LOCUS       NM_003864               1097 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens Sin3A associated protein 30 (SAP30), mRNA.
ACCESSION   NM_003864
VERSION     NM_003864.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1097)
  AUTHORS   Cao,Y., Yao,W., Lu,R., Zhao,H., Wei,W., Lei,X., Zhang,Z. and Liu,B.
  TITLE     Reveal the correlation between hub hypoxia/immune-related genes and
            immunity and diagnosis, and the effect of SAP30 on cell apoptosis,
            ROS and MDA production in cerebral ischemic stroke
  JOURNAL   Aging (Albany NY) 15 (24), 15161-15182 (2023)
   PUBMED   38154101
  REMARK    GeneRIF: Reveal the correlation between hub hypoxia/immune-related
            genes and immunity and diagnosis, and the effect of SAP30 on cell
            apoptosis, ROS and MDA production in cerebral ischemic stroke.
REFERENCE   2  (bases 1 to 1097)
  AUTHORS   Bao,L., Kumar,A., Zhu,M., Peng,Y., Xing,C., Wang,J.E., Wang,Y. and
            Luo,W.
  TITLE     SAP30 promotes breast tumor progression by bridging the
            transcriptional corepressor SIN3 complex and MLL1
  JOURNAL   J Clin Invest 133 (17), e168362 (2023)
   PUBMED   37655663
  REMARK    GeneRIF: SAP30 promotes breast tumor progression by bridging the
            transcriptional corepressor SIN3 complex and MLL1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1097)
  AUTHORS   Hu,C.L., Chen,B.Y., Li,Z., Yang,T., Xu,C.H., Yang,R., Yu,P.C.,
            Zhao,J., Liu,T., Liu,N., Shan,B., Zhang,Q., Song,J., Fei,M.Y.,
            Zong,L.J., Zhang,J.Y., Wu,J.C., Chen,S.B., Wang,Y., Chang,B.,
            Hou,D., Liu,P., Jiang,Y., Li,X., Chen,X., Deng,C.H., Ren,Y.Y.,
            Wang,R., Jin,J., Xue,K., Zhang,Y., Du,M., Shi,J., Wu,L.Y.,
            Chang,C.K., Shen,S., Chen,Z., Chen,S.J., Liu,X., Sun,X.J., Zheng,M.
            and Wang,L.
  TITLE     Targeting UHRF1-SAP30-MXD4 axis for leukemia initiating cell
            eradication in myeloid leukemia
  JOURNAL   Cell Res 32 (12), 1105-1123 (2022)
   PUBMED   36302855
  REMARK    GeneRIF: Targeting UHRF1-SAP30-MXD4 axis for leukemia initiating
            cell eradication in myeloid leukemia.
REFERENCE   4  (bases 1 to 1097)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 1097)
  AUTHORS   Snezhkina,A.V., Nyushko,K.M., Zaretsky,A.R., Shagin,D.A.,
            Sadritdinova,A.F., Fedorova,M.S., Guvatova,Z.G., Abramov,I.S.,
            Pudova,E.A., Alekseev,B.Y., Dmitriev,A.A. and Kudryavtseva,A.V.
  TITLE     [Transcription Factor SAP30 Is Involved in the Activation of NETO2
            Gene Expression in Clear Cell Renal Cell Carcinoma]
  JOURNAL   Mol Biol (Mosk) 52 (3), 451-459 (2018)
   PUBMED   29989576
  REMARK    GeneRIF: upregulation of NETO2 gene is first stipulated by the
            isoform 1 (NM_018092.4), and the probable mechanism of its
            activation is associated with the increased expression of SAP30
            transcription factor.
REFERENCE   6  (bases 1 to 1097)
  AUTHORS   Zhang,Y., LeRoy,G., Seelig,H.P., Lane,W.S. and Reinberg,D.
  TITLE     The dermatomyositis-specific autoantigen Mi2 is a component of a
            complex containing histone deacetylase and nucleosome remodeling
            activities
  JOURNAL   Cell 95 (2), 279-289 (1998)
   PUBMED   9790534
REFERENCE   7  (bases 1 to 1097)
  AUTHORS   Laherty,C.D., Billin,A.N., Lavinsky,R.M., Yochum,G.S., Bush,A.C.,
            Sun,J.M., Mullen,T.M., Davie,J.R., Rose,D.W., Glass,C.K.,
            Rosenfeld,M.G., Ayer,D.E. and Eisenman,R.N.
  TITLE     SAP30, a component of the mSin3 corepressor complex involved in
            N-CoR-mediated repression by specific transcription factors
  JOURNAL   Mol Cell 2 (1), 33-42 (1998)
   PUBMED   9702189
REFERENCE   8  (bases 1 to 1097)
  AUTHORS   Zhang,Y., Sun,Z.W., Iratni,R., Erdjument-Bromage,H., Tempst,P.,
            Hampsey,M. and Reinberg,D.
  TITLE     SAP30, a novel protein conserved between human and yeast, is a
            component of a histone deacetylase complex
  JOURNAL   Mol Cell 1 (7), 1021-1031 (1998)
   PUBMED   9651585
REFERENCE   9  (bases 1 to 1097)
  AUTHORS   Zhang,Y., Iratni,R., Erdjument-Bromage,H., Tempst,P. and
            Reinberg,D.
