LOCUS       NM_013260               2500 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens SAP30 binding protein (SAP30BP), transcript variant 2,
            mRNA.
ACCESSION   NM_013260
VERSION     NM_013260.8
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2500)
  AUTHORS   Fukumura,K., Sperotto,L., Seuss,S., Kang,H.S., Yoshimoto,R.,
            Sattler,M. and Mayeda,A.
  TITLE     SAP30BP interacts with RBM17/SPF45 to promote splicing in a subset
            of human short introns
  JOURNAL   Cell Rep 42 (12), 113534 (2023)
   PUBMED   38065098
  REMARK    GeneRIF: SAP30BP interacts with RBM17/SPF45 to promote splicing in
            a subset of human short introns.
REFERENCE   2  (bases 1 to 2500)
  AUTHORS   Barros,R.S.M., Sant' Anna,C.C., Alcantara,D.D.F.A.,
            Pantoja,K.B.C.C., Fernandes,M.R., Bentes,L.G.B., Pimentel,A.L.J.C.,
            Lemos,R.S., Almeida,N.R.C., Fernandes,M.R.N., da Cruz,T.S.,
            Candido,A.A. and Burbano,R.M.R.
  TITLE     Association between the rs820218 Variant within the SAP30BP Gene
            and Rotator Cuff Rupture in an Amazonian Population
  JOURNAL   Genes (Basel) 14 (2), 367 (2023)
   PUBMED   36833294
  REMARK    GeneRIF: Association between the rs820218 Variant within the
            SAP30BP Gene and Rotator Cuff Rupture in an Amazonian Population.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2500)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 2500)
  AUTHORS   Tian,B., Kang,X., Zhang,L., Zheng,J. and Zhao,Z.
  TITLE     SAP30BP gene is associated with the susceptibility of rotator cuff
            tear: a case-control study based on Han Chinese population
  JOURNAL   J Orthop Surg Res 15 (1), 356 (2020)
   PUBMED   32843068
  REMARK    GeneRIF: SAP30BP gene is associated with the susceptibility of
            rotator cuff tear: a case-control study based on Han Chinese
            population.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2500)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 2500)
  AUTHORS   Naukkarinen,J., Surakka,I., Pietilainen,K.H., Rissanen,A.,
            Salomaa,V., Ripatti,S., Yki-Jarvinen,H., van Duijn,C.M.,
            Wichmann,H.E., Kaprio,J., Taskinen,M.R. and Peltonen,L.
  CONSRTM   ENGAGE Consortium
  TITLE     Use of genome-wide expression data to mine the 'Gray Zone' of GWA
            studies leads to novel candidate obesity genes
  JOURNAL   PLoS Genet 6 (6), e1000976 (2010)
   PUBMED   20532202
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2500)
  AUTHORS   Gao,J., Li,W.X., Feng,S.Q., Yuan,Y.S., Wan,D.F., Han,W. and Yu,Y.
  TITLE     A protein-protein interaction network of transcription factors
            acting during liver cell proliferation
  JOURNAL   Genomics 91 (4), 347-355 (2008)
   PUBMED   18255255
REFERENCE   8  (bases 1 to 2500)
  AUTHORS   Li,J.F., Liu,L.D., Ma,S.H., Che,Y.C., Wang,L.C., Dong,C.H.,
            Zhao,H.L., Liao,Y. and Li,Q.H.
  TITLE     HTRP--an immediate-early gene product induced by HSV1 infection in
            human embryo fibroblasts, is involved in cellular co-repressors
  JOURNAL   J Biochem 136 (2), 169-176 (2004)
   PUBMED   15496587
  REMARK    GeneRIF: HTRP is involved in cellular co-repressors
REFERENCE   9  (bases 1 to 2500)
  AUTHORS   Hu,R.M., Han,Z.G., Song,H.D., Peng,Y.D., Huang,Q.H., Ren,S.X.,
            Gu,Y.J., Huang,C.H., Li,Y.B., Jiang,C.L., Fu,G., Zhang,Q.H.,
            Gu,B.W., Dai,M., Mao,Y.F., Gao,G.F., Rong,R., Ye,M., Zhou,J.,
            Xu,S.H., Gu,J., Shi,J.X., Jin,W.R., Zhang,C.K., Wu,T.M.,
            Huang,G.Y., Chen,Z., Chen,M.D. and Chen,J.L.
  TITLE     Gene expression profiling in the human
            hypothalamus-pituitary-adrenal axis and full-length cDNA cloning
  JOURNAL   Proc Natl Acad Sci U S A 97 (17), 9543-9548 (2000)
   PUBMED   10931946
REFERENCE   10 (bases 1 to 2500)
  AUTHORS   Zhang,Y., Sun,Z.W., Iratni,R., Erdjument-Bromage,H., Tempst,P.,
            Hampsey,M. and Reinberg,D.
  TITLE     SAP30, a novel protein conserved between human and yeast, is a
            component of a histone deacetylase complex
  JOURNAL   Mol Cell 1 (7), 1021-1031 (1998)
   PUBMED   9651585
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF450482.1 and BC011724.2.
