LOCUS       NM_024632               6185 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens SAP30 like (SAP30L), transcript variant 1, mRNA.
ACCESSION   NM_024632
VERSION     NM_024632.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6185)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 6185)
  AUTHORS   Qin,X., Zhu,W., Lu,A., Wang,G., Ye,X. and Weng,G.
  TITLE     Long non-coding RNA SAP30L-AS1 promotes prostate cancer growth
            through repressing SAP30L
  JOURNAL   Gene 690, 120-128 (2019)
   PUBMED   30599235
  REMARK    GeneRIF: Results show that expression of SAP30L was negatively
            associated with that of SAP30L-AS1 in prostate cancer specimens.
            Its expression is directly repressed by SAP30L-AS1 in prostate
            neoplasm. Also, SAP30L overexpression attenuated the roles of
            SAP30L-AS1 in prostate cancer proliferation and apoptosis.
REFERENCE   3  (bases 1 to 6185)
  AUTHORS   Streubel,G., Fitzpatrick,D.J., Oliviero,G., Scelfo,A., Moran,B.,
            Das,S., Munawar,N., Watson,A., Wynne,K., Negri,G.L., Dillon,E.T.,
            Jammula,S., Hokamp,K., O'Connor,D.P., Pasini,D., Cagney,G. and
            Bracken,A.P.
  TITLE     Fam60a defines a variant Sin3a-Hdac complex in embryonic stem cells
            required for self-renewal
  JOURNAL   EMBO J 36 (15), 2216-2232 (2017)
   PUBMED   28554894
REFERENCE   4  (bases 1 to 6185)
  AUTHORS   Laitaoja,M., Tossavainen,H., Pihlajamaa,T., Valjakka,J., Viiri,K.,
            Lohi,O., Permi,P. and Janis,J.
  TITLE     Redox-dependent disulfide bond formation in SAP30L corepressor
            protein: Implications for structure and function
  JOURNAL   Protein Sci 25 (3), 572-586 (2016)
   PUBMED   26609676
  REMARK    GeneRIF: Upon oxidative stress SAP30L undergoes the formation of
            two specific disulfide bonds, a vicinal Cys29-Cys30 and
            Cys38-Cys74, with a concomitant release of the coordinated zinc
            ion. The oxidized protein was shown to remain folded in solution
            and to bind signaling phospholipids.
REFERENCE   5  (bases 1 to 6185)
  AUTHORS   Hong,K.W., Lim,J.E., Kim,J.W., Tabara,Y., Ueshima,H., Miki,T.,
            Matsuda,F., Cho,Y.S., Kim,Y. and Oh,B.
  TITLE     Identification of three novel genetic variations associated with
            electrocardiographic traits (QRS duration and PR interval) in East
            Asians
  JOURNAL   Hum Mol Genet 23 (24), 6659-6667 (2014)
   PUBMED   25035420
REFERENCE   6  (bases 1 to 6185)
  AUTHORS   Assmann,E.M., Alborghetti,M.R., Camargo,M.E. and Kobarg,J.
  TITLE     FEZ1 dimerization and interaction with transcription regulatory
            proteins involves its coiled-coil region
  JOURNAL   J Biol Chem 281 (15), 9869-9881 (2006)
   PUBMED   16484223
REFERENCE   7  (bases 1 to 6185)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   8  (bases 1 to 6185)
  AUTHORS   Lindfors,K., Viiri,K.M., Niittynen,M., Heinonen,T.Y., Maki,M. and
            Kainulainen,H.
  TITLE     TGF-beta induces the expression of SAP30L, a novel nuclear protein
  JOURNAL   BMC Genomics 4 (1), 53 (2003)
   PUBMED   14680513
  REMARK    GeneRIF: SAP30L, a nuclear protein, is upregulated by transforming
            growth factor-beta in intestinal epithelial cells
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 6185)
  AUTHORS   Boultwood,J., Fidler,C., Strickson,A.J., Watkins,F., Kostrzewa,M.,
            Jaju,R.J., Muller,U. and Wainscoat,J.S.
