LOCUS       NM_001330301            4084 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens Sin3A associated protein 130 (SAP130), transcript
            variant 5, mRNA.
ACCESSION   NM_001330301 XM_005263768
VERSION     NM_001330301.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4084)
  AUTHORS   Metselaar,P.I., Hos,C., Welting,O., Bosch,J.A., Kraneveld,A.D., de
            Jonge,W.J. and Te Velde,A.A.
  TITLE     Ambiguity about Splicing Factor 3b Subunit 3 (SF3B3) and Sin3A
            Associated Protein 130 (SAP130)
  JOURNAL   Cells 10 (3), 590 (2021)
   PUBMED   33800128
  REMARK    GeneRIF: Ambiguity about Splicing Factor 3b Subunit 3 (SF3B3) and
            Sin3A Associated Protein 130 (SAP130).
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4084)
  AUTHORS   Streubel,G., Fitzpatrick,D.J., Oliviero,G., Scelfo,A., Moran,B.,
            Das,S., Munawar,N., Watson,A., Wynne,K., Negri,G.L., Dillon,E.T.,
            Jammula,S., Hokamp,K., O'Connor,D.P., Pasini,D., Cagney,G. and
            Bracken,A.P.
  TITLE     Fam60a defines a variant Sin3a-Hdac complex in embryonic stem cells
            required for self-renewal
  JOURNAL   EMBO J 36 (15), 2216-2232 (2017)
   PUBMED   28554894
REFERENCE   3  (bases 1 to 4084)
  AUTHORS   Smith,K.T., Sardiu,M.E., Martin-Brown,S.A., Seidel,C.,
            Mushegian,A., Egidy,R., Florens,L., Washburn,M.P. and Workman,J.L.
  TITLE     Human family with sequence similarity 60 member A (FAM60A) protein:
            a new subunit of the Sin3 deacetylase complex
  JOURNAL   Mol Cell Proteomics 11 (12), 1815-1828 (2012)
   PUBMED   22984288
REFERENCE   4  (bases 1 to 4084)
  AUTHORS   Munoz,I.M., MacArtney,T., Sanchez-Pulido,L., Ponting,C.P., Rocha,S.
            and Rouse,J.
  TITLE     Family with sequence similarity 60A (FAM60A) protein is a cell
            cycle-fluctuating regulator of the SIN3-HDAC1 histone deacetylase
            complex
  JOURNAL   J Biol Chem 287 (39), 32346-32353 (2012)
   PUBMED   22865885
REFERENCE   5  (bases 1 to 4084)
  AUTHORS   Icardi,L., Mori,R., Gesellchen,V., Eyckerman,S., De Cauwer,L.,
            Verhelst,J., Vercauteren,K., Saelens,X., Meuleman,P.,
            Leroux-Roels,G., De Bosscher,K., Boutros,M. and Tavernier,J.
  TITLE     The Sin3a repressor complex is a master regulator of STAT
            transcriptional activity
  JOURNAL   Proc Natl Acad Sci U S A 109 (30), 12058-12063 (2012)
   PUBMED   22783022
REFERENCE   6  (bases 1 to 4084)
  AUTHORS   Truty,M.J., Lomberk,G., Fernandez-Zapico,M.E. and Urrutia,R.
  TITLE     Silencing of the transforming growth factor-beta (TGFbeta) receptor
            II by Kruppel-like factor 14 underscores the importance of a
            negative feedback mechanism in TGFbeta signaling
  JOURNAL   J Biol Chem 284 (10), 6291-6300 (2009)
   PUBMED   19088080
  REMARK    GeneRIF: the TGFbeta pathway activation leads to recruitment of a
            KLF14-mSin3A-HDAC2 repressor complex to the TGFbetaRII promoter, as
            well as the remodeling of chromatin to increase histone marks that
            associate with transcriptional silencing.
REFERENCE   7  (bases 1 to 4084)
  AUTHORS   Fleischer,T.C., Yun,U.J. and Ayer,D.E.
