LOCUS       NM_015077              10277 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens sterile alpha and TIR motif containing 1 (SARM1),
            mRNA.
ACCESSION   NM_015077
VERSION     NM_015077.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10277)
  AUTHORS   Geisler,S.
  TITLE     Augustus Waller's foresight realized: SARM1 in peripheral
            neuropathies
  JOURNAL   Curr Opin Neurobiol 87, 102884 (2024)
   PUBMED   38852438
  REMARK    GeneRIF: Augustus Waller's foresight realized: SARM1 in peripheral
            neuropathies.
            Review article
REFERENCE   2  (bases 1 to 10277)
  AUTHORS   Hinz,F.I., Villegas,C.L.M., Roberts,J.T., Yao,H., Gaddam,S.,
            Delwig,A., Green,S.A., Fredrickson,C., Adrian,M., Asuncion,R.R.,
            Cheung,T.K., Hayne,M., Hackos,D.H., Rose,C.M., Richmond,D. and
            Hoogenraad,C.C.
  TITLE     Context-Specific Stress Causes Compartmentalized SARM1 Activation
            and Local Degeneration in Cortical Neurons
  JOURNAL   J Neurosci 44 (24), e2424232024 (2024)
   PUBMED   38692735
  REMARK    GeneRIF: Context-Specific Stress Causes Compartmentalized SARM1
            Activation and Local Degeneration in Cortical Neurons.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 10277)
  AUTHORS   Garb,J., Amitai,G., Lu,A., Ofir,G., Brandis,A., Mehlman,T.,
            Kranzusch,P.J. and Sorek,R.
  TITLE     The SARM1 TIR domain produces glycocyclic ADPR molecules as minor
            products
  JOURNAL   PLoS One 19 (4), e0302251 (2024)
   PUBMED   38635746
  REMARK    GeneRIF: The SARM1 TIR domain produces glycocyclic ADPR molecules
            as minor products.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 10277)
  AUTHORS   Icso,J.D. and Thompson,P.R.
  TITLE     A phase transition reduces the threshold for nicotinamide
            mononucleotide-based activation of SARM1, an NAD(P) hydrolase, to
            physiologically relevant levels
  JOURNAL   J Biol Chem 299 (11), 105284 (2023)
   PUBMED   37742918
  REMARK    GeneRIF: A phase transition reduces the threshold for nicotinamide
            mononucleotide-based activation of SARM1, an NAD(P) hydrolase, to
            physiologically relevant levels.
REFERENCE   5  (bases 1 to 10277)
  AUTHORS   Czech,V.L., O'Connor,L.C., Philippon,B., Norman,E. and Byrne,A.B.
  TITLE     TIR-1/SARM1 inhibits axon regeneration and promotes axon
            degeneration
  JOURNAL   Elife 12, e80856 (2023)
   PUBMED   37083456
  REMARK    GeneRIF: TIR-1/SARM1 inhibits axon regeneration and promotes axon
            degeneration.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 10277)
  AUTHORS   Ulrichts,P., Peelman,F., Beyaert,R. and Tavernier,J.
  TITLE     MAPPIT analysis of TLR adaptor complexes
  JOURNAL   FEBS Lett 581 (4), 629-636 (2007)
   PUBMED   17258210
REFERENCE   7  (bases 1 to 10277)
  AUTHORS   Carty,M., Goodbody,R., Schroder,M., Stack,J., Moynagh,P.N. and
            Bowie,A.G.
  TITLE     The human adaptor SARM negatively regulates adaptor protein
            TRIF-dependent Toll-like receptor signaling
  JOURNAL   Nat Immunol 7 (10), 1074-1081 (2006)
   PUBMED   16964262
  REMARK    GeneRIF: TIR adaptor SARM is a negative regulator of Toll-like
            receptor signaling.
REFERENCE   8  (bases 1 to 10277)
  AUTHORS   Mink,M. and Csiszar,K.
