LOCUS       NM_152703               7150 bp    mRNA    linear   PRI 06-OCT-2024
DEFINITION  Homo sapiens sterile alpha motif domain containing 9 like (SAMD9L),
            transcript variant 1, mRNA.
ACCESSION   NM_152703 XM_005250192 XM_374489 XM_499341
VERSION     NM_152703.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7150)
  AUTHORS   Zhang,L., Chen,W., Shi,Z. and Shang,Z.
  TITLE     PARP14 correlates with GBM proliferation and poor prognosis by
            elevating expression of SAMD/SAMD9L
  JOURNAL   Ir J Med Sci 193 (2), 585-593 (2024)
   PUBMED   37612499
  REMARK    GeneRIF: PARP14 correlates with GBM proliferation and poor
            prognosis by elevating expression of SAMD/SAMD9L.
REFERENCE   2  (bases 1 to 7150)
  AUTHORS   Kaixuan,X., Xiaobin,Z., Jiaxuan,T., Shihui,L., Xinxin,W.,
            Shuwei,H., Penggao,D. and Xiang,L.
  TITLE     Functional Study of SAMD9L in Familial Gastric Cancer
  JOURNAL   Turk J Gastroenterol 34 (5), 472-482 (2023)
   PUBMED   37158533
  REMARK    GeneRIF: Functional Study of SAMD9L in Familial Gastric Cancer.
REFERENCE   3  (bases 1 to 7150)
  AUTHORS   Gahr,S., Perinetti Casoni,G., Falk-Paulsen,M., Maschkowitz,G.,
            Bryceson,Y.T. and Voss,M.
  TITLE     Viral host range factors antagonize pathogenic SAMD9 and SAMD9L
            variants
  JOURNAL   Exp Cell Res 425 (2), 113541 (2023)
   PUBMED   36894052
  REMARK    GeneRIF: Viral host range factors antagonize pathogenic SAMD9 and
            SAMD9L variants.
REFERENCE   4  (bases 1 to 7150)
  AUTHORS   Shang,Q.W., Xue,L., Zhang,L.P. and Lu,A.D.
  TITLE     [Pancytopenia in children caused by SAMD9/9L mutation: 5 cases
            report and literature review]
  JOURNAL   Zhonghua Xue Ye Xue Za Zhi 44 (4), 340-343 (2023)
   PUBMED   37357006
  REMARK    GeneRIF: [Pancytopenia in children caused by SAMD9/9L mutation: 5
            cases report and literature review].
            Review article
REFERENCE   5  (bases 1 to 7150)
  AUTHORS   Hensel,J., Duex,J.E., Owens,C., Dancik,G.M., Edwards,M.G.,
            Frierson,H.F. and Theodorescu,D.
  TITLE     Patient Mutation Directed shRNA Screen Uncovers Novel Bladder Tumor
            Growth Suppressors
  JOURNAL   Mol Cancer Res 13 (9), 1306-1315 (2015)
   PUBMED   26078295
REFERENCE   6  (bases 1 to 7150)
  AUTHORS   Wang,Q., Zhai,Y.Y., Dai,J.H., Li,K.Y., Deng,Q. and Han,Z.G.
  TITLE     SAMD9L inactivation promotes cell proliferation via facilitating
            G1-S transition in hepatitis B virus-associated hepatocellular
            carcinoma
  JOURNAL   Int J Biol Sci 10 (8), 807-816 (2014)
   PUBMED   25076857
  REMARK    GeneRIF: The findings highlight a novel tumor-suppressive role of
            SAMD9L inactivation by somatic mutation and decreased expression in
            human HBV-related HCC
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 7150)
  AUTHORS   Nagamachi,A., Matsui,H., Asou,H., Ozaki,Y., Aki,D., Kanai,A.,
            Takubo,K., Suda,T., Nakamura,T., Wolff,L., Honda,H. and Inaba,T.
  TITLE     Haploinsufficiency of SAMD9L, an endosome fusion facilitator,
            causes myeloid malignancies in mice mimicking human diseases with
            monosomy 7
  JOURNAL   Cancer Cell 24 (3), 305-317 (2013)
   PUBMED   24029230
REFERENCE   8  (bases 1 to 7150)
  AUTHORS   Lemos de Matos,A., Liu,J., McFadden,G. and Esteves,P.J.