  TITLE     Identification and characterization of three new components of the
            mSin3A corepressor complex
  JOURNAL   Mol Cell Biol 23 (10), 3456-3467 (2003)
   PUBMED   12724404
REFERENCE   8  (bases 1 to 4084)
  AUTHORS   Martinez,E., Palhan,V.B., Tjernberg,A., Lymar,E.S., Gamper,A.M.,
            Kundu,T.K., Chait,B.T. and Roeder,R.G.
  TITLE     Human STAGA complex is a chromatin-acetylating transcription
            coactivator that interacts with pre-mRNA splicing and DNA
            damage-binding factors in vivo
  JOURNAL   Mol Cell Biol 21 (20), 6782-6795 (2001)
   PUBMED   11564863
REFERENCE   9  (bases 1 to 4084)
  AUTHORS   Zhang,Y., Sun,Z.W., Iratni,R., Erdjument-Bromage,H., Tempst,P.,
            Hampsey,M. and Reinberg,D.
  TITLE     SAP30, a novel protein conserved between human and yeast, is a
            component of a histone deacetylase complex
  JOURNAL   Mol Cell 1 (7), 1021-1031 (1998)
   PUBMED   9651585
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC118060.4 and AC012306.11.
            
            On Jun 2, 2019 this sequence version replaced NM_001330301.1.
            
            Summary: SAP130 is a subunit of the histone deacetylase (see HDAC1;
            MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex
            (Fleischer et al., 2003 [PubMed 12724404]).[supplied by OMIM, Mar
            2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853558.14633.1,
                                           SRR11853561.16732.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000643581.2/ ENSP00000494423.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-120               AC118060.4         25507-25626         c
            121-238             AC118060.4         23748-23865         c
            239-474             AC118060.4         15247-15482         c
            475-633             AC118060.4         13956-14114         c
            634-745             AC118060.4         12370-12481         c
            746-870             AC118060.4         10597-10721         c
            871-995             AC118060.4         7836-7960           c
            996-1143            AC012306.11        149507-149654       c
            1144-1234           AC012306.11        149256-149346       c
            1235-1339           AC012306.11        148941-149045       c
            1340-1481           AC012306.11        145550-145691       c
            1482-1603           AC012306.11        142387-142508       c
            1604-1906           AC012306.11        138764-139066       c
            1907-2084           AC012306.11        135985-136162       c
            2085-2189           AC012306.11        127185-127289       c
            2190-2548           AC012306.11        104186-104544       c
            2549-2797           AC012306.11        99360-99608         c
            2798-2923           AC012306.11        99069-99194         c
            2924-3027           AC012306.11        94656-94759         c
            3028-3141           AC012306.11        91624-91737         c
            3142-4084           AC012306.11        90422-91364         c
FEATURES             Location/Qualifiers
     source          1..4084
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q14.3"
     gene            1..4084
                     /gene="SAP130"
                     /note="Sin3A associated protein 130"
