LOCUS       NM_001129993            4578 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens SANT and BTB domain regulator of CSR (SANBR),
            transcript variant 1, mRNA.
ACCESSION   NM_001129993
VERSION     NM_001129993.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4578)
  AUTHORS   Zheng,S., Matthews,A.J., Rahman,N., Herrick-Reynolds,K., Sible,E.,
            Choi,J.E., Wishnie,A., Ng,Y.K., Rhodes,D., Elledge,S.J. and
            Vuong,B.Q.
  TITLE     The uncharacterized SANT and BTB domain-containing protein SANBR
            inhibits class switch recombination
  JOURNAL   J Biol Chem 296, 100625 (2021)
   PUBMED   33831416
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA222969.1, AL833595.1, AB058744.1 and CA421892.1.
            
            On May 17, 2019 this sequence version replaced NM_001129993.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.257722.1,
                                           SRR1660807.217111.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000402291.6/ ENSP00000385579.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-555               DA222969.1         1-555
            556-1204            AL833595.1         495-1143
            1205-3828           AL833595.1         1145-3768
            3829-4349           AB058744.1         2941-3461
            4350-4578           CA421892.1         15-243              c
FEATURES             Location/Qualifiers
     source          1..4578
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p15"
     gene            1..4578
                     /gene="SANBR"
                     /gene_synonym="KIAA1841"
                     /note="SANT and BTB domain regulator of CSR"
                     /db_xref="GeneID:84542"
                     /db_xref="HGNC:HGNC:29387"
                     /db_xref="MIM:620213"
     exon            1..157
                     /gene="SANBR"
                     /gene_synonym="KIAA1841"
                     /inference="alignment:Splign:2.1.0"
     exon            158..294
                     /gene="SANBR"
                     /gene_synonym="KIAA1841"
                     /inference="alignment:Splign:2.1.0"
     exon            295..453
                     /gene="SANBR"
                     /gene_synonym="KIAA1841"
                     /inference="alignment:Splign:2.1.0"
     CDS             304..2460
                     /gene="SANBR"
                     /gene_synonym="KIAA1841"
                     /note="isoform a is encoded by transcript variant 1; SANT
                     and BTB domain regulator of class switch recombination"
                     /codon_start=1
                     /product="SANT and BTB domain regulator of class switch
                     recombination isoform a"
                     /protein_id="NP_001123465.1"
                     /db_xref="CCDS:CCDS46296.1"
                     /db_xref="GeneID:84542"
                     /db_xref="HGNC:HGNC:29387"
                     /db_xref="MIM:620213"
                     /translation="MSRGYSENNNFLNNNNQMVLDMILYPLIGIPQTINWETIARLVP
                     GLTPKECAKRFDELKSSGSSPVDNQYNSLMAAGESPVETLATYIKSSLLDIHGEFQET
                     PVGHDAVSKTGRHSIASTRNCSSESENCTTHNGGEMTEESEGPNMVIHVCDEAKNLKE
                     DFTCPRDLLISEMKYFAEYLSMDAQRWEEVDISVHCDVHIFNWLIKYIKRNTKENKDC