  TITLE     Evolution and divergence of the mammalian SAMD9/SAMD9L gene family
  JOURNAL   BMC Evol Biol 13, 121 (2013)
   PUBMED   23758988
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 7150)
  AUTHORS   Li,C.F., MacDonald,J.R., Wei,R.Y., Ray,J., Lau,K., Kandel,C.,
            Koffman,R., Bell,S., Scherer,S.W. and Alman,B.A.
  TITLE     Human sterile alpha motif domain 9, a novel gene identified as
            down-regulated in aggressive fibromatosis, is absent in the mouse
  JOURNAL   BMC Genomics 8, 92 (2007)
   PUBMED   17407603
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 7150)
  AUTHORS   Raskind,W.H., Chen,D.H. and Bird,T.
  TITLE     SAMD9L Ataxia-Pancytopenia Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   28570036
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC000119.1, AY195586.1,
            BC127117.1 and AB095926.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_152703.4.
            
            Summary: This gene encodes a cytoplasmic protein that acts as a
            tumor suppressor but also plays a key role in cell proliferation
            and the innate immune response to viral infection. The encoded
            protein contains an N-terminal sterile alpha motif domain.
            Naturally occurring mutations in this gene are associated with
            myeloid disorders such as juvenile myelomonocytic leukemia, acute
            myeloid leukemia, and myelodysplastic syndrome. Naturally occurring
            mutations are also associated with hepatitis-B related
            hepatocellular carcinoma, normophosphatemic familial tumoral
            calcinosis, and ataxia-pancytopenia syndrome. [provided by RefSeq,
            Apr 2017].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1-9 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB095926.1, SRR1163657.340727.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000318238.9/ ENSP00000326247.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                AC000119.1         136753-136792       c
            41-1443             AY195586.1         1-1403
            1444-5010           BC127117.1         683-4249
            5011-7150           AB095926.1         4982-7121
FEATURES             Location/Qualifiers
     source          1..7150
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q21.2"
     gene            1..7150
                     /gene="SAMD9L"
                     /gene_synonym="ATXPC; C7DELq; C7orf6; DEL7q; DRIF2;
                     M7MLS1; MLSM7; SCA49; UEF1"
                     /note="sterile alpha motif domain containing 9 like"
                     /db_xref="GeneID:219285"
                     /db_xref="HGNC:HGNC:1349"
                     /db_xref="MIM:611170"
     exon            1..192
                     /gene="SAMD9L"
                     /gene_synonym="ATXPC; C7DELq; C7orf6; DEL7q; DRIF2;
                     M7MLS1; MLSM7; SCA49; UEF1"
                     /inference="alignment:Splign:2.1.0"
     exon            193..456
                     /gene="SAMD9L"
                     /gene_synonym="ATXPC; C7DELq; C7orf6; DEL7q; DRIF2;
                     M7MLS1; MLSM7; SCA49; UEF1"
                     /inference="alignment:Splign:2.1.0"
     exon            457..1112
                     /gene="SAMD9L"
                     /gene_synonym="ATXPC; C7DELq; C7orf6; DEL7q; DRIF2;
