LOCUS       NM_178448               3814 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens suppressor APC domain containing 2 (SAPCD2), mRNA.
ACCESSION   NM_178448
VERSION     NM_178448.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3814)
  AUTHORS   Li,J., Chen,Y., Wang,X., He,W., Liu,C., Feng,F., Zhang,W., Cao,H.,
            Long,Q., Gao,F. and Sun,W.
  TITLE     Homologous proteins SAPCD2X1 and SAPCD2 have significantly
            different carcinogenic capacities in human colorectal cancer cells
            based on structural prediction and functional verification
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 69 (13), 8-15 (2023)
   PUBMED   38158695
  REMARK    GeneRIF: Homologous proteins SAPCD2X1 and SAPCD2 have significantly
            different carcinogenic capacities in human colorectal cancer cells
            based on structural prediction and functional verification.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3814)
  AUTHORS   Wei,D.
  TITLE     MiR-486-5p specifically suppresses SAPCD2 expression, which
            attenuates the aggressive phenotypes of lung adenocarcinoma cells
  JOURNAL   Histol Histopathol 37 (9), 909-917 (2022)
   PUBMED   35467005
  REMARK    GeneRIF: MiR-486-5p specifically suppresses SAPCD2 expression,
            which attenuates the aggressive phenotypes of lung adenocarcinoma
            cells.
REFERENCE   3  (bases 1 to 3814)
  AUTHORS   Zhang,Z.M., Cao,H.B., Li,Z.H., Zhuo,R., Tao,Y.F., Li,X.L., Li,G.,
            Liao,X.M., Fang,F., Xie,Y., Wu,D., Wang,H.R., Wang,J.W., Chen,Y.L.,
            Yu,J.J., Jia,S.Q., Yang,R.D., Guo,X.Y., Yang,Y., Feng,C.X.,
            Xu,Y.Y., Qian,G.H. and Pan,J.
  TITLE     SAPCD2 promotes neuroblastoma progression by altering the
            subcellular distribution of E2F7
  JOURNAL   Cell Death Dis 13 (2), 174 (2022)
   PUBMED   35197448
  REMARK    GeneRIF: SAPCD2 promotes neuroblastoma progression by altering the
            subcellular distribution of E2F7.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3814)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 3814)
  AUTHORS   Yang,Z., Ding,H., Pan,Z., Li,H., Ding,J. and Chen,Q.
  TITLE     YY1-inudced activation of lncRNA DUXAP8 promotes proliferation and
            suppresses apoptosis of triple negative breast cancer cells through
            upregulating SAPCD2
  JOURNAL   Cancer Biol Ther 22 (3), 216-224 (2021)
   PUBMED   33683171
  REMARK    GeneRIF: YY1-inudced activation of lncRNA DUXAP8 promotes
            proliferation and suppresses apoptosis of triple negative breast
            cancer cells through upregulating SAPCD2.
REFERENCE   6  (bases 1 to 3814)
  AUTHORS   Mao,L., Sun,W., Li,W., Cui,J., Zhang,J., Xing,R. and Lu,Y.
  TITLE     Cell cycle-dependent expression of p42.3 promotes mitotic
            progression in malignant transformed cells
  JOURNAL   Mol Carcinog 53 (5), 337-348 (2014)
   PUBMED   23192843
  REMARK    GeneRIF: p42.3 overexpression is associated with mitotic
            progression in malignant transformed cells.
REFERENCE   7  (bases 1 to 3814)
  AUTHORS   Yuan,X.S., Zhang,Y., Guan,X.Y., Dong,B., Zhao,M., Mao,L.L.,
            Lu,Y.Y., Tian,X.Y. and Hao,C.Y.
  TITLE     p42.3: a promising biomarker for the progression and prognosis of
            human colorectal cancer
  JOURNAL   J Cancer Res Clin Oncol 139 (7), 1211-1220 (2013)
   PUBMED   23576022
  REMARK    GeneRIF: p42.3 might play an important role in the progression of
            colorectal cancer.
