LOCUS       NM_020150               5902 bp    mRNA    linear   PRI 12-DEC-2024
DEFINITION  Homo sapiens secretion associated Ras related GTPase 1A (SAR1A),
            transcript variant 2, mRNA.
ACCESSION   NM_020150
VERSION     NM_020150.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5902)
  AUTHORS   Tang,V.T., Xiang,J., Chen,Z., McCormick,J., Abbineni,P.S.,
            Chen,X.W., Hoenerhoff,M., Emmer,B.T., Khoriaty,R., Lin,J.D. and
            Ginsburg,D.
  TITLE     Functional overlap between the mammalian Sar1a and Sar1b paralogs
            in vivo
  JOURNAL   Proc Natl Acad Sci U S A 121 (19), e2322164121 (2024)
   PUBMED   38687799
  REMARK    GeneRIF: Functional overlap between the mammalian Sar1a and Sar1b
            paralogs in vivo.
REFERENCE   2  (bases 1 to 5902)
  AUTHORS   Zhan,F., Deng,Q., Chen,Z., Xie,C., Xiang,S., Qiu,S., Tian,L.,
            Wu,C., Ou,Y., Chen,J. and Xu,L.
  TITLE     SAR1A regulates the RhoA/YAP and autophagy signaling pathways to
            influence osteosarcoma invasion and metastasis
  JOURNAL   Cancer Sci 113 (12), 4104-4119 (2022)
   PUBMED   36047971
  REMARK    GeneRIF: SAR1A regulates the RhoA/YAP and autophagy signaling
            pathways to influence osteosarcoma invasion and metastasis.
REFERENCE   3  (bases 1 to 5902)
  AUTHORS   Chen,J., Ou,Y., Luo,R., Wang,J., Wang,D., Guan,J., Li,Y., Xia,P.,
            Chen,P.R. and Liu,Y.
  TITLE     SAR1B senses leucine levels to regulate mTORC1 signalling
  JOURNAL   Nature 596 (7871), 281-284 (2021)
   PUBMED   34290409
REFERENCE   4  (bases 1 to 5902)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 5902)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 5902)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   7  (bases 1 to 5902)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
REFERENCE   8  (bases 1 to 5902)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 5902)
  AUTHORS   Jones,B., Jones,E.L., Bonney,S.A., Patel,H.N., Mensenkamp,A.R.,
            Eichenbaum-Voline,S., Rudling,M., Myrdal,U., Annesi,G., Naik,S.,
            Meadows,N., Quattrone,A., Islam,S.A., Naoumova,R.P., Angelin,B.,
            Infante,R., Levy,E., Roy,C.C., Freemont,P.S., Scott,J. and
            Shoulders,C.C.
  TITLE     Mutations in a Sar1 GTPase of COPII vesicles are associated with
            lipid absorption disorders
  JOURNAL   Nat Genet 34 (1), 29-31 (2003)
   PUBMED   12692552
REFERENCE   10 (bases 1 to 5902)
  AUTHORS   South,S.T., Sacksteder,K.A., Li,X., Liu,Y. and Gould,S.J.
  TITLE     Inhibitors of COPI and COPII do not block PEX3-mediated peroxisome
            synthesis
  JOURNAL   J Cell Biol 149 (7), 1345-1360 (2000)
   PUBMED   10871277
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB216796.1, BC003658.2, DR763562.1, AL731540.4, EB388518.1 and
            AW128933.1.