                     M7MLS1; MLSM7; SCA49; UEF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1214
                     /gene="SAMD9L"
                     /gene_synonym="ATXPC; C7DELq; C7orf6; DEL7q; DRIF2;
                     M7MLS1; MLSM7; SCA49; UEF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..7150
                     /gene="SAMD9L"
                     /gene_synonym="ATXPC; C7DELq; C7orf6; DEL7q; DRIF2;
                     M7MLS1; MLSM7; SCA49; UEF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             1235..5989
                     /gene="SAMD9L"
                     /gene_synonym="ATXPC; C7DELq; C7orf6; DEL7q; DRIF2;
                     M7MLS1; MLSM7; SCA49; UEF1"
                     /note="neutrophil migration; SAM domain-containing protein
                     9-like"
                     /codon_start=1
                     /product="sterile alpha motif domain-containing protein
                     9-like"
                     /protein_id="NP_689916.2"
                     /db_xref="CCDS:CCDS34681.1"
                     /db_xref="GeneID:219285"
                     /db_xref="HGNC:HGNC:1349"
                     /db_xref="MIM:611170"
                     /translation="MSKQVSLPEMIKDWTKEHVKKWVNEDLKINEQYGQILLSEEVTG
                     LVLQELTEKDLVEMGLPWGPALLIKRSYNKLNSKSPESDNHDPGQLDNSKPSKTEHQK
                     NPKHTKKEEENSMSSNIDYDPREIRDIKQEESILMKENVLDEVANAKHKKKGKLKPEQ
                     LTCMPYPFDQFHDSHRYIEHYTLQPETGALNLIDPIHEFKALTNTETATEVDIKMKFS
                     NEVFRFASACMNSRTNGTIHFGVKDKPHGEIVGVKITSKAAFIDHFNVMIKKYFEESE
                     INEAKKCIREPRFVEVLLQNNTPSDRFVIEVDTIPKHSICNDKYFYIQMQICKDKIWK
                     QNQNLSLFVREGASSRDILANSKQRDVDFKAFLQNLKSLVASRKEAEEEYGMKAMKKE
                     SEGLKLVKLLIGNRDSLDNSYYDWYILVTNKCHPNQIKHLDFLKEIKWFAVLEFDPES
                     MINGVVKAYKESRVANLHFPNQYEDKTTNMWEKISTLNLYQQPSWIFCNGRSDLKSET
                     YKPLEPHLWQRERASEVRKLILFLTDENIMTRGKFLVVFLLLSSVESPGDPLIETFWA
                     FYQALKGMENMLCISVNSHIYQRWKDLLQTRMKMEDELTNHSISTLNIELVNSTILKL
                     KSVTRSSRRFLPARGSSSVILEKKKEDVLTALEILCENECTETDIEKDKSKFLEFKKS
                     KEEHFYRGGKVSWWNFYFSSENYSSDFVKRDSYEKLKDLIHCWAESPKPIFAKIINLY
                     HHPGCGGTTLAMHVLWDLKKNFRCAVLKNKTTDFAEIAEQVINLVTYRAKSHQDYIPV
                     LLLVDDFEEQENVYFLQNAIHSVLAEKDLRYEKTLVIILNCMRSRNPDESAKLADSIA
                     LNYQLSSKEQRAFGAKLKEIEKQHKNCENFYSFMIMKSNFDETYIENVVRNILKGQDV
                     DSKEAQLISFLALLSSYVTDSTISVSQCEIFLGIIYTSTPWEPESLEDKMGTYSTLLI
                     KTEVAEYGRYTGVRIIHPLIALYCLKELERSYHLDKCQIALNILEENLFYDSGIGRDK
                     FQHDVQTLLLTRQRKVYGDETDTLFSPLMEALQNKDIEKVLSAGSRRFPQNAFICQAL
                     ARHFYIKEKDFNTALDWARQAKMKAPKNSYISDTLGQVYKSEIKWWLDGNKNCRSITV
                     NDLTHLLEAAEKASRAFKESQRQTDSKNYETENWSPQKSQRRYDMYNTACFLGEIEVG
                     LYTIQILQLTPFFHKENELSKKHMVQFLSGKWTIPPDPRNECYLALSKFTSHLKNLQS
                     DLKRCFDFFIDYMVLLKMRYTQKEIAEIMLSKKVSRCFRKYTELFCHLDPCLLQSKES
                     QLLQEENCRKKLEALRADRFAGLLEYLNPNYKDATTMESIVNEYAFLLQQNSKKPMTN
                     EKQNSILANIILSCLKPNSKLIQPLTTLKKQLREVLQFVGLSHQYPGPYFLACLLFWP
                     ENQELDQDSKLIEKYVSSLNRSFRGQYKRMCRSKQASTLFYLGKRKGLNSIVHKAKIE
                     QYFDKAQNTNSLWHSGDVWKKNEVKDLLRRLTGQAEGKLISVEYGTEEKIKIPVISVY
