tcttcagttc
      421 caacaaaagg tctgtcatct gataacaaac ctatggttaa cttggataag ctgaaggaaa
      481 gagctcaaag atttggtttg aatgtctctt caatctccag aaagtctgaa gatgatgaga
      541 aactgaaaaa gaggaaggag cgatttggga ttgtcacaag ttcagctgga actggaacca
      601 cagaggatac agaggcaaag aagaggaaaa gagcagagcg ctttgggatt gcctgatgaa
      661 aagttcctga tactttctgt tctccagtgt tttccatttc tctccttctt cttggtcaca
      721 tatatgccta aatgcacagt catgtgccta cgtcctgcct cgcaatgagg gagcatgtac
      781 cccaggtaca tccatgaact gcggcagcag tttgacttat tgctgtttca gctttaaggt
      841 tgttgtgttt ttgtttttga ttatgttgct tgttaataaa aaaaaataga aaagagaa
//