  TITLE     SARM1: A candidate gene in the onset of hereditary
            infectious/inflammatory diseases
  JOURNAL   Clin Immunol 115 (3), 333-334 (2005)
   PUBMED   15893701
  REMARK    GeneRIF: Candidate gene in the onset of hereditary
            infectious/inflammatory diseases.
REFERENCE   9  (bases 1 to 10277)
  AUTHORS   Liberati,N.T., Fitzgerald,K.A., Kim,D.H., Feinbaum,R.,
            Golenbock,D.T. and Ausubel,F.M.
  TITLE     Requirement for a conserved Toll/interleukin-1 resistance domain
            protein in the Caenorhabditis elegans immune response
  JOURNAL   Proc Natl Acad Sci U S A 101 (17), 6593-6598 (2004)
   PUBMED   15123841
REFERENCE   10 (bases 1 to 10277)
  AUTHORS   Mink,M., Fogelgren,B., Olszewski,K., Maroy,P. and Csiszar,K.
  TITLE     A novel human gene (SARM) at chromosome 17q11 encodes a protein
            with a SAM motif and structural similarity to
            Armadillo/beta-catenin that is conserved in mouse, Drosophila, and
            Caenorhabditis elegans
  JOURNAL   Genomics 74 (2), 234-244 (2001)
   PUBMED   11386760
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK314609.1, BC122860.1, AB011096.1, BC040429.1, BG820141.1 and
            AC015917.30.
            
            On Nov 23, 2018 this sequence version replaced NM_015077.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ290445.1, AB011096.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000585482.6/ ENSP00000468032.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1771              AK314609.1         33-1803
            1772-2565           BC122860.1         1112-1905
            2566-2874           AB011096.1         1850-2158
            2875-4395           BC040429.1         2495-4015
            4396-6136           AB011096.1         3680-5420
            6137-6151           BG820141.1         522-536
            6152-7273           AB011096.1         5435-6556
            7274-10277          AC015917.30        108953-111956       c
FEATURES             Location/Qualifiers
     source          1..10277
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q11.2"
     gene            1..10277
                     /gene="SARM1"
                     /gene_synonym="hSARM1; HsTIR; MyD88-5; SAMD2; SARM"
                     /note="sterile alpha and TIR motif containing 1"
                     /db_xref="GeneID:23098"
                     /db_xref="HGNC:HGNC:17074"
                     /db_xref="MIM:607732"
     exon            1..809
                     /gene="SARM1"
                     /gene_synonym="hSARM1; HsTIR; MyD88-5; SAMD2; SARM"
                     /inference="alignment:Splign:2.1.0"
     CDS             340..2514
                     /gene="SARM1"
                     /gene_synonym="hSARM1; HsTIR; MyD88-5; SAMD2; SARM"
                     /EC_number="3.2.2.6"
                     /note="sterile alpha and HEAT/Armadillo motif protein,
                     ortholog of Drosophila; sterile alpha and TIR