            
            On Nov 22, 2018 this sequence version replaced NM_013260.7.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon in the 5' coding region compared to variant 1. This variant
            encodes isoform 2, which is shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC030233.1, SRR1803615.244414.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000584667.6/ ENSP00000462116.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1159              AF450482.1         223-1381
            1160-2500           BC011724.2         1066-2406
FEATURES             Location/Qualifiers
     source          1..2500
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.1"
     gene            1..2500
                     /gene="SAP30BP"
                     /gene_synonym="HCNGP; HTRG; HTRP"
                     /note="SAP30 binding protein"
                     /db_xref="GeneID:29115"
                     /db_xref="HGNC:HGNC:30785"
                     /db_xref="MIM:610218"
     exon            1..141
                     /gene="SAP30BP"
                     /gene_synonym="HCNGP; HTRG; HTRP"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..962
                     /gene="SAP30BP"
                     /gene_synonym="HCNGP; HTRG; HTRP"
                     /note="isoform 2 is encoded by transcript variant 2; HSV-1
                     binding; transcriptional regulator protein HCNGP"
                     /codon_start=1
                     /product="SAP30-binding protein isoform 2"
                     /protein_id="NP_037392.1"
                     /db_xref="CCDS:CCDS11726.1"
                     /db_xref="GeneID:29115"
                     /db_xref="HGNC:HGNC:30785"
                     /db_xref="MIM:610218"
                     /translation="MAGKKNVLSSLAVYAEDSEPESDGEAGIEAVGSAAEEKGGLVSD
                     AYGEDDFSRLGGDEDGYEEEEDENSRQSEDDDSETEKPEADDPKDNTEAEKRDPQELV
                     ASFSERVRNMSPDEIKIPPEPPGRCSNHLQDKIQKLYERKIKEGMDMNYIIQRKKEFR
                     NPSIYEKLIQFCAIDELGTNYPKDMFDPHGWSEDSYYEALAKAQKIEMDKLEKAKKER
                     TKIEFVTGTKKGTTTNATSTTTTTASTAVADAQKRKSKWDSAIPVTTIAQPTILTTTA
                     TLPAVVTVTTSASGSKTTVISAVGTIVKKAKQ"
     exon            142..251
                     /gene="SAP30BP"
                     /gene_synonym="HCNGP; HTRG; HTRP"
                     /inference="alignment:Splign:2.1.0"
     exon            252..299
                     /gene="SAP30BP"
                     /gene_synonym="HCNGP; HTRG; HTRP"
                     /inference="alignment:Splign:2.1.0"
     exon            300..342
                     /gene="SAP30BP"
                     /gene_synonym="HCNGP; HTRG; HTRP"
                     /inference="alignment:Splign:2.1.0"
     exon            343..431
                     /gene="SAP30BP"
                     /gene_synonym="HCNGP; HTRG; HTRP"
                     /inference="alignment:Splign:2.1.0"
     exon            432..523
                     /gene="SAP30BP"
                     /gene_synonym="HCNGP; HTRG; HTRP"
                     /inference="alignment:Splign:2.1.0"
     exon            524..584
                     /gene="SAP30BP"
                     /gene_synonym="HCNGP; HTRG; HTRP"
                     /inference="alignment:Splign:2.1.0"
     exon            585..636
                     /gene="SAP30BP"
                     /gene_synonym="HCNGP; HTRG; HTRP"
                     /inference="alignment:Splign:2.1.0"
     exon            637..695
                     /gene="SAP30BP"
                     /gene_synonym="HCNGP; HTRG; HTRP"
                     /inference="alignment:Splign:2.1.0"
     exon            696..780
                     /gene="SAP30BP"
                     /gene_synonym="HCNGP; HTRG; HTRP"
                     /inference="alignment:Splign:2.1.0"
     exon            781..2500
                     /gene="SAP30BP"
                     /gene_synonym="HCNGP; HTRG; HTRP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1178..1183
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SAP30BP"
                     /gene_synonym="HCNGP; HTRG; HTRP"
                     /note="hexamer: ATTAAA"
     polyA_site      1198
                     /gene="SAP30BP"