                     SGPLRSGRNIERVSFYLGFSIEGPLAYDIEVI"
     regulatory      6281..6286
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SAMD9L"
                     /gene_synonym="ATXPC; C7DELq; C7orf6; DEL7q; DRIF2;
                     M7MLS1; MLSM7; SCA49; UEF1"
                     /note="hexamer: AATAAA"
     polyA_site      6303
                     /gene="SAMD9L"
                     /gene_synonym="ATXPC; C7DELq; C7orf6; DEL7q; DRIF2;
                     M7MLS1; MLSM7; SCA49; UEF1"
                     /note="major polyA site"
     regulatory      7126..7131
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SAMD9L"
                     /gene_synonym="ATXPC; C7DELq; C7orf6; DEL7q; DRIF2;
                     M7MLS1; MLSM7; SCA49; UEF1"
                     /note="hexamer: AATAAA"
     polyA_site      7150
                     /gene="SAMD9L"
                     /gene_synonym="ATXPC; C7DELq; C7orf6; DEL7q; DRIF2;
                     M7MLS1; MLSM7; SCA49; UEF1"
                     /note="major polyA site"
ORIGIN      
        1 actctgacac accctcagaa agtcagagta ctgggagaac agaagacttc acaatttaat
       61 gcctcagttt ttaaaaaagg atccttacac ttcatgtctc ctagccatca gaagaggaat
      121 gagacagcaa aagttcaaat ggcctgtttc aagtttctga tataaaacga tgacattttc
      181 aggaaaatcc tgcatttcca gagagagact ggctggttaa atttctgaaa gaggacacca
      241 gctaaaagaa ggtattgcat ctcacccgag cagactgtgt ctgtggaaag tgtaagcccc
      301 ttgccagaag agcagcttcc cagcaaaggc agagggtgaa aacagcaaag gtcttaagac
      361 actggggacc tagagtcaaa agggacctcc tccagggaaa acgctgtgtg agaaatggcc
      421 tcattcggtg actgtgagtg acacagcaga aagttgggtc attccggctg cttttttgag
      481 aagtccctga agagatcaat aacagcaaga gggaacctgg caaggaagct attcctataa
      541 tccaggaaag agatgaggaa ggcttggacc aggtggtagt ggtgtcaggt agtcaaatgc
      601 tgggtatatt ttgaagatac accccatagg atttgctcca cattgaatgt ggaatgctgg
      661 aagagagata aagtgtacct gtcacatact ttttgagttt tatttatttt cttagaagta
      721 agtacacaaa gagatgctac ctaggagaag ggtattcttt tcactattct ttcaaatttt
      781 ctgtatgttc aaacattttc atagtagaaa gttgggggga aaatctgttt cataaacatt
      841 tcctcagcag cagtccagtc tattgcattt taattggttg tgatatcatt gttttatgca
      901 atacgttctc aacaagtata tcctccggca aactgaacaa ggaccaagtc tgttctgcct
      961 acagctctgc ttcctcatag ctgctttcca gaacgtgact cttgcaaatt atcaagaaag
     1021 gggaactaat ctaagggatc cagatcaaac agcctcatga agacttattt tatgtttcta
     1081 atataaagat agaagttttc agaaaagccc tgctacacag aggatcagag caggggtggg
     1141 cctgctgggc tgcagctggg attctgagca tcctttcccg gaggcacgga aagtgagtga
     1201 gtgagcccag tgaggaagaa gttgaagctt tgatatgagt aaacaagtat ctctacctga
     1261 aatgattaaa gactggacca aagagcatgt gaaaaaatgg gtaaatgaag accttaagat
     1321 taatgagcaa tacgggcaaa ttctgctcag tgaagaagta acaggattag tcctgcagga
     1381 attaactgag aaggaccttg tagaaatggg gctaccatgg ggtccagcac ttttgataaa
     1441 acgttcatac aacaaattga atagtaagtc ccctgaaagt gacaatcatg atccgggaca
     1501 attagataat tcaaaaccgt ccaaaacaga acaccagaaa aatccaaaac acaccaaaaa
     1561 ggaagaagaa aattcaatgt catctaatat tgattatgat cccagagaga tcagagatat
     1621 caaacaagaa gaatcaattc ttatgaaaga aaatgtgtta gatgaagtag caaatgctaa
     1681 acacaagaaa aagggtaagc taaaacctga acaattgact tgtatgccat atccttttga
     1741 tcagttccat gacagccatc gctacataga acattatact ctacaacctg aaacaggagc
     1801 actcaatctc attgatccaa tacatgagtt caaagctctc acaaacacag aaacagccac