                     EMPTLEPGNVISILISSEFLKMDSLVEQCIQYCHKNMNAIVATPCNMNCINANLLTRI
                     ADLFSHNEVDDLKDKKDKFKSKLFCKKIERLFDPEYLNPDSRSNAATLYRCCLCKKLL
                     TKETERRIPCIPGKINVDRRGNIVYIHIRDKTWDVHEYLNSLFEELKSWRDVYWRLWG
                     TINWLTCSRCYQAFLCIEFSHCQYHSETVVYPTAASSLNTVGTGIYPCCNQKVLRFDP
                     TQLTKGCKVRDHMVTLRDQGEGGDLPSCPTARMLDDLHKYRDVIVVPFSKDTVSDVGV
                     GLCDEKGIECDVLLEPNTPWGPKTGELNAFLSLKNWTLQLKQQSLFSEEEEYTTGSEV
                     TEDEVGDEEEVSKKQRKKEKPKKFTRQPKKQVSSPCAQRKEKALEKSASRDVSPFVMS
                     MQKNKWDATRSLRFNQDAQREDDQRRMTEITGHLIKMRLGDLDRVKSKEAKEFAGGIY
                     SRLEAQIKASVPVSARQSSSEKNTRSKSRFGQGRPA"
     exon            454..640
                     /gene="SANBR"
                     /gene_synonym="KIAA1841"
                     /inference="alignment:Splign:2.1.0"
     exon            641..734
                     /gene="SANBR"
                     /gene_synonym="KIAA1841"
                     /inference="alignment:Splign:2.1.0"
     exon            735..973
                     /gene="SANBR"
                     /gene_synonym="KIAA1841"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1032
                     /gene="SANBR"
                     /gene_synonym="KIAA1841"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1193
                     /gene="SANBR"
                     /gene_synonym="KIAA1841"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1280
                     /gene="SANBR"
                     /gene_synonym="KIAA1841"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1391
                     /gene="SANBR"
                     /gene_synonym="KIAA1841"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1515
                     /gene="SANBR"
                     /gene_synonym="KIAA1841"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1668
                     /gene="SANBR"
                     /gene_synonym="KIAA1841"
                     /inference="alignment:Splign:2.1.0"
     exon            1669..1814
                     /gene="SANBR"
                     /gene_synonym="KIAA1841"
                     /inference="alignment:Splign:2.1.0"
     exon            1815..1914
                     /gene="SANBR"
                     /gene_synonym="KIAA1841"
                     /inference="alignment:Splign:2.1.0"
     exon            1915..1947
                     /gene="SANBR"
                     /gene_synonym="KIAA1841"
                     /inference="alignment:Splign:2.1.0"
     exon            1948..2047
                     /gene="SANBR"
                     /gene_synonym="KIAA1841"
                     /inference="alignment:Splign:2.1.0"
     exon            2048..2139
                     /gene="SANBR"
                     /gene_synonym="KIAA1841"
                     /inference="alignment:Splign:2.1.0"
     exon            2140..2168
                     /gene="SANBR"
                     /gene_synonym="KIAA1841"
                     /inference="alignment:Splign:2.1.0"
     exon            2169..2242
                     /gene="SANBR"
                     /gene_synonym="KIAA1841"
                     /inference="alignment:Splign:2.1.0"
     exon            2243..2331