                     motif-containing protein 1; tir-1 homolog; SAM
                     domain-containing protein 2; sterile alpha and Armadillo
                     repeat protein; sterile alpha motif domain-containing
                     protein 2; NADase SARM1; NADP(+) hydrolase SARM1; NAD(+)
                     hydrolase SARM1"
                     /codon_start=1
                     /product="NAD(+) hydrolase SARM1 precursor"
                     /protein_id="NP_055892.2"
                     /db_xref="CCDS:CCDS11230.2"
                     /db_xref="GeneID:23098"
                     /db_xref="HGNC:HGNC:17074"
                     /db_xref="MIM:607732"
                     /translation="MVLTLLLSAYKLCRFFAMSGPRPGAERLAVPGPDGGGGTGPWWA
                     AGGRGPREVSPGAGTEVQDALERALPELQQALSALKQAGGARAVGAGLAEVFQLVEEA
                     WLLPAVGREVAQGLCDAIRLDGGLDLLLRLLQAPELETRVQAARLLEQILVAENRDRV
                     ARIGLGVILNLAKEREPVELARSVAGILEHMFKHSEETCQRLVAAGGLDAVLYWCRRT
                     DPALLRHCALALGNCALHGGQAVQRRMVEKRAAEWLFPLAFSKEDELLRLHACLAVAV
                     LATNKEVEREVERSGTLALVEPLVASLDPGRFARCLVDASDTSQGRGPDDLQRLVPLL
                     DSNRLEAQCIGAFYLCAEAAIKSLQGKTKVFSDIGAIQSLKRLVSYSTNGTKSALAKR
                     ALRLLGEEVPRPILPSVPSWKEAEVQTWLQQIGFSKYCESFREQQVDGDLLLRLTEEE
                     LQTDLGMKSGITRKRFFRELTELKTFANYSTCDRSNLADWLGSLDPRFRQYTYGLVSC
                     GLDRSLLHRVSEQQLLEDCGIHLGVHRARILTAAREMLHSPLPCTGGKPSGDTPDVFI
                     SYRRNSGSQLASLLKVHLQLHGFSVFIDVEKLEAGKFEDKLIQSVMGARNFVLVLSPG
                     ALDKCMQDHDCKDWVHKEIVTALSCGKNIVPIIDGFEWPEPQVLPEDMQAVLTFNGIK
                     WSHEYQEATIEKIIRFLQGRSSRDSSAGSDTSLEGAAPMGPT"
     exon            810..1428
                     /gene="SARM1"
                     /gene_synonym="hSARM1; HsTIR; MyD88-5; SAMD2; SARM"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..1641
                     /gene="SARM1"
                     /gene_synonym="hSARM1; HsTIR; MyD88-5; SAMD2; SARM"
                     /inference="alignment:Splign:2.1.0"
     exon            1642..1733
                     /gene="SARM1"
                     /gene_synonym="hSARM1; HsTIR; MyD88-5; SAMD2; SARM"
                     /inference="alignment:Splign:2.1.0"
     exon            1734..1969
                     /gene="SARM1"
                     /gene_synonym="hSARM1; HsTIR; MyD88-5; SAMD2; SARM"
                     /inference="alignment:Splign:2.1.0"
     exon            1970..2072
                     /gene="SARM1"
                     /gene_synonym="hSARM1; HsTIR; MyD88-5; SAMD2; SARM"
                     /inference="alignment:Splign:2.1.0"
     exon            2073..2262
                     /gene="SARM1"
                     /gene_synonym="hSARM1; HsTIR; MyD88-5; SAMD2; SARM"
                     /inference="alignment:Splign:2.1.0"
     exon            2263..2384
                     /gene="SARM1"