  TITLE     Histone deacetylases and SAP18, a novel polypeptide, are components
            of a human Sin3 complex
  JOURNAL   Cell 89 (3), 357-364 (1997)
   PUBMED   9150135
REFERENCE   10 (bases 1 to 1097)
  AUTHORS   Ayer,D.E., Lawrence,Q.A. and Eisenman,R.N.
  TITLE     Mad-Max transcriptional repression is mediated by ternary complex
            formation with mammalian homologs of yeast repressor Sin3
  JOURNAL   Cell 80 (5), 767-776 (1995)
   PUBMED   7889570
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AW236579.1, BC016757.1 and
            AF055993.1.
            
            On Nov 22, 2018 this sequence version replaced NM_003864.3.
            
            Summary: Histone acetylation plays a key role in the regulation of
            eukaryotic gene expression. Histone acetylation and deacetylation
            are catalyzed by multisubunit complexes. The protein encoded by
            this gene is a component of the histone deacetylase complex, which
            includes SIN3, SAP18, HDAC1, HDAC2, RbAp46, RbAp48, and other
            polypeptides. This complex is active in deacetylating core histone
            octamers, but inactive in deacetylating nucleosomal histones. A
            pseudogene of this gene is located on chromosome 3. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF055993.1, BC016757.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296504.4/ ENSP00000296504.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AW236579.1         260-265             c
            7-1094              BC016757.1         14-1101
            1095-1097           AF055993.1         1106-1108
FEATURES             Location/Qualifiers
     source          1..1097
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q34.1"
     gene            1..1097
                     /gene="SAP30"
                     /note="Sin3A associated protein 30"
                     /db_xref="GeneID:8819"
                     /db_xref="HGNC:HGNC:10532"
                     /db_xref="MIM:603378"
     exon            1..544
                     /gene="SAP30"
                     /inference="alignment:Splign:2.1.0"
     CDS             230..892
                     /gene="SAP30"
                     /note="Sin3 corepressor complex subunit SAP30;
                     Sin3-associated polypeptide, 30kDa; sin3-associated
                     polypeptide, 30 kDa; sin3-associated polypeptide p30; 30
                     kDa Sin3-associated polypeptide; Sin3A-associated protein,
                     30kDa"
                     /codon_start=1
                     /product="histone deacetylase complex subunit SAP30"
                     /protein_id="NP_003855.1"
                     /db_xref="CCDS:CCDS3817.1"
                     /db_xref="GeneID:8819"
                     /db_xref="HGNC:HGNC:10532"
                     /db_xref="MIM:603378"
                     /translation="MNGFTPDEMSRGGDAAAAVAAVVAAAAAAASAGNGTGAGTGAEV
                     PGAGAVSAAGPPGAAGPGPGQLCCLREDGERCGRAAGNASFSKRIQKSISQKKVKIEL
                     DKSARHLYICDYHKNLIQSVRNRRKRKGSDDDGGDSPVQDIDTPEVDLYQLQVNTLRR
                     YKRHFKLPTRPGLNKAQLVEIVGCHFRSIPVNEKDTLTYFIYSVKNDKNKSDLKVDSG
                     VH"
     exon            545..670
                     /gene="SAP30"
                     /inference="alignment:Splign:2.1.0"
     exon            671..769
                     /gene="SAP30"
                     /inference="alignment:Splign:2.1.0"
     exon            770..1097
                     /gene="SAP30"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1078..1083
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SAP30"
                     /note="hexamer: AATAAA"
     polyA_site      1097
                     /gene="SAP30"
                     /note="major polyA site"
ORIGIN      
        1 agtgagcggg gtccccgctc caggagacgc tcgagtctgc gtcccggccc tcagcactgt
       61 ccactgtttc ggtgccagca gagaccagca ggcccgggac agttggtgtt tggccgtgcc
      121 gctgtctaac ttggtgtgca gagtgaattg ccgctgccgg agcggagaga ggcggagcgg
      181 ccaggagaga ggggatttct gtcagcgccg gcctcgggag ctcggagaca tgaacggctt
      241 cacgcctgac gagatgagcc gcggcgggga tgcggccgcc gcagtggccg cagtggtcgc
      301 tgccgcggcc gccgccgcct cggcggggaa cgggaccggc gcgggcaccg gggctgaggt
      361 gccgggcgcg ggggcggtct cagcggctgg gcccccgggg gcggccgggc cgggccccgg
      421 gcaactgtgc tgcctgcggg aggatggtga gcggtgcggc cgggcggcag gcaacgccag
      481 cttcagcaag aggatccaga agagcatctc ccagaagaag gtgaagatcg agctggataa
      541 gagcgcaagg catctttaca tatgtgatta tcataaaaac ttaattcaga gtgttcgaaa
      601 cagaagaaag agaaaaggga gtgatgatga tggaggtgat tcacctgttc aagatattga
      661 taccccagag gttgatttat accaattaca agtaaataca cttaggagat acaaaagaca
      721 cttcaagcta ccaaccagac caggacttaa taaagcacaa cttgttgaga tagttggttg
      781 ccactttagg tctattccag tgaatgaaaa agacacctta acatatttca tctactcagt
      841 gaagaatgac aagaacaaat cagatctcaa ggttgatagt ggtgttcact aggagacgtg
      901 gaattgagac taataacttg gatgttaaca ctgtttactg ttttttcaca tgtagaaatg
      961 ttctttgtgt attttttcta cagaggattt tctctgattt tattttcttt gtttctgact
     1021 ctaataatta gttggaaact catataaaat gagctttcct aaattaaatc tattttaaat
     1081 aaaggttatt actatta
//