            
            On Nov 22, 2018 this sequence version replaced NM_020150.4.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.151337.1,
                                           SRR1660803.128191.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467144, SAMEA2467146
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373241.9/ ENSP00000362338.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                DB216796.1         16-35
            21-1078             BC003658.2         1-1058
            1079-1783           DR763562.1         75-779
            1784-2059           AL731540.4         93674-93949         c
            2060-2582           EB388518.1         90-612
            2583-2987           AW128933.1         17-421              c
            2988-5902           AL731540.4         89831-92745         c
FEATURES             Location/Qualifiers
     source          1..5902
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q22.1"
     gene            1..5902
                     /gene="SAR1A"
                     /gene_synonym="masra2; SAR1; Sara; SARA1"
                     /note="secretion associated Ras related GTPase 1A"
                     /db_xref="GeneID:56681"
                     /db_xref="HGNC:HGNC:10534"
                     /db_xref="MIM:607691"
     exon            1..102
                     /gene="SAR1A"
                     /gene_synonym="masra2; SAR1; Sara; SARA1"
                     /inference="alignment:Splign:2.1.0"
     exon            103..176
                     /gene="SAR1A"
                     /gene_synonym="masra2; SAR1; Sara; SARA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..715
                     /gene="SAR1A"
                     /gene_synonym="masra2; SAR1; Sara; SARA1"
                     /EC_number="3.6.5.2"
                     /note="GTP-binding protein SAR1a; COPII-associated small
                     GTPase; SAR1a gene homolog 1; SAR1 gene homolog A; SAR1
                     homolog A"
                     /codon_start=1
                     /product="small COPII coat GTPase SAR1A"
                     /protein_id="NP_064535.1"
                     /db_xref="CCDS:CCDS7298.1"
                     /db_xref="GeneID:56681"
                     /db_xref="HGNC:HGNC:10534"
                     /db_xref="MIM:607691"
                     /translation="MSFIFEWIYNGFSSVLQFLGLYKKSGKLVFLGLDNAGKTTLLHM
                     LKDDRLGQHVPTLHPTSEELTIAGMTFTTFDLGGHEQARRVWKNYLPAINGIVFLVDC
                     ADHSRLVESKVELNALMTDETISNVPILILGNKIDRTDAISEEKLREIFGLYGQTTGK
                     GNVTLKELNARPMEVFMCSVLKRQGYGEGFRWLSQYID"
     exon            177..296
                     /gene="SAR1A"
                     /gene_synonym="masra2; SAR1; Sara; SARA1"
                     /inference="alignment:Splign:2.1.0"
     exon            297..362
                     /gene="SAR1A"
                     /gene_synonym="masra2; SAR1; Sara; SARA1"
                     /inference="alignment:Splign:2.1.0"
     exon            363..466
                     /gene="SAR1A"
                     /gene_synonym="masra2; SAR1; Sara; SARA1"
                     /inference="alignment:Splign:2.1.0"
     exon            467..598
                     /gene="SAR1A"
                     /gene_synonym="masra2; SAR1; Sara; SARA1"
                     /inference="alignment:Splign:2.1.0"
     exon            599..5902
                     /gene="SAR1A"
                     /gene_synonym="masra2; SAR1; Sara; SARA1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      731..736
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SAR1A"
                     /gene_synonym="masra2; SAR1; Sara; SARA1"
                     /note="hexamer: AATAAA"
     polyA_site      764
                     /gene="SAR1A"
                     /gene_synonym="masra2; SAR1; Sara; SARA1"
                     /note="major polyA site"
     regulatory      2969..2974
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SAR1A"
                     /gene_synonym="masra2; SAR1; Sara; SARA1"