                     /db_xref="GeneID:79595"
                     /db_xref="HGNC:HGNC:29813"
                     /db_xref="MIM:609697"
     exon            1..120
                     /gene="SAP130"
                     /inference="alignment:Splign:2.1.0"
     exon            121..238
                     /gene="SAP130"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..3300
                     /gene="SAP130"
                     /EC_number="3.2.1.3"
                     /note="isoform e is encoded by transcript variant 5;
                     histone deacetylase complex subunit SAP130;
                     Sin3-associated polypeptide p130; 130 kDa Sin3-associated
                     polypeptide; Sin3A associated protein 130kDa"
                     /codon_start=1
                     /product="histone deacetylase complex subunit SAP130
                     isoform e"
                     /protein_id="NP_001317230.1"
                     /db_xref="CCDS:CCDS86881.1"
                     /db_xref="GeneID:79595"
                     /db_xref="HGNC:HGNC:29813"
                     /db_xref="MIM:609697"
                     /translation="MSSQQFPRLGAPSTGLSQAPSQIANSGSAGLINPAATVNDESGR
                     DSEVSAREHMSSSSSLQSREEKQEPVVVRPYPQVQMLSTHHAVASATPVAVTAPPAHL
                     TPAVPLSFSEGLMKPPPKPTMPSRPIAPAPPSTLSLPPKVPGQVTVTMESSIPQASAI
                     PVATISGQQGHPSNLHHIMTTNVQMSIIRSNAPGPPLHIGASHLPRGAAAAAVMSSSK
                     VTTVLRPTSQLPNAATAQPAVQHIIHQPIQSRPPVTTSNAIPPAVVATVSATRAQSPV
                     ITTTAAHATDSALSRPTLSIQHPPSAAISIQRPAQSRDVTTRITLPSHPALGTPKQQL
                     HTMAQKTIFSTGTPVAAATVAPILATNTIPSATTAGSVSHTQAPTSTIVTMTVPSHSS
                     HATAVTTSNIPVAKVVPQQITHTSPRIQPDYPAERSSLIPISGHRASPNPVAMETRSD
                     NRPSVPVQFQYFLPTYPPSAYPLAAHTYTPITSSVSTIRQYPVSAQAPNSAITAQTGV
                     GVASTVHLNPMQLMTVDASHARHIQGIQPAPISTQGIQPAPIGTPGIQPAPLGTQGIH
                     SATPINTQGLQPAPMGTQQPQPEGKTSAVVLADGATIVANPISNPFSAAPAATTVVQT
                     HSQSASTNAPAQGSSPRPSILRKKPATDGMAVRKTLIPPQPPDVASPRVESSMRSTSG
                     SPRPAGAKPKSEIHVSMATPVTVSMETVSNQNNDQPTIAVPPTAQQPPPTIPTMIAAA
                     SPPSQPAVALSTIPGAVPITPPITTIAAAPPPSVTVGGSLSSVLGPPVPEIKVKEEVE
                     PMDIMRPVSAVPPLATNTVSPSLALLANNLSMPTSDLPPGASPRKKPRKQQHVISTEE
                     GDMMETNSTDDEKSTAKSLLVKAEKRKSPPKEYIDEEGVRYVPVRPRPPITLLRHYRN
                     PWKAAYHHFQRYSDVRVKEEKKAMLQEIANQKGVSCRAQGWKVHLCAAQLLQLTNLEH
                     DVYERLTNLQEGIIPKKKAATDDDLHRINELIQGNMQRCKLVMDQISEARDSMLKVLD
                     HKDRVLKLLNKNGTVKKVSKLKRKEKV"
     exon            239..474
                     /gene="SAP130"
                     /inference="alignment:Splign:2.1.0"
     exon            475..633
                     /gene="SAP130"
                     /inference="alignment:Splign:2.1.0"
     exon            634..745
                     /gene="SAP130"
                     /inference="alignment:Splign:2.1.0"
     exon            746..870
                     /gene="SAP130"
                     /inference="alignment:Splign:2.1.0"
     exon            871..995
                     /gene="SAP130"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1143
                     /gene="SAP130"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1234
                     /gene="SAP130"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1339