                     /gene_synonym="hSARM1; HsTIR; MyD88-5; SAMD2; SARM"
                     /inference="alignment:Splign:2.1.0"
     exon            2385..10277
                     /gene="SARM1"
                     /gene_synonym="hSARM1; HsTIR; MyD88-5; SAMD2; SARM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4370..4375
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SARM1"
                     /gene_synonym="hSARM1; HsTIR; MyD88-5; SAMD2; SARM"
                     /note="hexamer: AATACA"
     polyA_site      4395
                     /gene="SARM1"
                     /gene_synonym="hSARM1; HsTIR; MyD88-5; SAMD2; SARM"
                     /note="major polyA site"
     regulatory      7262..7267
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SARM1"
                     /gene_synonym="hSARM1; HsTIR; MyD88-5; SAMD2; SARM"
                     /note="hexamer: AAGAAA"
     polyA_site      7298
                     /gene="SARM1"
                     /gene_synonym="hSARM1; HsTIR; MyD88-5; SAMD2; SARM"
     regulatory      7847..7852
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SARM1"
                     /gene_synonym="hSARM1; HsTIR; MyD88-5; SAMD2; SARM"
                     /note="hexamer: ATTAAA"
     polyA_site      7866
                     /gene="SARM1"
                     /gene_synonym="hSARM1; HsTIR; MyD88-5; SAMD2; SARM"
     regulatory      10256..10261
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SARM1"
                     /gene_synonym="hSARM1; HsTIR; MyD88-5; SAMD2; SARM"
                     /note="hexamer: AATAAA"
     polyA_site      10277
                     /gene="SARM1"
                     /gene_synonym="hSARM1; HsTIR; MyD88-5; SAMD2; SARM"
ORIGIN      
        1 atctcccagc tcagccgagc ccgtgcccag gccacgcttt gttccagccg ccgcctcctc
       61 taccctacgg cgtccggagc catccctcgc ctgctcgctc tctcctttcg cccactccct
      121 gcatctgggc ctgcatcacc tttgccaacc gctcccccga tcctgccgac actcctcccc
      181 caaacttctg accggcaccc ttgcctggta cccttctctc cattcctccc cctccatctt
      241 ctttccccga cccctctcgg gtccctcttt tcccaaaacc cgggtctctc cgcgtggccc
      301 cgcctccagg ccggggatgt cccccgcggc cccgcgccca tggtcctgac gctgcttctc
      361 tccgcctaca agctgtgtcg cttcttcgcc atgtcgggcc cacggccggg cgccgagcgg
      421 ctggcggtgc ctgggccaga tgggggcggt ggcacgggcc catggtgggc tgcgggtggc
      481 cgcgggcccc gcgaagtgtc gccgggggca ggcaccgagg tgcaggacgc cctggagcgc
      541 gcgctgccgg agctgcagca ggccttgtcc gcgctgaagc aggcgggcgg cgcgcgggcc
      601 gtgggcgccg gcctggccga ggtcttccaa ctggtggagg aggcctggct gctgccggcc
      661 gtgggccgcg aggtagccca gggtctgtgc gacgccatcc gcctcgatgg cggcctcgac
      721 ctgctgttgc ggctgctgca ggcgccggag ttggagacgc gtgtgcaggc cgcgcgcctg
      781 ctggagcaga tcctggtggc tgagaaccga gaccgcgtgg cgcgcattgg gctgggcgtg
      841 atcctgaacc tggcgaagga acgcgaaccc gtagagctgg cgcggagcgt ggcaggcatc
      901 ttggagcaca tgttcaagca ttcggaggag acatgccaga ggctggtggc ggccggcggc
