LOCUS       NM_005870               2708 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens Sin3A associated protein 18 (SAP18), transcript
            variant 1, mRNA.
ACCESSION   NM_005870
VERSION     NM_005870.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2708)
  AUTHORS   Kumari,S., Rehman,A., Chandra,P. and Singh,K.K.
  TITLE     Functional role of SAP18 protein: From transcriptional repression
            to splicing regulation
  JOURNAL   Cell Biochem Funct 41 (7), 738-751 (2023)
   PUBMED   37486712
  REMARK    GeneRIF: Functional role of SAP18 protein: From transcriptional
            repression to splicing regulation.
            Review article
REFERENCE   2  (bases 1 to 2708)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 2708)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 2708)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2708)
  AUTHORS   Makishima,S., Boonvisut,S., Ishizuka,Y., Watanabe,K., Nakayama,K.
            and Iwamoto,S.
  TITLE     Sin3A-associated protein, 18 kDa, a novel binding partner of TRIB1,
            regulates MTTP expression
  JOURNAL   J Lipid Res 56 (6), 1145-1152 (2015)
   PUBMED   25921304
  REMARK    GeneRIF: These studies indicated that SAP18 expression enhanced the
            recruitment of mSin3A in coordination with TRIB1 to MTTP regulatory
            elements and increased MTTP expression.
REFERENCE   6  (bases 1 to 2708)
  AUTHORS   Joselin,A.P., Schulze-Osthoff,K. and Schwerk,C.
  TITLE     Loss of Acinus inhibits oligonucleosomal DNA fragmentation but not
            chromatin condensation during apoptosis
  JOURNAL   J Biol Chem 281 (18), 12475-12484 (2006)
   PUBMED   16537548
REFERENCE   7  (bases 1 to 2708)
  AUTHORS   Tange,T.O., Shibuya,T., Jurica,M.S. and Moore,M.J.
  TITLE     Biochemical analysis of the EJC reveals two new factors and a
            stable tetrameric protein core
  JOURNAL   RNA 11 (12), 1869-1883 (2005)
   PUBMED   16314458
REFERENCE   8  (bases 1 to 2708)
  AUTHORS   Schwerk,C., Prasad,J., Degenhardt,K., Erdjument-Bromage,H.,
            White,E., Tempst,P., Kidd,V.J., Manley,J.L., Lahti,J.M. and
            Reinberg,D.
  TITLE     ASAP, a novel protein complex involved in RNA processing and
            apoptosis
  JOURNAL   Mol Cell Biol 23 (8), 2981-2990 (2003)
   PUBMED   12665594
REFERENCE   9  (bases 1 to 2708)
  AUTHORS   Koipally,J., Renold,A., Kim,J. and Georgopoulos,K.
  TITLE     Repression by Ikaros and Aiolos is mediated through histone
            deacetylase complexes
  JOURNAL   EMBO J 18 (11), 3090-3100 (1999)
   PUBMED   10357820
REFERENCE   10 (bases 1 to 2708)
  AUTHORS   Zhang,Y., Iratni,R., Erdjument-Bromage,H., Tempst,P. and
            Reinberg,D.
  TITLE     Histone deacetylases and SAP18, a novel polypeptide, are components
            of a human Sin3 complex
  JOURNAL   Cell 89 (3), 357-364 (1997)
   PUBMED   9150135
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL158032.32.
            
            On Jun 8, 2021 this sequence version replaced NM_005870.4.
            
            Summary: Histone acetylation plays a key role in the regulation of
            eukaryotic gene expression. Histone acetylation and deacetylation
            are catalyzed by multisubunit complexes. The protein encoded by
            this gene is a component of the histone deacetylase complex, which
            includes SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and other
            polypeptides. This protein directly interacts with SIN3 and
            enhances SIN3-mediated transcriptional repression when tethered to
            the promoter. A pseudogene has been identified on chromosome 2.
