LOCUS       NM_001348680            1111 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens Sin3A associated protein 25 (SAP25), transcript
            variant 1, mRNA.
ACCESSION   NM_001348680 XM_005250096
VERSION     NM_001348680.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1111)
  AUTHORS   Goswami,P., Banks,C.A.S., Thornton,J., Bengs,B.D., Sardiu,M.E.,
            Florens,L. and Washburn,M.P.
  TITLE     Distinct Regions within SAP25 Recruit O-Linked Glycosylation, DNA
            Demethylation, and Ubiquitin Ligase and Hydrolase Activities to the
            Sin3/HDAC Complex
  JOURNAL   J Proteome Res 23 (11), 5016-5029 (2024)
   PUBMED   39435885
  REMARK    GeneRIF: Distinct Regions within SAP25 Recruit O-Linked
            Glycosylation, DNA Demethylation, and Ubiquitin Ligase and
            Hydrolase Activities to the Sin3/HDAC Complex.
REFERENCE   2  (bases 1 to 1111)
  AUTHORS   Shiio,Y., Rose,D.W., Aur,R., Donohoe,S., Aebersold,R. and
            Eisenman,R.N.
  TITLE     Identification and characterization of SAP25, a novel component of
            the mSin3 corepressor complex
  JOURNAL   Mol Cell Biol 26 (4), 1386-1397 (2006)
   PUBMED   16449650
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC069281.6.
            
            On Nov 23, 2018 this sequence version replaced NM_001348680.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000622764.3/ ENSP00000481773.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-304               AC069281.6         29267-29570
            305-408             AC069281.6         29767-29870
            409-515             AC069281.6         29955-30061
            516-669             AC069281.6         30154-30307
            670-767             AC069281.6         30416-30513
            768-1111            AC069281.6         30596-30939
FEATURES             Location/Qualifiers
     source          1..1111
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.1"
     gene            1..1111
                     /gene="SAP25"
                     /note="Sin3A associated protein 25"
                     /db_xref="GeneID:100316904"
                     /db_xref="HGNC:HGNC:41908"
                     /db_xref="MIM:619230"
     exon            1..304
                     /gene="SAP25"
                     /inference="alignment:Splign:2.1.0"
     CDS             159..1052
                     /gene="SAP25"
                     /note="isoform 1 is encoded by transcript variant 1;
                     sin3A-binding protein 25; sin3-associated polypeptide,
                     25kDa; 25 kDa Sin3-associated polypeptide; Sin3
                     corepressor complex subunit SAP25; Histone deacetylase
                     complex subunit SAP25; Sin3A-associated protein, 25kDa"
                     /codon_start=1
                     /product="histone deacetylase complex subunit SAP25
                     isoform 1"
                     /protein_id="NP_001335609.1"
                     /db_xref="CCDS:CCDS87529.1"
                     /db_xref="GeneID:100316904"
                     /db_xref="HGNC:HGNC:41908"
                     /db_xref="MIM:619230"
                     /translation="MLPWSPPRWGAGPEEAPEGPGLPAGKDQGEPWSAGADAPRELGT
                     PPWDSPQPPSRSPSWIWREQLLLPHHLPGPATEQPPGAPDPRSPQVAWEVAPSRMTPL
                     APWDPKYEAKAGPRPVWGANCSSGASFSGRTLCHPSFWPLYEAASGRGLRPVAPATGH
                     WNGQQAPPDAGFPVVCCEDVFLSDPLLPRGQRVPLYLSKAPQQMMGSLKLLPPPPIMS
                     ARVLPRPSPSRGPSTAWLSGPELIALTGLLQMSQGEPRPSSSAVGPPDHTSDPPSPCG
                     SPSSSQGADLSLPQTPDTHCP"
     exon            305..408
                     /gene="SAP25"
                     /inference="alignment:Splign:2.1.0"
     exon            409..515
                     /gene="SAP25"
                     /inference="alignment:Splign:2.1.0"
     exon            516..669
                     /gene="SAP25"
                     /inference="alignment:Splign:2.1.0"
     exon            670..767
                     /gene="SAP25"
                     /inference="alignment:Splign:2.1.0"
     exon            768..1111
                     /gene="SAP25"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1087..1092
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SAP25"
                     /note="hexamer: AATAAA"
     polyA_site      1111
                     /gene="SAP25"
                     /note="major polyA site"
ORIGIN      
        1 acgtggccgg gagacgcaca gggcgccagc gtcgccgcga ggcctctggg gtgggttcgc
       61 caggagggca cgttcgcgcc gcgccgcgga gggaggctga gagggccggg ccgggcggcg
      121 gggacacggc ggtaccgtcc tgcgctcggg aacgcggaat gttgccctgg tcgccgccgc
      181 ggtggggcgc gggcccggag gaggcgcccg agggaccagg ccttccggcg ggcaaggacc
      241 agggcgagcc ctggagcgcc ggagcggacg cccccaggga gctggggaca cccccatggg
      301 acagcccaca gcccccatcc cgtagccctt cctggatctg gagagagcag ctgctgctgc
      361 cccaccacct gccaggcccg gccactgagc agccccccgg agccccagat ccccgttccc
      421 cccaggtggc ctgggaggtg gccccctcga ggatgactcc actagcgccc tgggacccca
      481 agtatgaagc caaagcagga cctcggccgg tgtggggggc caactgtagc tcaggagcct
      541 cgttctcagg ccggacgctg tgtcacccct cattctggcc gctgtatgaa gcagcctcgg
      601 gcaggggtct caggcccgtg gcccctgcca cagggcactg gaatggacag caggcgcccc
      661 cagatgcagg gttcccggtg gtgtgctgtg aagatgtctt cctctcggac cctctgctgc
      721 cccgggggca gcgtgttccc ctgtacctgt ccaaggcccc ccagcagatg atgggctccc
      781 tgaaactgct gccgccgccc cccatcatgt ctgccagggt gctcccccgc ccatcaccct
      841 cccggggccc ctccactgcc tggctcagcg ggccggagct gatcgctctc actggcctgc
      901 tgcagatgag ccagggggag cctaggccca gctcctccgc ggttggcccc ccagaccata
      961 cctctgaccc acccagcccc tgtggtagcc ccagcagttc tcagggtgct gacctctctc
     1021 tcccacagac cccagacacc cattgtccat agccttctca gggcagagtg ggctggttgt
     1081 gttgacaata aaacagtgtt ggtttgcaaa a
//