     1861 ggaagtggac attaagatga aattcagcaa tgaagtcttc cgatttgcat cagcttgtat
     1921 gaattcacgc accaatggca ccatccattt tggagtcaag gacaaacccc atggagaaat
     1981 tgttggtgtg aaaatcacca gtaaggctgc cttcattgac cacttcaatg taatgatcaa
     2041 aaagtatttt gaagaaagtg agatcaatga agccaagaag tgtattcggg agccaaggtt
     2101 tgtggaagtc cttctgcaga acaatacacc atctgacaga tttgtcattg aagttgatac
     2161 tattccaaaa cactctatat gtaatgataa gtatttctac attcagatgc aaatttgtaa
     2221 agataaaata tggaaacaaa accaaaatct ttcactgttt gtaagagaag gggctagctc
     2281 tagggatatc ctggccaatt ccaagcaacg ggatgtagat ttcaaggcat ttttacaaaa
     2341 tttaaagtca ctggtagcat ctagaaaaga ggctgaagaa gagtatggaa tgaaggcaat
     2401 gaagaaggag agtgaaggac taaagctggt taaacttctc ataggaaacc gagactcact
     2461 ggataattca tactatgact ggtacattct tgtaacaaat aaatgccatc caaaccaaat
     2521 aaagcactta gattttttaa aagaaattaa atggtttgct gtgttggagt ttgatcctga
     2581 atctatgatc aatggagtgg tcaaagctta caaagaaagt cgggtggcaa accttcactt
     2641 tccaaatcaa tatgaagaca agacaactaa catgtgggag aagatttcta ctcttaatct
     2701 ttaccaacag cccagctgga ttttctgcaa cggcagatca gacctgaaaa gcgagacata
     2761 taaacctcta gaaccacatt tatggcagag agaaagagct tcagaagtca ggaaactaat
     2821 tttatttctc acagatgaaa atataatgac aagaggaaaa tttttggtag tgtttctatt
     2881 actctcttca gtggaaagcc caggagatcc actcattgaa actttctggg ctttctatca
     2941 agctctcaaa ggaatggaaa atatgttgtg tatctctgta aactcacata tttatcaacg
     3001 atggaaagat ctactacaaa caagaatgaa gatggaagat gaactaacaa accacagtat
     3061 ttccacttta aatatagaac tggtaaacag cactatcctt aaactaaaat cggtgactcg
     3121 gtcatcaaga aggtttttgc ccgcccgtgg atcttcttca gttatcctag agaaaaagaa
     3181 agaggatgtc ttgactgcac tggaaatcct ctgtgaaaat gagtgtacag agacagacat
     3241 cgagaaagac aaatctaaat tcctggagtt taagaaatca aaagaagaac acttttatcg
     3301 aggtggcaaa gtatcctggt ggaacttcta tttttcttct gaaaactatt cttcagattt
     3361 tgttaaaagg gacagttatg aaaagcttaa agatttaata cactgctggg cagagtctcc
     3421 taaaccaata tttgcaaaaa tcatcaatct ttatcatcat ccaggctgtg gaggtaccac
     3481 actggctatg catgttctct gggacttaaa gaaaaacttc agatgtgctg tgttaaaaaa
     3541 caagacaact gattttgcag aaattgcaga gcaagtgatc aatctggtca cctatagggc
     3601 aaagagccat caggattaca ttcctgtgct tctccttgtg gatgattttg aagaacaaga
     3661 aaatgtctac tttctacaaa atgccatcca ttccgtttta gcagaaaagg atttgcgata
     3721 tgaaaaaaca ttggtaatta tcttaaactg catgagatcc cggaatccag atgaaagtgc
     3781 aaaattggca gacagtattg cactaaatta ccaactttct tccaaggaac aaagagcttt
     3841 tggtgccaaa ctgaaggaaa ttgaaaagca gcacaagaac tgtgaaaact tttattcctt
     3901 catgatcatg aaaagcaatt ttgatgaaac atatatagaa aatgtagtca ggaatatcct
     3961 aaaaggacag gatgttgaca gcaaggaagc acaactcatt tccttcctgg ctttactcag
     4021 ctcttatgtt actgactcta caatttcagt ttcacagtgt gaaatatttt tgggaatcat
     4081 atacactagt acaccctggg aacctgaaag cttagaagac aagatgggaa cttattctac
     4141 acttctaata aaaacagaag ttgcagaata tgggagatac acaggtgtgc gtatcattca
     4201 ccctctgatt gccctgtact gtctaaaaga actggaaaga agctatcact tggataaatg
     4261 tcaaattgca ttgaatatat tagaagagaa tttattctat gattctggaa taggaagaga
     4321 caaatttcaa catgatgttc aaactcttct gcttacaaga cagcgcaagg tgtatggaga
     4381 tgaaacagac actctgtttt ccccattaat ggaagcttta cagaataaag acattgaaaa
     4441 ggtcttgagt gcaggaagta gacgattccc acaaaatgca ttcatttgtc aagccttagc