                     /gene="SANBR"
                     /gene_synonym="KIAA1841"
                     /inference="alignment:Splign:2.1.0"
     exon            2332..2423
                     /gene="SANBR"
                     /gene_synonym="KIAA1841"
                     /inference="alignment:Splign:2.1.0"
     exon            2424..4578
                     /gene="SANBR"
                     /gene_synonym="KIAA1841"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4559..4564
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SANBR"
                     /gene_synonym="KIAA1841"
                     /note="hexamer: AATAAA"
     polyA_site      4578
                     /gene="SANBR"
                     /gene_synonym="KIAA1841"
                     /note="major polyA site"
ORIGIN      
        1 agtctccgca gccgcctgca agcgggcggg ggcggggtgt gaggcgctgc ggacggggtt
       61 gcgggctcgg tagcggcagc ttcagggcgc gagcgcgggc ggtgccgacc actgcaggta
      121 acagaggcgc tgcgagggca gccgcggccc tgtggagatg aggaaattga ggcacagaga
      181 ttaactaatc tgaaccagat aatgccataa gtagtagaac tgcgatgcaa acttggacag
      241 tctgactcca gagtctgcac acttaaccac tccactattc tggccttcta caagttccaa
      301 aagatgagtc gtggatattc agaaaacaac aatttcctga acaataataa ccaaatggta
      361 ttggacatga tcctttatcc attaattgga atccctcaga ctatcaactg ggaaactata
      421 gcaaggctcg tgcctggatt aacaccaaaa gagtgtgcaa aaaggtttga tgaattaaag
      481 agcagtggaa gctcgcctgt tgacaaccag tataattccc taatggctgc tggagagagt
      541 cctgttgaaa ctttagccac atatatcaaa tcctcacttc ttgacataca tggagaattt
      601 caggagactc cagttggaca tgatgcagtt tccaaaactg gaagacatag tatagcttcc
      661 acaaggaatt gttcttcaga aagtgaaaat tgtactactc ataatggtgg agaaatgact
      721 gaagaatctg aagggccaaa catggtgatc catgtgtgtg atgaagcaaa aaacttgaaa
      781 gaagatttta cttgcccgcg agatcttttg atatcagaaa tgaagtactt tgctgaatat
      841 ttatctatgg atgcccagcg ctgggaagag gtggacattt cagttcattg cgacgttcac
      901 attttcaact ggttgataaa atacattaaa aggaacacta aggagaataa agattgtgag
      961 atgcccactt tagagccagg aaatgtcatt tcaattctta tttcttcgga gtttttaaaa
     1021 atggattcac tagttgaaca gtgtattcag tattgccaca aaaatatgaa tgccatagta
     1081 gctaccccat gcaacatgaa ctgtattaat gcaaatcttc tcacacgtat agctgatctg
     1141 ttctcacaca atgaagttga tgatttaaag gacaaaaaag ataaatttaa aagcaaactt
     1201 ttttgtaaga agattgaaag actgtttgat cctgagtact tgaatccaga ttctcggagt
     1261 aatgcagcaa cattgtatag atgctgtttg tgtaagaaac ttttaacaaa agaaacagaa
     1321 agaagaattc cttgcattcc tggaaaaatc aatgtggatc gacgtggaaa tattgtctat
     1381 attcacataa gagataagac atgggatgtt catgagtatt tgaatagtct tttcgaagaa
     1441 ttaaaatctt ggagagatgt atactggcga ttgtggggaa caatcaattg gctgacttgt
     1501 tcaagatgtt atcaggcctt tctctgtatt gaattttcac attgtcaata ccactcagaa
     1561 acagtggttt atcctactgc agcaagttca ttgaatactg ttggcactgg aatttatccc
     1621 tgctgtaacc aaaaggttct tcggtttgat cctactcagc ttacaaaggg ctgtaaagtg
     1681 agggaccaca tggttacact tcgtgatcaa ggtgaaggcg gagatttgcc gtcctgtccc
     1741 actgctagaa tgttggacga tttgcacaag tacagagatg tcattgttgt gcctttttca
     1801 aaagatacag ttagtgatgt tggggttggc ctctgtgatg aaaagggtat agaatgtgat
     1861 gttttactgg agccaaatac accatggggt cccaaaactg gggagctcaa tgctttcttg
     1921 tcattgaaaa actggactct acaactgaaa caacagtcac tgttttcaga agaagaagaa