                     /gene="SAP130"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1481
                     /gene="SAP130"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..1603
                     /gene="SAP130"
                     /inference="alignment:Splign:2.1.0"
     exon            1604..1906
                     /gene="SAP130"
                     /inference="alignment:Splign:2.1.0"
     exon            1907..2084
                     /gene="SAP130"
                     /inference="alignment:Splign:2.1.0"
     exon            2085..2189
                     /gene="SAP130"
                     /inference="alignment:Splign:2.1.0"
     exon            2190..2548
                     /gene="SAP130"
                     /inference="alignment:Splign:2.1.0"
     exon            2549..2797
                     /gene="SAP130"
                     /inference="alignment:Splign:2.1.0"
     exon            2798..2923
                     /gene="SAP130"
                     /inference="alignment:Splign:2.1.0"
     exon            2924..3027
                     /gene="SAP130"
                     /inference="alignment:Splign:2.1.0"
     exon            3028..3141
                     /gene="SAP130"
                     /inference="alignment:Splign:2.1.0"
     exon            3142..4084
                     /gene="SAP130"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4058..4063
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SAP130"
                     /note="hexamer: AATAAA"
     polyA_site      4084
                     /gene="SAP130"
                     /note="major polyA site"
ORIGIN      
        1 agagtgctag ctccccggcg gtggctgcgg gtccggagcc tggggacgtc ggccccacag
       61 acggagagcg cgcgggagcg agctcaaggc ggcgcggcgg ccactgggcg cagcacccag
      121 gtggaaatga gttctcaaca gtttcctcgg ttaggagccc cttctaccgg gctgagccag
      181 gccccttctc agattgcaaa cagtggttct gctggattga taaacccagc tgctacagtc
      241 aatgatgaat ctggtcgaga ttctgaagtc agtgccaggg agcacatgag ttccagcagc
      301 tccctccagt cccgggagga gaagcaagag cctgttgtgg taaggcccta tccacaggtg
      361 cagatgttgt cgacacacca tgctgtcgca tcagccacac ctgttgcagt gacagccccg
      421 ccagcacacc tgacgccagc agtgccactt tcattttcgg agggacttat gaagccgccc
      481 ccgaagccca ccatgcctag ccgtcccatt gctcctgctc caccttctac cctgtcactt
      541 ccccccaagg ttccagggca ggttaccgtt accatggaga gtagcatccc tcaagcttca
      601 gccattcctg tggcaacaat cagtggacaa cagggccatc ccagtaacct gcatcacatc
      661 atgactacaa atgtgcaaat gtctatcatc cgcagcaatg ctcctgggcc ccctcttcac
      721 attggagctt ctcatttacc tcgaggtgca gctgctgctg ctgtgatgtc cagttctaaa
      781 gtaaccacag tcctgaggcc gacctcacag ctgccaaatg ctgctactgc tcagccagca
      841 gtacagcaca tcattcacca accaatccag tctcggccac ctgtgaccac ctccaatgcc
      901 atccctcctg ctgtggtagc aactgtctca gccaccagag ctcagtctcc agtcatcact
      961 acgacagcgg cgcatgctac tgattcagca cttagtaggc caaccttgtc tatccagcat
     1021 cctccatctg cagcaatcag tattcagcgt cctgcccagt cacgagatgt cacaacaaga
     1081 atcacactac catctcaccc tgcattaggg acgccaaaac agcagcttca tacaatggct
     1141 cagaaaacaa tcttcagtac tggcacgcca gtggctgcag ccacagtagc acctattttg
     1201 gcaaccaaca ccattccttc agcgaccaca gctggatctg tgtcacacac gcaagctccc
     1261 acaagtacca ttgttaccat gacagtaccc tcccattcct cccatgctac tgctgtgacc
     1321 acctcaaaca tcccagtcgc caaggtggtg ccccagcaga tcacgcacac ttctcctcgg