REFERENCE   8  (bases 1 to 3814)
  AUTHORS   Zhang,J., Lu,C., Shang,Z., Xing,R., Shi,L. and Lv,Y.
  TITLE     p42.3 gene expression in gastric cancer cell and its protein
            regulatory network analysis
  JOURNAL   Theor Biol Med Model 9 (1), 53 (2012)
   PUBMED   23228105
  REMARK    GeneRIF: p42.3 protein plays an important role in the generation
            and development of gastric cancer.
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 3814)
  AUTHORS   Cui,Y., Su,W.Y., Xing,J., Wang,Y.C., Wang,P., Chen,X.Y., Shen,Z.Y.,
            Cao,H., Lu,Y.Y. and Fang,J.Y.
  TITLE     MiR-29a inhibits cell proliferation and induces cell cycle arrest
            through the downregulation of p42.3 in human gastric cancer
  JOURNAL   PLoS One 6 (10), e25872 (2011)
   PUBMED   21998710
  REMARK    GeneRIF: the regulatory relationship between miRNAs and the p42.3
            gene
REFERENCE   10 (bases 1 to 3814)
  AUTHORS   Xu,X., Li,W., Fan,X., Liang,Y., Zhao,M., Zhang,J., Liang,Y.,
            Tong,W., Wang,J., Yang,W. and Lu,Y.
  TITLE     Identification and characterization of a novel p42.3 gene as
            tumor-specific and mitosis phase-dependent expression in gastric
            cancer
  JOURNAL   Oncogene 26 (52), 7371-7379 (2007)
   PUBMED   17525738
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC048267.1, BX332104.2 and BC042162.1.
            
            On Nov 22, 2018 this sequence version replaced NM_178448.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ150361.1, BC048267.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000409687.5/ ENSP00000386348.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-92                BC048267.1         20-111
            93-396              BX332104.2         74-377
            397-2670            BC048267.1         416-2689
            2671-3814           BC042162.1         208-1351
FEATURES             Location/Qualifiers
     source          1..3814
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.3"
     gene            1..3814
                     /gene="SAPCD2"
                     /gene_synonym="C9orf140; p42.3"
                     /note="suppressor APC domain containing 2"
                     /db_xref="GeneID:89958"
                     /db_xref="HGNC:HGNC:28055"
                     /db_xref="MIM:612057"
     exon            1..668
                     /gene="SAPCD2"
                     /gene_synonym="C9orf140; p42.3"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..1282
                     /gene="SAPCD2"
                     /gene_synonym="C9orf140; p42.3"
                     /note="2010317E24Rik; protein C9orf140; tumor specificity
                     and mitosis phase-dependent expression protein; TS/MDEP"
                     /codon_start=1
                     /product="suppressor APC domain-containing protein 2"
                     /protein_id="NP_848543.2"
                     /db_xref="CCDS:CCDS7027.2"
                     /db_xref="GeneID:89958"
                     /db_xref="HGNC:HGNC:28055"
                     /db_xref="MIM:612057"
                     /translation="MAGAAMAERGRVPPPAPAPSTEGLPRAFLQSLRTLFDILDDRRR
