LOCUS       NM_152556               3940 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  Homo sapiens S-adenosylmethionine sensor upstream of mTORC1
            (SAMTOR), mRNA.
ACCESSION   NM_152556
VERSION     NM_152556.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3940)
  AUTHORS   Tang,X., Zhang,Y., Wang,G., Zhang,C., Wang,F., Shi,J., Zhang,T. and
            Ding,J.
  TITLE     Molecular mechanism of S-adenosylmethionine sensing by SAMTOR in
            mTORC1 signaling
  JOURNAL   Sci Adv 8 (26), eabn3868 (2022)
   PUBMED   35776786
REFERENCE   2  (bases 1 to 3940)
  AUTHORS   Gu,X., Orozco,J.M., Saxton,R.A., Condon,K.J., Liu,G.Y.,
            Krawczyk,P.A., Scaria,S.M., Harper,J.W., Gygi,S.P. and
            Sabatini,D.M.
  TITLE     SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway
  JOURNAL   Science 358 (6364), 813-818 (2017)
   PUBMED   29123071
  REMARK    GeneRIF: SAMTOR is a S-adenosylmethionine sensor that links
            methionine and one-carbon metabolism to mTORC1 signaling.
REFERENCE   3  (bases 1 to 3940)
  AUTHORS   Sharma,S., Watzinger,P., Kotter,P. and Entian,K.D.
  TITLE     Identification of a novel methyltransferase, Bmt2, responsible for
            the N-1-methyl-adenosine base modification of 25S rRNA in
            Saccharomyces cerevisiae
  JOURNAL   Nucleic Acids Res 41 (10), 5428-5443 (2013)
   PUBMED   23558746
REFERENCE   4  (bases 1 to 3940)
  AUTHORS   Anney,R.J., Lasky-Su,J., O'Dushlaine,C., Kenny,E., Neale,B.M.,
            Mulligan,A., Franke,B., Zhou,K., Chen,W., Christiansen,H.,
            Arias-Vasquez,A., Banaschewski,T., Buitelaar,J., Ebstein,R.,
            Miranda,A., Mulas,F., Oades,R.D., Roeyers,H., Rothenberger,A.,
            Sergeant,J., Sonuga-Barke,E., Steinhausen,H., Asherson,P.,
            Faraone,S.V. and Gill,M.
  TITLE     Conduct disorder and ADHD: evaluation of conduct problems as a
            categorical and quantitative trait in the international multicentre
            ADHD genetics study
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 147B (8), 1369-1378 (2008)
   PUBMED   18951430
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA738444.1, BC114615.1, AL834437.1 and AK056380.1.
            
            On Nov 23, 2018 this sequence version replaced NM_152556.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL834437.1, SRR1803615.134529.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000297145.9/ ENSP00000297145.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 DA738444.1         3-8
            7-1375              BC114615.1         1-1369
            1376-2609           AL834437.1         1173-2406
            2610-2927           AK056380.1         2613-2930
            2928-3940           AL834437.1         2725-3737
FEATURES             Location/Qualifiers
     source          1..3940
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q31.1"
     gene            1..3940
                     /gene="SAMTOR"
                     /gene_synonym="BMT2; C7orf60"
                     /note="S-adenosylmethionine sensor upstream of mTORC1"
                     /db_xref="GeneID:154743"
                     /db_xref="HGNC:HGNC:26475"
                     /db_xref="MIM:617855"
     exon            1..285
                     /gene="SAMTOR"
                     /gene_synonym="BMT2; C7orf60"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..1343
                     /gene="SAMTOR"
                     /gene_synonym="BMT2; C7orf60"
                     /note="UPF0532 protein C7orf60; probable methyltransferase