  TITLE     Transcription mapping of the 5q- syndrome critical region: cloning
            of two novel genes and sequencing, expression, and mapping of a
            further six novel cDNAs
  JOURNAL   Genomics 66 (1), 26-34 (2000)
   PUBMED   10843801
REFERENCE   10 (bases 1 to 6185)
  AUTHORS   Zhang,Y., Sun,Z.W., Iratni,R., Erdjument-Bromage,H., Tempst,P.,
            Hampsey,M. and Reinberg,D.
  TITLE     SAP30, a novel protein conserved between human and yeast, is a
            component of a histone deacetylase complex
  JOURNAL   Mol Cell 1 (7), 1021-1031 (1998)
   PUBMED   9651585
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK021588.1, BC009829.2, AC008625.5, AC026688.7 and AW874393.1.
            
            On Nov 23, 2018 this sequence version replaced NM_024632.5.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.147635.1,
                                           SRR1803616.118055.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000297109.11/ ENSP00000297109.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                AK021588.1         41-66
            27-1279             BC009829.2         1-1253
            1280-4769           AC008625.5         1-3490              c
            4770-6132           AC026688.7         6475-7837
            6133-6185           AW874393.1         19-71               c
FEATURES             Location/Qualifiers
     source          1..6185
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q33.2"
     gene            1..6185
                     /gene="SAP30L"
                     /gene_synonym="NS4ATP2"
                     /note="SAP30 like"
                     /db_xref="GeneID:79685"
                     /db_xref="HGNC:HGNC:25663"
                     /db_xref="MIM:610398"
     exon            1..809
                     /gene="SAP30L"
                     /gene_synonym="NS4ATP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             609..1160
                     /gene="SAP30L"
                     /gene_synonym="NS4ATP2"
                     /note="isoform 1 is encoded by transcript variant 1; Sin3A
                     associated protein p30-like; histone deacetylase complex
                     subunit SAP30L; sin3-associated protein p30-like; sin3
                     corepressor complex subunit SAP30L; HCV non-structural
                     protein 4A-transactivated protein 2"
                     /codon_start=1
                     /product="histone deacetylase complex subunit SAP30L
                     isoform 1"
                     /protein_id="NP_078908.1"
                     /db_xref="CCDS:CCDS4326.1"
                     /db_xref="GeneID:79685"
                     /db_xref="HGNC:HGNC:25663"
                     /db_xref="MIM:610398"
                     /translation="MNGFSTEEDSREGPPAAPAAAAPGYGQSCCLIEDGERCVRPAGN
                     ASFSKRVQKSISQKKLKLDIDKSVRHLYICDFHKNFIQSVRNKRKRKTSDDGGDSPEH
                     DTDIPEVDLFQLQVNTLRRYKRHYKLQTRPGFNKAQLAETVSRHFRNIPVNEKETLAY