                     /note="hexamer: AATAAA"
     polyA_site      2987
                     /gene="SAR1A"
                     /gene_synonym="masra2; SAR1; Sara; SARA1"
                     /note="major polyA site"
     regulatory      5884..5889
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SAR1A"
                     /gene_synonym="masra2; SAR1; Sara; SARA1"
                     /note="hexamer: ATTAAA"
     polyA_site      5902
                     /gene="SAR1A"
                     /gene_synonym="masra2; SAR1; Sara; SARA1"
ORIGIN      
        1 gtacatccgg cgagtagctg gcggtcccgg gtgctgctgg ttagtgtgct ctgagggagg
       61 gtccgagcca gccgctgttt tgccggagga gcccctcagg ccgtagtaag cattaataat
      121 gtctttcatc tttgagtgga tctacaatgg cttcagcagt gtgctccagt tcctaggact
      181 gtacaagaaa tctggaaaac ttgtattctt aggtttggat aatgcaggca aaaccactct
      241 tcttcacatg ctcaaagatg acagattggg ccaacatgtt ccaacactac atccgacatc
      301 agaagagcta acaattgctg gaatgacctt tacaactttt gatcttggtg ggcacgagca
      361 agcacgtcgc gtttggaaaa attatctccc agcaattaat gggattgtct ttctggtgga
      421 ctgtgcagat cattctcgcc tcgtggaatc caaagttgag cttaatgctt taatgactga
      481 tgaaacaata tccaatgtgc caatccttat cttgggtaac aaaattgaca gaacagatgc
      541 aatcagtgaa gaaaaactcc gtgagatatt tgggctttat ggacagacca caggaaaggg
      601 gaatgtgacc ctgaaggagc tgaatgctcg ccccatggaa gtgttcatgt gcagtgtgct
      661 caagaggcaa ggttacggcg agggtttccg ctggctctcc cagtatattg actgatgttt
      721 ggacggtgaa aataaaagag ttttacttct ctggactgat cctattcaca gcttcctcat
      781 gaacttttct aatagaacaa ggaaagctct ccaaccatgt ctggcgttga gaagccaaga
      841 gtctctgtca actctctcat tgcccagtgg tgacatgtgc tcttctccac actgttggga
      901 ggtaatgctg ccccacgtgc tggtgcaggt cagtatcctg ggacttggaa gctggcagga
      961 tttgccgggt aaagctgtat gccatcatgg ggcacctgaa aagaaaaaca cgtctcacca
     1021 ctgtggttga ttcaaaagaa agtgattcta ttttttaaag aaagcgttgt taatgtaatt
     1081 ggtatccctc ctaacttttt gagttcacaa tttacttggt ccagagtttt ctattctttt
     1141 ttttttttaa actaatgaat gacatttaga tacttcataa aattatgaac agatatggag
     1201 gccagagctc atttgggtaa acttactcct gctgagttag caggttggtg agagaagctc
     1261 ccctgagctc acctgtctct ctgactgcct tggagtaggt ggcataacct tgtgcacaga
     1321 gaactagaaa aggggcagaa ccccggcctt gcagttgtgg caggtttcca ctgtggtaag
     1381 ctaggttcat tcctcatcaa ggaatgtgta gcagattgtt cactgtggag gagttaatta
     1441 tagaatgggt tattgttgtt attcttactc atgaagttac agattttagc cagtctttgc
     1501 ttttatactt ttgtgaaatt taatttctct ctatagcacc ttcctttttc gttttcagtt
     1561 atcaaaagtg actttgacct cataaaagag ttgagaacat ctctcgtgtc acatactgca
     1621 ggtgcatcag ttacttttgc acagattcta gggggacatt tttctgaata ggaagacagg
     1681 acaaagttaa cagcttaagg gctcttaatt ctgtgagttg aggacttaaa agtattgtag
     1741 catttgtttg gatccatgaa aaatgtattc agtgggcttt aaaatttcca tttgcagaat
     1801 ttggtctctc aggctgtttg ggagctcttt tttttacatt ttttctcctt tgacacctat
     1861 tttattggtg tttaaagtaa aggttaacat ctgtagcttt tccaggtttt tttttttttt
     1921 tttttttttt tggtatgaaa ttgtctttct ccattgcaga aataagctag ggaaacacta
     1981 acccaaaaac tttctgtaga gctgttcctt tggaggcagc atcacttatt ggcagtaaag
     2041 actcagtata aaagcaccgg catccctact tgggtgatgg ggattaattt tatagcattc
     2101 cattttccta gtgccacatg tgaaattgga ttttgatgat cttaatctat attctaccct
     2161 tataataaaa gatcaaaaga tatatctcct atgaacagat tggagatagg agatgaaaag
     2221 ttgggaggat gtctttattc taatgtgagg gtagggaaaa tgtggataac attactgggg
     2281 tgagggaggc attgttcttt agttggagtt ctcattctta ttctccagta ctgacttgtg
     2341 gggaaagcat actttttcac tgccaggtac tgaatgcaga ggctcagtga agtatatatg
     2401 tgggaagtgc atgcatttcg tttattagca aacatagctg gattaagaca aagttgttgg
     2461 tttggaaagg ggttaaagcc ttaagtgaac aaatctagct aacagtgaat gaactaggta
     2521 atataacttg catattttta atttcctttg gttaaaggtc ccccatactt ctctgttcgg
     2581 agacatgaga agtatgatta cttcagtgtt agttttctta attttttttt tcccctattt
     2641 gtcccttgtc actttgttgc aagctagaaa tctgtgggtt atacataggg cagctctttg