                     BTM2 homolog; probable methyltransferase BMT2 homolog;
                     base methyltransferase of 25S rRNA 2 homolog"
                     /codon_start=1
                     /product="S-adenosylmethionine sensor upstream of mTORC1"
                     /protein_id="NP_689769.2"
                     /db_xref="CCDS:CCDS43634.1"
                     /db_xref="GeneID:154743"
                     /db_xref="HGNC:HGNC:26475"
                     /db_xref="MIM:617855"
                     /translation="MEPGAGGRNTARAQRAGSPNTPPPREQERKLEQEKLSGVVKSVH
                     RRLRKKYREVGDFDKIWREHCEDEETLCEYAVAMKNLADNHWAKTCEGEGRIEWCCSV
                     CREYFQNGGKRKALEKDEKRAVLATKTTPALNMHESSQLEGHLTNLSFTNPEFITELL
                     QASGKIRLLDVGSCFNPFLKFEEFLTVGIDIVPAVESVYKCDFLNLQLQQPLQLAQDA
                     IDAFLKQLKNPIDSLPGELFHVVVFSLLLSYFPSPYQRWICCKKAHELLVLNGLLLII
                     TPDSSHQNRHAMMMKSWKIAIESLGFKRFKYSKFSHMHLMAFRKISLKTTSDLVSRNY
                     PGMLYIPQDFNSIEDEEYSNPSCYVRSDIEDEQLAYGFTELPDAPYDSDSGESQASSI
                     PFYELEDPILLLS"
     exon            286..427
                     /gene="SAMTOR"
                     /gene_synonym="BMT2; C7orf60"
                     /inference="alignment:Splign:2.1.0"
     exon            428..598
                     /gene="SAMTOR"
                     /gene_synonym="BMT2; C7orf60"
                     /inference="alignment:Splign:2.1.0"
     exon            599..713
                     /gene="SAMTOR"
                     /gene_synonym="BMT2; C7orf60"
                     /inference="alignment:Splign:2.1.0"
     exon            714..3940
                     /gene="SAMTOR"
                     /gene_synonym="BMT2; C7orf60"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3916..3921
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SAMTOR"
                     /gene_synonym="BMT2; C7orf60"
                     /note="hexamer: ATTAAA"
     polyA_site      3940
                     /gene="SAMTOR"
                     /gene_synonym="BMT2; C7orf60"
                     /note="major polyA site"
ORIGIN      
        1 gtcgctccgg ttcctctgcc tcctctggct gctgcctccg cagctccctc ctcctacccc
       61 acctcctcca tctggggagc gtctgcgggg gcctgagggg cggcggcggc ggcggcggct
      121 gcgatatgga gccaggggcc ggcggccgaa atactgctcg tgcgcagagg gccgggtccc
      181 cgaacactcc gccgccccgg gagcaggagc ggaaactgga gcaggagaag ctctccggtg
      241 tggtgaagag cgtccaccgg cggctccgca agaagtaccg agaagtggga gattttgata
      301 agatctggcg agaacactgt gaggatgaag aaactctttg tgaatatgcc gttgcaatga
      361 aaaatttggc agataatcat tgggcaaaaa cttgtgaggg cgaaggtcgt attgaatggt
      421 gttgtagtgt atgcagagaa tatttccaaa atggtgggaa gagaaaagca cttgagaaag
      481 atgaaaaaag agctgtactt gccactaaga ccactccagc cttaaatatg catgagtctt
      541 ctcaacttga aggtcattta accaacctca gctttacaaa ccctgaattt ataactgagt
      601 tgctacaagc ctcaggaaaa atcagattac ttgatgttgg cagctgcttt aacccatttc
      661 tgaagtttga agaatttcta actgttggca tagatattgt acctgctgta gagagtgtct
      721 ataaatgtga tttcctgaac ttacagcttc agcaaccact ccagcttgca caggatgcta
      781 tagatgcttt tttgaagcag ctgaaaaacc ctattgattc tcttcctgga gagcttttcc
      841 atgtggttgt tttctctctc cttctttctt attttccatc tccttaccag cgatggattt
      901 gctgcaagaa agcccatgaa ctgttagtgt taaatggttt attactaatc atcacacctg
      961 attcctccca tcagaaccgt catgctatga tgatgaaaag ctggaagatt gctatagagt
     1021 ccctgggctt taaacgcttc aagtactcaa aattttcaca tatgcatctg atggcattta
     1081 ggaaaatctc tctaaaaacc acaagtgact tggttagtag gaactaccca ggaatgttat