                     FIYMVKSNKSRLDQKSEGGKQLE"
     exon            810..932
                     /gene="SAP30L"
                     /gene_synonym="NS4ATP2"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1031
                     /gene="SAP30L"
                     /gene_synonym="NS4ATP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..6185
                     /gene="SAP30L"
                     /gene_synonym="NS4ATP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1257..1262
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SAP30L"
                     /gene_synonym="NS4ATP2"
                     /note="hexamer: AATAAA"
     polyA_site      1279
                     /gene="SAP30L"
                     /gene_synonym="NS4ATP2"
                     /note="major polyA site"
     regulatory      6164..6169
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SAP30L"
                     /gene_synonym="NS4ATP2"
                     /note="hexamer: AATAAT"
     polyA_site      6185
                     /gene="SAP30L"
                     /gene_synonym="NS4ATP2"
ORIGIN      
        1 gtggtgcgga gcgttcggcg ggcggcggcc gggcggccca ggggctgccg cgggactcgg
       61 ggcgcagccg agtggctgca ggggtggagt gggccggacg agccgcgggg cccgggtgcc
      121 gcgggttcga ggccgggccc cgcgcgagga ggccgcgcca ccccggggga gctgcccggc
      181 agcgagtttg ccccgctgcc gaaagaaggc gggagccggc aggggccttc gaaaccccct
      241 ggcaacccag gcccggagtc cttggggagc ggctgtttcc tgggacgccc tcccggacac
      301 ccccgctgca gggttacggt tctgggcccc cggcagaagg ctcctccggg tgacccccgg
      361 cggggccctg cgagccgcgg gagccgaccc cggggcctcg agccgggagg aagggggctt
      421 ccggaggcgg agggccgggg gccgagggag ccgggcctct cggacgcggg gcagggcagc
      481 gcccgggctg gagacggact ctgggaccct cggctgcggg ggtctcagcg acctgccccg
      541 cggcaagcgc ggccgcggag tggcctaccg gggaccctcc cccagaggga ccggcccggg
      601 gcggggagat gaacggcttc agcacggagg aggacagccg cgaagggccc cccgccgccc
      661 cagctgccgc cgccccgggc tacggccaga gctgctgcct catcgaggac ggcgagcgct
      721 gcgtccggcc cgcgggcaac gcctccttca gcaagagggt ccagaagagc atctcgcaga
      781 agaaactcaa gctggacatc gacaagagcg taaggcacct atatatctgt gattttcaca
      841 aaaatttcat ccagagtgtc cgaaataaaa ggaagaggaa gacaagtgac gatggcggag
      901 attctcccga gcacgacact gacattcctg aggttgatct gttccagctg caggtgaaca
      961 ccctacgacg ttataaacga cactacaagt tgcagaccag accaggcttc aataaggccc
     1021 agttagcaga aactgtgagt cgacacttca ggaacatacc tgtgaatgaa aaagagaccc
     1081 ttgcctactt catctacatg gtgaagagta acaagagtag actggaccag aaatcggagg
     1141 gtggcaagca gcttgagtga ggatgaagca catcttaaag gaatgaagtg taatgcttga
     1201 tgcacaggtg atatctacta catttaagcc cataaagact gttaaatatt attgtaaata
     1261 aaaaagtttg aatgatgaat actgtaaatc tttttggtca ggaggattat attctcatga
     1321 ttcagcatgt gtatagaaag actttctttt acgataactc tggactaaaa aaatcaggat
     1381 cattaaaaga attaaaaact atgtatttca gcattcaaca aagcattaaa tcaattctac