      961 ctggacgcgg tgctgtattg gtgccgccgc acggaccccg cgctgctgcg ccactgcgcg
     1021 ctggcgctgg gcaactgcgc gctgcacggg ggccaggcgg tgcagcgacg catggtagag
     1081 aagcgcgcag ccgagtggct cttcccgctc gccttctcca aggaggacga gctgcttcgg
     1141 ctgcacgcct gcctcgcagt agcggtgttg gcgactaaca aggaggtgga gcgcgaggtg
     1201 gagcgctcgg gcacgctggc gctcgtggag ccgcttgtgg cctcgctgga ccctggccgc
     1261 ttcgcccgct gtctggtgga cgccagcgac acaagccagg gccgcgggcc cgacgacctg
     1321 cagcgcctcg tgccgttgct cgactctaac cgcttggagg cgcagtgcat cggggctttc
     1381 tacctctgcg ccgaggctgc catcaagagc ctgcaaggca agaccaaggt gttcagcgac
     1441 atcggcgcca tccagagcct gaaacgcctg gtttcctact ctaccaatgg cactaagtcg
     1501 gcgctggcca agcgcgcgct gcgcctgctg ggcgaggagg tgccacggcc catcctgccc
     1561 tccgtgccca gctggaagga ggccgaggtt cagacgtggc tgcagcagat cggtttctcc
     1621 aagtactgcg agagcttccg ggagcagcag gtggatggcg acctgcttct gcggctcacg
     1681 gaggaggaac tccagaccga cctgggcatg aaatcgggca tcacccgcaa gaggttcttt
     1741 agggagctca cggagctcaa gaccttcgcc aactattcta cgtgcgaccg cagcaacctg
     1801 gcggactggc tgggcagcct ggacccgcgc ttccgccagt acacctacgg cctggtcagc
     1861 tgcggcctgg accgctccct gctgcaccgc gtgtctgagc agcagctgct ggaagactgc
     1921 ggcatccacc tgggcgtgca ccgcgcccgc atcctcacgg cggccagaga aatgctacac
     1981 tccccgctgc cctgtactgg tggcaaaccc agtggggaca ctccagatgt cttcatcagc
     2041 taccgccgga actcaggttc ccagctggcc agtctcctga aggtgcacct gcagctgcat
     2101 ggcttcagtg tcttcattga tgtggagaag ctggaagcag gcaagttcga ggacaaactc
     2161 atccagagtg tcatgggtgc ccgcaacttt gtgttggtgc tatcacctgg agcactggac
     2221 aagtgcatgc aagaccatga ctgcaaggat tgggtgcata aggagattgt gactgcttta
     2281 agctgcggca agaacattgt gcccatcatt gatggcttcg agtggcctga gccccaggtc
     2341 ctgcctgagg acatgcaggc tgtgcttact ttcaacggta tcaagtggtc ccacgaatac
     2401 caggaggcca ccattgagaa gatcatccgc ttcctgcagg gccgctcctc ccgggactca
     2461 tctgcaggct ctgacaccag tttggagggt gctgcaccca tgggtccaac ctaaccagtc
     2521 cccagttccc cagccctgct gtgacttcca tttccatcgt cctttctgaa ggaacagctc
     2581 ctgaaaccag tctccctggg ctgagacaac ctgggctctt cttaggaaat ggctctccct
     2641 ccccctgtcc cccaccctca tggcccacct ccaacccact ttcctcagta tctggagagg
     2701 gaagggaagt caggcttggg cacgggaggt tagaactccc ccaggccctg ccattgggtt
     2761 gtctgtctcc gtcatgggga gggtccctgc tcagttctgg agacactgga gttggggtgg
     2821 gggtggttct gcattccctt ctcctgctga tagcagtcag cttgaggagg atgacggaag
     2881 gcagcctcag acaggaatta aggcaatgcc caggcgggcc tgggcactgt attctgagca
     2941 agggcctggg cccaggagcc agccagggat gagtgccatc atggctctcc actcagactg
     3001 tgcctggccc ctgcacttac aacttcctgc cgctctgtgg ccttgccctg taatcactca
     3061 gtgcccttag ctagcctgac taagtcccag atcccctaca gcttccttcg gtgtggtatc
     3121 ttttgccaca tccagggcga gggttgaggc aaaccagccc tccctctgac ttccttgtca
     3181 ctgcagccag ctttgctgca cttgctggtg cacaggagcc tcctgtttgg gcctgggtct
     3241 gggcatgggg aggccgtgcc tcaaagccca ccctacccca tgccttggtg ctgtgcctca