     2701 tgaaagtggt ttattccact ggagaaaggg gattgaaaat cagttagaac caatgtattt
     2761 cttgccccac ggaacactat tcctataaga tagctgaaag aagctgctgt gaggagctca
     2821 gctccaaaca caggatcagc accttgtata ggaattccca tgaattatga cttctcattc
     2881 tgttttatca gagtgcatat atgtcctact tcaggaaaag taaaacagtc atttacgaaa
     2941 gaaagtcaat ctgtatccta agcattttaa taaaaagtta aaacaaatac gctatttcct
     3001 tttttttttt tcattggttt gttctgagct ctgagtttga acaatgccgt ttatttgggg
     3061 aggcaaccaa aagttccctg catagaggaa gagacattta gggtgcgtgt gagatacttg
     3121 aattttgcca ccaggagggg gaaaaaggct ggggtactag aagtaataga tttagtacta
     3181 cttgagagat ttggaacatg ctgtggaccc agggttgttg gtcatctctg caacaggatg
     3241 gggatggcag atgtttgagc aaaatctata ttaacatgct agcaaggact agttctagtt
     3301 tagctgtgtt tcactcattt tacacagaat tagaattggc caggtgtggt ggctcacgct
     3361 gtaatcctag cactttggga ggctgaggtg ggtggattgt ctgagctcag gagtttgaga
     3421 ccagcctggg gaacagggtg aaaccccatc actactaaaa tacaaaaaaa ttagctgggc
     3481 attgtggtac atggagtagc tcccagctac tctggaggct gaggcggaga atcgcttgaa
     3541 ctaggaggtg gagattgaag tgagccgaga tcatgccact gtactcctgc ctgggtgaca
     3601 gagcaagact ctctctagct caaaaaaaaa aaaaaaaaaa aaatcaatta aatgctacat
     3661 ttggcaaaat gagaaagaaa gaatttcctt tactaggctt gtaggaagac tgcttttaca
     3721 aaaacccaaa tgagatcata aaactaaagt actgggacaa acagtgggaa acagtgcaat
     3781 gggttctttt caaccaagta ttaaagtatt ggagatattg ccgggcgcgg tggctcacgt
     3841 ctgtaatcct agcgctttgg gaggccaagg cgggcgggtc atgaggtcag gagttcaagg
     3901 ccagcctgac caacatggca gagctccgtc tctactaaaa atacaaaaat tagccaggca
     3961 cggtgggacg cacctttaat cccagctact caggaggctg aagcaggaga atcgcttgaa
     4021 tcggggaagc ggaggttgca gtgagccgag atcgcgccac tgcactccag cctgggtgac
     4081 tcccatctca aaaaaaataa aaagtactgg aggtgtcctg ttgtccttgt tactgtgaaa
     4141 ggatgccatg ggttgtatgg gcaaatgagt tgttttgttt gaggcagagt ggaaaataag
     4201 attaggctca gtccatgagc ctagcactca acagatctta ctttggcgtt ctggctgtga
     4261 cttgggactt ctttttacca tggtctgctg taaacacaga aaaacccaat gcctaacagt
     4321 tcatgctgga gtcttgagcg ttgagggaga atcactggac tcgagagaga aagtttgttt
     4381 gtttgtttgt ttgtttgttt tttgagttgg tctcactctg tcgcccaggc tggagtgcag
     4441 tggtatgaac ataggtcact gcagccttga cctcctgggc ttaagtgatc ctcccatctc
     4501 agcctcccaa gtagcttggg accacagggt tgcaccaccg tgctcagcta gttttcaaaa
     4561 tttttgtaga gttaaggtct catcatgttg cccaggctgg tctcaaactc ctgggctcag
     4621 gaaattctcc tacctcagcc tcccaacgtg ctgggattcc aagtgtgagc ccctgtgctc
     4681 caccaagaga aaaactcttt gattgctagg aagttgggat aaagaaattg tgctgtgatc
     4741 aagccacctt ctgtgtcata gaaccaaaag aagaccgcct gctatggcaa gatggcctaa
     4801 ttttattcct gcctcatact atcatggata atcgttttcc tttctctagc aggtttgtgt
     4861 cactgggagt actgggagca ttatcctgtg ttgtgctggg gttataccaa gcagtgttaa
     4921 ctttatttaa agaattcagg cagaaagatt agagaattta agtagcaatt gtatatggta
     4981 agcaatacag taaccttaat aaaaattaat gatggccggg tacggtggct cacgcctgta
     5041 atcccagcac tttgggaggc cgaggcgggc ggatcacaag gtcaggagat cgagaccatc
     5101 ctggctaaca cggtgaaacc ccgtctctac taaaaataca aaaaattagc tgggcgtggt
     5161 ggcaggcgcc tgtagtccca gcgactgggg aggctgaggc aggagaatag cgtgaaccca
     5221 ggaggcggag tttgcagtga gcggagatcg caccattgca ctccagcctg ggcgacagag
     5281 cgagactccg tctcaaaaaa ataaataaat aaataaaaaa taatgtgtat tttatcaatt
     5341 cagtgataaa gcagaccttt gtaaactgtc tagcttgtgg tgactgattg agggtatcat
     5401 gaagctccgc gcccccccac tccccgacat actcgttcat cctcctctgt cctaaagcgt
     5461 acttctttgg aaaagtagag cagtttatgt tagtgtacac tagagatggt aaactatgcc
     5521 ttgtgggtca aatcgggcct gctgcctgtg tttgtatggc ctgtgagcaa agaaaggttt
     5581 ttacatattt aaatggttgg aaaaaatatt taaagaatgc tatttttgga cacaaaaaat
     5641 tgtatgaaat taaaatttca atgtctgtat ctttttattg ggacacagcc accgccattc
     5701 ctttagcttt tgtatgcaac agctgcagag ttgactattt gagacaagtt gtatggtccc
     5761 cccaaactgg aactgtttcc attctggcct tctacagaaa gtatttggac cctggcctag
     5821 ataaatcctg gctggtggtt atgttatgtg aaatgtgcac actgtaaaat ataggcctgt
     5881 atgattaaaa tttttgattt ca
//