     1441 tggaaatgtg ggataagaaa tattttggta atcaccttat ccaccaggct gccacgtgtg
     1501 agctgtagct tggaatagca gcaaggtgca attggccatg gaagtgcatg agcagaccca
     1561 catctggact tgcatgctgc ccgctggcga catagatatc ccgcccgctt tgttgcaagc
     1621 tttgtcattt atcagcagat cagtttgaca ctggtccccc tcactcaccc tgtgccttgt
     1681 acacagtagg cactcaatca gtaggtattg gctaattgag ctgtcactaa tagtgccagc
     1741 cttgtaacat ccgcttcaca cctctcatga ctgagacctc tgccatttct gttgctcacc
     1801 acttaactgc tagaatgtgg aggaaatcct gatgcaccaa caaggaagtt tctgatcaga
     1861 taaggatttc aggacagttg catgtgcaaa actattcgtt gaggttccag aaacactgat
     1921 atagagaccc tcacagaaga tacggtccct tatgcacccc actatgcttc actctttggg
     1981 gtgcagttag atattatgac ttcagccaag cttcttggta ataaatgcat tgacacactg
     2041 acatatttag taggttgggg caagtatttt tagaagtttt catcctaagt tcacaaccac
     2101 catgcaagct gccaggggcc atgtgattcc tgcccagaag ttcagcttag gattgaaagt
     2161 ctggctggcc ttgactccct gggctctggt catcagcaaa tcatgagttt gggcaacaaa
     2221 ggtcaattcc atctgatgct catttttgtg aacaatttgc ctccctctta gggagaaaga
     2281 ttgctaaaat aatttttgaa aattacctaa tttttttgtt gttcaaaacg ttgaactcct
     2341 caatctaatt atatcagagc caaagtatcc tgtgaaaaca aagctttata tccaaaaatg
     2401 tgcttttgca aaattcttta atctgtgtaa tggagggcag agggtatggg gtaggagggt
     2461 gggagaaaga aaagaaaaga atttggattc taatttatga ccatcttgac atatggtcaa
     2521 aggtgtcatt ttcctactca gtttcaattc tgagttaatt tcttaagcct taaataataa
     2581 gaacaatgga cagcctggcc tggcagagag tttcacagat gacttaatct gagcaccatc
     2641 acagagaagt caggactaaa ccccctactg agcagggcgg cggagtgtcc aaaggtctca
     2701 gttctgtgga gcagagtacc acgctttctg tggaatgggg acagggtcac cacgctcact
     2761 aaaatgcagt atgttccatt gcagcaaagc tttcgcctgt gttcaaaatg catgtctagc
     2821 agattgcagc cttttaaatt aaatatatat aaatggttgt atatagaata tactctggac
     2881 tgtgagggca tcctattttg gtatgcctcc tggctgtgga tggcatgtcc agtgctctgt
     2941 gagtgttttc agtcattcac attcactatg tgtttagaga ttctctccct gcttacagct
     3001 gaaggatgtt gatacaggca tcaagaaggc tgaggggcag atggggcctg caggttaagg
     3061 cattgttaac ttgctccatg gaaatgtcca tatcttaatg agtaaaaaag tgtatttttc
     3121 tgatacgtaa accagaattg tgggcgtgta ggtcacatca ctatttcttt agcagcaaat
     3181 ctgttttccc agttgagaga gacaatagct tctgcacaag aatatatgat ggtaggatcc
     3241 atctgttcaa ttgtgtctga aagaatcttt attccaaagc gaaacctggg gaaatgtttt
     3301 accttcagcc agatgctgtg tgtgtacttg ggtcccttgt ctttcctcta aggagaggtg
     3361 cttgtggaaa gtggaggttg tgggcatctt ttcaaccttt tcaatctgac ctttcaacag
     3421 gtcaggtgag agaaaagaca aagctatttg aacctatgtt tttcttatgt ccagaaatct
     3481 gttctttcat caaaccacta aaccactcgc cttagcctct tctgcagttt ctggtggctc
     3541 tatctgtggg caagggactc ctgcctgtga gaagtggcca ggccctccag agcaacgggg
     3601 tctggcttca gggagcagtg gggtgtgggg aaagcaatgt tcatcttggc tgctccattt
     3661 ttataccatc catcaaggac tcttgcgctt ctctccacct gtgacgtagc agcattgcct
     3721 tctttcctct tggtgcttct gggcaaaact ggaatttgaa atccagaact ggcgttgtct
     3781 tcttaaagag tatggttcct gcctcagttc cagcctggta tggttctttg atatgccctg