     1141 atattcctca agatttcaac agtatagaag atgaggaata ttctaaccct tcctgctatg
     1201 ttcgatcaga tatagaagat gaacaactag catatggttt cacagaactc cctgatgcgc
     1261 catatgactc agattctgga gaaagtcaag ccagctctat tcctttctat gagctagaag
     1321 accccatatt acttttaagt taatatagaa gcaaaaagcc cctttcagtc caggctccta
     1381 aactaattgc ttacaccaat tggaaatact aacatgaact cagtactgaa aacctggttt
     1441 gcataaaaga aatgcagagg tttacagagt ttgctatttt tttctacttc tcaattttaa
     1501 aatttattct tatatagaaa gcttaaagtt tcatgcagag tgactcatgt catagcagaa
     1561 actactgtta ctttagcatt tagcactatc atagaaaggt acctttttct ctttagtgct
     1621 attgtgaaaa caagcataat ttgctatatg ttttcctttt caacttttca gtgttgacta
     1681 taaaccattg aatggaaaac tttaagatgt agaaagctgt agattgcact ttgatgactc
     1741 acaagttaaa tgtgatacag aaaaatagat cggttagttg ttttgtgatg cacttatctt
     1801 tttctttttt ctaactaaaa ttgtgatgtt acagaaagtc attttatgtt ccttttttgt
     1861 ctgatgatcc aatatttact gaactttttg taattggtga taattctttt tatttcttcc
     1921 ttatattaaa agctcatttg acagcatcag acattggggg agagatgtcc cccaaagtgt
     1981 gtattctaat tttattagcc ctatccaata aacaccattg ccaaagtagt attttcataa
     2041 ctttcttgtt gatttgggcc ttggtgtgaa gtatatttac ctgagagttc acttttactt
     2101 ttcttaaact taggcttcat ttacaaaatg ttttatttaa gcaaggaaca atgtaatact
     2161 caataatgac ctaaaacacc tttttgaaag ggtttgcact tggaagagag tttatgttct
     2221 gttgaaacca actttgatag ggtcctcacc tttccgttaa ggaggtgccg cactacaagt
     2281 ttcaaattat atggaaaaac ctaaaattaa ccctctgttg gtgatctcat aaaatggttt
     2341 tgaccttttg gtatcttaat ttctatctaa actttatcag aaaattttct ttgaatatat
     2401 caattagttg gctgtgggaa ttttcccttt ccacattaat aaatgccttt ctgtgtttct
     2461 gaatcagaag caaatgatta gggaaaaata tatgtccaaa caagacaaga ttagtttaaa
     2521 cagttaagaa catttagtcc acattgtctt gtcagccagc aattgtcatg gaagctatca
     2581 tttttaagag tgccactgtg tggatttttt tttcaagtgg ttattacatt aaaattacct
     2641 catactgagg tttttgcact gaaatatcac agtttcagat ttcatggtta atgttgtgcg
     2701 tatgtttgta tgtttttaaa ggaaacttgc attttcaata gttgatccta aatttcataa
     2761 actgcacttc tttactctgg taaagctgat gtttttgtgc ttattgtgaa ttgccgtagt
     2821 acctttgaat gtcaaacttt atttagaaat ataaaactta tcctttatga tataaatggt
     2881 tgagtgtatg tacccagtat ttctaattaa atttcacatg ctaaattaat gaaagtaaca
     2941 agattgtaat tttttaaagt cagttgatta aatgcaataa atattggttg ctcaaatatg
     3001 ccacaaataa ctcgaaattt ttcatttact ttcaacagca taagattctt taatatttag
     3061 gattgactgt tctttccagt taagcactga aggattatgt cttgtagctt ccccaagaga
     3121 aggggaagga aaaaaaagca ctatgttaag gataatacag aactcttttg aactattttg
     3181 gtagtacctt ttaccatact gtttgctttt tgatttgggt aaatatctta agagcaaaga
     3241 aaacaataca ccaaatgaaa atgctttgaa agtaaatgaa aacagcgctt ttgaaaggct
     3301 ggtatagtat gaccctggag tcagcctttg tgttacagcg aaaatgttgg tgctataaat
     3361 tctgattgtt tacagatgtt gattctgctt atgctccaaa gtgtgcatga tgtattttac
     3421 gtagtactct gaggaagtct ctttataaaa cctactacca cttagtataa atttgtttga
     3481 atttatatca tttgttactg taaattcagc ttattccaat taggttggca cagatttaaa
     3541 ctgatacaca ttccacaaaa accaattcag tgtataagta ttgaagtata agcagtcatt
     3601 gcagcttgat gccagatcat gtatgtaata acaagtggaa gttaataggg ccttctaata
     3661 ctgtatgggt actcctaaga attatttcat tttggatata aagaagttat gaggcctcct
     3721 gtcacattca cagctggttc tccaaaataa tttggttgtt tcaaaaacaa atggtaatca
     3781 tttggttgga ttcttcagta tcatgactag atcatgtggt tttaccatag ttgccaagtg
     3841 gtgggaggta gcatacctga aaatgtacgt gtgtgtttgt tgtatttttt cacattttgt
     3901 gaacaaagca catttattaa aaattttaaa ttttctagta
//