     3301 ggctccttcc tggtctggcc cagctggctt ccccagcccc tcagccatcc agggctaccc
     3361 actgcttact cagggaccag gcagccccca tggcagtaaa agcagcctag acagaacctg
     3421 cagctctgtg gaaagaggca aagtcctgaa aaggcaaagg gttgtcactt agggcagctt
     3481 ctccaacttt aacatgcatc caagtcacct gggaatgttg ttaaaatcag gagatctggg
     3541 gtggggccta ggactctgca tttcttacag attcccaggt gagctgatgc tggtggttaa
     3601 gggtagcaaa tctctaaagc acgaagccct cacaaatctt tgccatttcc caaacactcc
     3661 gctccatggt ctccagtcat cagagcaact ctacctggta ttatcatccc cattttacag
     3721 ataatgacac tgaggctcag aaaggttgag gataagccca ctttcctgtc attagtggca
     3781 gccccagatc cagacctagg cctcctggca cccagtccac tggcagtgga attgctttcc
     3841 tgagaatcat tctgaggctg ggctattgct tctcccttgc ttcaaagaat ctagcagcgg
     3901 gggataggat tttgcaacaa aaagctgacc cagaggccat acagagcagg aatatcccat
     3961 tgccccctcc tccactgggt tcagagggta agaaagcacc ctccaataaa cccaggctcc
     4021 aggccgtggg ggctgctgaa ggctctttcc ccgcaagggc caggtgttga caccttaaag
     4081 ctggctgcgc ccccagcccc actcttggct gtgctggcca ggtgactcct agttcttggc
     4141 cacatcatca gaaagtcaaa ggtctcactc caggtttggg gctccttcct tccactcccc
     4201 tccctgccag agtctgtctt ggccagtgcc agcctcgatg ctttggtttt gaccccacct
     4261 gatcctcctt tcctcatgca gcacaagtgc tcaccggggc cagagccagg gcatggatat
     4321 gacaagcagg gcagcctgga cactgccctc acaggacagc gccaataaca atacagtgtc
     4381 tgagtatctc caggggatga tttctggctc tttgtctcca atcagtccca ctccctcctg
     4441 aggtccccaa gggcagtatt cagagaggtt tcctgcgttt tatttctatt tggtataccc
     4501 tccactgttg tccactgccc tgtgtggcct tctggttgac ctctgcccga tcttctgtct
     4561 ctctgaggga atcagagtcc agcatccagc cccagctgga acagctgaag tcacaagcct
     4621 cctctaagcc aaggccagtg tgttcagagg tgactgccac ccatactagg acaaacacag
     4681 ctcagatcac caggtcaagc acctaggcct ggcttctcct gagacagagg actcagaagt
     4741 ggcctttcct ccaaagcctg ctcagacaca ggtctgtagg gccagggtgt tctgcttggc
     4801 tgggctgcag ctgctacccc tcggttgggg ctgagtcagc cagatcctcc ccctacttct
     4861 ccccaagggc caagaactgc tcagggacat taaaggtcaa aagtccagcc acactcattc
     4921 atcctttccc caggcccatg aagagaggca tctcattgta gaatgtatga ggaagtggga
     4981 agtatctcag agaatcagct aagtttccta acttgtccat ccaaatgtga tcaccacgat
     5041 tcaacaattt ggggcattgc tgatctagcc gttcctagtg gggcttgctc aaggttgcac
     5101 agcgagtcag tagaagccct ggctggcccc acttggtacc aatccaccag gcagctcagg
     5161 gctcctgccc agcccagcag cttctgttgt ctaacgtatg gcaggcagac tgggagcagg
     5221 aaaacagagg gccccaaagc ccaaggcacc agaaggtttg tttcagtttg ctgaagctga
     5281 tttgtaatga ttggcactct tcagccaggg gagtgggtag gccatagcca aggatcgatt
     5341 ccccaaccac agcaaaggca acactcttcc tccagagatc accaagcccc tcttacctcc
     5401 ctccctcctt cccaaggctg gcactaacca ggtaccacat tcattgttaa ggaatggctg
     5461 atgactgcta cacgtgttgg gaacctggtt ggggctgtgc agtttgggct ggaaggagag
     5521 atgccagccc tcgtgctgcc tctggtccct gaagtgtcac ctctctcagg acctctcctc
     5581 tggcctgtgg ggttataagt gatggatagc agaaagggag aactgactcc tgtcccaaat