            [provided by RefSeq, Dec 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC030836.1, AL533520.3 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000382533.9/ ENSP00000371973.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-563               AL158032.32        2983-3545
            564-673             AL158032.32        3750-3859
            674-796             AL158032.32        9669-9791
            797-2708            AL158032.32        10050-11961
FEATURES             Location/Qualifiers
     source          1..2708
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q12.11"
     gene            1..2708
                     /gene="SAP18"
                     /gene_synonym="2HOR0202; SAP18P"
                     /note="Sin3A associated protein 18"
                     /db_xref="GeneID:10284"
                     /db_xref="HGNC:HGNC:10530"
                     /db_xref="MIM:602949"
     exon            1..563
                     /gene="SAP18"
                     /gene_synonym="2HOR0202; SAP18P"
                     /inference="alignment:Splign:2.1.0"
     CDS             435..953
                     /gene="SAP18"
                     /gene_synonym="2HOR0202; SAP18P"
                     /note="isoform 1 is encoded by transcript variant 1;
                     histone deacetylase complex subunit SAP18; histone
                     deacetlyase complex subunit SAP18; sin3-associated
                     polypeptide, p18; cell growth inhibiting protein 38;
                     sin3-associated polypeptide, 18 kDa; 18 kDa
                     Sin3-associated polypeptide; cell growth-inhibiting gene
                     38 protein; Sin3A-associated protein, 18kDa; epididymis
                     secretory sperm binding protein"
                     /codon_start=1
                     /product="histone deacetylase complex subunit SAP18
                     isoform 1"
                     /protein_id="NP_005861.2"
                     /db_xref="CCDS:CCDS9295.2"
                     /db_xref="GeneID:10284"
                     /db_xref="HGNC:HGNC:10530"
                     /db_xref="MIM:602949"
                     /translation="MLAAGVGGQGERLAGRRRKMAVESRVTQEEIKKEPEKPIDREKT
                     CPLLLRVFTTNNGRHHRMDEFSRGNVPSSELQIYTWMDATLKELTSLVKEVYPEARKK
                     GTHFNFAIVFTDVKRPGYRVKEIGSTMSGRKGTDDSMTLQSQKFQIGDYLDIAITPPN
                     RAPPPSGRMRPY"
     exon            564..673
                     /gene="SAP18"
                     /gene_synonym="2HOR0202; SAP18P"
                     /inference="alignment:Splign:2.1.0"
     exon            674..796
                     /gene="SAP18"
                     /gene_synonym="2HOR0202; SAP18P"
                     /inference="alignment:Splign:2.1.0"
     exon            797..2708
                     /gene="SAP18"
                     /gene_synonym="2HOR0202; SAP18P"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1000..1005
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SAP18"
                     /gene_synonym="2HOR0202; SAP18P"
                     /note="hexamer: AATAAA"
     polyA_site      1027
                     /gene="SAP18"
                     /gene_synonym="2HOR0202; SAP18P"
                     /note="major polyA site"
     regulatory      1196..1201
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SAP18"
                     /gene_synonym="2HOR0202; SAP18P"
                     /note="hexamer: AATATA"
     polyA_site      1214
                     /gene="SAP18"
                     /gene_synonym="2HOR0202; SAP18P"
                     /note="major polyA site"
     regulatory      1941..1946
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SAP18"
                     /gene_synonym="2HOR0202; SAP18P"
                     /note="hexamer: AATAAA"
     polyA_site      1966
                     /gene="SAP18"
                     /gene_synonym="2HOR0202; SAP18P"
     regulatory      2427..2432
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SAP18"
                     /gene_synonym="2HOR0202; SAP18P"
                     /note="hexamer: AATAAA"
     polyA_site      2449