     1381 atccagccag actaccctgc cgagaggagt agcctgattc ccatctccgg acatcgggcc
     1441 tctcccaatc ctgtggccat ggaaacccga agtgacaaca gaccgtctgt tcccgttcag
     1501 ttccaatatt ttttgccaac ttacccccct tctgcatacc cactggcggc acatacctac
     1561 accccaatca ccagttccgt gtccactatc cgacagtatc cagtttcagc tcaggctcca
     1621 aactctgcca tcacagctca gactggtgtt ggggtagcgt ctaccgtcca cctaaacccc
     1681 atgcagttga tgacagtgga tgcatcgcat gctcgacata ttcaagggat ccagccagca
     1741 cccatcagta cccagggtat ccagccggcc cccattggga ccccagggat acagcctgca
     1801 ccacttggca cacagggaat tcactcagca accccaatca acacacaagg gcttcagcct
     1861 gcacctatgg gtactcagca gcctcagcct gaaggaaaga cttcagcagt ggtgttggca
     1921 gatggagcca caattgtggc caaccctatt agcaatccat tcagtgctgc tccagcagca
     1981 acaaccgtgg tgcagaccca cagccagagt gctagcacca acgctcccgc ccagggctca
     2041 tcgccacggc caagcatact ccggaagaaa cctgccacag atggaatggc agttcggaaa
     2101 accctcattc ctcctcagcc tcctgatgtt gctagtcctc gagtggaaag ctctatgcgg
     2161 agtacgtctg ggtcacctag gcctgcaggt gccaaaccca agtctgaaat ccacgtgtct
     2221 atggccactc cggtcactgt gtccatggag actgtatcca atcaaaataa tgatcagcct
     2281 accattgccg tccctccaac tgcccagcag cccccaccga ccattccaac tatgattgca
     2341 gcagccagtc ccccgtcaca accagccgtt gccctttcaa ccattcctgg agcggtcccc
     2401 atcactccac ccatcaccac cattgcagct gcaccacctc catcagtcac tgtgggtggc
     2461 agtctttcct ccgtcttggg ccctcccgtt cctgaaatta aagtgaaaga agaagtagaa
     2521 ccaatggata tcatgaggcc agtttctgca gttcctccac tggctaccaa cactgtgtct
     2581 ccatctcttg cattgctggc aaacaacttg tccatgccta caagtgacct accacctggt
     2641 gcctccccaa ggaaaaagcc tcgaaagcaa cagcatgtga tctcaacaga agaaggtgac
     2701 atgatggaga caaacagcac tgatgatgag aagtccactg ccaagagtct tctggtgaag
     2761 gctgagaagc gcaagtctcc tcccaaggag tatattgatg aggaaggtgt gagatatgtc
     2821 ccagtgcgtc caagaccccc cattactttg cttcgtcact atcggaaccc ctggaaagct
     2881 gcttaccacc actttcagag gtacagtgac gtccgggtca aagaggagaa gaaagctatg
     2941 ctgcaggaaa tagctaatca gaaaggagta tcctgtcgtg ctcaaggctg gaaagtccac
     3001 ctctgtgctg cccagttact acagctgacg aatctagaac atgatgtcta tgaaagactt
     3061 actaacctgc aggaagggat tatcccaaag aaaaaagcag caacagatga tgatctccac
     3121 cgaataaacg aactgataca gggaaatatg cagaggtgta aacttgtgat ggatcaaatc
     3181 agtgaagcca gagactccat gcttaaggtt ttagatcata aagaccgtgt cctgaagctg
     3241 cttaacaaga acgggactgt caaaaaagtg tccaaattga agcgaaagga aaaagtctag
     3301 acccagaaca atcaggagat tggaagcaaa tttatgaaga atgatggtgg gggtgggggg
     3361 agggttttgg ttttttccaa agtggaacat tgaaataaag gaagtgttcc ttagttcccg
     3421 tgtgaaagca gaggaaccca tgacatccaa gggcgtgaaa ggatcagagc tgactggaca
     3481 tagtgagctg ccttcttgcg ttcgggtgca cccctgttaa acctgatctg tgtcataagt
     3541 gactccggat gcatcagtgt ccaccagttg gaagcaatga caaggatggc tggctggtgt
     3601 ttttcagcct tccggtttat agactgtatt tatctagtgg attcctgcag gccccatact
     3661 gagcctggac tgaaagtatc cactcggacc atctgttatc tctctacact gaaaataaaa
     3721 cctcttccac ccaccccatt cggttcttct gcctgacctt caaatgccca tgttggcctt
     3781 ttacagcagt gccacggcac caagcgagct gccacatctc acactctaaa gggtttgaac
     3841 tattagttct tgtcattttt taaaaaaaac cattcccaag tgaaattgtt atatcgtctg
     3901 tcttgcgtgt gtcagaactg ggtttttgtg gaggttcaga gcaggcaaca ccataagttg
     3961 ctctcagatc cttgttctga agtacattct tggttatctg tacttctgta gctggtgtga
     4021 tgctgttaat tgtatgtacc acacatctcc agacgttaat aaaggactca aagaggtttt
     4081 tgta
//