     5641 agctcctctg ccacctgtcc tgcagtgggc ctgtgtgggt tatgattcta gatcctagac
     5701 agaggctggg tcagctgtgg atggggtggt gccttggtct ctcttgacta cctcgtccaa
     5761 agagagcact gcccttagac aagagttgct tgtcctgctg tgggctgggc ttccagctgc
     5821 agacctccag ttgcttggtg ttcactttgc tcctcttgcc ctctgtcttc tggtccaggc
     5881 agatcagggg ctctggggaa actgctggaa ctcgaggtga ggatcagcct tttccagcat
     5941 cctgtgagag accagagaga gagtttggat ttcatgtggg gaaccctcaa ggcctgtctg
     6001 gagaagtgac acaggattta ctggggtggg ctggtccagg tagctctcct gaacctcctc
     6061 cttccccaag ctgagaagct gagagctgga ggacaatatc cagggacatg gctctggaaa
     6121 ataacttttt tttttttaag agacagggtc ttgctctgtt gtccaggctg gagggcagtg
     6181 acataatcat agctcactgt acccttgaac tcctgggctc aagtgatcct cctgcctcag
     6241 cctccttagt agctgggact accagtgcat accaccatgc ctgggtgatt ttttaaattt
     6301 tttatacaga caaggtcttg ctatgttgcc caggctgatc ttgaattccc gggctcaagt
     6361 ggtcctcctg cctcagcctc ccacaggatc gggattacag gcaagagcct ccacgcccgg
     6421 ccatgaaata taattcttaa tatcatacag gaaaaagtca gcgggtcaag ctagcctgtg
     6481 gcccagccac aactagctga caaagcttcc tggccttccc tttaacacag ttctgctgcc
     6541 atagttccat ctataaaatg ggaatggagg gaaatagggg aactgggaga gagaacacag
     6601 ccttgccaag cagcaatgtt agcctgatcc ttcctccacc tagctcgcca tctcgccctt
     6661 ggaaaatggc tcctggagga ttaggcagcc atctgcaagg agaggggcaa cctgggacaa
     6721 gacacccaga gggtaaggat tccaggaatg aagctgccat ttctggttgg gaggagaaga
     6781 ggaaactttt aagagaaagg gctccattat gagcatgggt tcagggccct gcattaccca
     6841 atcagaacag ccgggatgag caggaggcca gctcccagga ggaaggggaa ccccttcata
     6901 aagttcagag tggctgggta gagtgagttg aagatgccgg aggccgtcag catggccagg
     6961 ctattcacac aggccacagc agaaaagaga gcacctgtga agaaataaat accatactct
     7021 ggagtccgaa agggccatat tccaactctg gcaccaccac ctcacagctg tgtgaccggg
     7081 agtagtcact taacctatgt ctccccttcc tcaccagtaa atcctgctac atcatgtact
     7141 gtgacaagga ttcagtaagg tcatatgtgg acagtagctg gcacagaggg gctactaaac
     7201 aaatggctgc tattaaatcc acattaaaag tacatgtgat ctgacagaac ccagcacata
     7261 aaagaaaaaa aaagtacatg tgatattgtc tgatgaaagc ttgatggaaa tggctttttt
     7321 ctggtttatc ctctttggaa tcatctcctg tttgggatta actgctggtc tgatcagttc
     7381 caatattcat agcggtgtca ccactgaata gcttcttatc ctttgggttc ctgttcctcc
     7441 ttctgctaaa taaggataat acctatttcc tagattgtga gcaacattaa gttcacatgg
     7501 aaatcaccca tcactgggcc tggtcccctg gaagtagcta gttagtaagg gctgttcttt
     7561 tctcctgttt ctcttgacat ctctgggcac agagaaagtg ctgggaaaaa aagtttaggt
     7621 gaatgaatga agacacatgg attctgggga caccagaacc cacagtgggc tctgtatggc
     7681 accagagtct ctgtcatcat cagatcctca ttccaggaca gatggaaaaa gatgaatgtt
     7741 tccagactgg ggcataaaga cccagaggct ggagaagctg ttctttatag atataccagg
     7801 agaacccaca gtttacaaaa tgtgcaacaa cccaacagaa gttgagatta aattctgtca
     7861 catctagagg ggtctgtgat gtcatcaaaa gcaaaccacc cacatcacag atgaagaaac
     7921 aggcctgtgg cagggctcgg actaaaaccc agatcctgag accagctgct tttaaacaca