                     GCVHLREIESRWQGTDARELPRGVLEGLRQVAPASGYLTFERFVAGLRTSLLSADGGP
                     RDPTRAPARPGDQPPPPPQRLVFAPADEPRTVLERKPLPLGVRAPLAGPSAAARSPEQ
                     LCAPAEAAPCPAEPERSQSAALEPSSSADAGAVACRALEADSGDARRAPRARGERRRH
                     TIASGVDCGLLKQMKELEQEKEVLLQGLEMMARGRDWYQQQLQRVQERQRRLGQSRAS
                     ADFGAAGSPRPLGRLLPKVQEVARCLGELLAAACASRALPPSSSGPPCPALTSTSPPV
                     WQQQTILMLKEQNRLLTQEVTEKSERITQLEQEKSALIKQLFEARALSQQDGGPLDST
                     FI"
     exon            669..781
                     /gene="SAPCD2"
                     /gene_synonym="C9orf140; p42.3"
                     /inference="alignment:Splign:2.1.0"
     exon            782..928
                     /gene="SAPCD2"
                     /gene_synonym="C9orf140; p42.3"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1036
                     /gene="SAPCD2"
                     /gene_synonym="C9orf140; p42.3"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1153
                     /gene="SAPCD2"
                     /gene_synonym="C9orf140; p42.3"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..3814
                     /gene="SAPCD2"
                     /gene_synonym="C9orf140; p42.3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3788..3793
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SAPCD2"
                     /gene_synonym="C9orf140; p42.3"
                     /note="hexamer: AATAAA"
     polyA_site      3814
                     /gene="SAPCD2"
                     /gene_synonym="C9orf140; p42.3"
                     /note="major polyA site"
ORIGIN      
        1 gctattgtcg ccgtgggctg agctcgccgg gccggcccct ccgtggggcc gcgctgggac
       61 gcacgcgggt ggacgagggg accgatcccg ggcgcccatg gccggggccg ccatggccga
      121 gcggggccgc gtgcctcccc ccgcacccgc gcccagcacg gaggggctgc cgcgcgcctt
      181 cctgcagagc ctgcgcaccc tgttcgacat cctggacgac cggcggcgcg gctgcgtgca
      241 cctgcgcgag atcgagtccc gctggcaggg caccgacgcg cgggagctgc cccgcggggt
      301 gctggagggc ttgcgccagg tggccccggc cagcggctac ctgaccttcg agcgcttcgt
      361 ggccggcctg cgcacctccc tgctgagcgc cgacggcggc ccccgggacc ccacgcgcgc
      421 cccggcccgg cccggggatc agccgccgcc gccgccgcag cgcctggtgt tcgctccggc
      481 cgacgagccg cggacggtcc tggagaggaa gcccctgccc ctgggcgtgc gcgcccctct
      541 ggccggtccc agcgccgccg cccgcagccc ggagcagctg tgcgccccgg ctgaggcggc
      601 gccctgcccc gcggagcccg agcggtccca gagcgcggcg ctggaaccga gctccagcgc
      661 ggacgcaggt gcagtggcgt gcagggccct ggaggcggac tcaggggatg cccggcgggc
      721 tccccgtgcc cgaggggaac gtcggaggca caccatcgcc agcggcgtgg actgcggcct
      781 gctgaagcag atgaaggagc tggagcagga gaaggaggtg ctgctgcagg gtttggagat
      841 gatggcgcgg ggccgcgact ggtaccagca gcagctgcaa cgagtgcagg agcgccagcg
      901 ccgcctgggc cagagcagag ccagcgccga ctttggggct gcagggagcc cccgcccact
      961 ggggcggcta ctgcccaagg tacaagaggt ggcccggtgc ctgggggagc tgctggctgc
     1021 agcctgtgcc agccgggccc tgcccccgtc ctcctccggg cccccctgcc ctgccctgac
     1081 gtccacctca cccccggtct ggcagcagca gaccatcctc atgctgaagg agcagaaccg
     1141 actcctcacc caggaggtga ccgagaagag tgagcgcatc acgcagctgg agcaggagaa
     1201 gtcggcgctc attaagcagc tgtttgaggc ccgcgccctg agccagcagg acgggggacc