     3841 aaggttctca catggaaaca tcagtatcct gccattcatg ttgttttaag atgttttaaa
     3901 aaccaatgga caaacttctt gcttcaagga acaaactctt aggttggcaa cagcatataa
     3961 aaaaaaagat cacagctgaa tctcatgaaa gattaaaaac caaaggattc aagaccggtg
     4021 ttgtaaaatg aagaggaatt ttacttacat gttacagctg ccaagttttt agatgttcct
     4081 gtcatagcta aatagtcact gctagccttt cagagaacag atagtaacaa ttgtttgcag
     4141 ctgcagtgtt gcatctaatt ttggtgttta ggctttttat tttgtgggaa gctttttgtt
     4201 aatatcctgc agggcaactg cctgttggga gggagaggat ggaagaagga gcttactctg
     4261 ggggccttgc ctattgaggg aggctgttgc ccagagcagt tgcttcatgg aagtcatcca
     4321 aaggcgctct cagtcattac aatgacagga tctcaaagtt gggaaagggc tgttaagtca
     4381 tccagtctag tctccacata ggtgctgaca ttctgcctac aaccatccca ccaaggggtt
     4441 gagcagtctg gacttaaaca cctccgagga cagagaaccc actacctcgt ggagaagcct
     4501 gttctttgta aacctctggc ttttctatgt tctctgtaat ttccatctta gtctctgccc
     4561 catgggggcc acatgggaca agttattttt ggcaaagcac ctaattgctg gcactgtccc
     4621 aaagcatagc gtttgccttt tggaaagaaa caatgctagg acatggacac tttggtacac
     4681 tgtccttacc cctgagtatt agtccactca gttccttgtt ggagaatgtt gagaaaaccc
     4741 tactggctgg cttgtttctg ccaaagcttg gggagaggag agggggatga gaagatgtta
     4801 gcagcctgct aaacctcaga cagatgagga ctcagttctg tgcttgcccc acaaaaacgg
     4861 atgctcacat catcaggaaa ttgttcagct ggaggattta taacttcgtt gctttgcatg
     4921 aagtttaaag ttttcatggt tgcccagggc ttgtacctta gattcctgta aggactttgc
     4981 actgtttttg ctgagaaaac aacgcttcag gacttaaggt ctaagcgtca gagaagtgcc
     5041 gtattttcaa ggtggaaagt ctgttaagct tgctgttgtc caatcatccg tttttagaga
     5101 tggggaaact aaaactcaaa aagatgtgcc tgaggtcata tggcattatc agaaccaacc
     5161 tctggccctc ttgacctgtc tagcattctt tctttctgac ctataggatg actctaattc
     5221 agtctaaatc ggctgccctc agattcttga gaacttaaaa ttgagcagaa attcccaagg
     5281 ccaacctagc tctcagggac caacctgcag aactcaagat tgagcgaaat gtttaggcca
     5341 gttgagtttt gcaaaatgag tggtaaggga aaacagatct agcctgttat ttaaaaccag
     5401 ggttcaaaag ccctattggg agaggtagta ttgtcctagc atttaaattc tcatgaaatg
     5461 tgcttggtct gtgatctctt ggtcagatat ctgccttcca ggcgatcctt tgaggttgtg
     5521 taattcagct ggccctggct cctggtccct gttactgagc tgggcagtcg aaccgaaggg
     5581 cagatgagct caagatcatg ccttgggaag catggtgctc taggggtgcc tttttattcc
     5641 tttcattgta ttatagactg tttccaagtt tatggttaga aatggtaaag tgggtctggt
     5701 gttttgaggt agaacccagc ctagggcaag atatgaactg ttcttgaggt agaaatgtct
     5761 acagtcagtt gtttcatcta gcttgcatct taaaacacaa acccttcagt tgctttcact
     5821 taatgcacac atttgccaat gacagagggt tatacaggat ccttctttta catttctatt
     5881 gtctgctacg ctcatcagag tatattttgg ggtacaaggt tttgggggtt ttttttccca
     5941 ttttgtaact gccttattga aaagtaagtg cccttccatt ccaggcctcc tcatattgta
     6001 cttgtttcct gccaaatctg ggggatcatt tgtattttaa cttcgtaatc tatggctctg
     6061 tactgttgaa aggctctcaa ttctgtgggg tctccttagt atgtatgtga cttttcatgt
     6121 tgcaatatca cacgatggga tggcccgact tttgctctta ataaataatc tgaatgagta
     6181 agaga
//