                     /gene_synonym="HCNGP; HTRG; HTRP"
                     /note="major polyA site"
     regulatory      2089..2094
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SAP30BP"
                     /gene_synonym="HCNGP; HTRG; HTRP"
                     /note="hexamer: AATAAA"
     polyA_site      2116
                     /gene="SAP30BP"
                     /gene_synonym="HCNGP; HTRG; HTRP"
     regulatory      2423..2428
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SAP30BP"
                     /gene_synonym="HCNGP; HTRG; HTRP"
                     /note="hexamer: AATAAA"
     polyA_site      2455
                     /gene="SAP30BP"
                     /gene_synonym="HCNGP; HTRG; HTRP"
     regulatory      2478..2483
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SAP30BP"
                     /gene_synonym="HCNGP; HTRG; HTRP"
                     /note="hexamer: TATAAA"
     polyA_site      2500
                     /gene="SAP30BP"
                     /gene_synonym="HCNGP; HTRG; HTRP"
ORIGIN      
        1 ataggagtga gccacgcccg ggctgtggga ataagatggc ggggaagaag aatgttctgt
       61 cgtctctcgc agtttacgcg gaagattcag agcccgagtc tgatggcgag gctggaatcg
      121 aggcggtggg cagcgcggct gaggagaaag gcggattggt atctgatgcc tatggggagg
      181 atgacttttc tcgtctaggg ggtgatgaag atggttatga agaagaagaa gatgagaaca
      241 gtagacagtc ggaagatgac gattcagaga ctgaaaaacc tgaggctgat gacccaaagg
      301 ataatacaga agcagaaaag cgagaccccc aggaactcgt ggcctccttt tctgaaagag
      361 ttcggaacat gtcgcctgat gaaatcaaga tcccgccaga accccctggc agatgttcaa
      421 atcacttgca agacaagatc cagaagcttt atgaacgaaa gataaaggag ggaatggata
      481 tgaactacat tatccaaagg aagaaagaat ttcggaaccc tagcatctac gagaagctga
      541 tccagttctg tgccattgac gagcttggca ccaactaccc aaaggatatg tttgatcccc
      601 atggctggtc tgaggactcc tactatgagg cattagccaa ggcccagaaa attgagatgg
      661 acaaattgga aaaggccaaa aaggagcgaa caaaaattga gtttgtgacg ggcaccaaaa
      721 aaggcaccac gaccaacgcc acgtccacca ccactaccac tgccagcaca gctgttgcag
      781 atgctcagaa gagaaagagc aagtgggatt cggctatccc agtgacaacg atagcccagc
      841 ccaccatcct caccaccaca gccaccctgc cagctgttgt cacggtcacc accagcgcca
      901 gcggctccaa gaccaccgtc atctctgctg tgggcaccat tgtgaagaag gccaagcagt
      961 gacctgaggg gccaccctag gacttgaaag gaccgtgcag cccagtgacc actgcccagt
     1021 gggaggcgcc actttgtata tttcaggact gggacctact ccccagatgc cacctgagag
     1081 gagcttctgt ttggcattcc agatggaagg acaggcagca cgggagccag gcgctgtgga
     1141 cagggtctgt ccacgcacca cctggggtct gccgcctatt aaaagtgccg tattcttacc
     1201 tcttggcatc tcagatgcac tggcctctcc tgcattctgt ttgcaggcaa atgcttcagc
     1261 tcacatgtcc cccaagactc aatagtcttg gttgggacta ttgcctcagg gttgacaaca
     1321 gggtgatgga ggcctgggac gctgttcaga ggggtgaccc aagaagtcac cgttgttatc
     1381 cgtgtatgcc tctgggcatg gacaggcggg agtccccgag ccccacgtat gccccatctg
     1441 ccgccttgat cccaaaaccc agccagttct cgggtgatgg tggagctgtg ctcccttgag
     1501 tgcacttgag cactccccag accagatcac tttttggaca cacccaggaa ggcttttgaa
     1561 gtcaagccag tttccagaag ggctggggtg agatcctgac ctgtgcagag agtggggagg
     1621 cgtcagcgcc tggccagggc tgccccagtc ctttggtgcc cggtgagcgc agccagcagg
     1681 agctgagcag cgggggagat gaatcacctc ctgccttggc gaggcggcag ctcattgttt
     1741 acaggcaagc cctgctcctg ggagggctcc tgccacccca cccttcctct gtgtgttatc
     1801 tctgccccac agcagcccct gggcagcacc agtggccact gggctccccc cggggttgaa
     1861 acgggtttcc cagaccaggg gttcagagga gactatttac ccttcatgat ctttggcgat
     1921 tctccactgg agcggaaggg ctgtgtgtca aaagaaggaa gccaggctgt gaagggccgt
     1981 gttgctttca gtgggtgggc agaggtttag aaaggtggtt ctgaaatggc acctggtact
     2041 cttgtgggac ctggggaata taaggaactc tgtgcatgag gtttcaaaaa taaaaattga
     2101 gtccactctc cccgtacaca cacactcggg cacttcagga ggtcagttct caccccttcc
     2161 tcgatggggc tttaaagctc tggggagaag agctgctccc cactcatgcc ccagagggac
     2221 tgtgaaaagg cttcctgtga cctccgatgg cggcccctca ttggccaagg gcactgtgga
     2281 tgttttgtgg gaggcagcat ggcaccgtgg aaagggcagt agacgtggag ccggcacctc
     2341 tggtctggat tccacttaaa accagttgag tggtctcaag cccttaacct ctgtaagcct
     2401 gtttcttctc tgaaatcaca gtaataaagc gtcgtaagat ggttgggaag aaccagaggt
     2461 gacttatgca aaagctttat aaactgtaaa gttcctgcca
//