     1261 tctggattcc accttcatct agtccttgtg ggccgcgtgg gcccccaggg ccagcctggc
     1321 actcagccct tcgagggtgg gcgccccatc gcacccaccc tctctggctg gagacccccg
     1381 gcaggcccag gcacagtccc ggagtgggcg ccttcctgcc gcccttgcca gatgggctcc
     1441 ccaggcctgc ccccggctgg tccccgcacc gagcgcttga ctccgttttg gctcctggtg
     1501 ctgacatggg ctggggctct cttgagtccg catagtccgc agctactact gccgctgtca
     1561 gtggacagtg gggtacccct ccatgagtta gcgtcccccc gtttccagcg gtgccgccct
     1621 gggtcccatc ttcagggaaa ggcactgccc acgccaggct gcacttccaa caacgggcag
     1681 cagagggcgc ggggcggctc cgacgcgggt ccaagggcag cttcccgctc aaccagggca
     1741 ccaggacgag gtggctgtag ctcggacgga cggaagtaga tggagggggt ggggacggcc
     1801 tgtaagcggg gggtgcctgc ctggctgggg agccccaggg atagcggtcg gacttcaggt
     1861 tctggccaag gctgagggac cctggctgca gcggatcggc acgccgggtg ggcgagagct
     1921 tggcctgcat gtgcctccca cagaccctgg ggtgatggcc ttccccctct tggccgggac
     1981 gttgccccac gttgagtccc acacaacatc ctgtgagcct ggctccccag gagggccccc
     2041 agacagctcc caggcacgtc ataggcaaag cctgttcccc cgactcagga tttccaaggc
     2101 ctggggtcct gctcaccccc ctttgctctc acgcccagcc tgtccccagg tttcagctgg
     2161 gagaggccac ctccctcagc caaggaaaac gagaaccccc agggtacagg aggaggctgg
     2221 ggcaggtccc cttgggtgtc actccctcag cccctgccca ggcccactcc cgctggtgct
     2281 ggagtacgca ctggtggggg ggccctgctc agcccaacct ggagggtccc agtgtcacca
     2341 gaaccagggg cacggcaaca gcatcgatgg gttctgcagc ccagggcccc cgatgcgggg
     2401 tcagtgcgtg gggggcgcag ggcccccgat gccgatgcgg ggtcagtgtg tgtggggcgc
     2461 agggcctccg atgcggggtc agtgcgtggg gggcgcaggg ccccctcgtg tccagggcac
     2521 tttggtacac tgtcccacaa ggcacctgtc tcagaggagg ggccctggca ggcagcgtgg
     2581 caactccctt ccggagccca gctccatgct aacctgccca cagcaacccc acagagccac
     2641 attccctgct gcacctggtc tgcaggggtg tcccaggaca ggcccaagtc agcccagcat
     2701 gcagctgccc tcctaccctg aagatgggag tgggctttcc aggggacata aggatgtcag
     2761 gcctggacct cctgggcagg aaagggtgca ggtcctgagg gcctgtgccc cacagcccca
     2821 gcaccaggtg gactgcagcg cagtgggtgg gccagtggca gccagggaga agccccccgt
     2881 cagcaggctg gggtctgccc accagggcct ccccacgtct gcctttgagg gtgcctgcca
     2941 tgccctgggg gatcctggca tctttactgg actggaagca ggagacagaa cagtgtctgt
     3001 cccggggtga cttcatcagg agaccgccca catagagctg gaccccgcag ctgaagcgga
     3061 aatgtgagac aggctggcac ctccggaaaa actgcctttc agccttggtg ttccgtgcaa
     3121 ggtgaaaaga aataggtcct cccagtttac agcttgaaat caggctagtg agtggccctg
     3181 gagaccacga ggggagaatt taaaggcccc ggctggcagg gtctaggtgg ctggcagagg
     3241 cacatgcaga ccctgcctgg agcctgccct aggacgctgg gcgggtcagt ctccgtgcag
     3301 gatgtgagca gcgtccctgg gctctatccg cgaggtgcca gtagcgtgtg caggtacata
     3361 cacgtgcgtg cacactgtga tgacacccgg aaatgtctca ggatgttgaa atgtgtcctt
     3421 gggggcagaa gtgtccccag ttgagaatct gccccagagg aacacaccca caccaggcct
     3481 caggattttg tgttgatcaa gttccaagga aaaggaacat ctcagccggg cgtggtggtt
     3541 cacgcctgga atcccagcac ttgaggccag gagttccaga gcagcctggg caacgcagtg
     3601 agagacccca tctctacaaa aaaaaaaaag aaagaaagaa aatgagagat ccaggtttaa
     3661 aaattcataa acaccacaag gaaacaatac actatgagac ccagcagaag caacagattg
     3721 actctagacc cagatactag aattatcaga gagaatataa agtaacagtg ttttatatat
     3781 ctaaagaaat aaaagagatt tctggaaaca tgaa
//