     7981 gacgtaggtt tgcatcctag ctccaccatt tactgagtaa ccttgggtga gccaatgtaa
     8041 ccccctgggt ctctgtttct ttatctgtca actgtggaaa atgaaaccca tgtcacaagg
     8101 ttgttcactt ctgggcttgt acacgctgac cccagagaaa cagggaactc tggcatcacc
     8161 acacccatct tacagacgga aaagctgagg tctgcagaga gtaaatcctc tgctctggtt
     8221 atctagaaag aacataattg tgctctgctg actgcaaatc ccaactctgc ggtttgaaaa
     8281 tccaaggtgg catgatcctc tgcccattgt gggcaatttc acagaaatgt gtttgttttg
     8341 gccacttact tctccagggt gagagggggg aaggcaagct gttcccccag ccatggctgc
     8401 ccatcagccc gtttcgggca gcactggaca tgaggaacca gacacaggtg ggttctgaca
     8461 ctcaccctgc tctgtctctc tcaccagctt ggagagttta gcccggatga caggtgtgat
     8521 gactaatgac aggaaaagca acccatatcc tgtggagaaa caaacactca tcaggaaaat
     8581 ggggctgggg agaggggcgt ccaagggaaa ggcagcagag ctcctatcca taccccacgt
     8641 ggggcttagg ttagacccag gaagaacttc cttgatggtg agggtgggaa gacagtagtc
     8701 aaggaggaat ggagactgcc cttgtctggg cttggccacc tgctagctct catgaatgaa
     8761 tgctaattcc cattgattgc tttcttgtct gaacctcttg tggtcacagc aggcatcacc
     8821 cacccacttg gcacttagta gggatatggc agggcacaga aaacaagcat gggctttgga
     8881 gtcagccctg agttcaaaac ctgatgccat tacatattat ctgtgtggcc tggggtactt
     8941 accctctctg atcctgactc cctgtatgag gaagataata aggccttcat cacaggatgg
     9001 ttctgaggca taggaggctg aataatggtg cccaatggca tcagattcat agccctggaa
     9061 cctgtaaata ctaccttatt tggaaaatga gtctatgcag gtgtgcagtt aagcctcctg
     9121 agagagcaga gttatcctgg attaggttgg gccctaaatg ccgtcacaca tatctttata
     9181 agaggaaagc agacggagat ttggcaccga cagaattgag aaggcacaaa gaggaggaga
     9241 gtcaatgtga gcacagaggc agagactggt gatggccgcc ccaagccaag gaatgccagc
     9301 agccccagaa gctggaagaa atgagaaaca cgttctctcc tggaggcttg caagggagca
     9361 ctgcctgctg actgcttcca ttcagcccgg tggtactgac tttggacttc tggcctccag
     9421 aactgtgaga gaatatgttt ctgttgtgtt aagcccccaa gtttgtggta tgtcattaca
     9481 gcaatctcag ggaaccaata catgaggtaa aaaggtaaca tctatgaaga gcatggcata
     9541 gggacacagc aaatgggagt tccttttccc tttgcattca gttacttaca ggcttcctgt
     9601 tttcttcata accatttctc tccctgtgcg actgctgact cctcagcaaa actgcaaact
     9661 cctacaggac agtggatcct ccaaagaagg tatacgatga ggcatccagg gaccctagca
     9721 gtgtcaggcc cctcaaatcc cactctgttg agacctcccc ccgacccaga gcaatgacag
     9781 catctttatc atctctgcat cccccagggc catcagcagg agggaaaggt tcccttctgc
     9841 ttaattgtca gacaagcagt tgagttaaga aatctgtgat tattgtattg ttgactatac
     9901 acagcacatt ttagggctct atcaaaataa atctgtccct ttaaaaaaag ttaactaaag
     9961 ccgggcacgg tggctcatgc ctgtaatccc aacactttgg gaggctgagg caggcggatc
    10021 cttgagctca ggagttagag acctggactg ggcaaaatgg tgaggacccc atctctataa
    10081 aaaatacaaa aattagcaag gtgtggtaat gtgcaccagt ggtcccagct actagagagg
    10141 ccaaggtggg aggatcatct gggcccgggg gatgaggctg cagtgagcca tgatcgtgcc
    10201 actgcactct agcctgggta acaaagcgag accctgtctc taaatacatc aatcaaataa
    10261 aaattttaaa aagttaa
//