     4501 aagacatttc tacattaaag agaaggactt taacacagct ctggactggg cacgtcaggc
     4561 caaaatgaaa gcacctaaaa attcctatat ttcagataca ctaggtcaag tctacaaaag
     4621 tgaaatcaaa tggtggttgg atgggaacaa aaactgtagg agcattactg ttaatgacct
     4681 aacacatctc ctagaagctg cggaaaaagc ctcaagagct ttcaaagaat cccaaaggca
     4741 aactgatagt aaaaactatg aaaccgagaa ctggtcacca cagaagtccc agagacgata
     4801 tgacatgtat aacacagctt gtttcttggg tgaaatagaa gttggtcttt acactatcca
     4861 gattcttcag ctcactccct ttttccacaa agaaaatgaa ttatccaaaa aacatatggt
     4921 gcaattttta tcaggaaagt ggaccattcc tcctgatccc agaaatgaat gttatttggc
     4981 tcttagcaag ttcacatccc acctaaaaaa tttacaatca gatctgaaaa ggtgctttga
     5041 cttttttatt gattatatgg ttcttctgaa aatgaggtat acccaaaaag aaattgcaga
     5101 aatcatgtta agcaagaaag tcagtcgttg tttcaggaaa tacacagaac ttttctgtca
     5161 tttggatcca tgtctattac aaagtaaaga gagtcaatta ctccaggagg agaattgcag
     5221 gaaaaagcta gaagctctga gagcagatag gtttgctgga ctcttggaat atcttaatcc
     5281 aaactacaaa gatgctacca ccatggaaag tatagtgaat gaatatgcct tcctactgca
     5341 gcaaaactca aaaaagccca tgacaaatga gaaacaaaat tccattttgg ccaacattat
     5401 tctgagttgt ctaaagccca actccaagtt aattcaacca cttaccacgc taaaaaaaca
     5461 actccgagag gtcttgcaat ttgtaggact aagtcatcaa tatccaggtc cttatttctt
     5521 ggcctgcctc ctgttctggc cagaaaatca agagctagat caagattcca aactaataga
     5581 aaagtatgtt tcatccttaa atagatcctt caggggacag tacaagcgca tgtgcaggtc
     5641 caagcaggca agcacacttt tctatctggg caaaaggaag ggtctaaaca gtattgttca
     5701 caaggccaaa atagagcagt actttgataa agcacaaaat acaaattccc tctggcacag
     5761 tggggatgtg tggaaaaaaa atgaagtcaa agacctcctg cgtcgtctaa ctggtcaggc
     5821 tgaaggcaag ctaatctctg tagaatatgg aacagaggaa aaaataaaaa taccagtaat
     5881 atctgtttat tcaggtccac tcagaagtgg taggaacata gaaagagtgt ctttctacct
     5941 aggattttcc attgaaggcc ctctggcata tgatatagaa gtaatttaag acaatacatc
     6001 acctgtagtt caaatacgtt tatttatatc tttatgattt tattctctct ctctattctc
     6061 atggcacttt cataacatta tggctaacct ctaattacag attttgcttt tgcctccctg
     6121 aatgaattac aagccttttt aagatatgaa atatgcctac ccgcagagct tggcacaaag
     6181 tggagtcaat cttttaatgt tttaaatatg cattttcaga ctcaaataat taagaagttt
     6241 cattgatatc cactggtcac atcataactg tctatagggc aataaaatct gtgttaaact
     6301 caattgcttt tataagtttt ctaaattatt tcttcactgt gacagcaaag atttaaataa
     6361 gatgaatgta aaagagaaag cttattggac tcaaacccac agatccacac cagagttcta
     6421 tttacctcat cttggtatca ataaaaactt atgtggaagg taaatatatt gttccccatc
     6481 caccacataa cactctcccc aacacacaca cacacacaca cacacacaca cacacacaca
     6541 cacactcctt gtaccccttg cccttctccc agctcattgc tccaggagag agaagagttc
     6601 aaaaaataaa gtaatcataa acttgaactc tctccattct cttgttccca tttacaggtg
     6661 aatctcttcc tttaagccat ttttgtctcc tgtgaataca gccttatctc cacctgtttc
     6721 ttagatccca tctcccctgg cttatttttt ccattcatta ccctctttgt tccctttact
     6781 tctcaacctg tgctatatac atgctgttct ctctgttgag attgccttat ttccatctaa
     6841 cattctctct cctgctattc tgatttgtca ttcacaactg atttcaagag tcaccttcac
     6901 caggaagtct tccttgacca ccatcattcc tgcctgatta gagggcttcc tcatggtaat
     6961 atgtgttctc aagttttcag tgtcaaggaa tgccatccca gaagctcatt ctcagatgca
     7021 caacagccag aacagtctca agcagcattc tagagcttgg aatttaagaa ctacgcattg
     7081 cctataaagt gaaacatagg ctaatataga ttaaattgaa tattgaataa aaaatatatt
     7141 tatttatcca
//