     1981 tataccactg gatctgaggt cactgaagat gaagttggag atgaagaaga agtatccaag
     2041 aaacaaagga aaaaggagaa gccaaagaag ttcactagac aaccaaaaaa gcaggtatct
     2101 tcaccctgtg cccagaggaa agaaaaggca ttggagaagt cagcttctag agatgtgtct
     2161 cctttcgtta tgagtatgca gaagaataag tgggatgcca caagatcctt gagattcaac
     2221 caggatgcac aaagagaaga cgatcaacgg cgaatgactg aaattacagg gcacctaata
     2281 aaaatgagat tgggggatct ggaccgagtc aagtcaaagg aagcaaaaga atttgcagga
     2341 ggtatttatt ccaggctgga agcacaaatc aaggcctcag tgccagttag tgcacgccaa
     2401 agcagctcag agaaaaacac aaggtctaaa agtcgttttg gtcaagggcg tcctgcataa
     2461 agtaccttaa aatataagta aaaagagaga aggcactctt ctggacatct gaaattgctc
     2521 acttcttgaa gatcttcaga acaatgactt ccaactgttt tatgttatta ttattttaat
     2581 ccacataaat cataattcta aaagaaatgc atagttaggt tttatgaaaa tctaattgta
     2641 aatatgaaac tttttaaatc tgattttctt ctaatatcat tctaggctat gtagaaagca
     2701 attatttaca aatttgcata gttgagactc ccagtgtttt cctttattta tttgaaaaag
     2761 aaaggcctaa actgtcaggt agccaagttt ttttaagacc ttaaaagtta ggggaacaca
     2821 actggtagtg ttaccatgca tggcactgat tgtagtatgt ctttggagct gtaaatcttg
     2881 agatagcatt gagaactgca ggttgtgtga cgaaattccc aatgatgcta attttaagtc
     2941 tgcatgaata ttaaggagtg acaggtctca agactgcatt aaatgaagtt tcagggtaag
     3001 gtatttcagt actgtgttgg gcagaagggt taattttttt cagcattata tcgtggaaag
     3061 tacaatgtta atccaacttt tttttctttc agtttttaat gcttatctat tgatcatctg
     3121 agctggaatt actgattatt actctgtcct ctgtgaaact agtggcattc tgaatttggt
     3181 aaaataacca ttgatagttt taggatagta aatcatttct gttatatgag acacccactg
     3241 tacagttctc agggctctaa aacccaacca tatttctgta accattcaaa taactcctta
     3301 aaacagttat acttgctagt tcggtctaaa attttccaaa tacattagat aggtgaaaat
     3361 ttgcatatat tcaagaaaaa tcaaaataaa attctatttt ataaatcatg tttaaatttt
     3421 tctagccagg cagaaagagt gctcagggaa aatttgttcc aaactataac catataataa
     3481 attatgtgtt tgtaaattat atgtaggtct ctgaaaaact ttaagatgca ctgtttctat
     3541 ttttttaagt cttaatttgc cttataactg acatttcttc aaattattca gagaacagac
     3601 tttaataatg tgtgacaaaa gagcaatttc cattgaaata ttgaagtgtt acactcagtt
     3661 tacacgtaca gaaatcattc tttttagtga gtcttttagt tgataaatga agctagatgt
     3721 tatttgataa ctggctttgc caaggttttt gaactgctgt ttagaaattt tgttcccatt
     3781 tatatttgtt tcaattgttt gatactgtgg aaatagactt ttattttcga aagaaaatgt
     3841 cttgtagtac atattatatg taagtactct gttaaatacc agagtttttt ttgtagttta
     3901 ctgtgttttc tgattaaagg atttggattt gtacatgtaa acagtgctgt aatggtcacg
     3961 actagataag gaaaaaatat atatgctctt ttgattttta actgatggta aaaaggcaaa
     4021 ctgcttctcc cctgggaggc ctataccact gaattaattt ttacaaacca gagtttatca
     4081 gaatttgatt ctcttcagaa tgcttttggc caggtgtagt ggctcacgcc agtaatccca
     4141 gcactttggg aggccgaggc gggcagatca cctgaggtca ggagtttgag accagcctgg
     4201 ccaacgtggt gaaaccctat ctctactaaa aatacaaaaa gattagccag gcatggtggc
     4261 atacacctgt agtcccagct actcgggagg ctgaggcaca agaattgttt gaacccgggt
     4321 ggcagaggtt gcagtgagct gagatcatgt ttctgcgctc ctagcctggg tgacagagca
     4381 agactccatc tcaatttaaa acaaaaaaag aatgtgtttt taattttgtt aatgtttgtc
     4441 tgttatacat agcactggta ccgcaaacat tttacttaaa ctcttaatag catttctttc
     4501 gccagatact ttaatatttc accttacatt aatcctggat tcacatttct ttaattgaaa
     4561 taaatgttaa tgacaaaa
//