                     /gene="SAP18"
                     /gene_synonym="2HOR0202; SAP18P"
     regulatory      2670..2675
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SAP18"
                     /gene_synonym="2HOR0202; SAP18P"
                     /note="hexamer: AATAAA"
     regulatory      2674..2679
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SAP18"
                     /gene_synonym="2HOR0202; SAP18P"
                     /note="hexamer: AATAAG"
     polyA_site      2693
                     /gene="SAP18"
                     /gene_synonym="2HOR0202; SAP18P"
     polyA_site      2708
                     /gene="SAP18"
                     /gene_synonym="2HOR0202; SAP18P"
ORIGIN      
        1 aagccacccg aactgtgtgt ggctggaagg atcgctccat gaccacgtac gctggcggcc
       61 cctcttccgg cttacctcag gggctggtat cgcgggcctg ttctttcatc agaaagatct
      121 atattttgct aataaaggaa cgctttgtgt ccaataaggt tttcgtcatt acgcatgaaa
      181 acgccacctt aagcttatgt cgcctgtgaa tatttaaggg aaaaaaacat cccggcaacc
      241 aactgctagg cgacggacgc taagcacctc ctccccgcgg acgtcagcac ccgccttttc
      301 ccgaagtcgc aacacgcagg cgcgctccgg ctcgctcacc acgcacggaa gtgcgcctgc
      361 gccaggagac gccccgccca gcccctggcc gactataaag tgtcgagctt ctcctcgcga
      421 gagacttagt gctcatgctc gctgcagggg tcggaggtca gggcgagcgt ctcgcaggcc
      481 gtaggaggaa gatggcggtg gagtcgcgcg ttacccagga ggaaattaag aaggagccag
      541 agaaaccgat cgaccgcgag aagacatgcc cactgttgct acgggtcttc accaccaata
      601 acggccgcca ccaccgaatg gacgagttct cccggggaaa tgtaccgtcc agcgagttgc
      661 agatctacac ttggatggat gcaaccttga aagaactgac aagcttagta aaagaagtct
      721 acccagaagc tagaaagaag ggcactcact tcaattttgc aatcgttttt acagatgtta
      781 aaagacctgg ctatcgagtt aaggagattg gcagcaccat gtctggcaga aaggggactg
      841 atgattccat gaccctgcag tcgcagaagt tccagatagg agattacttg gacatagcaa
      901 ttacccctcc aaatcgggca ccacctcctt cagggcgcat gagaccatat taaattctat
      961 ttactatttg ttgaatttat ttttccgtca gttatgtaaa ataaacatac tcttcttcct
     1021 cccctgatta ttgccattaa gcctttaaat tctaaacaaa ttataatgca tcatctattt
     1081 aggagttaga tttggatgtg ctattgtatg attacgaata gtctgtatgt ttcaagccct
     1141 tctgtaaaat atgaagaaaa gtgctcttag cattctgtgt aaaactgtac tgttaaatat
     1201 atgtgtgtaa tcagcctgag tgtgaaagtt aatggaggcc tgggaacagg gtttatacta
     1261 agtagtggag gagcgtatgg ttaagcccaa aggggcagaa caagaaagcc acgggattgt
     1321 atgaaatcaa acatgagttt gtggtgtaga ctgctgtatg cagttggaaa ggacacgtga
     1381 gagtgagctc aagtggcagc agaggcagtt tggaataagc tgcggcaagt tgaagaagct
     1441 gtgttggacg agattgcccc gccttgatca gggtaccatg acataaaagg ttaaagaaca
     1501 ggcaacacaa tgagcactta agtttttaac atgtggggaa tagggcattt taaaggctgg
     1561 aaccagttca gaggaaacaa gggtttgggt agaggtagaa aggtttaatt aaccctggag
     1621 atctgcaaat ggagggaggg gtgaaggagg aatcttaaga ccgagggaga agagccaagg
     1681 acaaggtcag gttgaatgag taggaggtgt tcacacatcc tcttgtgtgc taggtagtgg
     1741 cgtgcatctg atctgagagg cagtaaagca gtgatgaaga cagtgcagca gaacattgaa
     1801 gtcctgattg cagcagtgac tctgcaacct tggataaatt atttcaatct ttattttgta
     1861 aaacggagat aacggcctat aggattgtta agactgaata ttttaaaaga gcttagaatg
     1921 gtgcctgaca aatgagaaac aataaatact gattattggc cataaagtgg tattaaaact
     1981 ggatctcttt tcttccatgg cactactctc attttgaagt ttatgaacag tacgacagtg
     2041 tattgtaaat tccctttagt ttgttacagt agccaattga aaatgtatat cccaaaattt
     2101 aaaaaaaaaa gtaccagcag caataaaatt gcactagttt tatctggtac atacaaaaac
     2161 agccatttaa aatctgatga ttctgtggaa ttggtgtccc tgttagcaat ggcagagacc
     2221 agcctggagc ctagatctgg tgcttcttct gtgctgtggt ttaccccaaa cctttaggtt
     2281 gtttattcat tcagattaga tagactggag ccataaagtt aatttgcacc tagctttttg
     2341 gagaatagcc atgattaact gctattcgtg gtgggggtgg gggggaaccc tatgatttac
     2401 tatgcagatg aagagggtag gaactaaata aaggactttg taagccaaag tggttgggct
     2461 gctttgtcaa attccaccct ttgcttggtt ccaacatgga atttctcctt taaagatttc
     2521 aatatcccat caaaagtaca gttagagaat acctagtgaa tttattgaat ataatgctaa
     2581 gaatcaaaag acttgtacta gtttacctct ggctttggta agtgtggctt tgagtaataa
     2641 ctgagctgtt tccccgcata taaaatagaa ataaataagt agtcatcatg acagcatctt
     2701 gctcagtg
//
